| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Jia, Wenxue Liu, Keyin Zhang, Zhigang Wang, Ruisha Li, Jun Pan, Jianjun Yang, Dongjin Wan. Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice. Molecular medicine reports. vol 29. issue 3. 2024-01-26. PMID:38275127. |
the results indicated that treatment with tac or ang ii leads to significant hypertrophy and dysfunction of the heart or h9c2 cells, accompanied by an increase in er stress, apoptosis and activation of the mtor signaling pathway, and a decrease in autophagy. |
2024-01-26 |
2024-01-28 |
mouse |
| Yi-Jiang Liu, Jia-Jia Xu, Cui Yang, Yan-Lin Li, Min-Wei Chen, Shi-Xiao Liu, Xiang-Hui Zheng, Ping Luo, Rui Li, Di Xiao, Zhong-Gui Sha. Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways. Molecular biology reports. vol 51. issue 1. 2023-12-29. PMID:38158445. |
although many studies have confirmed the cardioprotective effects of muscone, the effects of muscone on cardiac hypertrophy and its potential mechanisms are unclear.the aim of the present study was to investigate the effect of muscone on angiotensin (ang) ii-induced cardiac hypertrophy. |
2023-12-29 |
2024-01-05 |
Not clear |
| Poonam, Shashi Chaudhar. Interactions between AT1R and GRKs: the determinants for activation of signaling pathways involved in blood pressure regulation. Molecular biology reports. vol 51. issue 1. 2023-12-29. PMID:38158508. |
the structural insights and mutational studies of ang ii-at1r have brought about the vision to design ang ii analogs that selectively activate the pathways with beneficial and cardioprotective effects such as cell survival and hinder the deleterious effects such as hypertrophy and cell death. |
2023-12-29 |
2024-01-05 |
Not clear |
| Lintao Wang, Suya Zhang, Hongxia Liu, Li Gao, Lu He, Yue Chen, Junsheng Zhang, Miaomiao Yang, Chaoyong H. STING activation in cardiomyocytes drives hypertrophy-associated heart failure via NF-κB-mediated inflammatory response. Biochimica et biophysica acta. Molecular basis of disease. 2023-12-24. PMID:38142758. |
furthermore, deleting or pharmacologically inhibiting sting attenuated cardiac hypertrophy and dysfunction in tac or ang ii-treated mice. |
2023-12-24 |
2023-12-27 |
mouse |
| Zhenyu Feng, Ningning Zhang, Jie Bai, Qiu-Yue Lin, Yunpeng Xie, Yun-Long Xi. Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-13. PMID:38091641. |
bca inhibited ang ii-induced cell hypertrophy and oxidative stress in nrcms in vitro and ang ii-induced cf migration, proliferation, and collagen secretion. |
2023-12-13 |
2023-12-17 |
mouse |
| Qian Xu, Kunping Zhuo, Xiaotian Zhang, Yanru Zhen, Limin Liu, Lu Zhang, Yufan Gu, Hui Jia, Qing Chen, Meixi Liu, Jiawei Dong, Ming-Sheng Zho. The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling. European journal of pharmacology. vol 962. 2023-12-12. PMID:38061470. |
treatment with verteporfin significantly reduced ang ii-induced cardiac and vascular hypertrophy with a mild reduction in systolic blood pressure (sbp), verteporfin attenuated ang ii-induced cardiac and aortic fibrosis with the inhibition of transform growth factor (tgf)β/smad2/3 fibrotic signaling and extracellular matrix collagen i deposition. |
2023-12-12 |
2023-12-17 |
Not clear |
| Xiaoyan Lin, Hailin Zhang, Yong Chu, Yuze Zhang, Changsheng Xu, Hong Xie, Qinyun Ruan, Jinxiu Lin, Chun-Kai Huang, Dajun Cha. Honokiol ameliorates angiotensin II-induced cardiac hypertrophy by promoting dissociation of the Nur77-LKB1 complex and activating the AMPK pathway. Journal of cellular and molecular medicine. 2023-11-20. PMID:37985436. |
