| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongyi Zhai, Yong Ma, Jingying Liu, Yulin Zhu, Kun Xie, Lingzhi Yu, Hao Zhan. Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-28. PMID:31885368. |
background brain-derived neurotrophic factor (bdnf) is one of the neurotrophic factors that modulate critical metabolic activities, including apoptosis, proliferation, and differentiation modulation. |
2020-05-28 |
2023-08-13 |
human |
| Yongyi Zhai, Yong Ma, Jingying Liu, Yulin Zhu, Kun Xie, Lingzhi Yu, Hao Zhan. Brain-Derived Neurotrophic Factor Alleviates Ropivacaine-Induced Neuronal Damage by Enhancing the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-28. PMID:31885368. |
conclusions bdnf can alleviate ropivacaine-induced neuronal injury by activating akt signaling pathway, consequently modulating the proliferation and apoptosis of neurons. |
2020-05-28 |
2023-08-13 |
human |
| Qingfa Chen, Hongling Ma, Xuewen Guo, Jia Liu, Ting Gui, Zhibo Ga. Farnesoid X Receptor (FXR) Aggravates Amyloid-β-Triggered Apoptosis by Modulating the cAMP-Response Element-Binding Protein (CREB)/Brain-Derived Neurotrophic Factor (BDNF) Pathway In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31812977. |
farnesoid x receptor (fxr) aggravates amyloid-β-triggered apoptosis by modulating the camp-response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) pathway in vitro. |
2020-05-21 |
2023-08-13 |
mouse |
| Qingfa Chen, Hongling Ma, Xuewen Guo, Jia Liu, Ting Gui, Zhibo Ga. Farnesoid X Receptor (FXR) Aggravates Amyloid-β-Triggered Apoptosis by Modulating the cAMP-Response Element-Binding Protein (CREB)/Brain-Derived Neurotrophic Factor (BDNF) Pathway In Vitro. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-05-21. PMID:31812977. |
low expression of fxr mostly reversed the aß-triggered neuronal apoptosis effect and prevented the reduction in creb and bdnf. |
2020-05-21 |
2023-08-13 |
mouse |
| Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wan. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochemistry international. vol 129. 2020-05-11. PMID:31220473. |
dexmedetomidine ameliorated ka-induced apoptosis, and this neuroprotective effect was accompanied by inhibited the ka-induced caspase-3 expression as well as mapks phosphorylation, and reversed bcl-2 down-expression, coupled with increased nrf2, bdnf and trkb expression in ka-treated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Hong Jin, Yi Zhu, Yiping Li, Xiuyu Ding, Wenqi Ma, Xiqiong Han, Bilei Wan. BDNF-mediated mitophagy alleviates high-glucose-induced brain microvascular endothelial cell injury. Apoptosis : an international journal on programmed cell death. vol 24. issue 5-6. 2020-05-05. PMID:30877409. |
the high-glucose treatment caused cell dysfunction, as evaluated by oxidative stress and cell apoptosis, which could be alleviated by bdnf. |
2020-05-05 |
2023-08-13 |
Not clear |
| Lu Gan, Menghuan Guo, Jing Si, Jinhua Zhang, Zhiyuan Liu, Jin Zhao, Fang Wang, Junfang Yan, Hongyan Li, Hong Zhan. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-03-23. PMID:31713449. |
in addition, expression levels of multiple genes related to neural development and apoptosis (sod2, bdnf, ache, p53, bax, and bcl-2) were compared by rt-pcr and associated protein expression levels by western blotting. |
2020-03-23 |
2023-08-13 |
cat |
| Feng Qiu, Yubo Zhou, Yeke Deng, Junzhi Yi, Mengting Gong, Ning Liu, Chenxi Wei, Shuanglin Xian. Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway. Chemosphere. vol 241. 2020-02-20. PMID:31683445. |
we found that exposure to dehp induced apoptosis and downregulated the expression of brain-derived neurotrophic factor (bdnf), synaptic proteins psd 95 and synapsin-1 while upregulated the expression of tnfaip1 and decreased the levels of phosphorylated akt, camk Ⅳ, catalytic subunits of pka and creb in creb signaling pathway. |
2020-02-20 |
2023-08-13 |
mouse |
| Feng Qiu, Yubo Zhou, Yeke Deng, Junzhi Yi, Mengting Gong, Ning Liu, Chenxi Wei, Shuanglin Xian. Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway. Chemosphere. vol 241. 2020-02-20. PMID:31683445. |
knockdown of tnfaip1 using tnfaip1 small interfering rna (sirna) expression vector prevented dehp from inhibiting creb pathway, thus reduced apoptosis and restored expression of bdnf, psd 95 and synapsin-1. |
2020-02-20 |
2023-08-13 |
mouse |
| Qin-Ying Li, Qiang Miao, Ruo-Xuan Sui, Liang Cao, Cun-Gen Ma, Bao-Guo Xiao, Wei Xiao, Wen-Bo Y. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis. International immunopharmacology. vol 75. 2020-02-13. PMID:31421546. |
further findings suggest that igf/pi3k, but not bdnf, was induced in the corpus callosum after gk treatment, revealing that nrf2 activation inhibited caspase-3 and apoptosis in o4+ oligodendrocytes possibly through igf/pi3k signaling molecules. |
