| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Kun Ma, Xin-Yi Han, Shu-Huai Zan, Hui-Ting Liu, Xue-Yan Zhou, Dan-Xue Zhao, Rui Xing, Peng Zha. Microrna363-5p targets thrombospondin3 to regulate pathological cardiac remodeling. Molecular and cellular biochemistry. 2024-10-07. PMID:39373825. |
firstly, we established an in vivo model of cardiac remodeling by transverse aortic narrow (tac), and then we stimulated a human cardiomyocyte cell line (ac16) and a human cardiac fibroblast cell line (hcf) using 1 μmol/l angiotensin ii (ang ii) to establish an in vitro model of cardiac hypertrophy and an in vitro model of myocardial fibrosis, respectively. |
2024-10-07 |
2024-10-09 |
human |
| Keying Mi, Xiaoyan Wang, Chao Ma, Yinghua Tan, Gang Zhao, Xinran Cao, Haitao Yua. NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy. Biochimica et biophysica acta. Molecular cell research. 2024-10-02. PMID:39357547. |
whereas over-expression of nlrx1 mitigated the expression levels of p-sting, as well as the endoplasmic reticulum stress markers, including transcription activating factor 4 (atf4), c/ebp homologous protein (chop) and the ratios of phosphorylated perk to perk, phosphorylated ire1 to ire1 and phosphorylated eif2α to eif2α in an angiotensin ii (ang ii)-induced cellular model of cardiac hypertrophy. |
2024-10-02 |
2024-10-05 |
mouse |
| Keying Mi, Xiaoyan Wang, Chao Ma, Yinghua Tan, Gang Zhao, Xinran Cao, Haitao Yua. NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy. Biochimica et biophysica acta. Molecular cell research. 2024-10-02. PMID:39357547. |
our findings provide the evidence that nlrx1 attenuates the perk-eif2α-atf4-chop axis of endoplasmic reticulum stress response via inhibition of p-sting in ang ii-treated cardiomyocytes, thereby ameliorating the development of cardiac hypertrophy. |
2024-10-02 |
2024-10-05 |
mouse |
| Qiuling Wu, Qilong Zhou, Chengyu Wan, Guang Xin, Tao Wang, Yu Gao, Ting Liu, Xiuxian Yu, Boli Zhang, Wen Huan. Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337549. |
in this study, in combination with network pharmacology, the antihypertensive and cardioprotective effects of ca in a two-kidney, one-clip (2k1c) mice model and its ability to mitigate angiotensin ii (ang ii)-induced hypertrophy in h9c2 cells were investigated. |
2024-09-28 |
2024-10-01 |
mouse |
| Abdel-Aziz S Shata. The P2X Purinergic signalling. 2024-09-20. PMID:39304596. |
moreover, this study provides evidence that ang ii increases the expression of p2x7 receptors (p2x7r) in cardiac tissues and that both silencing and pharmacological inhibition of p2x7r significantly inhibited ang ii-induced ferroptosis and hypertrophy. |
2024-09-20 |
2024-09-23 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
in this study, a model of angiotensin ii (ang ii)-induced myocardial hypertrophy was established using subcutaneous administration with a micropump. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
echocardiography, wheat germ agglutinin staining, and western blot analysis were used to evaluate the myocardial hypertrophy model after 5, 10, and 15 days of ang ii treatment. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
the findings demonstrated that mice developed myocardial hypertrophy following subcutaneous administration of ang ii. |
2024-09-13 |
2024-09-16 |
mouse |
| Jingjing Zhang, Jiacheng Sun, Xiaosong Gu, Yuntian Shen, Hualin Su. Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. Biochemical pharmacology. 2024-09-13. PMID:39270943. |
treatment with meloxicam improved ang ii-induced myocardial hypertrophy. |
2024-09-13 |
2024-09-16 |
mouse |
| Shushu Yu, Mingliang Wang, Yun Xie, Bo Wang, Yawei X. MiR-495-3p promotes cardiac hypertrophy by targeting Pum2. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 8. 2024-09-12. PMID:39262254. |
cellular hypertrophy in h9c2 rat cardiomyocytes was stimulated by angiotensin ii (ang ii) treatment. |
2024-09-12 |
2024-09-14 |
rat |
