| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W G Tatton, R M Chalmers-Redma. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749585. |
we have extended those findings to a neuronal model of apoptosis caused by trophic withdrawal, by showing that a decrease in delta psim is an early event occurring 2 to 6 hours before the degradative events of apoptosis. |
1998-10-07 |
2023-08-12 |
Not clear |
| W G Tatton, R M Chalmers-Redma. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749585. |
because delta psim is generated by the pumping of protons out across the inner mitochondrial membrane at the mitochondrial complexes, particularly complex i, we hypothesized that the decrease in complex activity could result in a decrease in delta psim that would render pd substantia nigra neurons vulnerable to apoptosis. |
1998-10-07 |
2023-08-12 |
Not clear |
| W G Tatton, R M Chalmers-Redma. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749585. |
if a decrease in delta psim consequent on decreased complex activity is an intrinsic defect in some pd patients, it would open a number of new avenues for the reduction of neuronal apoptosis in pd. |
1998-10-07 |
2023-08-12 |
Not clear |
| W G Tatton, R M Chalmers-Redma. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Annals of neurology. vol 44. issue 3 Suppl 1. 1998-10-07. PMID:9749585. |
accordingly, agents that maintain delta psim and ptp closure may offer new and effective means of treating neurodegenerative apoptosis. |
1998-10-07 |
2023-08-12 |
Not clear |
| B Li, H Bassiri, M D Rossman, P Kramer, A F Eyuboglu, M Torres, E Sada, T Imir, S R Cardin. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 3. 1998-08-12. PMID:9686624. |
however, during culture mtb ags induced apoptosis in a large proportion of v gamma 9+v delta 2+ peripheral blood t cells from healthy subjects (30-45%) and tb patients (55-68%); this was increased further in the presence of il-2. |
1998-08-12 |
2023-08-12 |
human |
| B Li, H Bassiri, M D Rossman, P Kramer, A F Eyuboglu, M Torres, E Sada, T Imir, S R Cardin. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 3. 1998-08-12. PMID:9686624. |
by contrast, anti-cd3 did not induce any significant level of apoptosis in gamma delta t cells from healthy subjects or tb patients. |
1998-08-12 |
2023-08-12 |
human |
| B Li, H Bassiri, M D Rossman, P Kramer, A F Eyuboglu, M Torres, E Sada, T Imir, S R Cardin. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 3. 1998-08-12. PMID:9686624. |
blockade of fas-fasl interactions reduced the level of mtb-mediated gamma delta t cell apoptosis by 75 to 80%. |
1998-08-12 |
2023-08-12 |
human |
| B Li, H Bassiri, M D Rossman, P Kramer, A F Eyuboglu, M Torres, E Sada, T Imir, S R Cardin. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 3. 1998-08-12. PMID:9686624. |
collectively, these findings demonstrate that mtb-reactive gamma delta t cells are more susceptible to aicd and that the fas-fasl pathways of apoptosis is involved. |
1998-08-12 |
2023-08-12 |
human |
| H Kojima, K Endo, H Moriyama, Y Tanaka, E S Alnemri, C A Slapak, B Teicher, D Kufe, R Datt. Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance. The Journal of biological chemistry. vol 273. issue 27. 1998-08-06. PMID:9642215. |
in contrast to parental cells, the scc-25/cddp-resistant variant failed to exhibit activation of caspase-3, cleavage of protein kinase c delta, and other characteristics of apoptosis in response to cddp. |
1998-08-06 |
2023-08-12 |
Not clear |
| D S Cassarino, R H Swerdlow, J K Parks, W D Parker, J P Bennet. Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochemical and biophysical research communications. vol 248. issue 1. 1998-08-06. PMID:9675105. |
we propose the novel hypothesis that the cox defect and resulting oxidative stress in ad may pathologically activate the mtp, resulting in lower delta psi m and the release of mitochondrial factors involved in apoptosis. |
1998-08-06 |
2023-08-12 |
Not clear |
| S Tada-Oikawa, S Oikawa, S Kawanish. Role of ultraviolet A-induced oxidative DNA damage in apoptosis via loss of mitochondrial membrane potential and caspase-3 activation. Biochemical and biophysical research communications. vol 247. issue 3. 1998-07-31. PMID:9647755. |
