| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H S Kim, J H Lee, I K Ki. Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. Prostaglandins. vol 51. issue 6. 1997-01-14. PMID:8873236. |
the delta 12-pgj2-induced apoptosis was augmented by gsh depletion resulted from pretreatment with buthioninine sulfoximine (bso), an inhibitor of gamma-glutamylcysteine synthetase. |
1997-01-14 |
2023-08-12 |
human |
| H S Kim, J H Lee, I K Ki. Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. Prostaglandins. vol 51. issue 6. 1997-01-14. PMID:8873236. |
on the contrary, n-acetyl-cysteine (nac), a precursor of cysteine, elevated the gsh level and protected cells from initiating apoptosis by delta 12-pgj2. |
1997-01-14 |
2023-08-12 |
human |
| H S Kim, J H Lee, I K Ki. Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. Prostaglandins. vol 51. issue 6. 1997-01-14. PMID:8873236. |
these results suggest that the apoptosis-inducing activity of delta 12-pgj2 is due to thiol-reactivity and intracellular gsh modulates the delta 12-pgj2-induced apoptosis by regulating the accessibility of delta 12-pgj2 to target proteins containing thiol groups. |
1997-01-14 |
2023-08-12 |
human |
| P Marchetti, T Hirsch, N Zamzami, M Castedo, D Decaudin, S A Susin, B Masse, G Kroeme. Mitochondrial permeability transition triggers lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 11. 1996-12-27. PMID:8943385. |
protoporphyrin ix (ppix), a ligand of the mitochondrial benzodiazepin receptor that is well known for its pt-triggering capacity, induces delta psi(m) disruption, enhanced generation of superoxide anions, as well as signs of nuclear apoptosis in thymocytes and in t cells. |
1996-12-27 |
2023-08-12 |
Not clear |
| P Marchetti, T Hirsch, N Zamzami, M Castedo, D Decaudin, S A Susin, B Masse, G Kroeme. Mitochondrial permeability transition triggers lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 11. 1996-12-27. PMID:8943385. |
in contrast, inhibitors of mrna or protein synthesis fail to suppress ppix-induced delta psi(m) disruption and apoptosis. |
1996-12-27 |
2023-08-12 |
Not clear |
| S A Susin, N Zamzami, M Castedo, T Hirsch, P Marchetti, A Macho, E Daugas, M Geuskens, G Kroeme. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. The Journal of experimental medicine. vol 184. issue 4. 1996-12-13. PMID:8879205. |
we and others have shown previously that the first biochemical alteration detectable in cells undergoing apoptosis, well before nuclear changes become manifest, is a collapse of the mitochondrial inner membrane potential (delta psi m), suggesting the involvement of mitochondrial products in the apoptotic cascade. |
1996-12-13 |
2023-08-12 |
Not clear |
| M Castedo, T Hirsch, S A Susin, N Zamzami, P Marchetti, A Macho, G Kroeme. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752896. |
when cells undergo nuclear apoptosis (chromatin condensation, dna fragmentation), they already manifest at least three alterations that can be quantified cytofluorometrically at the single-cell level: 1) a loss of mitochondrial transmembrane potential (delta psi m), 2) an increased production of superoxide anions, and 3) the aberrant exposure of phosphatidylserine (ps) residues on the outer plasma membrane leaflet. |
1996-11-07 |
2023-08-12 |
Not clear |
| M Castedo, T Hirsch, S A Susin, N Zamzami, P Marchetti, A Macho, G Kroeme. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752896. |
in this work, we show that cells first undergo the delta psi m disruption and that ps exposure only affects cells that already have a low delta psi m. pharmacologic modulation of apoptosis with inhibitors of macromolecule synthesis or proteases, as well as with drugs stabilizing the delta psi m, indicates that delta psi m disruption and ps exposure are coregulated. |
1996-11-07 |
2023-08-12 |
Not clear |
| M Castedo, T Hirsch, S A Susin, N Zamzami, P Marchetti, A Macho, G Kroeme. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752896. |
in all conditions in which apoptosis is prevented, the delta psi m remains stable and ps cannot be detected on the cell surface. |
1996-11-07 |
2023-08-12 |
Not clear |
| M Castedo, T Hirsch, S A Susin, N Zamzami, P Marchetti, A Macho, G Kroeme. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 2. 1996-11-07. PMID:8752896. |
first, among thymocytes undergoing apoptosis in response to dexamethasone, delta psi mlow cells first expose ps and then hyperproduce superoxide anion. |
1996-11-07 |
2023-08-12 |
Not clear |
| R Datta, D Banach, H Kojima, R V Talanian, E S Alnemri, W W Wong, D W Kuf. Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood. vol 88. issue 6. 1996-10-24. PMID:8822910. |
ara-c induced apoptosis is associated with proteolytic cleavage of poly(adp-ribose) polymerase (parp) and protein kinase c (pkc) delta. |
1996-10-24 |
2023-08-12 |
human |
| R Datta, D Banach, H Kojima, R V Talanian, E S Alnemri, W W Wong, D W Kuf. Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood. vol 88. issue 6. 1996-10-24. PMID:8822910. |
