| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Correction: Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer research. vol 77. issue 23. 2019-11-20. PMID:29196417. |
correction: myc induces mirna-mediated apoptosis in response to hdac inhibition in hematologic malignancies. |
2019-11-20 |
2023-08-13 |
Not clear |
| Sara Ota, Zi-Qiang Zhou, Peter J Hurli. Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. Oncotarget. vol 9. issue 3. 2019-11-20. PMID:29423038. |
the superior anti-tumor activity of tubacin was linked to its ability to not only inhibit accumulation of mutant fgfr3, but also to cause robust downregulation of myc and cyclin d1, and to induce a dna damage response and apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Sara Ota, Zi-Qiang Zhou, Peter J Hurli. Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. Oncotarget. vol 9. issue 3. 2019-11-20. PMID:29423038. |
neither hdac6 deficiency nor treatment with tubastatin a altered myc or cyclin d1 levels, and neither induced a dna damage response or apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| Kari Högstrand, Stephanie Darmanin, TachaZi Plym Forshell, Alf Grandie. Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765548. |
transformation of mouse t cells requires myc and akt activity in conjunction with inhibition of intrinsic apoptosis. |
2019-11-20 |
2023-08-13 |
mouse |
| John Anto Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A Wolfe, Lihua Julie Zhu, Job Dekker, John Hackett Bushweller, Lucio Hernán Castill. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. vol 174. issue 5. 2019-11-20. PMID:30142347. |
cbfβ-smmhc inhibition triggers apoptosis by disrupting myc chromatin dynamics in acute myeloid leukemia. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xiaohui Duan, Bo Jiang, Jianhui Yang, Lixue Zhou, Bingzhang Tian, Xianhai Ma. FOXP3 inhibits MYC expression via regulating miR-198 and influences cell viability, proliferation and cell apoptosis in HepG2. Cancer medicine. vol 7. issue 12. 2019-11-14. PMID:30378283. |
foxp3 inhibits myc expression via regulating mir-198 and influences cell viability, proliferation and cell apoptosis in hepg2. |
2019-11-14 |
2023-08-13 |
Not clear |
| Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell, Lars-Gunnar Larsso. MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. Cell cycle (Georgetown, Tex.). vol 17. issue 24. 2019-11-12. PMID:30526305. |
myc and ras are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. |
2019-11-12 |
2023-08-13 |
human |
| Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell, Lars-Gunnar Larsso. MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. Cell cycle (Georgetown, Tex.). vol 17. issue 24. 2019-11-12. PMID:30526305. |
this cooperativity is at least in part based on suppression of ras-induced cellular senescence by myc and block of myc-induced apoptosis by ras - thereby canceling out two main barriers against tumor development. |
2019-11-12 |
2023-08-13 |
human |
| Mark Mensink, Natasha S Anstee, Mikara Robati, Robyn L Schenk, Marco J Herold, Suzanne Cory, Cassandra J Vandenber. Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells. Cell death and differentiation. vol 25. issue 4. 2019-09-12. PMID:29339775. |
since myc promotes apoptosis under conditions of stress, such as limited availability of nutrients or cytokines, myc-driven cells are very much dependent on signals that inhibit cell death. |
2019-09-12 |
2023-08-13 |
mouse |
| Dyana T Saenz, Warren Fiskus, Taghi Manshouri, Christopher P Mill, Yimin Qian, Kanak Raina, Kimal Rajapakshe, Cristian Coarfa, Raffaella Soldi, Prithviraj Bose, Gautam Borthakur, Tapan M Kadia, Joseph D Khoury, Lucia Masarova, Agnieszka J Nowak, Baohua Sun, David N Saenz, Steven M Kornblau, Steve Horrigan, Sunil Sharma, Peng Qiu, Craig M Crews, Srdan Verstovsek, Kapil N Bhall. Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML. Leukemia. vol 33. issue 6. 2019-09-06. PMID:30575820. |
this induced apoptosis of not only jaki-sensitive but also jaki-persister/resistant post-mpn saml bpcs, associated with attenuation of tcf4 transcriptional targets myc, bcl-2, and survivin. |
2019-09-06 |
2023-08-13 |
mouse |
| Ying He, Dongmei Zhang, Yi Zeng, Junlei Ma, Jing Wang, Hui Guo, Ji Zhang, Mengqin Wang, Weijie Zhang, Nianqiao Gon. Bone Marrow-Derived Mesenchymal Stem Cells Protect Islet Grafts Against Endoplasmic Reticulum Stress-Induced Apoptosis During the Early Stage After Transplantation. Stem cells (Dayton, Ohio). vol 36. issue 7. 2019-08-20. PMID:29569832. |
