| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alfia Khaibullina, Luis E F Almeida, Sayuri Kamimura, Patricia M Zerfas, Meghann L Smith, Sebastian Vogel, Paul Wakim, Olavo M Vasconcelos, Martha M Quezado, Iren Horkayne-Szakaly, Zenaide M N Quezad. Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities. Blood cells, molecules & diseases. vol 86. 2021-06-30. PMID:32927249. |
strokes are feared complications of sickle cell disease (scd) and yield significant neurologic and neurocognitive deficits. |
2021-06-30 |
2023-08-13 |
mouse |
| Shantel A Vital, Elena Y Senchenkova, Junaid Ansari, Felicity N E Gavin. Targeting AnxA1/Formyl Peptide Receptor 2 Pathway Affords Protection against Pathological Thrombo-Inflammation. Cells. vol 9. issue 11. 2021-06-30. PMID:33202930. |
stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (scd). |
2021-06-30 |
2023-08-13 |
mouse |
| Yaqiong Chai, Chaoran Ji, Julie Coloigner, Soyoung Choi, Melissa Balderrama, Chau Vu, Benita Tamrazi, Thomas Coates, John C Wood, Sharon H O'Neil, Natasha Lepor. Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke. Brain and behavior. vol 11. issue 3. 2021-06-30. PMID:33434353. |
scd patients are at increased risks for strokes and neurocognitive deficit, even though neurovascular screening and treatments have lowered the rate of overt strokes. |
2021-06-30 |
2023-08-13 |
Not clear |
| Olivia Justice, Lori C Jordan, Chelsea A Lee, Niral J Patel, Spencer Waddle, Sumit Pruthi, L Taylor Davis, Adetola A Kassim, Manus J Donahu. Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease. Radiology research and practice. vol 2021. 2021-06-01. PMID:34055410. |
sickle cell disease (scd) is a well-characterized hemoglobinopathy affecting more than 20 million individuals worldwide and carries an increased risk of cerebral vasculopathy, cerebral infarct, and stroke. |
2021-06-01 |
2023-08-13 |
Not clear |
| Ramiro Manzano Núñez, Carlos Andrés Portilla Figueroa, Herney Andrés García-Perdom. Hydroxyurea can be used in children with sickle cell disease and cerebral vasculopathy for the prevention of chronic complications? A meta-analysis. Journal of child health care : for professionals working with children in the hospital and community. vol 24. issue 1. 2021-05-31. PMID:30606035. |
trials enrolling pediatric patients with scd and cerebral vasculopathy with or without previous episode of stroke and that reported outcomes of occurrence of stroke and other events were included. |
2021-05-31 |
2023-08-13 |
Not clear |
| Seung Yup Lee, Kyle R Cowdrick, Bharat Sanders, Eashani Sathialingam, Courtney E McCracken, Wilbur A Lam, Clinton H Joiner, Erin M Buckle. Noninvasive optical assessment of resting-state cerebral blood flow in children with sickle cell disease. Neurophotonics. vol 6. issue 3. 2021-05-14. PMID:31482101. |
indeed, the risk of stroke is 250 times higher in children with scd than in the general population. |
2021-05-14 |
2023-08-13 |
Not clear |
| Julie Coloigner, Chau Vu, Matthew Borzage, Adam Bush, Soyoung Choi, Xin Miao, Yaqiong Chai, Cristina Galarza, Natasha Lepore, Benita Tamrazi, Thomas D Coates, John C Woo. Transient Hypoxia Model Revealed Cerebrovascular Impairment in Anemia Using BOLD MRI and Near-Infrared Spectroscopy. Journal of magnetic resonance imaging : JMRI. vol 52. issue 5. 2021-05-14. PMID:32648323. |
obstructive sleep apnea and nocturnal oxygen desaturations, which are prevalent in sickle cell disease (scd) and chronic anemia disorders, have been linked to risks of stroke and silent cerebral infarcts (sci). |
2021-05-14 |
2023-08-13 |
Not clear |
| Caterina P Minniti, Ahmar U Zaidi, Mehdi Nouraie, Deepa Manwani, Gary D Crouch, Andrew S Crouch, Michael U Callaghan, Sarah Carpenter, Charleen Jacobs, Jin Han, Jena Simon, Jeffrey Glassberg, Victor R Gordeuk, Elizabeth S Kling. Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection. Blood advances. vol 5. issue 1. 2021-02-23. PMID:33570644. |
individuals with scd aged >50 years, with preexisting cardiopulmonary, renal disease, and/or stroke not receiving hydroxyurea, who present with high serum creatinine, lactate dehydrogenase, and d-dimer levels, are at higher risk of death, irrespective of genotype or sex. |
2021-02-23 |
2023-08-13 |
Not clear |
| Jia-Li Fen. Incidence and Predictors of Sudden Cardiac Death After a Major Non-Fatal Cardiovascular Event. Heart, lung & circulation. vol 29. issue 5. 2021-01-20. PMID:31109887. |
sudden cardiac death (scd) still accounts for the majority of deaths from the four major cardiovascular events (myocardial infarction (mi), heart failure (hf), atrial fibrillation (af), and stroke) despite substantial progress on prevention. |
2021-01-20 |
2023-08-13 |
Not clear |
| Hanne Stotesbury, Jamie M Kawadler, Patrick W Hales, Dawn E Saunders, Christopher A Clark, Fenella J Kirkha. Vascular Instability and Neurological Morbidity in Sickle Cell Disease: An Integrative Framework. Frontiers in neurology. vol 10. 2021-01-10. PMID:31474929. |
