| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Sirove. New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochimica et biophysica acta. vol 1432. issue 2. 1999-08-20. PMID:10407139. |
furthermore, other investigations suggest that gapdh is involved in apoptosis, age-related neurodegenerative disease, prostate cancer and viral pathogenesis. |
1999-08-20 |
2023-08-12 |
Not clear |
| P P Michel, N Lambeng, M Ruber. Neuropharmacologic aspects of apoptosis: significance for neurodegenerative diseases. Clinical neuropharmacology. vol 22. issue 3. 1999-07-21. PMID:10367178. |
neuropharmacologic aspects of apoptosis: significance for neurodegenerative diseases. |
1999-07-21 |
2023-08-12 |
Not clear |
| R Seidl, S Fang-Kircher, B Bidmon, N Cairns, G Lube. Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neuroscience letters. vol 260. issue 1. 1999-06-18. PMID:10027687. |
upregulation of p53 and apo-1/fas (cd95) precedes apoptosis in many cell types, and a potential role for these molecules has already been demonstrated in alzheimer's disease (ad) and several other neurodegenerative diseases. |
1999-06-18 |
2023-08-12 |
Not clear |
| P Klevenyi, O Andreassen, R J Ferrante, J R Schleicher, R M Friedlander, M F Bea. Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport. vol 10. issue 3. 1999-06-10. PMID:10208603. |
increasing evidence implicates apoptosis as a major mechanism of cell death in neurodegenerative diseases. |
1999-06-10 |
2023-08-12 |
mouse |
| R M Friedlander, J Yua. ICE, neuronal apoptosis and neurodegeneration. Cell death and differentiation. vol 5. issue 10. 1999-05-06. PMID:10203693. |
understanding the basic mechanisms mediating cell death in neurodegenerative disease may lead to the development of novel approaches for the treatment of diseases featuring apoptosis. |
1999-05-06 |
2023-08-12 |
Not clear |
| M Grilli, M Mem. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell death and differentiation. vol 6. issue 1. 1999-04-29. PMID:10200544. |
apoptosis is now recognized as an important component in many progressive and acute neurodegenerative diseases. |
1999-04-29 |
2023-08-12 |
Not clear |
| M Grilli, M Mem. Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell death and differentiation. vol 6. issue 1. 1999-04-29. PMID:10200544. |
identification of such mechanisms could be relevant for understanding the apoptosis associated with various neurodegenerative diseases as well as for developing novel strategies of pharmacological intervention. |
1999-04-29 |
2023-08-12 |
Not clear |
| D L Gelowitz, I A Paterso. Neuronal sparing and behavioral effects of the antiapoptotic drug, (-)deprenyl, following kainic acid administration. Pharmacology, biochemistry, and behavior. vol 62. issue 2. 1999-04-26. PMID:9972692. |
given deprenyl's antiapoptotic actions, it is proposed that (-)deprenyl may be beneficial in the treatment of a variety of neurodegenerative diseases where evidence of apoptosis exists, such as parkinson's and alzheimer's disease, by slowing the disease process itself. |
1999-04-26 |
2023-08-12 |
human |
| Y Miyata, S Takashim. [Child neurology and neuronal apoptosis: introductory remarks]. No to hattatsu = Brain and development. vol 31. issue 2. 1999-04-19. PMID:10191632. |
recently, it is suggested that apoptosis occurs in some neurodegenerative diseases of childhood as well as adulthood. |
1999-04-19 |
2023-08-12 |
Not clear |
| R P Mason, P R Leeds, R F Jacob, C J Hough, K G Zhang, P E Mason, D M Chuan. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. Journal of neurochemistry. vol 72. issue 4. 1999-04-13. PMID:10098848. |
agents such as amlodipine that block voltage-sensitive ca2+ channels and inhibit cellular oxidative stress may be effective in the treatment of cerebrovascular stroke and neurodegenerative diseases associated with excessive apoptosis. |