furthermore, cocultured bmscs protected islets against ers-induced apoptosis as well as improved their insulin secretion, and bmscs alleviated ers by improving myc expression through both stromal cell-derived factor 1 signal and contact effect. |
2019-08-20 |
2023-08-13 |
mouse |
| Jan Dusek, Josef Skoda, Ondrej Holas, Alzbeta Horvatova, Tomas Smutny, Lenka Linhartova, Petra Hirsova, Otto Kucera, Stanislav Micuda, Albert Braeuning, Petr Pave. Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. Toxicology letters. vol 313. 2019-07-29. PMID:31170421. |
tms did not change or down-regulate genes involved in liver proliferation or apoptosis such as mki67, foxm1, myc, mcl1, pcna, bcl2, or mdm2, which were up-regulated by another car ligand tcpobop. |
2019-07-29 |
2023-08-13 |
mouse |
| Victoria J Gennaro, Helen Wedegaertner, Steven B McMaho. Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC. BMC cancer. vol 19. issue 1. 2019-07-18. PMID:30902071. |
the oncoprotein myc has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. |
2019-07-18 |
2023-08-13 |
Not clear |
| Eduard Stefan, Klaus Biste. MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer. Current topics in microbiology and immunology. vol 407. 2019-06-20. PMID:28466200. |
fundamental cellular processes including distinct catabolic and anabolic branches of metabolism, cell cycle regulation, cell growth and proliferation, differentiation, stem cell regulation, and apoptosis are under myc control. |
2019-06-20 |
2023-08-13 |
human |
| Xia Liang, Zhao Dong, Wu Bin, Nie Dekang, Zhu Xuhang, Zhang Shuyuan, Li Liwen, Jin Kai, Sun Caixin. PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways. Journal of molecular neuroscience : MN. vol 68. issue 1. 2019-05-29. PMID:30826985. |
besides, pax3 overexpression promoted cell proliferation and cell cycle progression, while it inhibited cell apoptosis by altering the expressions of important molecules associated with the wnt signaling pathway, including β-catenin, myc, vegf, cyclind1, mmp7, and wnt1. |
2019-05-29 |
2023-08-13 |
human |
| Xuan Kang, Yun Feng, Zhixue Gan, Shiyang Zeng, Xiaobo Guo, Xirui Chen, Ye Zhang, Chen Wang, Kuinan Liu, Xuelin Chen, Xiaoxue Jiang, Shuting Song, Yabin Li, Su Chen, Feng Sun, Zhiyong Mao, Xiaomei Yang, Jianfeng Chan. NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:30076957. |
this also resulted in a synergistic effect on enhanced apoptosis with myc and p53 decreases. |
2019-05-20 |
2023-08-13 |
Not clear |
| Heidi M Haikala, Johanna M Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I Nieminen, Timo Otonkoski, Julia Schüler, Teemu D Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi Heikkilä, Marjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D Leverson, Juha Klefströ. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nature communications. vol 10. issue 1. 2019-04-11. PMID:30728358. |
elevated myc expression sensitizes tumor cells to apoptosis but the therapeutic potential of this mechanism remains unclear. |
2019-04-11 |
2023-08-13 |
Not clear |
| Jimmy Lee, Liang Leo Zhang, Wenjun Wu, Hui Guo, Yan Li, Madina Sukhanova, Girish Venkataraman, Shengjian Huang, Hui Zhang, Mir Alikhan, Pin Lu, Ailin Guo, Natalie Galanina, Jorge Andrade, Michael L Wang, Y Lynn Wan. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood advances. vol 2. issue 16. 2019-04-04. PMID:30115641. |
last, we showed that pu-h71 induced apoptosis and downregulated myc protein in mcl cells derived from patients who were clinically resistant to ibrutinib. |
2019-04-04 |
2023-08-13 |
Not clear |
| Yong Li, Quanyu Cai, Wanhu Li, Feiling Feng, Liang Yan. Long non-coding RNA EPIC1 promotes cholangiocarcinoma cell growth. Biochemical and biophysical research communications. vol 504. issue 4. 2019-03-25. PMID:30205958. |
myc knockout also suppresses the cca cell growth, colony formation and cell apoptosis. |
2019-03-25 |
2023-08-13 |
human |
| John Anto Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A Wolfe, Lihua Julie Zhu, Job Dekker, John Hackett Bushweller, Lucio Hernán Castill. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. vol 174. issue 1. 2019-03-21. PMID:29958106. |
cbfβ-smmhc inhibition triggers apoptosis by disrupting myc chromatin dynamics in acute myeloid leukemia. |
2019-03-21 |
2023-08-13 |
mouse |