| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Jiang, Wenyao Cai, Guangtao Lei, Guorong Cai, Qinghua Wu, Peng L. Deubiquitinase USP47 ameliorates cardiac hypertrophy through reducing protein O-GlcNAcylation. Journal of cardiovascular pharmacology. 2024-10-22. PMID:39436323. |
adenovirus-mediated gain- and loss-of-function approaches indicated that usp47 overexpression significantly attenuated ang ii-induced cardiac hypertrophy in vitro and in vivo, whereas endogenous usp47 deficiency promoted the pro-hypertrophic effect of ang ii. |
2024-10-22 |
2024-10-24 |
rat |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
role of klf4 and siat7a interaction accelerates myocardial hypertrophy induced by ang ii. |
2024-10-21 |
2024-10-23 |
Not clear |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
nevertheless, the potential involvement of klf4 in regulating siat7a expression in ang ii-induced hypertrophic cardiomyocytes remains uncertain. |
2024-10-21 |
2024-10-23 |
Not clear |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
this study seeks to deepen the underlying mechanisms of the klf4 and siat7a interaction in the progression of ang ii-induced cardiac hypertrophy. |
2024-10-21 |
2024-10-23 |
Not clear |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
the results showed a concurrent increase in siat7a and klf4 levels in hypertrophic myocardium of essential hypertension patients and in hypertrophic cardiomyocytes stimulated by ang ii. |
2024-10-21 |
2024-10-23 |
Not clear |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
in vitro experiments revealed that reducing klf4 levels led to a decrease in both siat7a synthesis and sialyl-tn antigen expression, consequently inhibiting ang ii-induced cardiomyocyte hypertrophy. |
2024-10-21 |
2024-10-23 |
Not clear |
| Qiying Yao, Xinrui Hu, Tiantian Bian, Qing Zhang, Zhao Xue, Yuesheng Lv, Shupeng Ren, Yue Chen, Dongmei Zhang, Liang Che. Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II. Journal of cellular and molecular medicine. vol 28. issue 20. 2024-10-21. PMID:39431583. |
these findings suggest a positive feedback loop between klf4 and siat7a-sialyl-tn, ultimately promoting ang ii-induced cardiac hypertrophy. |
2024-10-21 |
2024-10-23 |
Not clear |
| Huiye Yang, Xiaotao Wan. A Comparative Discussion on the Selection of Cardiac Hypertrophy Models: TAC Surgery Vs Ang II Infusion [Letter]. Drug design, development and therapy. vol 18. 2024-10-16. PMID:39411153. |
a comparative discussion on the selection of cardiac hypertrophy models: tac surgery vs ang ii infusion [letter]. |
2024-10-16 |
2024-10-18 |
Not clear |
| Tianyu Wu, Yao Lu, Yue Yu, Yan Hua, Gaoyuan Ge, Wei Zhao, Kaiyan Chen, Zhuen Zhong, Fengxiang Zhan. Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-10-12. PMID:39395058. |
the altered ventricular lncrnas in the mice between sham and transverse aortic constriction (tac) group were identified by microarray analysis, and a novel lncrna ak144717 was found to gradually upregulate during the development of pathological cardiac hypertrophy induced by tac surgery or angiotensin ii (ang ii) stimulation. |
2024-10-12 |
2024-10-15 |
mouse |
| Yu-Kun Ma, Xin-Yi Han, Shu-Huai Zan, Hui-Ting Liu, Xue-Yan Zhou, Dan-Xue Zhao, Rui Xing, Peng Zha. Microrna363-5p targets thrombospondin3 to regulate pathological cardiac remodeling. Molecular and cellular biochemistry. 2024-10-07. PMID:39373825. |
firstly, we established an in vivo model of cardiac remodeling by transverse aortic narrow (tac), and then we stimulated a human cardiomyocyte cell line (ac16) and a human cardiac fibroblast cell line (hcf) using 1 μmol/l angiotensin ii (ang ii) to establish an in vitro model of cardiac hypertrophy and an in vitro model of myocardial fibrosis, respectively. |
