| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R U Ostrovskaya, S S Yagubova, T A Gudasheva, S B Seredeni. Antidiabetic Properties of Low-Molecular-Weight BDNF Mimetics Depend on the Type of Activation of Post-Receptor Signaling Pathways. Bulletin of experimental biology and medicine. vol 164. issue 6. 2018-09-19. PMID:29658083. |
reduced proliferation and enhanced apoptosis of β cells in diabetes mellitus are associated with a deficiency of brain-derived neurotrophic factor (bdnf). |
2018-09-19 |
2023-08-13 |
mouse |
| Lili Zhang, Zhaomin Fan, Yuechen Han, Lei Xu, Wenwen Liu, Xiaohui Bai, Meijuan Zhou, Jianfeng Li, Haibo Wan. Valproic Acid Promotes Survival of Facial Motor Neurons in Adult Rats After Facial Nerve Transection: a Pilot Study. Journal of molecular neuroscience : MN. vol 64. issue 4. 2018-09-18. PMID:29532368. |
but treatment of vpa significantly reduced cell apoptosis by decreasing the expression of bax protein and increased neuronal survival by upregulating the level of brain-derived neurotrophic factor (bdnf) and growth associated protein-43 (gap-43) expression in injured fmns compared with group ns. |
2018-09-18 |
2023-08-13 |
rat |
| Nevim Aygu. Biological and Genetic Features of Neuroblastoma and Their Clinical Importance. Current pediatric reviews. vol 14. issue 2. 2018-09-05. PMID:29380702. |
tyrosine kinase receptors trka, trkb and trkc, their ligands ngf, brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), and aurora kinase a (aurka) play a regulatory role in differentiation, apoptosis, cell proliferation, tumourigenesis, angiogenesis or metastasis of neuroblastoma. |
2018-09-05 |
2023-08-13 |
Not clear |
| Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Fahimeh Faraji, Shiva Mozaffar. The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28608236. |
in contrast, various doses of curcumin attenuated nicotine-induced apoptosis, oxidative stress and inflammation; while elevating p-creb and bdnf levels. |
2018-08-07 |
2023-08-13 |
rat |
| Alessia Bachis, Lee A Campbell, Kierra Jenkins, Erin Wenzel, Italo Mocchett. Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor. Neurotoxicity research. vol 32. issue 3. 2018-08-06. PMID:28776309. |
however, little is known about the effect of morphine withdrawal on bdnf and its precursor protein, or probdnf, which induces neuronal apoptosis. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
background melatonin therapy shows positive effects on neuroprotective factor brain-derived neurotrophic factor (bdnf) expression and neuronal apoptosis in neonatal hemolytic hyperbilirubinemia. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
brain tissue levels of neuronal apoptosis, bdnf expression, plc activity, ip3 content, phospho- and total ca2+/calmodulin-dependent protein kinase type iv (camkiv) expression, and phospho- and total camp response element binding protein (creb) expression were also assayed. |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
phz-induced hemolytic hyperbilirubinemia significantly decreased serum bdnf, brain bdnf, and plc/ip3/ca2+ pathway activation while increasing neuronal apoptosis levels (p<0.05), all of which were partially rescued by melatonin therapy (p<0.05). |
2018-08-06 |
2023-08-13 |
rat |
| Yong Luo, Mei Peng, Hong We. Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-08-06. PMID:29247156. |
pre-treatment with the plc inhibitor u73122 largely abolished the positive effects of melatonin on plc/ip3/ca2+ pathway activation, downstream bdnf levels, and neuronal apoptosis (p<0.05). |
2018-08-06 |
2023-08-13 |
rat |
| Jianhua Yuan, Ying Zhang, Xiaolin Wang, Hongbiao M. Exogenous Brain-Derived Neurotrophic Factor at a 50 ng/mL Concentration has a Significant Protective Effect on Bilirubin-Induced Cerebral Cortex Neuronal Injury. Clinical laboratory. vol 63. issue 9. 2018-08-01. PMID:28879697. |
this study aimed to investigate the effect of exogenous bdnf on the apoptosis and survival of in vitro cultured neurons injured by bilirubin as well as determine the optimal bdnf concentration. |
2018-08-01 |
2023-08-13 |
Not clear |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
long noncoding rna bdnf-as inversely regulated bdnf and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
the effects of bdnf-as downregulation on dgi apoptosis and bdnf expression were assessed by tunel assay, qpcr, and western blot, respectively. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
sirna-mediated bdnf-as downregulation ameliorated dgi apoptosis and upregulated bdnf in arpe-19 cells. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
in addition, inhibiting bdnf reversed the protective effect of bdnf-as downregulation on dgi apoptosis. |
2018-07-06 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
our results suggest that bdnf-as, through inverse regulation of bdnf, might play a critical role in the process of dgi apoptosis in diabetic retinopathy. |
2018-07-06 |
2023-08-13 |
human |
| Meng Ji, Wei Wang, Shujuan Li, Wenli H. Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983620. |
bmscs‑ad (bmscs infected with control lentiviral particles) and bmscs‑ad‑mir‑705 markedly mitigated neurological injury, suppressed morphological damage and inhibited neuronal apoptosis, however promoted the mrna levels of brain‑derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) examined by reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2018-06-26 |
2023-08-13 |
mouse |
| Meng Ji, Wei Wang, Shujuan Li, Wenli H. Implantation of bone mesenchymal stem cells overexpressing miRNA‑705 mitigated ischemic brain injury. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983620. |
these data indicated that bmscs‑ad‑mir‑705 promoted the secretion of vegf and bdnf, suppressed neuronal apoptosis, and stimulated neuronal regeneration, in turn mitigating the impairment of ischemic brain damage. |
2018-06-26 |
2023-08-13 |
mouse |
| Marika Cordaro, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposit. Fumaric Acid Esters Attenuate Secondary Degeneration after Spinal Cord Injury. Journal of neurotrauma. vol 34. issue 21. 2018-06-22. PMID:27889959. |
faes significantly reduced the severity of inflammation by a modulation of pro-inflammatory cytokines and apoptosis factors, and increased neutrophic factors such as anti-brain-derived neurotrophic factor (bdnf), anti-glial cell-derived neurotrophic factor (gdnf), and neurotrophin-3 (nt3). |
2018-06-22 |
2023-08-13 |
mouse |
| Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Matheus Grunevald, Letícia F Pettenuzzo, Giselli Scaini, Emilio L Streck, Carlos A Netto, Angela T S Wys. Methylphenidate Causes Behavioral Impairments and Neuron and Astrocyte Loss in the Hippocampus of Juvenile Rats. Molecular neurobiology. vol 54. issue 6. 2018-05-10. PMID:27324900. |
bdnf and ptrkb immunocontents and ngf levels were decreased, while tnf-α and il-6 levels, iba-1 and caspase 3 cleaved immunocontents (microglia marker and active apoptosis marker, respectively) were increased. |
2018-05-10 |
2023-08-13 |
rat |
| Jian-Bin Zhong, Xie Li, Si-Ming Zhong, Jiu-Di Liu, Chi-Bang Chen, Xiao-Yan W. Knockdown of long noncoding antisense RNA brain-derived neurotrophic factor attenuates hypoxia/reoxygenation-induced nerve cell apoptosis through the BDNF-TrkB-PI3K/Akt signaling pathway. Neuroreport. vol 28. issue 14. 2018-05-02. PMID:28777258. |
brain-derived neurotrophic factor (bdnf) plays an important role in neuronal cell apoptosis. |
2018-05-02 |
2023-08-13 |
human |