| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria G Hernandez, Kendra J Lechtenberg, Todd C Peterson, Li Zhu, Tawaun A Lucas, Justice O Owah, Alanna I Dorsey, Andrew J Gentles, Marion S Buckwalte. Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824949. |
translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. |
2023-02-24 |
2023-08-14 |
Not clear |
| Victoria G Hernandez, Kendra J Lechtenberg, Todd C Peterson, Li Zhu, Tawaun A Lucas, Justice O Owah, Alanna I Dorsey, Andrew J Gentles, Marion S Buckwalte. Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824949. |
microglia initiated a rapid response to stroke at 4 hours by adopting an inflammatory profile associated with the recruitment of immune cells. |
2023-02-24 |
2023-08-14 |
Not clear |
| Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhan. CD11c Cell death & disease. vol 14. issue 2. 2023-02-24. PMID:36828819. |
additionally, the precise molecular communications between microglia and white matter repair during the stroke rehabilitation phase remain elusive. |
2023-02-24 |
2023-08-14 |
mouse |
| Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhan. CD11c Cell death & disease. vol 14. issue 2. 2023-02-24. PMID:36828819. |
in this current study, mri dti scan and immunofluorescence staining were performed to trace white matter and microglia in the mouse transient middle cerebral artery occlusion (tmcao) stroke model. |
2023-02-24 |
2023-08-14 |
mouse |
| Sanna H Loppi, Marco A Tavera-Garcia, Danielle A Becktel, Boaz K Maiyo, Kristos E Johnson, Thuy-Vi V Nguyen, Rick G Schnellmann, Kristian P Doyl. Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-02-11. PMID:36772984. |
increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke. |
2023-02-11 |
2023-08-14 |
mouse |
| Sanna H Loppi, Marco A Tavera-Garcia, Danielle A Becktel, Boaz K Maiyo, Kristos E Johnson, Thuy-Vi V Nguyen, Rick G Schnellmann, Kristian P Doyl. Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-02-11. PMID:36772984. |
these results indicate that chronic metabolic differences exist between stroked and control brains, including alterations in fatty acid metabolism and glycolysis within microglia in areas of degenerating white matter for at least 12 weeks after stroke. |
2023-02-11 |
2023-08-14 |
mouse |
| Komal Thapa, Kumar Shivam, Heena Khan, Amarjot Kaur, Kamal Dua, Sachin Singh, Thakur Gurjeet Sing. Emerging Targets for Modulation of Immune Response and Inflammation in Stroke. Neurochemical research. 2023-02-10. PMID:36763312. |
the innate immune activation stimulated by microglia during stroke results in the migration of macrophages and lymphocytes into the brain and are responsible for tissue damage. |
2023-02-10 |
2023-08-14 |
Not clear |
| A D Roseborough, S J Myers, R Khazaee, Y Zhu, L Zhao, E Iorio, F M Elahi, S H Pasternak, S N Whitehea. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-01. PMID:36721258. |
plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. |
2023-02-01 |
2023-08-14 |
Not clear |
| A D Roseborough, S J Myers, R Khazaee, Y Zhu, L Zhao, E Iorio, F M Elahi, S H Pasternak, S N Whitehea. Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-01. PMID:36721258. |
the aim of this study was to identify activation-state specific microglia evs (mevs) in vitro followed by validation in an experimental stroke model. |
2023-02-01 |
2023-08-14 |
Not clear |
| Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu, Yue Chen, Xuemei Li, Jun Wen, Qin Yan. Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway. Molecular biology reports. 2023-02-01. PMID:36725745. |
cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. |
2023-02-01 |
2023-08-14 |
Not clear |
| Vivianne E Morrison, Gregory J Bi. The meal Maketh the Microglia: Why studying microglial phagocytosis is critical to stroke research. Neurochemistry international. 2023-01-27. PMID:36707032. |
the meal maketh the microglia: why studying microglial phagocytosis is critical to stroke research. |
2023-01-27 |
2023-08-14 |
Not clear |
| Seung Gyu Choi, Juhee Shin, Ka Young Lee, Hyewon Park, Song I Kim, Yoon Young Yi, Dong Woon Kim, Hee-Jung Song, Hyo Jung Shi. PINK1 siRNA-loaded poly(lactic-co-glycolic acid) nanoparticles provide neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Glia. 2023-01-19. PMID:36655313. |
application of nanoparticles for pink1 inhibition attenuates rb-induced photothrombotic ischemic injury by inhibiting microglia responses, suggesting that a nanomedical approach targeting the pink1 pathway may provide a therapeutic avenue for stroke treatment. |
2023-01-19 |
2023-08-14 |
mouse |
| Sol Beccari, Virginia Sierra-Torre, Jorge Valero, Marta Pereira-Iglesias, Mikel García-Zaballa, Federico N Soria, Laura De Las Heras-Garcia, Alejandro Carretero-Guillen, Estibaliz Capetillo-Zarate, Maria Domercq, Paloma R Huguet, David Ramonet, Ahmed Osman, Wei Han, Cecilia Dominguez, Travis E Faust, Omar Touzani, Olatz Pampliega, Patricia Boya, Dorothy Schafer, Guillermo Mariño, Emmanuelle Canet-Soulas, Klas Blomgren, Ainhoa Plaza-Zabala, Amanda Sierr. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy. Autophagy. 2023-01-09. PMID:36622892. |
whereas microglia are very competent phagocytes under physiological conditions, we report their dysfunction in mouse and preclinical monkey models of stroke (macaques and marmosets) by transient occlusion of the medial cerebral artery (tmcao). |
2023-01-09 |
2023-08-14 |
mouse |
| Elias Sideris, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, Tatiana Segur. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. vol 5. issue 8. 2023-01-02. PMID:36589207. |
here, we show that the direct injection of a hyaluronic acid based microporous annealed particle (map) hydrogel into the stroke core in mice reduces the percent of highly reactive astrocytes, increases the percent of alternatively activated microglia, decreases cerebral atrophy and preserves nf200 axonal bundles. |
2023-01-02 |
2023-08-14 |
mouse |
| Elias Sideris, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, Tatiana Segur. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. vol 5. issue 8. 2023-01-02. PMID:36589207. |
this work shows that the injection of a porous scaffold into the stroke core can lead to clinically relevant decrease in cerebral atrophy and modulates astrocytes and microglia towards a pro-repair phenotype. |
2023-01-02 |
2023-08-14 |
mouse |
| Justin N Nguyen, Anjali Chauha. Bystanders or not? Microglia and lymphocytes in aging and stroke. Neural regeneration research. vol 18. issue 7. 2022-12-26. PMID:36571333. |
microglia and lymphocytes in aging and stroke. |
2022-12-26 |
2023-08-14 |
human |
| Justin N Nguyen, Anjali Chauha. Bystanders or not? Microglia and lymphocytes in aging and stroke. Neural regeneration research. vol 18. issue 7. 2022-12-26. PMID:36571333. |
preclinical strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged subjects. |
2022-12-26 |
2023-08-14 |
human |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
aged lipid-laden microglia display impaired responses to stroke. |
2022-12-21 |
2023-08-14 |
mouse |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
we tested whether this strategy restored microglia function and ameliorated stroke outcome in old mice. |
2022-12-21 |
2023-08-14 |
mouse |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
old microglia accumulated lipids under steady state and displayed exacerbated innate immune responses to stroke. |
2022-12-21 |
2023-08-14 |
mouse |