2020-02-13 |
2023-08-13 |
Not clear |
| Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & function. vol 10. issue 9. 2020-02-11. PMID:31482900. |
in cultured mesencephalic dopamine neurons and sh-sy5y cell line, it was found that thsg protected the integrity of the cell body and neurite branching from mpp+-induced toxicity by restoring the expression of fgf2 and bdnf and their downstream signaling pathways to inhibit apoptosis and promote cell survival. |
2020-02-11 |
2023-08-13 |
mouse |
| Yutaro Obara, Norimichi Nakahat. The Signaling Pathway of Neurotrophic Factor Biosynthesis. Drug news & perspectives. vol 15. issue 5. 2019-11-20. PMID:12677225. |
there are various neurotrophic factors, such as nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), glial cell line-derived neurotrophic factor (gdnf) and interleukin-6 (il-6), which are essential for the promotion of neuronal survival (prevention of apoptosis), differentiation and regeneration in the central nervous system. |
2019-11-20 |
2023-08-12 |
Not clear |
| Alessia Bachis, Stuart J Rabin, Marina Del Fiacco, Italo Mocchett. Gangliosides prevent excitotoxicity through activation of TrkB receptor. Neurotoxicity research. vol 4. issue 3. 2019-11-20. PMID:12829403. |
we first examined the relative potency of the neurotrophins, brain derived neurotrophic factor (bdnf), neurotrophin-3 and nerve growth factor to prevent glutamate-mediated apoptosis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Alessia Bachis, Stuart J Rabin, Marina Del Fiacco, Italo Mocchett. Gangliosides prevent excitotoxicity through activation of TrkB receptor. Neurotoxicity research. vol 4. issue 3. 2019-11-20. PMID:12829403. |
both liga20 and bdnf blocked glutamate-mediated activation of caspase-3 and consequently apoptosis; however, the anticaspase-3 activity was seen only when these compounds were added to the cultures several hours before glutamate, suggesting that liga20 and bdnf share an identical molecular mechanism. |
2019-11-20 |
2023-08-12 |
Not clear |
| Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress. Brain research. vol 1701. 2019-11-04. PMID:30244113. |
in conclusion, our study revealed that resveratrol and dmf exerted promising antidepressant-like effects in cums rats that are mediated in part by suppressing the neuroinflammation, oxidative stress, apoptosis and up-regulating hippocampal bdnf and β-catenin levels. |
2019-11-04 |
2023-08-13 |
rat |
| Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa Liu, Feng-Yi Yan. Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction. Scientific reports. vol 8. issue 1. 2019-10-03. PMID:29615782. |
lipus pretreatment could also significantly decrease the neuronal cell apoptosis and upregulation of apoptosis-related signaling molecules and downregulation of brain-derived neurotrophic factor (bdnf) in brain tissues of mcao-treated mice. |
2019-10-03 |
2023-08-13 |
mouse |
| Chang-Mu Chen, Cheng-Tien Wu, Ting-Hua Yang, Shing-Hwa Liu, Feng-Yi Yan. Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction. Scientific reports. vol 8. issue 1. 2019-10-03. PMID:29615782. |
these results demonstrate that lipus effectively prevented the cerebral ischemia/reperfusion injury through apoptosis reduction and bdnf induction in a mcao mouse model. |
2019-10-03 |
2023-08-13 |
mouse |
| Maria S Spagnuolo, Aldo Donizetti, Lucia Iannotta, Vincenza Aliperti, Chiara Cupidi, Amalia C Bruni, Luisa Ciglian. Brain-derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29323721. |
the level of apoptosis markers, that is, cleaved caspase 3 and poly adp ribose polymerase (parp), was found increased in neurons treated with high cholesterol, but significantly lower when the cells were exposed to cholesterol in the presence of bdnf, thus suggesting a neuroprotective role of the neurotrophin, likely through its reducing effect of neuronal cholesterol uptake. |
2019-09-30 |
2023-08-13 |
human |
| Nandini H S, Yam Nath Paudel, Krishna K . Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk. Life sciences. vol 233. 2019-09-30. PMID:31348946. |
however, there is a growing understanding that metformin demonstrates its anti-epileptic effect mainly via ameliorating brain oxidative damage, activation of ampk, inhibition of mtor pathway, downregulation of α-synuclein, reducing apoptosis, downregulation of bdnf and trkb level. |
2019-09-30 |
2023-08-13 |
Not clear |
| Khaled S Abd-Elrahman, Stephen S G Ferguso. Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice. Molecular brain. vol 12. issue 1. 2019-07-31. PMID:30961637. |
we also show that ctep can facilitate camp response element-binding protein (creb)-mediated expression of brain-derived neurotrophic factor (bdnf) to foster neuronal survival and reduce apoptosis. |
2019-07-31 |
2023-08-13 |
mouse |