| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiayu Ren, Yilin Che, Heyu Li, Haijun Gao, Yue Wang, Ying Wang, Hongtong Su, Zhihan Li, Jing Li, Peng Q. SGK3 deficiency in macrophages suppresses angiotensin II-induced cardiac remodeling via regulating Ndufa13-mediated mitochondrial oxidative stress. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-19. PMID:39158709. |
macrophage sgk3 deficiency attenuated ang ii-induced macrophage infiltration, myocardial hypertrophy, myocardial fibrosis, and mitochondrial oxidative stress. |
2024-08-19 |
2024-08-21 |
mouse |
| Weihan Sun, Xinyu Fang, Heng Zhang, Yijian Lu, Peiyan Wang, Jiaxin Li, Mengyang L. Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1. Acta biochimica et biophysica Sinica. 2024-08-09. PMID:39118568. |
endogenous rbm4 prevents ang ii-induced cardiomyocyte hypertrophy via downregulating the expression of ptbp1. |
2024-08-09 |
2024-08-12 |
Not clear |
| Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi Zhang, Ye Yuan, Baofeng Yang, Weijie D. The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 11. issue 29. 2024-08-07. PMID:38810124. |
it is found that mettl1 is upregulated in human failing hearts and hypertrophic murine hearts following transverse aortic constriction (tac) and angiotensin ii (ang ii) infusion. |
2024-08-07 |
2024-08-09 |
human |
| Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi Zhang, Ye Yuan, Baofeng Yang, Weijie D. The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 11. issue 29. 2024-08-07. PMID:38810124. |
mettl1 knockout alleviates cardiac hypertrophy and dysfunction upon pressure overload from tac or ang ii stimulation. |
2024-08-07 |
2024-08-09 |
human |
| Caijie Shen, Nan Wu, Xiaomin Chen, Jianye Peng, Mingjun Feng, Jian Wang, Yibo Y. Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-04. PMID:38963241. |
we found knockout of il-5 significantly increased the expression of cardiac hypertrophy markers, elevated myocardial cell cross-sectional areas and worsened cardiac dysfunction in ang ii-infused mice. |
2024-07-04 |
2024-07-08 |
mouse |
| Caijie Shen, Nan Wu, Xiaomin Chen, Jianye Peng, Mingjun Feng, Jian Wang, Yibo Y. Interleukin-5 alleviates cardiac remodelling via the STAT3 pathway in angiotensin II-infused mice. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-04. PMID:38963241. |
il-5 knockout significantly increased the ang ii-induced mrna expression of cardiac hypertrophy markers in myocardial cells that were co-cultured with macrophages, and this effect was reversed by s31-201. |
2024-07-04 |
2024-07-08 |
mouse |
| Laura Castiglioni, Paolo Gelosa, Majeda Muluhie, Benedetta Mercuriali, Joanna Rzemieniec, Marco Gotti, Fabio Fiordaliso, Giuseppe Busca, Luigi Siron. Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy. European journal of pharmacology. 2024-06-23. PMID:38909934. |
in cultured h9c2 cardiomyoblasts, fenofibrate reversed the ang ii-induced mrna up-regulation of hypertrophy markers nppa and myh7, accumulation of reactive oxygen species and depolarization of the mitochondrial membrane exerting protection mediated by up-regulation of the uncoupling protein 2. |
2024-06-23 |
2024-06-26 |
rat |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
this research aimed to clarify the impacts of cannflavin-c on angiotensin ii (ang ii)-induced cardiac hypertrophy and their potential role in modulating cytochrome p450 1b1 (cyp1b1) and arachidonic acid (aa) metabolites. |
2024-06-05 |
2024-06-08 |
human |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
ang ii induced hypertrophic markers myosin heavy chain (β/α-mhc), atrial natriuretic peptide (anp), and brain natriuretic peptide (bnp) and increased cell surface area, while cannflavin-c mitigated these effects. |
2024-06-05 |
2024-06-08 |
human |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
this study provides novel insights into the potential of cannflavin-c in modulating arachidonic acid metabolites and attenuating ang ii-induced cardiac hypertrophy, highlighting the importance of this compound as potential therapeutic agents for cardiac hypertrophy. |
2024-06-05 |
2024-06-08 |
human |
| Zhao Fang, Ming Lu, Rui Huang, Guangji Wang, Feierkaiti Yushanjiang, Xuejun Jiang, Jun L. Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice. Phytotherapy research : PTR. 2024-06-04. PMID:38831669. |