drawing upon work from other vascular beds in scd, as well as the wider stroke literature, we propose that macro-circulatory hyper-perfusion, regions of relative micro-circulatory hypo-perfusion, and an exhaustion of cerebral reserve mechanisms, together lead to a state of cerebral vascular instability. |
2021-01-10 |
2023-08-13 |
Not clear |
| Melanie E Fields, Amy E Mirro, Kristin P Guilliams, Michael M Binkley, Luisa Gil Diaz, Jessica Tan, Slim Fellah, Cihat Eldeniz, Yasheng Chen, Andria L Ford, Joshua S Shimony, Allison A King, Hongyu An, Christopher D Smyser, Jin-Moo Le. Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease. Annals of neurology. vol 88. issue 5. 2020-12-14. PMID:32869335. |
children with sickle cell disease (scd) experience cognitive deficits even when unaffected by stroke. |
2020-12-14 |
2023-08-13 |
Not clear |
| Lucy Charlotte Brennan, Fenella Jane Kirkham, Johanna Cristine Gavla. Sleep-disordered breathing and comorbidities: role of the upper airway and craniofacial skeleton. Nature and science of sleep. vol 12. 2020-11-19. PMID:33204196. |
osas is relatively common in scd populations, with hypoxia as a key manifestation, and sequelae including increased risk of stroke. |
2020-11-19 |
2023-08-13 |
Not clear |
| Motunrayo Oluwabukola Adekunle, Adeola Barakat Animasahun, Ijeoma Nnenna Diaku-Akinwumi, Olisamedua Fidelis Njokanm. Pattern of Cerebral Blood Flow Velocity Using Transcranial Doppler Ultrasonography in Children with Sickle Cell Disorder in Lagos State, Nigeria. Mediterranean journal of hematology and infectious diseases. vol 9. issue 1. 2020-10-01. PMID:28894559. |
the stroke prevention trial in sickle cell anaemia study (stop) recommends routine screening with transcranial doppler ultrasonography in children aged two to sixteen years with scd. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yaqiong Chai, Yi Lao, Yicen Li, Chaoran Ji, Sharon O'Neil, Yalin Wang, Natasha Lepore, John Woo. Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease. Proceedings of SPIE--the International Society for Optical Engineering. vol 10160. 2020-10-01. PMID:31178616. |
the corpus callosum (cc), as the largest and most prominent white matter (wm) structure in the brain, can reflect the chronic cerebrovascular damage resulting from silent strokes or infarctions in asymptomatic scd patients. |
2020-10-01 |
2023-08-13 |
human |
| Georg Stussi, Andreas Buser, Andreas Holbr. Red Blood Cells: Exchange, Transfuse, or Deplete. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. vol 46. issue 6. 2020-10-01. PMID:31933570. |
rbc exchange transfusions are standard treatment in scd patients with a history of or a risk for acute stroke and are clinical options for other acute complications of scd. |
2020-10-01 |
2023-08-13 |
Not clear |
| Baba P D Inusa, Laura Sainati, Corrina MacMahon, Raffaella Colombatti, Maddalena Casale, Silverio Perrotta, Paola Rampazzo, Claire Hemmaway, Soundrie T Padayache. An Educational Study Promoting the Delivery of Transcranial Doppler Ultrasound Screening in Paediatric Sickle Cell Disease: A European Multi-Centre Perspective. Journal of clinical medicine. vol 9. issue 1. 2020-09-28. PMID:31878188. |
effective stroke prevention in sickle cell disease (scd) is recommended for children with sickle cell anaemia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Fang-Fang Liu, Juan Wang, Fan Hu, Qing Wei, Ke L. Gene coexpression networks analysis of sickle stroke risk. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-08. PMID:31020690. |
stroke is one of the most destructive complications of sickle cell disease (scd), and scd is also the most common cause of childhood stroke. |
2020-09-08 |
2023-08-13 |
Not clear |
| Fang-Fang Liu, Juan Wang, Fan Hu, Qing Wei, Ke L. Gene coexpression networks analysis of sickle stroke risk. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-08. PMID:31020690. |
hub genes identified in this study could be potential targets for screening and prevention of stroke risk in scd children. |
2020-09-08 |
2023-08-13 |
Not clear |
| Danielle Terrell, Amey R Savardekar, Stephen Garrett Whipple, Rimal H Dossani, Robert F Spetzler, Hai Su. Cerebral Revascularization for Moyamoya Syndrome Associated with Sickle Cell Disease: A Systematic Review of the Literature on the Role of Extracranial-Intracranial Bypass in Treating Neurologic Manifestations of Pediatric Patients with Sickle Cell Disease. World neurosurgery. vol 137. 2020-07-13. PMID:32014541. |
moyamoya syndrome (mms) in patients with sickle cell disease (scd) accentuates the risk of recurrent strokes. |
2020-07-13 |
2023-08-13 |
Not clear |
| Danielle Terrell, Amey R Savardekar, Stephen Garrett Whipple, Rimal H Dossani, Robert F Spetzler, Hai Su. Cerebral Revascularization for Moyamoya Syndrome Associated with Sickle Cell Disease: A Systematic Review of the Literature on the Role of Extracranial-Intracranial Bypass in Treating Neurologic Manifestations of Pediatric Patients with Sickle Cell Disease. World neurosurgery. vol 137. 2020-07-13. PMID:32014541. |
chronic transfusion therapy (ctt) is an excellent option for preventing recurrent strokes in most patients with scd. |
2020-07-13 |
2023-08-13 |
Not clear |