| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qun Wang, Albert Y Sun, Agnes Simonyi, Michael D Jensen, Phullara B Shelat, George E Rottinghaus, Ruth S MacDonald, Dennis K Miller, Dennis E Lubahn, Gary A Weisman, Grace Y Su. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. Journal of neuroscience research. vol 82. issue 1. 2006-02-07. PMID:16075466. |
these ischemic changes were preceded by a rapid increase in lipid peroxidation and followed by decrease in mitochondrial membrane potential, increased cytochrome c release, and subsequently caspase-3 activation and apoptosis. |
2006-02-07 |
2023-08-12 |
Not clear |
| Jörn M Schattenberg, Rajat Singh, Yongjun Wang, Jay H Lefkowitch, Raina M Rigoli, Philipp E Scherer, Mark J Czaj. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology (Baltimore, Md.). vol 43. issue 1. 2006-01-24. PMID:16374858. |
jnk promoted the development of steatohepatitis as mcd diet-fed jnk1 null mice had significantly reduced levels of hepatic triglyceride accumulation, inflammation, lipid peroxidation, liver injury, and apoptosis compared with wild-type and jnk2 -/- mice. |
2006-01-24 |
2023-08-12 |
mouse |
| Sirikarnt Dhitavat, Daniela Ortiz, Eugene Rogers, Ezequiel Rivera, Thomas B She. Folate, vitamin E, and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain research. vol 1061. issue 2. 2006-01-17. PMID:16256963. |
the neurotoxic peptide amyloid-beta (abeta) contributes to oxidative damage in ad by inducing lipid peroxidation, which in turn generates additional downstream cytosolic free radicals and reactive oxygen species (ros), leading to mitochondrial and cytoskeletal compromise, depletion of atp, and ultimate apoptosis. |
2006-01-17 |
2023-08-12 |
human |
| Nicolo Merendino, Barbara Loppi, Massimo D'Aquino, Romina Molinari, Gloria Pessina, Chiara Romano, Francesca Velott. Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. Nutrition and cancer. vol 52. issue 2. 2006-01-12. PMID:16201853. |
docosahexaenoic acid induces apoptosis in the human paca-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. |
2006-01-12 |
2023-08-12 |
human |
| Nicolo Merendino, Barbara Loppi, Massimo D'Aquino, Romina Molinari, Gloria Pessina, Chiara Romano, Francesca Velott. Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. Nutrition and cancer. vol 52. issue 2. 2006-01-12. PMID:16201853. |
an oxidative process was implicated in apoptosis induced by dha because butylated hydroxytoluene and vitamin e prevented lipid peroxidation and reversed apoptosis. |
2006-01-12 |
2023-08-12 |
human |
| Nicolo Merendino, Barbara Loppi, Massimo D'Aquino, Romina Molinari, Gloria Pessina, Chiara Romano, Francesca Velott. Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. Nutrition and cancer. vol 52. issue 2. 2006-01-12. PMID:16201853. |
inhibition of active gsh extrusion from the cell by cystathionine or methionine completely reversed lipid peroxidation and apoptosis. |
2006-01-12 |
2023-08-12 |
human |
| Mauro Maccarrone, Monica Bari, Valeria Gasperi, Barbara Demmig-Adam. The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells. Anticancer research. vol 25. issue 6B. 2006-01-05. PMID:16309173. |
this study examined the effect of zeaxanthin on neuroblastoma cells in which apoptosis can be induced with lipid peroxidation products. |
2006-01-05 |
2023-08-12 |
Not clear |
| Mauro Maccarrone, Monica Bari, Valeria Gasperi, Barbara Demmig-Adam. The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells. Anticancer research. vol 25. issue 6B. 2006-01-05. PMID:16309173. |
since zeaxanthin can inhibit lipid peroxidation and beta-carotene inhibits lipoxygenase (lox) activity, it was of concern that zeaxanthin might inhibit apoptosis in these cancer cells. |
2006-01-05 |
2023-08-12 |
Not clear |
| Kesheng Zhao, Guoxiong Luo, Serena Giannelli, Hazel H Szet. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines. Biochemical pharmacology. vol 70. issue 12. 2005-12-30. PMID:16216225. |
treatment with tert-butyl hydroperoxide (tbhp) for 24 h resulted in lipid peroxidation and significant cell death via apoptosis in both n2a and sh-sy5y cells, with phosphatidylserine translocation, nuclear condensation and increased caspase activity. |
2005-12-30 |
2023-08-12 |
Not clear |
| Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamur. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Digestive diseases and sciences. vol 50 Suppl 1. 2005-11-14. PMID:16184425. |
rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial rgm-1 cells. |
2005-11-14 |
2023-08-12 |
Not clear |
| Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamur. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Digestive diseases and sciences. vol 50 Suppl 1. 2005-11-14. PMID:16184425. |
