| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinchun Ye, Lu Yu, Dandan Zuo, Liang Zhang, Jie Zu, Jinxia Hu, Jiao Tang, Lei Bao, Chengcheng Cui, Ruixue Zhang, Guoliang Jin, Kun Zan, Zuohui Zhang, Xinxin Yang, Hongjuan Shi, Zunsheng Zhang, Qihua Xiao, Yonghai Liu, Jie Xiang, Xueling Zhang, Guiyun Cu. Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway. Neuroscience letters. vol 654. 2018-04-17. PMID:28642149. |
morever, pretreatment with exogenous bdnf protected bv2 cells against ogd/r induced apoptosis and release of inflammatory cytokines. |
2018-04-17 |
2023-08-13 |
Not clear |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
in rats with sepsis, a sharp decline in survival was observed after clp, with significantly reduced cardiac bdnf expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (no) synthase (enos) and no. |
2018-04-17 |
2023-08-13 |
rat |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
supplementation with recombined bdnf protein (rhbdnf) enhanced myocardial bdnf and increased survival rate with improved cardiac function, reduced oxidative stress, and myocardial apoptosis, which were associated with increased enos expression, no production, and trk-b, a bdnf receptor. |
2018-04-17 |
2023-08-13 |
rat |
| Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xia. Brain-Derived Neurotrophic Factor Attenuates Septic Myocardial Dysfunction via eNOS/NO Pathway in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28770018. |
it is concluded that bdnf protects the heart against septic cardiac dysfunction by reducing oxidative stress and apoptosis via trk-b, and it does so through activation of enos/no pathway. |
2018-04-17 |
2023-08-13 |
rat |
| Jin Chen, Yuanyuan Yang, Lihua Shen, Wensen Ding, Xiang Chen, Erbing Wu, Kefu Cai, Guohua Wan. Hypoxic Preconditioning Augments the Therapeutic Efficacy of Bone Marrow Stromal Cells in a Rat Ischemic Stroke Model. Cellular and molecular neurobiology. vol 37. issue 6. 2018-04-10. PMID:27858286. |
moreover, hp decreased neuronal apoptosis and enhanced the expression of bdnf and vegf in the ischemic brain. |
2018-04-10 |
2023-08-13 |
rat |
| Bangkun Yang, Jun Qin, Ying Nie, Yong Li, Qianxue Che. Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells. Neuroreport. vol 28. issue 12. 2018-04-02. PMID:28640008. |
the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and the apoptosis assay were used to assess the effects of the bdnf propeptide on the growth and apoptosis of glioma cells. |
2018-04-02 |
2023-08-13 |
Not clear |
| Bangkun Yang, Jun Qin, Ying Nie, Yong Li, Qianxue Che. Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells. Neuroreport. vol 28. issue 12. 2018-04-02. PMID:28640008. |
we found that the bdnf propeptide promoted c6 glioma cell apoptosis and decreased in-vitro cell growth. |
2018-04-02 |
2023-08-13 |
Not clear |
| D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenk. [The Effects of Chronic Alcoholization on the Expression of Brain-Derived Neurotrophic Factor and Its Receptors in the Brains of Mice Genetically Predisposed to Depressive-Like Behavior]. Molekuliarnaia biologiia. vol 51. issue 4. 2018-03-23. PMID:28900083. |
precursor protein of this factor (probdnf) can initiate apoptosis in the brain, while the mature form of bdnf is involved in neurogenesis. |
2018-03-23 |
2023-08-13 |
mouse |
| Weidong Huang, Facai Meng, Jie Cao, Xiaobin Liu, Jie Zhang, Min L. Neuroprotective Role of Exogenous Brain-Derived Neurotrophic Factor in Hypoxia-Hypoglycemia-Induced Hippocampal Neuron Injury via Regulating Trkb/MiR134 Signaling. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28343294. |
we found that bdnf, p-trkb, and mir-134 expression levels decreased, and that exogenous bdnf increased survival and reduced apoptosis in hypoxic-hypoglycemic hippocampal neurons. |
2018-03-06 |
2023-08-13 |
Not clear |
| Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeri. Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors. European journal of cell biology. vol 96. issue 3. 2018-03-02. PMID:28336086. |
