| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Guzmán, E Domann, M Rohde, D Bruder, A Darji, S Weiss, J Wehland, T Chakraborty, K N Timmi. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Molecular microbiology. vol 20. issue 1. 1997-04-04. PMID:8861210. |
the ability to induce cellular apoptosis was retained by all mutants tested, except the prfa and delta hly mutants, both of which are unable to produce listeriolysin. |
1997-04-04 |
2023-08-12 |
mouse |
| P Marchetti, M Castedo, S A Susin, N Zamzami, T Hirsch, A Macho, A Haeffner, F Hirsch, M Geuskens, G Kroeme. Mitochondrial permeability transition is a central coordinating event of apoptosis. The Journal of experimental medicine. vol 184. issue 3. 1997-03-20. PMID:9064332. |
this delta psi m disruption is mediated by the opening of permeability transition (pt) pores and appears to be critical for the apoptotic cascade, since it is directly regulated by bcl-2 and since mitochondria induced to undergo pt in vitro become capable of inducing nuclear chromatinolysis in a cell-free system of apoptosis. |
1997-03-20 |
2023-08-12 |
Not clear |
| P Marchetti, M Castedo, S A Susin, N Zamzami, T Hirsch, A Macho, A Haeffner, F Hirsch, M Geuskens, G Kroeme. Mitochondrial permeability transition is a central coordinating event of apoptosis. The Journal of experimental medicine. vol 184. issue 3. 1997-03-20. PMID:9064332. |
in addition to abolishing the apoptotic delta psi m disruption, ba prevents a number of phenomena linked to apoptosis: depletion of nonoxidized glutathione, generation of reactive oxygen species, translocation of nf kappa b, exposure of phosphatidylserine residues on the outer plasma membrane, cytoplasmic vacuolization, chromatin condensation, and oligonucleosomal dna fragmentation. |
1997-03-20 |
2023-08-12 |
Not clear |
| C Lavallée, L Thibodea. [Cloning, expression and characterization of HIV-1 gp60 partially or completely deleted in the V3 loop]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 319. issue 11. 1997-03-19. PMID:9033843. |
in order to better understand the role of the immunodominant v3 loop in the type-specific immune response and also to determine if this sequence has a role in aids pathogenesis, notably in the induction of apoptosis in cd4+ cells, we have introduced 2 modifications in the env gene from pnl4-3: a partial deletion in the v3 loop, keeping only the conserved tip of the loop gpgraf consensus sequence (env delta v3-gpgraf) and, secondly, a complete deletion of v3 sequence plus 43 nucleotides in c3 (env delta v3+). |
1997-03-19 |
2023-08-12 |
Not clear |
| K Higashiyama, K Niiya, T Ozawa, Y Hayakawa, M Fujimaki, N Sakuragaw. Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. Prostaglandins. vol 52. issue 3. 1997-03-06. PMID:8908616. |
induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin j2 in human pl-21 myeloid leukemia and rc-k8 pre-b lymphoma cells. |
1997-03-06 |
2023-08-12 |
human |
| P Marchetti, D Decaudin, A Macho, N Zamzami, T Hirsch, S A Susin, G Kroeme. Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function. European journal of immunology. vol 27. issue 1. 1997-03-05. PMID:9022031. |
our data indicate that thymocyte apoptosis induced by diamide mimics natural apoptosis in the sense that mitochondrial transmembrane potential (delta psi(m)) disruption precedes nuclear chromatin degradation; that monovalent thiol-reactive compounds inhibit apoptosis induced by diamide, glucocorticoids, irradiation, and topoisomerase inhibition; that the critical thiols determining cell fate after exposure to diamide, glucocorticoids, or dna damage are likely to be located in the mitochondrial matrix; and that thiol oxidation and reduction are critical for apoptosis induction by some stimuli (glucocorticoids, dna damage), but not by fas/cd95 cross-linking. |
1997-03-05 |
2023-08-12 |
Not clear |
| A Macho, D Decaudin, M Castedo, T Hirsch, S A Susin, N Zamzami, G Kroeme. Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis. Cytometry. vol 25. issue 4. 1997-02-27. PMID:8946140. |
early apoptosis is invariably accompanied by a disruption of inner mitochondrial transmembrane potential (delta psi m). |
1997-02-27 |
2023-08-12 |
Not clear |
| M B Lachyankar, A H Ross, N S Litofsky, P J Condon, P J Quesenberry, L D Rech. TrkA expression decreases the in vivo aggressiveness of C6 glioma cells. Cancer research. vol 57. issue 3. 1997-02-20. PMID:9012486. |
histological studies revealed that c6trka cells were much less invasive than c6 or c6trka delta cells and had a greater rate of apoptosis. |
1997-02-20 |
2023-08-12 |
rat |