1999-04-13 |
2023-08-12 |
rat |
| A H Schapir. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia. Biochimica et biophysica acta. vol 1410. issue 2. 1999-03-18. PMID:10076024. |
this mode of cell death is thought to play an important role in neurodegenerative diseases and it is tempting to speculate that the observed mitochondrial defects in pd, hd and fa result directly in apoptotic cell death, or in the lowering of a cell's threshold to undergo apoptosis. |
1999-03-18 |
2023-08-12 |
Not clear |
| W G Tatton, C W Olano. Apoptosis in neurodegenerative diseases: the role of mitochondria. Biochimica et biophysica acta. vol 1410. issue 2. 1999-03-18. PMID:10076027. |
apoptosis in neurodegenerative diseases: the role of mitochondria. |
1999-03-18 |
2023-08-12 |
human |
| D Jesionek-Kupnicka, J Buczyński, R Kordek, T Sobów, I Kłoszewska, W Papierz, P P Libersk. Programmed cell death (apoptosis) in Alzheimer's disease and Creutzfeldt-Jakob disease. Folia neuropathologica. vol 35. issue 4. 1999-01-19. PMID:9833400. |
our study showed that apoptosis is a very important event in these neurodegenerative diseases and may become a basic mechanism in loss of neurons. |
1999-01-19 |
2023-08-12 |
mouse |
| Z Nagy, M M Esiri, A D Smit. The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience. vol 87. issue 4. 1998-12-30. PMID:9759963. |
recent research indicates that cell cycle disturbances may promote apoptosis in neurodegenerative diseases. |
1998-12-30 |
2023-08-12 |
human |
| P Desjardins, S Ledou. The role of apoptosis in neurodegenerative diseases. Metabolic brain disease. vol 13. issue 2. 1998-10-15. PMID:9699918. |
the role of apoptosis in neurodegenerative diseases. |
1998-10-15 |
2023-08-12 |
Not clear |
| I V Smirnova, S X Zhang, B A Citron, P M Arnold, B W Festof. Thrombin is an extracellular signal that activates intracellular death protease pathways inducing apoptosis in model motor neurons. Journal of neurobiology. vol 36. issue 1. 1998-09-30. PMID:9658339. |
important to concepts of disease and potential intervention is the exciting finding that apoptosis is also found after neurotrauma and in a number of neurodegenerative diseases. |
1998-09-30 |
2023-08-12 |
Not clear |
| P Kermer, N Klöcker, M Labes, M Bäh. Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 12. 1998-07-08. PMID:9614240. |
in summary, the data presented here provide further insight into the mechanisms of injury-induced neuronal apoptosis and could give rise to more effective therapeutic intervention strategies in cns trauma and neurodegenerative diseases. |
1998-07-08 |
2023-08-12 |
rat |
| M Dragunow, G A MacGibbon, P Lawlor, N Butterworth, B Connor, C Henderson, M Walton, A Woodgate, P Hughes, R L Faul. Apoptosis, neurotrophic factors and neurodegeneration. Reviews in the neurosciences. vol 8. issue 3-4. 1998-06-05. PMID:9548234. |
there is growing evidence supporting a role for apoptosis in some neurodegenerative diseases. |
1998-06-05 |
2023-08-12 |
human |
| M Dragunow, G A MacGibbon, P Lawlor, N Butterworth, B Connor, C Henderson, M Walton, A Woodgate, P Hughes, R L Faul. Apoptosis, neurotrophic factors and neurodegeneration. Reviews in the neurosciences. vol 8. issue 3-4. 1998-06-05. PMID:9548234. |
in this review we describe the evidence implicating apoptosis in neurodegenerative diseases with a particular emphasis on alzheimer's disease. |
1998-06-05 |
2023-08-12 |
human |
| T Kohji, M Hayashi, K Shioda, M Minagawa, Y Morimatsu, K Tamagawa, M Od. Cerebellar neurodegeneration in human hereditary DNA repair disorders. Neuroscience letters. vol 243. issue 1-3. 1998-05-14. PMID:9535131. |
recent findings have focused attention on the role of apoptosis in neurodegenerative diseases, however, the apoptotic process in child-onset brain disorders has been little investigated. |
1998-05-14 |
2023-08-12 |
human |