| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Xiong, Xiaofeng Deng, Yu Wen, Zhulin Yang, Xiongying Mia. Association of BDNF and BMPR1A with clinicopathologic parameters in benign and malignant gallbladder lesions. World journal of surgical oncology. vol 11. 2015-04-14. PMID:23531103. |
neurotrophic factors such as brain derived neurotrophic factor (bdnf) are synthesized in a variety of neural and non-neuronal cell types and regulate survival, proliferation and apoptosis. |
2015-04-14 |
2023-08-12 |
Not clear |
| B Yin, Z Y Ma, Z W Zhou, W C Gao, Z G Du, Z H Zhao, Q Q L. The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model. Oncogene. vol 34. issue 6. 2015-04-10. PMID:24531713. |
we showed that paclitaxel induced bdnf expression and apoptosis simultaneously in a cell cycle-dependent manner. |
2015-04-10 |
2023-08-12 |
mouse |
| Erica D Smith, G Aleph Prieto, Liqi Tong, Ilse Sears-Kraxberger, Jeffrey D Rice, Oswald Steward, Carl W Cotma. Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. The Journal of biological chemistry. vol 289. issue 30. 2015-02-11. PMID:24917666. |
these findings reveal a novel mechanism of bdnf neuroprotection; bdnf not only prevents apoptosis through inhibiting caspase activation but also promotes neuron survival through modulation of autophagy. |
2015-02-11 |
2023-08-13 |
rat |
| Jocelyn M Wessels, Liang Wu, Nicholas A Leyland, Hongmei Wang, Warren G Foste. The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (Ntrk2) are conserved in the mammalian uterus. PloS one. vol 9. issue 4. 2015-01-06. PMID:24714156. |
together bdnf and ntrk2 are capable of activating the adhesion, angiogenesis, apoptosis, and proliferation pathways. |
2015-01-06 |
2023-08-13 |
mouse |
| Xiao-Yuan Mao, Dan-Feng Cao, Xi Li, Ji-Ye Yin, Zhi-Bin Wang, Ying Zhang, Chen-Xue Mao, Hong-Hao Zhou, Zhao-Qian Li. Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. International journal of molecular sciences. vol 15. issue 5. 2015-01-06. PMID:24857910. |
it is concluded that hupa ameliorates dacd via modulating bdnf, oxidative stress, inflammation and apoptosis. |
2015-01-06 |
2023-08-13 |
rat |
| Xiao-Long Sun, Bei-Yu Chen, Li Duan, Yi Xia, Zhuo-Jing Luo, Jing-Jie Wang, Zhi-Ren Rao, Liang-Wei Che. The proform of glia cell line-derived neurotrophic factor: a potentially biologically active protein. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23934644. |
growing evidences have revealed that the proforms of several neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt3), by binding to p75 neurotrophin receptor and sortilin, could induce neuronal apoptosis and are implicated in the pathogenesis of various neurodegenerative diseases. |
2014-10-27 |
2023-08-12 |
Not clear |
| Gab Seok Kim, Seongeun Cho, James W Nelson, Gregory J Zipfel, Byung Hee Ha. TrkB agonist antibody pretreatment enhances neuronal survival and long-term sensory motor function following hypoxic ischemic injury in neonatal rats. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551199. |
we found that 29d7, to a similar extent to bdnf, significantly inhibited activation of caspase-3, a biochemical hallmark of apoptosis, following h-i injury. |
2014-10-21 |
2023-08-12 |
rat |
| Weiyun Li, Shucai Ling, Yang Yang, Zhiying Hu, Henry Davies, Marong Fan. Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments. Neuro endocrinology letters. vol 35. issue 2. 2014-09-25. PMID:24878979. |