| R Datta, H Kojima, D Banach, N J Bump, R V Talanian, E S Alnemri, R R Weichselbaum, W W Wong, D W Kuf. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. The Journal of biological chemistry. vol 272. issue 3. 1997-02-13. PMID:8999887. |
overexpression of the cowpox protein crma blocked tumor necrosis factor (tnf)-induced apoptosis but had no effect on ir-induced dna fragmentation or cleavage of poly(adp-ribose) polymerase and protein kinase c delta. |
1997-02-13 |
2023-08-12 |
Not clear |
| M S Vincent, K Roessner, D Lynch, D Wilson, S M Cooper, J Tschopp, L H Sigal, R C Bud. Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976167. |
apoptosis of fashigh cd4+ synovial t cells by borrelia-reactive fas-ligand(high) gamma delta t cells in lyme arthritis. |
1997-01-30 |
2023-08-12 |
human |
| M S Vincent, K Roessner, D Lynch, D Wilson, S M Cooper, J Tschopp, L H Sigal, R C Bud. Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976167. |
furthermore, synovial gamma delta t cell clones express elevated and sustained levels of the ligand for fas (apo-1, cd95) compared to alpha beta t cells, and induce apoptosis of fashigh cd4+ synovial lymphocytes. |
1997-01-30 |
2023-08-12 |
human |
| T Ghayur, M Hugunin, R V Talanian, S Ratnofsky, C Quinlan, Y Emoto, P Pandey, R Datta, Y Huang, S Kharbanda, H Allen, R Kamen, W Wong, D Kuf. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976194. |
proteolytic activation of protein kinase c delta by an ice/ced 3-like protease induces characteristics of apoptosis. |
1997-01-30 |
2023-08-12 |
Not clear |
| T Ghayur, M Hugunin, R V Talanian, S Ratnofsky, C Quinlan, Y Emoto, P Pandey, R Datta, Y Huang, S Kharbanda, H Allen, R Kamen, W Wong, D Kuf. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976194. |
recent studies have shown that protein kinase c (pkc) delta is proteolytically activated at the onset of apoptosis induced by dna-damaging agents, tumor necrosis factor, and anti-fas antibody. |
1997-01-30 |
2023-08-12 |
Not clear |
| T Ghayur, M Hugunin, R V Talanian, S Ratnofsky, C Quinlan, Y Emoto, P Pandey, R Datta, Y Huang, S Kharbanda, H Allen, R Kamen, W Wong, D Kuf. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976194. |
however, the relationship of pkc delta cleavage to induction of apoptosis is unknown. |
1997-01-30 |
2023-08-12 |
Not clear |
| T Ghayur, M Hugunin, R V Talanian, S Ratnofsky, C Quinlan, Y Emoto, P Pandey, R Datta, Y Huang, S Kharbanda, H Allen, R Kamen, W Wong, D Kuf. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. The Journal of experimental medicine. vol 184. issue 6. 1997-01-30. PMID:8976194. |
the findings suggest that proteolytic activation of pkc delta by a cpp32-like protease contributes to phenotypic changes associated with apoptosis. |
1997-01-30 |
2023-08-12 |
Not clear |
| D Decaudin, S Geley, T Hirsch, M Castedo, P Marchetti, A Macho, R Kofler, G Kroeme. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988042. |
circulating tumor cells from patients receiving chemotherapy in vivo also demonstrate a delta psi m disruption after in vitro culture that precedes nuclear apoptosis. |
1997-01-28 |
2023-08-12 |
Not clear |
| D Decaudin, S Geley, T Hirsch, M Castedo, P Marchetti, A Macho, R Kofler, G Kroeme. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988042. |
bcl-2-mediated inhibition of ceramide-induced delta psi m disruption is observed in normal as well as anucleate cells, indicating that bcl-2 acts on an extranuclear pathway of apoptosis. |
1997-01-28 |
2023-08-12 |
Not clear |
| D Decaudin, S Geley, T Hirsch, M Castedo, P Marchetti, A Macho, R Kofler, G Kroeme. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988042. |
in contrast to bcl-2 and bcl-xl, hyperexpression of the protease inhibitor cytokine response modifier a fails to protect tumor cells against chemotherapy-induced delta psi m disruption and apoptosis, although cytokine response modifier a does prevent the delta psi m collapse and posterior nuclear apoptosis triggered by cross-linking of fas/apo-1/cd95. |
1997-01-28 |
2023-08-12 |
Not clear |
| D Decaudin, S Geley, T Hirsch, M Castedo, P Marchetti, A Macho, R Kofler, G Kroeme. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer research. vol 57. issue 1. 1997-01-28. PMID:8988042. |
in conclusion, delta psi m disruption seems to be an obligatory step of early (pre-nuclear) apoptosis, and delta psi m is stabilized by two members of the bcl-2 gene family conferring resistance to chemotherapy. |
1997-01-28 |
2023-08-12 |
Not clear |
| H S Kim, J H Lee, I K Ki. Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. Prostaglandins. vol 51. issue 6. 1997-01-14. PMID:8873236. |
intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin j2. |
1997-01-14 |
2023-08-12 |
human |