| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmad H Alammari, Fadumo Ahmed Isse, Conor O'Croinin, Neal M Davies, Ayman O S El-Kad. Drug metabolism and disposition: the biological fate of chemicals. 2024-06-05. PMID:38839111. |
this study provides novel insights into the potential of cannflavin-c in modulating arachidonic acid metabolites and attenuating ang ii-induced cardiac hypertrophy, highlighting the importance of this compound as potential therapeutic agents for cardiac hypertrophy. |
2024-06-05 |
2024-06-08 |
human |
| Zhao Fang, Ming Lu, Rui Huang, Guangji Wang, Feierkaiti Yushanjiang, Xuejun Jiang, Jun L. Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice. Phytotherapy research : PTR. 2024-06-04. PMID:38831669. |
furthermore, carnosol significantly reduced ang ii-induced cardiomyocyte hypertrophy in nrcms and alleviated the upregulation of hypertrophy and fibrosis markers. |
2024-06-04 |
2024-06-06 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
previous studies suggest that micro-ribonucleic acids (mirnas) show promise for the early diagnosis and treatment of cardiomyocyte hypertrophy.to investigate the mir-378 expression in the cardiomyocyte hypertrophy model, reverse transcription-polymerase chain reaction (rt-qpcr), western blot, and immunofluorescence tests were conducted in angiotensin ii (ang ii)-induced h9c2 cells and ang ii-induced mouse model of cardiomyocyte hypertrophy. |
2024-06-02 |
2024-06-05 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
it was observed that the introduction of the mir-378 mimic inhibited the hypertrophy of cardiomyocytes induced by ang ii. |
2024-06-02 |
2024-06-05 |
mouse |
| Guili Wang, Linlin Feng, Chunxiang Liu, Zongqiang Han, Xia Che. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2. International heart journal. vol 65. issue 3. 2024-06-02. PMID:38825497. |
molecular investigations provided evidence that mir-378 negatively regulated akt2 expression by interacting with the 3' untranslated region (utr) of akt2 mrna.decreased mir-378 expression and akt2 activation are linked to ang ii-induced cardiomyocyte hypertrophy. |
2024-06-02 |
2024-06-05 |
mouse |
| Mengfei Cao, Qianru Zhao, Hao Xia, Shumei Lyu, Jie Luo, Kewei Fu, Rui Chen, Wei Yua. Intracellular and extracellular Cyclophilin a promote cardiac fibrosis through TGF-β signaling in response to angiotensin Ⅱ. Biochemical pharmacology. vol 225. 2024-05-11. PMID:38723722. |
inhibition of cypa significantly reversed ang Ⅱ-induced cardiac hypertrophy and fibrosis. |
2024-05-11 |
2024-05-27 |
mouse |
| Vasa Vemuri, Nicholas Kratholm, Darini Nagarajan, Dakotah Cathey, Ahmed Abdelbaset-Ismail, Yi Tan, Alex Straughn, Lu Cai, Jiapeng Huang, Sham S Kaka. Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia. Cells. vol 13. issue 9. 2024-05-10. PMID:38727319. |
the continuous infusion of ang ii resulted in the loss of the normal functions of the left ventricle (lv) (both systolic and diastolic), including a significant reduction in fractional shortening, an increase in heart weight and lv wall thickness, and the development of cardiac hypertrophy. |
2024-05-10 |
2024-05-27 |
mouse |
| Vasa Vemuri, Nicholas Kratholm, Darini Nagarajan, Dakotah Cathey, Ahmed Abdelbaset-Ismail, Yi Tan, Alex Straughn, Lu Cai, Jiapeng Huang, Sham S Kaka. Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia. Cells. vol 13. issue 9. 2024-05-10. PMID:38727319. |
the infusion of ang ii also resulted in the development of cardiac fibrosis, and significant increases in the expression levels of genes (anp, bnp, and mhcβ) associated with cardiac hypertrophy and the chemical staining of the collagen abundance as an indication of fibrosis. |
2024-05-10 |
2024-05-27 |
mouse |
| Cheng Chen, Song Hu, Heng-Jing Hu, Zhi-Xuan Liu, Xin-Teng Wu, Tao Zou, Hua S. Dronedarone Attenuates Ang II-Induced Myocardial Hypertrophy Through Regulating SIRT1/FOXO3/PKIA Axis. Korean circulation journal. vol 54. issue 4. 2024-04-24. PMID:38654563. |
dronedarone attenuates ang ii-induced myocardial hypertrophy through regulating sirt1/foxo3/pkia axis. |
2024-04-24 |
2024-04-28 |
mouse |
| Mohamed Lamine Aidara, Élisabeth Walsh-Wilkinson, Sara-Ève Thibodeau, Emylie-Ann Labbé, Audrey Morin-Grandmont, Geneviève Gagnon, Dominique K Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couë. Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle. American journal of physiology. Heart and circulatory physiology. vol 326. issue 4. 2024-04-03. PMID:38363584. |