this study aims to investigate the effect of hnk on angiotensin ii (ang ii)-induced myocardial hypertrophy and elucidate the underlying mechanisms. |
2023-11-20 |
2023-11-29 |
rat |
| Xiaoyan Lin, Hailin Zhang, Yong Chu, Yuze Zhang, Changsheng Xu, Hong Xie, Qinyun Ruan, Jinxiu Lin, Chun-Kai Huang, Dajun Cha. Honokiol ameliorates angiotensin II-induced cardiac hypertrophy by promoting dissociation of the Nur77-LKB1 complex and activating the AMPK pathway. Journal of cellular and molecular medicine. 2023-11-20. PMID:37985436. |
our results showed that hnk treatment protected against ang ii-induced myocardial hypertrophy, fibrosis and dysfunction in vivo and inhibited ang ii-induced hypertrophy in neonatal rat ventricular myocytes in vitro. |
2023-11-20 |
2023-11-29 |
rat |
| Chanyuan Lv, Liuyi Zhou, Yongkang Meng, Haitao Yuan, Jing Gen. PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway. Cellular signalling. 2023-11-16. PMID:37972803. |
pkd knockdown mitigates ang ii-induced cardiac hypertrophy and ferroptosis via the jnk/p53 signaling pathway. |
2023-11-16 |
2023-11-20 |
Not clear |
| Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Keigo Hirota, Shunichiro Tsukamoto, Ryutaro Morita, Ryu Kobayashi, Sho Kinguchi, Akio Yamashita, Hiromichi Wakui, Kouichi Tamur. Angiotensin II type 1 receptor-associated protein deletion combined with angiotensin II stimulation accelerates the development of diabetic kidney disease in mice on a C57BL/6 strain. Hypertension research : official journal of the Japanese Society of Hypertension. 2023-11-13. PMID:37957242. |
however, a combination of atrap deletion with ang ii stimulation accelerated the development of dkd as manifested by overt albuminuria, glomerular hypertrophy, podocyte loss, mesangial expansion, kidney interstitial fibrosis and functional insufficiency, concomitant with increased angiotensinogen and at1r expression in the kidneys. |
2023-11-13 |
2023-11-20 |
mouse |
| Si-Ting Xu, Yue-Xin Zhang, Si-Ling Liu, Fang Liu, Jian-Tao Y. Exosomes derived from cardiac fibroblasts with angiotensin II stimulation provoke hypertrophy and autophagy inhibition in cardiomyocytes. Biochemical and biophysical research communications. vol 682. 2023-10-12. PMID:37826943. |
these findings highlight a novel role of ang ii-cfs-exosomes in suppressing cardiomyocyte autophagy, which may help to better understand the pathogenesis of cardiac hypertrophy. |
2023-10-12 |
2023-10-15 |
mouse |
| Sukhwinder K Bhullar, Naranjan S Dhall. Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure. Canadian journal of physiology and pharmacology. 2023-09-25. PMID:37748204. |
this hormone is known to induce cardiac hypertrophy and heart failure and its actions are mediated by the interaction of both pro- and anti- hypertrophic ang ii receptors ( at1r and at2r). |
2023-09-25 |
2023-10-07 |
human |
| Shen Bin, Feng Xinyi, Pan Huan, Zhang Xiaoqin, Wu Jiming, He Yi, Li Ziyue, Zou Xiaochun, Lu Zhouqi, Zhou Bangwei, Jin Jing, Liu Shihui, Jinlai Ga. SOX4 as a potential therapeutic target for pathological cardiac hypertrophy. European journal of pharmacology. 2023-09-23. PMID:37741429. |
we found that the sox4 expression was elevated in hypertrophic hearts and angiotensin ii (ang ii)-treated neonatal rat cardiomyocytes (nrcms), and knocking down the sox4 expression in nrcms and mouse hearts significantly reduced the hypertrophic response. |
2023-09-23 |
2023-10-07 |
mouse |
| Teng Sun, Yu Han, Jia-Lei Li, Shuang Wang, Zhi-Jie Jing, Zi Yan, Lan Zhou, Lin Zuo, Jun-Li Yang, Ji-Min Ca. Synaptotagmin-7 Mediates Cardiac Hypertrophy by Targeting Autophagy. The FEBS journal. 2023-09-19. PMID:37724442. |