these results suggest that uva irradiation induces oxidative dna damage, followed by the loss of delta psi m and subsequent activation of caspase-3, resulting in apoptosis. |
1998-07-31 |
2023-08-12 |
Not clear |
| B G Heerdt, M A Houston, G M Anthony, L H Augenlich. Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer research. vol 58. issue 13. 1998-07-23. PMID:9661904. |
mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. |
1998-07-23 |
2023-08-12 |
human |
| B G Heerdt, M A Houston, G M Anthony, L H Augenlich. Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. Cancer research. vol 58. issue 13. 1998-07-23. PMID:9661904. |
here, we dissect the relationships among mitochondrial function, growth arrest, and apoptosis, reporting that initiation and maintenance of butyrate-mediated p53-independent p21waf1/cip1 induction and subsequent g0/g1 arrest require an intact mitochondrial membrane potential (delta psi(mt)) and that the process of dissipation of the delta psi(mt) is then essential for initiation of a butyrate-induced apoptotic cascade. |
1998-07-23 |
2023-08-12 |
human |
| T Hirsch, D Decaudin, S A Susin, P Marchetti, N Larochette, M Resche-Rigon, G Kroeme. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Experimental cell research. vol 241. issue 2. 1998-07-14. PMID:9637784. |
here we show that pk11195, a prototypic ligand of the 18-kda mbzr, facilitates the induction of delta psim disruption and subsequent apoptosis by a number of different agents,including agonists of the glucocorticoid receptor,chemotherapeutic agents (etoposide, doxorubicin),gamma irradiation, and the proapoptotic second messenger ceramide. |
1998-07-14 |
2023-08-12 |
Not clear |
| T Hirsch, D Decaudin, S A Susin, P Marchetti, N Larochette, M Resche-Rigon, G Kroeme. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Experimental cell research. vol 241. issue 2. 1998-07-14. PMID:9637784. |
this effect is observed at the level of delta psim dissipation as well as at the level of nuclear apoptosis. |
1998-07-14 |
2023-08-12 |
Not clear |
| S Camilleri-Broët, H Vanderwerff, E Caldwell, D Hockenber. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Experimental cell research. vol 239. issue 2. 1998-04-16. PMID:9521845. |
recent studies have shown that reduction in mitochondrial membrane potential (delta psi m) and generation of reactive oxygen species are early events in apoptosis. |
1998-04-16 |
2023-08-12 |
Not clear |
| S Camilleri-Broët, H Vanderwerff, E Caldwell, D Hockenber. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Experimental cell research. vol 239. issue 2. 1998-04-16. PMID:9521845. |
cycloheximide and bcl-2 overexpression inhibited the loss of delta psi m, as well as apoptosis. |
1998-04-16 |
2023-08-12 |
Not clear |
| M Jung, Y Zhang, A Dritschil. Expression of a dominant negative I kappa B-alpha modulates hypersensitivity of ataxia telangiectasia fibroblasts to streptonigrin-induced apoptosis. Radiation oncology investigations. vol 5. issue 6. 1998-02-27. PMID:9436242. |
in this study, we investigated apoptosis in at cells whose radiation sensitivity has been altered by transfection with a cdna expressing truncated i kappa b-alpha (delta i kappa b-alpha). |
1998-02-27 |
2023-08-12 |
Not clear |
| T Satoh, Y Enokido, H Aoshima, Y Uchiyama, H Hatanak. Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells. Journal of neuroscience research. vol 50. issue 3. 1998-02-19. PMID:9364326. |
bcl-2 prevented the decrease in delta psi m as well as apoptosis induced by oxidative stress. |
1998-02-19 |
2023-08-12 |
Not clear |
| T Satoh, Y Enokido, H Aoshima, Y Uchiyama, H Hatanak. Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells. Journal of neuroscience research. vol 50. issue 3. 1998-02-19. PMID:9364326. |
these observations suggest that the oxidative stress triggers apoptosis associated with both increased generation of ros and decreases in level of delta psi m and that bcl-2 prevents cell death as well as delta psi m but not ros production. |
1998-02-19 |
2023-08-12 |
Not clear |