furthermore, carnosol significantly reduced ang ii-induced cardiomyocyte hypertrophy in nrcms and alleviated the upregulation of hypertrophy and fibrosis markers. |
2024-06-04 |
2024-06-06 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
previous studies suggest that micro-ribonucleic acids (mirnas) show promise for the early diagnosis and treatment of cardiomyocyte hypertrophy.to investigate the mir-378 expression in the cardiomyocyte hypertrophy model, reverse transcription-polymerase chain reaction (rt-qpcr), western blot, and immunofluorescence tests were conducted in angiotensin ii (ang ii)-induced h9c2 cells and ang ii-induced mouse model of cardiomyocyte hypertrophy. |
2024-06-02 |
2024-06-05 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
it was observed that the introduction of the mir-378 mimic inhibited the hypertrophy of cardiomyocytes induced by ang ii. |
2024-06-02 |
2024-06-05 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
molecular investigations provided evidence that mir-378 negatively regulated akt2 expression by interacting with the 3' untranslated region (utr) of akt2 mrna.decreased mir-378 expression and akt2 activation are linked to ang ii-induced cardiomyocyte hypertrophy. |
2024-06-02 |
2024-06-05 |
mouse |
| Mengfei Cao, Qianru Zhao, Hao Xia, Shumei Lyu, Jie Luo, Kewei Fu, Rui Chen, Wei Yua. Intracellular and extracellular Cyclophilin a promote cardiac fibrosis through TGF-β signaling in response to angiotensin Ⅱ. Biochemical pharmacology. vol 225. 2024-05-11. PMID:38723722. |
inhibition of cypa significantly reversed ang Ⅱ-induced cardiac hypertrophy and fibrosis. |
2024-05-11 |
2024-05-27 |
mouse |
| Vasa Vemuri, Nicholas Kratholm, Darini Nagarajan, Dakotah Cathey, Ahmed Abdelbaset-Ismail, Yi Tan, Alex Straughn, Lu Cai, Jiapeng Huang, Sham S Kaka. Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia. Cells. vol 13. issue 9. 2024-05-10. PMID:38727319. |
the continuous infusion of ang ii resulted in the loss of the normal functions of the left ventricle (lv) (both systolic and diastolic), including a significant reduction in fractional shortening, an increase in heart weight and lv wall thickness, and the development of cardiac hypertrophy. |
2024-05-10 |
2024-05-27 |
mouse |
| Vasa Vemuri, Nicholas Kratholm, Darini Nagarajan, Dakotah Cathey, Ahmed Abdelbaset-Ismail, Yi Tan, Alex Straughn, Lu Cai, Jiapeng Huang, Sham S Kaka. Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia. Cells. vol 13. issue 9. 2024-05-10. PMID:38727319. |
the infusion of ang ii also resulted in the development of cardiac fibrosis, and significant increases in the expression levels of genes (anp, bnp, and mhcβ) associated with cardiac hypertrophy and the chemical staining of the collagen abundance as an indication of fibrosis. |
2024-05-10 |
2024-05-27 |
mouse |
| Cheng Chen, Song Hu, Heng-Jing Hu, Zhi-Xuan Liu, Xin-Teng Wu, Tao Zou, Hua S. Dronedarone Attenuates Ang II-Induced Myocardial Hypertrophy Through Regulating SIRT1/FOXO3/PKIA Axis. Korean circulation journal. vol 54. issue 4. 2024-04-24. PMID:38654563. |
dronedarone attenuates ang ii-induced myocardial hypertrophy through regulating sirt1/foxo3/pkia axis. |
2024-04-24 |
2024-04-28 |
mouse |
| Mohamed Lamine Aidara, Élisabeth Walsh-Wilkinson, Sara-Ève Thibodeau, Emylie-Ann Labbé, Audrey Morin-Grandmont, Geneviève Gagnon, Dominique K Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couë. Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle. American journal of physiology. Heart and circulatory physiology. vol 326. issue 4. 2024-04-03. PMID:38363584. |
ang ii and ang ii + hfd (metabolic-hypertensive stress, mhs) caused cardiac hypertrophy (ch) and myocardial fibrosis, left ventricular (lv) concentric remodeling, atrial enlargement, and reduced exercise capacity. |
2024-04-03 |
2024-04-05 |
mouse |
| Siqi Wang, Xin Wang, Li Ling, Cairong Li, Zhanhong Re. RICH1 is a novel key suppressor of isoproterenol‑ or angiotensin II‑induced cardiomyocyte hypertrophy. Molecular medicine reports. vol 29. issue 5. 2024-03-08. PMID:38456539. |
these findings suggested that rich1 may be a novel suppressor of iso‑ or ang ii‑induced cardiomyocyte hypertrophy. |
2024-03-08 |
2024-03-10 |
Not clear |