by contrast, overexpression of the cowpox virus protein crma blocked apoptosis induced by engagement of the fas receptor but not that induced by ara-c. crma overexpression also had no detectable effect on ara-c-induced cleavage of pkc delta. |
1996-10-24 |
2023-08-12 |
human |
| Y J Liu, C Arpin, O de Bouteiller, C Guret, J Banchereau, H Martinez-Valdez, S Lebecqu. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development. Seminars in immunology. vol 8. issue 3. 1996-10-17. PMID:8738916. |
further phenotypic, functional and ig gene analysis (igv gene sequences, expression of sterile transcripts and dna switch circles) allowed us to conclude the following: (1) sigm+ igd+ cd38- b cells are naive b cells (bm1 + 2), which carry unmutated antigen-receptors; (2) sigm+ igd+ cd38+ b cells are germinal center founder cells (bm2'), which become prone to undergo apoptosis before the onset of somatic mutation; (3) sigm-igd+ cd38+ are germinal center b cells (bm 3 delta), that have accumulated the highest number of somatic mutations ever reported in normal b cells; these cells may have undergone c mu-deletion by homologous recombination through sigma mu-sigma delta sequences: (4) sigd-cd38+ cd77+ b cells are centroblasts (bm3), in which somatic mutation machinery is activated; (5) sigd-cd38+ cd77- b cells are centrocytes (bm4), in which the isotype switching machinery is activated; (6) sigd-cd38- cells (bm5) represent somatically mutated resting memory b cells. |
1996-10-17 |
2023-08-12 |
human |
| Y H Gan, M Malkovsk. Mechanisms of simian gamma delta T cell cytotoxicity against tumor and immunodeficiency virus-infected cells. Immunology letters. vol 49. issue 3. 1996-10-17. PMID:8739316. |
we further determined that the target cells were induced to undergo apoptosis by the gamma delta t cell effectors. |
1996-10-17 |
2023-08-12 |
human |
| Z Pan, W Radding, T Zhou, E Hunter, J Mountz, J M McDonal. Role of calmodulin in HIV-potentiated Fas-mediated apoptosis. The American journal of pathology. vol 149. issue 3. 1996-10-17. PMID:8780394. |
our studies have shown that 1) transfection of h9 and molt-4 cells with a non-infectious hiv proviral clone, pfn, which expresses wild-type gp160, leads to enhanced fas-mediated apoptosis, 2) transfection of molt-4 cells with a pfn construct pfn delta 147, which expresses a carboxyl-terminally truncated gp160 lacking the calmodulin-binding domains, produces less fas-mediated apoptosis than transfection with pfn, and 3) the calmodulin antagonists trifluoperazine and tamoxifen completely inhibit the pfn enhancement of fas-mediated apoptosis in molt-4 cells. |
1996-10-17 |
2023-08-12 |
human |
| N Zamzami, P Marchetti, M Castedo, T Hirsch, S A Susin, B Masse, G Kroeme. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS letters. vol 384. issue 1. 1996-10-16. PMID:8797802. |
here we address the question as to whether mitochondrial permeability transition (pt) pores may account for the delta psi m dissipation in lymphocyte apoptosis. |
1996-10-16 |
2023-08-12 |
Not clear |
| N Zamzami, P Marchetti, M Castedo, T Hirsch, S A Susin, B Masse, G Kroeme. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS letters. vol 384. issue 1. 1996-10-16. PMID:8797802. |
moreover, pharmacological modulation of pt-mediated delta psi m dissipation can prevent apoptosis. |
1996-10-16 |
2023-08-12 |
Not clear |
| L Y Romanova, I A Alexandrov, G Schwab, D M Hilbert, J F Mushinski, R P Norda. Mechanism of apoptosis suppression by phorbol ester in IL-6-starved murine plasmacytomas: role of PKC modulation and cell cycle. Biochemistry. vol 35. issue 30. 1996-09-10. PMID:8703964. |
we show here that the mode of cell death in il-6-starved t1165 and t1198 plasmacytoma cell lines is apoptosis, and that it can be suppressed by phorbol ester (pma) treatment in a protein kinase c (pkc)-mediated process that involves alpha and/or delta isozymes. |
1996-09-10 |
2023-08-12 |
Not clear |
| F Poccia, S Boullier, H Lecoeur, M Cochet, Y Poquet, V Colizzi, J J Fournie, M L Gougeo. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 1. 1996-08-16. PMID:8683151. |
although peripheral v delta 2 t cells from some hiv-infected persons showed an increased susceptibility to spontaneous and activation-induced apoptosis, statistical comparison between hiv+ and hiv- donors indicated that there was no difference between both groups in the rate of v delta 2 apoptosis. |
1996-08-16 |
2023-08-12 |
human |
| N Zamzami, S A Susin, P Marchetti, T Hirsch, I Gómez-Monterrey, M Castedo, G Kroeme. Mitochondrial control of nuclear apoptosis. The Journal of experimental medicine. vol 183. issue 4. 1996-08-05. PMID:8666911. |
before cells exhibit common signs of nuclear apoptosis (chromatin condensation and endonuclease-mediated dna fragmentation), they undergo a reduction of the mitochondrial transmembrane potential (delta psi m) that may be due to the opening of mitochondrial permeability transition (pt) pores. |
1996-08-05 |
2023-08-12 |
Not clear |