2024-10-07 |
2024-10-09 |
human |
| Keying Mi, Xiaoyan Wang, Chao Ma, Yinghua Tan, Gang Zhao, Xinran Cao, Haitao Yua. NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy. Biochimica et biophysica acta. Molecular cell research. 2024-10-02. PMID:39357547. |
whereas over-expression of nlrx1 mitigated the expression levels of p-sting, as well as the endoplasmic reticulum stress markers, including transcription activating factor 4 (atf4), c/ebp homologous protein (chop) and the ratios of phosphorylated perk to perk, phosphorylated ire1 to ire1 and phosphorylated eif2α to eif2α in an angiotensin ii (ang ii)-induced cellular model of cardiac hypertrophy. |
2024-10-02 |
2024-10-05 |
mouse |
| Keying Mi, Xiaoyan Wang, Chao Ma, Yinghua Tan, Gang Zhao, Xinran Cao, Haitao Yua. NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy. Biochimica et biophysica acta. Molecular cell research. 2024-10-02. PMID:39357547. |
our findings provide the evidence that nlrx1 attenuates the perk-eif2α-atf4-chop axis of endoplasmic reticulum stress response via inhibition of p-sting in ang ii-treated cardiomyocytes, thereby ameliorating the development of cardiac hypertrophy. |
2024-10-02 |
2024-10-05 |
mouse |
| Qiuling Wu, Qilong Zhou, Chengyu Wan, Guang Xin, Tao Wang, Yu Gao, Ting Liu, Xiuxian Yu, Boli Zhang, Wen Huan. Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337549. |
in this study, in combination with network pharmacology, the antihypertensive and cardioprotective effects of ca in a two-kidney, one-clip (2k1c) mice model and its ability to mitigate angiotensin ii (ang ii)-induced hypertrophy in h9c2 cells were investigated. |
2024-09-28 |
2024-10-01 |
mouse |
| Abdel-Aziz S Shata. The P2X Purinergic signalling. 2024-09-20. PMID:39304596. |
moreover, this study provides evidence that ang ii increases the expression of p2x7 receptors (p2x7r) in cardiac tissues and that both silencing and pharmacological inhibition of p2x7r significantly inhibited ang ii-induced ferroptosis and hypertrophy. |
2024-09-20 |
2024-09-23 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
in this study, a model of angiotensin ii (ang ii)-induced myocardial hypertrophy was established using subcutaneous administration with a micropump. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
echocardiography, wheat germ agglutinin staining, and western blot analysis were used to evaluate the myocardial hypertrophy model after 5, 10, and 15 days of ang ii treatment. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
the findings demonstrated that mice developed myocardial hypertrophy following subcutaneous administration of ang ii. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
treatment with meloxicam improved ang ii-induced myocardial hypertrophy. |
2024-09-13 |
2024-09-16 |
mouse |
| Shushu Yu, Mingliang Wang, Yun Xie, Bo Wang, Yawei X. MiR-495-3p promotes cardiac hypertrophy by targeting Pum2. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 8. 2024-09-12. PMID:39262254. |
cellular hypertrophy in h9c2 rat cardiomyocytes was stimulated by angiotensin ii (ang ii) treatment. |
2024-09-12 |
2024-09-14 |
rat |
| Shuai-Shuai Zhao, Jinlong Liu, Qi-Cai Wu, Xue-Liang Zho. Lactate regulates pathological cardiac hypertrophy via histone lactylation modification. Journal of cellular and molecular medicine. vol 28. issue 16. 2024-08-29. PMID:39205384. |
the results demonstrate significant expression of hkla in cardiomyocytes derived from an animal model of cardiac hypertrophy induced by transverse aortic constriction surgery, and in neonatal mouse cardiomyocytes stimulated by ang ii. |
2024-08-29 |
2024-09-04 |
mouse |