neurotrophins, especially brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) both play various roles in the central nervous system (cns), attenuate apoptosis in cultured neurons, stimulate neurogenesis and increase survival and protect neuronal tissues from cell death induced by ischemia or depression. |
2014-09-25 |
2023-08-13 |
Not clear |
| Anna M Lavezzi, Melissa F Corna, Luigi Matturr. Disruption of the brain-derived neurotrophic factor (BDNF) immunoreactivity in the human Kölliker-Fuse nucleus in victims of unexplained fetal and infant death. Frontiers in human neuroscience. vol 8. 2014-09-19. PMID:25237300. |
we applied immunohistochemistry in formalin-fixed and paraffin-embedded brainstem samples (from 45 fetuses and newborns died of both known and unknown causes), to analyze bdnf, gliosis and apoptosis patterns of manifestation. |
2014-09-19 |
2023-08-13 |
human |
| Yongzhi Fan, Jingli Chen, Jun Ye, Hong Yan, Yi Ca. Proteinase-activated receptor 2 modulates corticotropin releasing hormone-induced brain-derived neurotrophic factor release from microglial cells. Cell biology international. vol 38. issue 1. 2014-07-24. PMID:24174309. |
tryptase-induced par2 activation reduced the frequency of apoptosis of microglia, but enhanced the bdnf levels in the culture medium, which was partially blocked by par2 antagonists. |
2014-07-24 |
2023-08-12 |
Not clear |
| Edward C Lauterbac. Neuroprotective effects of psychotropic drugs in Huntington's disease. International journal of molecular sciences. vol 14. issue 11. 2014-06-03. PMID:24248060. |
in hd preclinical models, while no psychotropic has convincingly affected huntingtin gene, hd modifying gene, or huntingtin protein expression, psychotropic neuroprotective effects include upregulated huntingtin autophagy (lithium), histone acetylation (lithium, valproate, lamotrigine), mir-222 (lithium-plus-valproate), mitochondrial protection (haloperidol, trifluoperazine, imipramine, desipramine, nortriptyline, maprotiline, trazodone, sertraline, venlafaxine, melatonin), neurogenesis (lithium, valproate, fluoxetine, sertraline), and bdnf (lithium, valproate, sertraline) and downregulated ap-1 dna binding (lithium), p53 (lithium), huntingtin aggregation (antipsychotics, lithium), and apoptosis (trifluoperazine, loxapine, lithium, desipramine, nortriptyline, maprotiline, cyproheptadine, melatonin). |
2014-06-03 |
2023-08-12 |
mouse |
| Jing Xiong, Li Zhou, Yoon Lim, Miao Yang, Yu-Hong Zhu, Zhi-Wei Li, Fiona H Zhou, Zhi-Cheng Xiao, Xin-Fu Zho. Mature BDNF promotes the growth of glioma cells in vitro. Oncology reports. vol 30. issue 6. 2014-05-13. PMID:24064679. |
in the present study using specific mature bdnf antibodies, we found that mature bdnf inhibited c6 glioma cell apoptosis and increased cell growth and migration in vitro. |
2014-05-13 |
2023-08-12 |
Not clear |
| Chih-Yang Lin, Sunny Li-Yun Chang, Yi-Chin Fong, Chin-Jung Hsu, Chih-Hsin Tan. Apoptosis signal-regulating kinase 1 is involved in brain-derived neurotrophic factor (BDNF)-enhanced cell motility and matrix metalloproteinase 1 expression in human chondrosarcoma cells. International journal of molecular sciences. vol 14. issue 8. 2014-04-07. PMID:23892595. |
apoptosis signal-regulating kinase 1 is involved in brain-derived neurotrophic factor (bdnf)-enhanced cell motility and matrix metalloproteinase 1 expression in human chondrosarcoma cells. |
2014-04-07 |
2023-08-12 |
human |
| Yun-Xiao Sun, Jian Yang, Ping-Yu Wang, You-Jie Li, Shu-Yang Xie, Ruo-Peng Su. Cisplatin regulates SH-SY5Y cell growth through downregulation of BDNF via miR-16. Oncology reports. vol 30. issue 5. 2014-04-07. PMID:24026226. |