mir-93 protected hearts against ang ii-induced hypertrophy through targeting syt7-autophagy pathway. |
2023-09-19 |
2023-10-07 |
mouse |
| Qianwen Huang, Qian Huan. Inhibition of lncRNA DANCR Prevents Heart Failure by Ameliorating Cardiac Hypertrophy and Fibrosis Via Regulation of the miR-758-3p/PRG4/Smad Axis. Journal of cardiovascular translational research. 2023-09-01. PMID:37656414. |
it was discovered that prg4 silencing attenuated cell hypertrophy and fibrosis and inactivated the smad pathway under ang ii treatment. |
2023-09-01 |
2023-09-07 |
rat |
| Qian Liu, Cheng Xu, Jing Jin, Wenxiang Li, Jingjia Liang, Shijie Zhou, Zhenkun Weng, Yong Zhou, Xudong Liao, Aihua G. Early-life exposure to lead changes cardiac development and compromises long-term cardiac function. The Science of the total environment. 2023-08-31. PMID:37652374. |
the results showed early-life lead exposure predisposed offspring mice to decreased ejection fraction, increased left ventricular volume, accompanied by hypertrophy and dilation, cardiomyocyte sarcomere dysplasia, abnormal mitochondrial structure, mitochondrial dysfunction, and decreased expression of key sarcomeric and mitochondrial genes, rendering them more susceptible to cardiac hypertrophy, vascular wall thickening, cardiac fibrosis, apoptosis, and heart failure induced by ang ii infusion. |
2023-08-31 |
2023-09-07 |
mouse |
| Jiahe Xie, Cankun Zheng, Mengjia Shen, Weiling Lu, Mingjue Li, Mingyuan He, Lu Chen, Siyuan Ma, Yingqi Zhu, Hairuo Lin, Jiancheng Xiu, Wangjun Liao, Jianping Bin, Yulin Lia. Pregnancy-induced physiological hypertrophic preconditioning attenuates pathological myocardial hypertrophy by activation of FoxO3a. Cellular and molecular life sciences : CMLS. vol 80. issue 9. 2023-08-25. PMID:37626241. |
the pluripara mice whose pregnancy-induced physiological hypertrophy regressed and the nulliparous mice underwent angiotensin ii (ang ii) infusion or transverse aortic constriction (tac). |
2023-08-25 |
2023-09-07 |
mouse |
| Jiahe Xie, Cankun Zheng, Mengjia Shen, Weiling Lu, Mingjue Li, Mingyuan He, Lu Chen, Siyuan Ma, Yingqi Zhu, Hairuo Lin, Jiancheng Xiu, Wangjun Liao, Jianping Bin, Yulin Lia. Pregnancy-induced physiological hypertrophic preconditioning attenuates pathological myocardial hypertrophy by activation of FoxO3a. Cellular and molecular life sciences : CMLS. vol 80. issue 9. 2023-08-25. PMID:37626241. |
compared with nulliparous mice, pathological cardiac hypertrophy induced by ang ii infusion, or tac was significantly attenuated and heart failure induced by tac was markedly improved in mice with php. |
2023-08-25 |
2023-09-07 |
mouse |
| Xi Zheng, Fuxiang Su, Ming Lei, Jingyuan Li, Chenyang Zhang, Yujia Zhang, Ming Wei, Wei Li, Sichong Chen, Yunzhu Liu, Qinghua Gao, Liying Ha. The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2. European journal of pharmacology. 2023-08-11. PMID:37567457. |
the novel peptide athycaltide-1 attenuates ang ii-induced pathological myocardial hypertrophy by reducing ros and inhibiting the activation of camkii and erk1/2. |
2023-08-11 |
2023-08-16 |
mouse |
| Xi Zheng, Fuxiang Su, Ming Lei, Jingyuan Li, Chenyang Zhang, Yujia Zhang, Ming Wei, Wei Li, Sichong Chen, Yunzhu Liu, Qinghua Gao, Liying Ha. The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2. European journal of pharmacology. 2023-08-11. PMID:37567457. |
the purpose of this research was to explore the molecular mechanism of a novel peptide athycaltide-1 (ath-1) in the treatment of ang ii-induced pathological myocardial hypertrophy. |
2023-08-11 |
2023-08-16 |
mouse |