ang ii and ang ii + hfd (metabolic-hypertensive stress, mhs) caused cardiac hypertrophy (ch) and myocardial fibrosis, left ventricular (lv) concentric remodeling, atrial enlargement, and reduced exercise capacity. |
2024-04-03 |
2024-04-05 |
mouse |
| Siqi Wang, Xin Wang, Li Ling, Cairong Li, Zhanhong Re. RICH1 is a novel key suppressor of isoproterenol‑ or angiotensin II‑induced cardiomyocyte hypertrophy. Molecular medicine reports. vol 29. issue 5. 2024-03-08. PMID:38456539. |
these findings suggested that rich1 may be a novel suppressor of iso‑ or ang ii‑induced cardiomyocyte hypertrophy. |
2024-03-08 |
2024-03-10 |
Not clear |
| Eduardo Nocchi, Sérgio Scalzo, Cibele Rocha-Resende, Pedro Almeida, Amanda Parreira, Kiany Miranda, Victor M Vidal, Robson A S Dos Santos, Silvia Guatimosi. The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production. Peptides. 2024-03-01. PMID:38428743. |
the mas agonist cgen-856s prevents ang ii induced cardiomyocyte hypertrophy via nitric oxide production. |
2024-03-01 |
2024-03-04 |
mouse |
| Eduardo Nocchi, Sérgio Scalzo, Cibele Rocha-Resende, Pedro Almeida, Amanda Parreira, Kiany Miranda, Victor M Vidal, Robson A S Dos Santos, Silvia Guatimosi. The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production. Peptides. 2024-03-01. PMID:38428743. |
in addition, cgen-856s prevented the ang ii induced hypertrophy and the nuclear translocation of grk5 in a culture model of rat neonatal cardiomyocytes. |
2024-03-01 |
2024-03-04 |
mouse |
| Eduardo Nocchi, Sérgio Scalzo, Cibele Rocha-Resende, Pedro Almeida, Amanda Parreira, Kiany Miranda, Victor M Vidal, Robson A S Dos Santos, Silvia Guatimosi. The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production. Peptides. 2024-03-01. PMID:38428743. |
in conclusion, we show that cgen-856s acting via receptor mas induces no raise to block ang ii induced cardiomyocyte hypertrophy. |
2024-03-01 |
2024-03-04 |
mouse |
| Qi-Qiang Zhang, Qing-Shan Chen, Fei Feng, Xiang Cao, Xiao-Fei Chen, Hai Zhan. Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure. Free radical biology & medicine. 2024-02-18. PMID:38369076. |
in this study, benzoylaconitine inhibited ang ii-induced cell hypertrophy and fibrosis in rat primary cardiomyocytes and rat fibroblasts, while attenuating cardiac function and cardiac remodeling in tac mice. |
2024-02-18 |
2024-02-21 |
mouse |
| Ya-Che Lee, Yeong-Chin Jou, Wan-Ching Chou, Kun-Ling Tsai, Cheng-Huang Shen, Shin-Da Le. Ellagic acid protects against angiotensin II-induced hypertrophic responses through ROS-mediated MAPK pathway in H9c2 cells. Environmental toxicology. 2024-02-15. PMID:38356441. |
this hypertrophic event of the heart is mediated by the interaction of ang type 1 receptors (at-r1), thereby modulating nadph oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. |
2024-02-15 |
2024-02-17 |
Not clear |
| Yitong Wang, Xiangbo An, Feng Wang, Yinong Jian. Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-15. PMID:38359490. |
in this study, a myocardial remodeling model was established using angiotensin (ang) ii, and the inhibitory effect of rh4 on myocardial hypertrophy and remodeling induced by ang ii was investigated using pathological staining and quantitative polymerase chain reaction (qpcr). |
2024-02-15 |
2024-02-18 |
mouse |
| Yitong Wang, Xiangbo An, Feng Wang, Yinong Jian. Ginsenoside RH4 inhibits Ang II-induced myocardial remodeling by interfering with NFIL3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-15. PMID:38359490. |
the findings indicated that rh4 could inhibit myocardial hypertrophy, inflammatory fibrosis, and oxidative stress induced by ang ii, suggesting potential cardiovascular protection effects. |
2024-02-15 |
2024-02-18 |
mouse |
| Xueqian Ouyang, Wei Chen, Guolong Peng, Huimei Liu, Sisi Fan, Qin Li, Liwen Wang, Linxi Chen, Lanfang L. 1,12-cyclic apelin-12 ameliorates Ang II and Apelin-13-induced cardiac hypertrophy by reducing mitochondrial oxidative damage. Chinese medical journal. 2024-02-07. PMID:38321846. |
1,12-cyclic apelin-12 ameliorates ang ii and apelin-13-induced cardiac hypertrophy by reducing mitochondrial oxidative damage. |
2024-02-07 |
2024-02-09 |
Not clear |
| Lei Shi, Yanzhen Tan, Wenying Zheng, Guojie Cao, Haitao Zhou, Panpan Li, Jun Cui, Yujie Song, Lele Feng, Hong Li, Wenju Shan, Bing Zhang, Wei Y. CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis. Cell death discovery. vol 10. issue 1. 2024-01-26. PMID:38278820. |
tac or ang ii resulted in compensatory activation of uprmt, but this was not sufficient to counteract pathologic cardiac hypertrophy. |
2024-01-26 |
2024-01-29 |
mouse |