in the present study, we observed the effect of cisplatin on bdnf expression in sh-sy5y cells and investigated the mechanism of cisplatin in inducing the apoptosis of sh-sy5y cells. |
2014-04-07 |
2023-08-12 |
mouse |
| Katsuhiro Takeda, Pouneh Kermani, Agustin Anastasia, Yusuke Obinata, Barbara L Hempstead, Hidemi Kurihar. BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 91. issue 5. 2014-04-03. PMID:24032685. |
bdnf protects human vascular endothelial cells from tnfα-induced apoptosis. |
2014-04-03 |
2023-08-12 |
human |
| Guan-nan Xia, Yu Zou, You-cui Wang, Qing-jie Xia, Bing-tuan Lu, Ting-hua Wang, Jian-guo Q. Neural stem cells grafts decrease neural apoptosis associated with caspase-7 downregulation and BDNF upregulation in rats following spinal cord hemisection. Cellular and molecular neurobiology. vol 33. issue 7. 2014-04-02. PMID:23963709. |
neural stem cells grafts decrease neural apoptosis associated with caspase-7 downregulation and bdnf upregulation in rats following spinal cord hemisection. |
2014-04-02 |
2023-08-12 |
rat |
| Guan-nan Xia, Yu Zou, You-cui Wang, Qing-jie Xia, Bing-tuan Lu, Ting-hua Wang, Jian-guo Q. Neural stem cells grafts decrease neural apoptosis associated with caspase-7 downregulation and BDNF upregulation in rats following spinal cord hemisection. Cellular and molecular neurobiology. vol 33. issue 7. 2014-04-02. PMID:23963709. |
intravenous nscs injection substantially upregulated the level of bdnf mrna but not its receptor trkb in hemisected spinal cord, while caspase-7, a downstream apoptosis gene of caspase-3, has been largely down-regulated. |
2014-04-02 |
2023-08-12 |
rat |
| Jiping Liu, Liang Feng, Dongying Ma, Minghua Zhang, Junfei Gu, Shuyuan Wang, Qiang Fu, Yu Song, Zhou Lan, Rong Qu, Shiping M. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neuroscience letters. vol 549. 2014-03-06. PMID:23791853. |
immunohistochemistry and tunel staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors bdnf and igf expressions, and also ameliorate aβ deposition in the hippocampus and cerebral cortex. |
2014-03-06 |
2023-08-12 |
rat |
| P F Jiang, T Zhu, J D Gao, F Gao, S S Mao, W T Zhao, W Z Gu, H M Y. The effect of maternal infection on cognitive development and hippocampus neuronal apoptosis, proliferation and differentiation in the neonatal rats. Neuroscience. vol 246. 2014-02-24. PMID:23597829. |
terminal deoxynucleotidyl transferase dutp nick end labeling assay was used to determine neuronal apoptosis, immunostaining was conducted to assess neurogenesis, and western blot for extracellular signal-regulated kinase (erk), cyclic amp responsive element-binding protein (creb) and brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2014-02-24 |
2023-08-12 |
rat |
| Nadka I Boyadjieva, Dipak K Sarka. Cyclic adenosine monophosphate and brain-derived neurotrophic factor decreased oxidative stress and apoptosis in developing hypothalamic neuronal cells: role of microglia. Alcoholism, clinical and experimental research. vol 37. issue 8. 2014-01-21. PMID:23550806. |
to study further the mechanism of etoh action on neuronal apoptosis, we determined the effects of 2 well-known pka activators, dibutyryl camp (dbcamp) and brain-derived neurotrophic factor (bdnf), on etoh-activated oxidative stress and apoptotic processes in the hypothalamic neurons in the presence and absence of microglial cells' influence. |
2014-01-21 |
2023-08-12 |
Not clear |