nsaids were recently reported to cause mitochondrial injury: to dissipate the mitochondrial transmembrane potential (mtp), and to induce mitochondrial permeability transition pore (ptp), which liberates cytochrome c. this enzyme generates reactive oxygen species (ros) thereby triggers caspase cascade and cellular lipid peroxidation, resulting in cellular apoptosis. |
2005-11-14 |
2023-08-12 |
Not clear |
| Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamur. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Digestive diseases and sciences. vol 50 Suppl 1. 2005-11-14. PMID:16184425. |
we examined the effect of rebamipide on 1) mtp change, 2) lipid peroxidation, 3) apoptosis, and 4) caspase activation using gastric mucosal epithelial cell-line treated with indomethacin. |
2005-11-14 |
2023-08-12 |
Not clear |
| Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamur. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Digestive diseases and sciences. vol 50 Suppl 1. 2005-11-14. PMID:16184425. |
with a specially designed fluorescence analyzing microscope system, mtp change, cellular lipid peroxidation, and cellular apoptosis were investigated with the small star, filled following fluorescent dyes, mitored, dppp, and hoechst 33,258, respectively. |
2005-11-14 |
2023-08-12 |
Not clear |
| Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamur. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Digestive diseases and sciences. vol 50 Suppl 1. 2005-11-14. PMID:16184425. |
indomethacin treatment decreased mtp but increased both cellular lipid peroxidation and cellular apoptosis via caspase 3 and 9 activation. |
2005-11-14 |
2023-08-12 |
Not clear |
| Irfan Rahma. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell biochemistry and biophysics. vol 43. issue 1. 2005-11-04. PMID:16043892. |
these include increased sequestration of neutrophils in the pulmonary microvasculature, oxidative inactivation of antiproteases and surfactants, hypersecretion of mucus, membrane lipid peroxidation, mitochondrial respiration, alveolar epithelial injury/permeability, breakdown/remodeling of extracellular matrix, and apoptosis. |
2005-11-04 |
2023-08-12 |
Not clear |
| Nadège Cassagno, Antonio Palos-Pinto, Pierre Costet, Dominique Breilh, Michel Darmon, Annie M Bérar. Low amounts of trans 18:1 fatty acids elevate plasma triacylglycerols but not cholesterol and alter the cellular defence to oxidative stress in mice. The British journal of nutrition. vol 94. issue 3. 2005-11-01. PMID:16176604. |
the 78 kda glucose-related protein (grp78) mrna expression increased 3-4-fold in liver, suggesting that a response against apoptosis was provoked by lipid peroxidation. |
2005-11-01 |
2023-08-12 |
mouse |
| Shoji Kimura, Guo-Xing Zhang, Akira Nishiyama, Takatomi Shokoji, Li Yao, Yu-Yan Fan, Matlubur Rahman, Takeo Suzuki, Hajime Maeta, Youichi Ab. Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension (Dallas, Tex. : 1979). vol 45. issue 5. 2005-10-27. PMID:15824196. |
both 5-hd and apocynin suppressed the enhanced cardiac lipid peroxidation and activation of the apoptosis signal-regulating kinase/p38, c-jun nh2-terminal kinase (jnk) pathways, but not the raf/mek/extracellular signal-regulated kinase pathway, elicited by acutely administered ang ii. |
2005-10-27 |
2023-08-12 |
rat |
| Nermin Serbecic, Sven Christoph Beutelspache. Vitamins inhibit oxidant-induced apoptosis of corneal endothelial cells. Japanese journal of ophthalmology. vol 49. issue 5. 2005-10-24. PMID:16187034. |
to determine the effects of vitamins a, c, and e supplementation on lipid peroxidation and apoptosis in corneal endothelial cells. |
2005-10-24 |
2023-08-12 |
Not clear |
| Maria Strassburger, Wilhelm Bloch, Silke Sulyok, Jutta Schüller, Alexander F Keist, Annette Schmidt, Jutta Wenk, Thorsten Peters, Meinhard Wlaschek, Jacek Lenart, Thomas Krieg, Martin Hafner, Angelika Kümin, Sabine Werner, Werner Müller, Karin Scharffetter-Kochane. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free radical biology & medicine. vol 38. issue 11. 2005-10-06. PMID:15890620. |
heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. |
2005-10-06 |
2023-08-12 |
mouse |
| Maria Strassburger, Wilhelm Bloch, Silke Sulyok, Jutta Schüller, Alexander F Keist, Annette Schmidt, Jutta Wenk, Thorsten Peters, Meinhard Wlaschek, Jacek Lenart, Thomas Krieg, Martin Hafner, Angelika Kümin, Sabine Werner, Werner Müller, Karin Scharffetter-Kochane. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free radical biology & medicine. vol 38. issue 11. 2005-10-06. PMID:15890620. |
in sharp contrast to initial publications on sod2(+/-) mice, the herein reported mice on a mixed genetic background (c57bl/6 x 129/ola) in their heterozygous state (sod(+/-)) revealed distinct ultrastructural damage of the myocard, with swelling and disruption of mitochondria and accumulation of lipid droplets, increased nitrotyrosine formation, and lipid peroxidation as well as activation of apoptosis signaling pathways in the heart in vivo. |
2005-10-06 |
2023-08-12 |
mouse |