we confirm these results by demonstrating that glp-1 and gip also inhibit apoptosis of primary murine microglia, and upregulate expression of bdnf by primary murine microglia. |
2018-03-02 |
2023-08-13 |
human |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal bdnf and mrna expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
we also examined alternations in hippocampal brain-derived neurotrophic factor (bdnf) and mrna expression of apoptosis - related proteins in a rat model of ptsd: the single prolonged stress (sps) model. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
sps rats also showed reduced hippocampal bdnf and enhanced apoptosis. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
moderate treadmill exercise, fluoxetine and the combined treatment alleviated the sps-induced alterations in terms of anxiety levels, hpa axis inhibition, ia conditioning and extinction, hippocampal bdnf and apoptosis markers. |
2018-02-26 |
2023-08-13 |
rat |
| Wenbo Li, Jiyu Lou, Liping Wei, Hongying Bai, Yaohui Zhang, Yuqing H. Ethyl pyruvate protects PC12 cells from oxygen-glucose deprivation: A potential role in ischemic cerebrovascular disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-02-05. PMID:28538193. |
result showed that ep alleviated ogd-diminished cells viability, ogd-induced apoptosis, and ogd-reduced expressions of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf) and nestin in pc-12 cells. |
2018-02-05 |
2023-08-13 |
rat |
| Shao-Hua Su, Yue-Qing Wang, Yi-Fang Wu, Da-Peng Wang, Qi Lin, Jian Ha. Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling. Behavioural brain research. vol 313. 2018-01-25. PMID:27424778. |
moreover, win and urb reversed the decreases in map-2 and synaptophysin expression resulting from cch, and stimulated bdnf and cb1 expression as well as creb, foxo3a, gsk-3β, and bad phosphorylation, confirming that win and urb mediate neuroprotection by preventing neuronal apoptosis and improving cognition via pi3k/akt signaling. |
2018-01-25 |
2023-08-13 |
rat |
| A B Ozer, S Ceribasi, A O Ceribasi, I Demirel, M K Bayar, B Ustundag, A Ileri, O L Erha. Effects of sevoflurane on apoptosis, BDNF and cognitive functions in neonatal rats. Bratislavske lekarske listy. vol 118. issue 2. 2017-12-08. PMID:28814087. |
effects of sevoflurane on apoptosis, bdnf and cognitive functions in neonatal rats. |
2017-12-08 |
2023-08-13 |
rat |
| Shahdat Hossain, Sujan Bhowmick, Sabrin Jahan, Liza Rozario, Marzan Sarkar, Saiful Islam, Mafroz Ahmed Basunia, Azizur Rahman, Bazlul Karim Choudhury, Hussain Shahjala. Maternal lead exposure decreases the levels of brain development and cognition-related proteins with concomitant upsurges of oxidative stress, inflammatory response and apoptosis in the offspring rats. Neurotoxicology. vol 56. 2017-11-20. PMID:27492863. |
we studied whether gestational/lactational pb-exposure affects oxidative stress, proinflammatory response, apoptosis and levels of brain development/cognition-related proteins, including presynaptic synaptosome-associated protein-25 (snap-25), postsynaptic density protein-95 (psd-95), brain-derived neurotropic factor (bdnf), tyrosine receptor-kinase protein b (trkb) and vesicular acetylcholine transporter (vacht) in the offspring. |
2017-11-20 |
2023-08-13 |
rat |
| Tae-Woon Kim, Yun-Hee Sun. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice. Neuroscience. vol 346. 2017-11-09. PMID:28108255. |
we found decreased memory ability in eae mice, accompanied by impaired myelination, increased apoptosis and cell proliferation, and decreased bdnf in the hippocampus. |
2017-11-09 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Yun-Hee Sun. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice. Neuroscience. vol 346. 2017-11-09. PMID:28108255. |
the memory decline and changes in demyelination, apoptosis, bdnf, and cell proliferation were partially reversed in eae+ex mice. |
2017-11-09 |
2023-08-13 |
mouse |