| Shuai-Shuai Zhao, Jinlong Liu, Qi-Cai Wu, Xue-Liang Zho. Lactate regulates pathological cardiac hypertrophy via histone lactylation modification. Journal of cellular and molecular medicine. vol 28. issue 16. 2024-08-29. PMID:39205384. |
the results demonstrate significant expression of hkla in cardiomyocytes derived from an animal model of cardiac hypertrophy induced by transverse aortic constriction surgery, and in neonatal mouse cardiomyocytes stimulated by ang ii. |
2024-08-29 |
2024-09-04 |
mouse |
| Jiayu Ren, Yilin Che, Heyu Li, Haijun Gao, Yue Wang, Ying Wang, Hongtong Su, Zhihan Li, Jing Li, Peng Q. SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-19. PMID:39158709. |
macrophage sgk3 deficiency attenuated ang ii-induced macrophage infiltration, myocardial hypertrophy, myocardial fibrosis, and mitochondrial oxidative stress. |
2024-08-19 |
2024-08-21 |
mouse |
| Weihan Sun, Xinyu Fang, Heng Zhang, Yijian Lu, Peiyan Wang, Jiaxin Li, Mengyang L. Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1. Acta biochimica et biophysica Sinica. 2024-08-09. PMID:39118568. |
endogenous rbm4 prevents ang ii-induced cardiomyocyte hypertrophy via downregulating the expression of ptbp1. |
2024-08-09 |
2024-08-12 |
Not clear |
| Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi Zhang, Ye Yuan, Baofeng Yang, Weijie D. The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 11. issue 29. 2024-08-07. PMID:38810124. |
it is found that mettl1 is upregulated in human failing hearts and hypertrophic murine hearts following transverse aortic constriction (tac) and angiotensin ii (ang ii) infusion. |
2024-08-07 |
2024-08-09 |
human |
| Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi Zhang, Ye Yuan, Baofeng Yang, Weijie D. The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 11. issue 29. 2024-08-07. PMID:38810124. |
mettl1 knockout alleviates cardiac hypertrophy and dysfunction upon pressure overload from tac or ang ii stimulation. |
2024-08-07 |
2024-08-09 |
human |
| Caijie Shen, Nan Wu, Xiaomin Chen, Jianye Peng, Mingjun Feng, Jian Wang, Yibo Y. Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-04. PMID:38963241. |
we found knockout of il-5 significantly increased the expression of cardiac hypertrophy markers, elevated myocardial cell cross-sectional areas and worsened cardiac dysfunction in ang ii-infused mice. |
2024-07-04 |
2024-07-08 |
mouse |
| Caijie Shen, Nan Wu, Xiaomin Chen, Jianye Peng, Mingjun Feng, Jian Wang, Yibo Y. Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-04. PMID:38963241. |
il-5 knockout significantly increased the ang ii-induced mrna expression of cardiac hypertrophy markers in myocardial cells that were co-cultured with macrophages, and this effect was reversed by s31-201. |
2024-07-04 |
2024-07-08 |
mouse |
| Laura Castiglioni, Paolo Gelosa, Majeda Muluhie, Benedetta Mercuriali, Joanna Rzemieniec, Marco Gotti, Fabio Fiordaliso, Giuseppe Busca, Luigi Siron. Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy. European journal of pharmacology. 2024-06-23. PMID:38909934. |
in cultured h9c2 cardiomyoblasts, fenofibrate reversed the ang ii-induced mrna up-regulation of hypertrophy markers nppa and myh7, accumulation of reactive oxygen species and depolarization of the mitochondrial membrane exerting protection mediated by up-regulation of the uncoupling protein 2. |
2024-06-23 |
2024-06-26 |
rat |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
this research aimed to clarify the impacts of cannflavin-c on angiotensin ii (ang ii)-induced cardiac hypertrophy and their potential role in modulating cytochrome p450 1b1 (cyp1b1) and arachidonic acid (aa) metabolites. |
2024-06-05 |
2024-06-08 |
human |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
ang ii induced hypertrophic markers myosin heavy chain (β/α-mhc), atrial natriuretic peptide (anp), and brain natriuretic peptide (bnp) and increased cell surface area, while cannflavin-c mitigated these effects. |
2024-06-05 |
2024-06-08 |
human |