| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongseok Park, Seungjoon Kim, Hyeonho Kim, Jungsu Shin, Hyeji Jung, Ji Won U. Seizure progression triggered by IQSEC3 loss is mitigated by reducing activated microglia in mice. Glia. vol 68. issue 12. 2021-04-06. PMID:32645240. |
in the current study, we show that mice with hippocampal dentate gyrus (dg)-specific iqsec3 knockdown (kd) exhibit microglial activation and death of dg granule cell. |
2021-04-06 |
2023-08-13 |
mouse |
| Ning-Ning Cai, Zheng-Zhu Wang, Xian-Chun Zhu, Yu Jiang, Wen-Qian Zhu, Rui Yang, Xue-Ming Zhan. Schisandrin A and B enhance the dentate gyrus neurogenesis in mouse hippocampus. Journal of chemical neuroanatomy. vol 105. 2021-04-02. PMID:32027950. |
since the neurogenesis in the hippocampal dentate gyrus (dg) is more important to learning, memory and cognition, here we further examined their effects on the adult dg neurogenesis. |
2021-04-02 |
2023-08-13 |
mouse |
| Branden R Nelson, Rebecca D Hodge, Ray Am Daza, Prem Prakash Tripathi, Sebastian J Arnold, Kathleen J Millen, Robert F Hevne. Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. eLife. vol 9. 2021-03-30. PMID:32238264. |
the hippocampal dentate gyrus (dg) is a unique brain region maintaining neural stem cells (ncss) and neurogenesis into adulthood. |
2021-03-30 |
2023-08-13 |
mouse |
| Aline Siteneski, Gislaine Olescowicz, Francis L Pazini, Anderson Camargo, Daiane B Fraga, Patricia S Brocardo, Joana Gil-Mohapel, Mauricio P Cunha, Ana Lúcia S Rodrigue. Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 3. 2021-03-26. PMID:31974720. |
immunohistochemical analyses to evaluate hippocampal cell proliferation, neuronal survival, and neuronal commitment and maturation, as well as expression of fndc5 c-terminal fragment were performed in the entire, dorsal, and ventral dentate gyrus (dg) of the hippocampus. |
2021-03-26 |
2023-08-13 |
mouse |
| Aline Siteneski, Gislaine Olescowicz, Francis L Pazini, Anderson Camargo, Daiane B Fraga, Patricia S Brocardo, Joana Gil-Mohapel, Mauricio P Cunha, Ana Lúcia S Rodrigue. Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 3. 2021-03-26. PMID:31974720. |
this antidepressant-like effect was accompanied by an increase in hippocampal cell proliferation, hippocampal neuronal differentiation, and neuronal survival in the dorsal and ventral dg. |
2021-03-26 |
2023-08-13 |
mouse |
| Aline Siteneski, Gislaine Olescowicz, Francis L Pazini, Anderson Camargo, Daiane B Fraga, Patricia S Brocardo, Joana Gil-Mohapel, Mauricio P Cunha, Ana Lúcia S Rodrigue. Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 3. 2021-03-26. PMID:31974720. |
finally, physical exercise also resulted in increased number of fndc5-positive cells in the hippocampal dg as well as elevated fndc5 c-terminal and fndc5/irisin immunocontent in the entire hippocampus. |
2021-03-26 |
2023-08-13 |
mouse |
| Xiaomin Zhang, Peter Jona. Integration of spatial and non-spatial information by heterogeneous dentate gyrus granule cells. Journal of life sciences (Westlake Village, Calif.). vol 2. issue 4. 2021-03-26. PMID:33409506. |
thus, the dg sits in a strategic position to gate the flow of information from the neocortex into the hippocampal network. |
2021-03-26 |
2023-08-13 |
Not clear |
| A González-Maciel, R M Romero-Velázquez, A Alfaro-Rodríguez, P Sanchez Aparicio, R Reynoso-Roble. Prenatal exposure to oxcarbazepine increases hippocampal apoptosis in rat offspring. Journal of chemical neuroanatomy. vol 103. 2021-03-23. PMID:31794794. |
apoptosis was detected at three postnatal ages using the tunel technique in the ca1, and ca3 regions of the hippocampus and in the dentate gyrus (dg); neurogenesis was assessed in the dg using an antibody against doublecortin. |
2021-03-23 |
2023-08-13 |
rat |
| Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong L. The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats. Frontiers in psychiatry. vol 12. 2021-03-23. PMID:33746787. |
also, few nissl bodies in the hippocampus ca1 and dg regions, less percentage of syn-positive cells, and downregulated expressions of syn, psd-95, and gap43 were found in the hippocampus of rats in ms+cums group. |
2021-03-23 |
2023-08-13 |
rat |
| Zane R Lybrand, Sonal Goswami, Jingfei Zhu, Veronica Jarzabek, Nikolas Merlock, Mahafuza Aktar, Courtney Smith, Ling Zhang, Parul Varma, Kyung-Ok Cho, Shaoyu Ge, Jenny Hsie. A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy. Nature communications. vol 12. issue 1. 2021-03-18. PMID:33658509. |
in the mammalian hippocampus, adult-born granule cells (abgcs) contribute to the function of the dentate gyrus (dg). |
2021-03-18 |
2023-08-13 |
mouse |
| Jasper O Nuninga, René C W Mandl, Marco P Boks, Steven Bakker, Metten Somers, Sophie M Heringa, Wendy Nieuwdorp, Hans Hoogduin, René S Kahn, Peter Luijten, Iris E C Somme. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Molecular psychiatry. vol 25. issue 7. 2021-03-17. PMID:30867562. |
in the animal analog of ect, neurogenesis in the dentate gyrus (dg) of the hippocampus is observed. |
2021-03-17 |
2023-08-13 |
human |
| Jasper O Nuninga, René C W Mandl, Marco P Boks, Steven Bakker, Metten Somers, Sophie M Heringa, Wendy Nieuwdorp, Hans Hoogduin, René S Kahn, Peter Luijten, Iris E C Somme. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Molecular psychiatry. vol 25. issue 7. 2021-03-17. PMID:30867562. |
if the volume increase of the hippocampus in humans is attributable to neurogenesis, it is expected to be exclusively present in the dg, whereas other processes (angiogenesis, synaptogenesis) also affect other subfields. |
2021-03-17 |
2023-08-13 |
human |
| Mathias Lundberg, Sophie Curbo, Hannes Bohman, Ingrid Agartz, Sven-Ove Ögren, Cesare Patrone, Shiva Mansour. Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31919522. |
the antipsychotic drug clozapine was shown to counteract the observed decrease in brdu-labelled cells in hippocampal dentate gyrus (dg). |
2021-03-16 |
2023-08-13 |
mouse |
| Amir Segev, Masaya Yanagi, Daniel Scott, Sarah A Southcott, Jacob M Lister, Chunfeng Tan, Wei Li, Shari G Birnbaum, Saïd Kourrich, Carol A Tamming. Reduced GluN1 in mouse dentate gyrus is associated with CA3 hyperactivity and psychosis-like behaviors. Molecular psychiatry. vol 25. issue 11. 2021-03-15. PMID:30038231. |
in this study, we used a subfield-specific glun1 knockout mouse with a disease-like molecular perturbation expressed only in hippocampal dentate gyrus (dg) and assessed its association with hippocampal physiology and psychosis-like behaviors. |
2021-03-15 |
2023-08-13 |
mouse |
| Hao Wang, Juntao Liu, Zeying Lu, Yuchuan Dai, Jingyu Xie, Shengwei Xu, Yilin Song, Guihua Xiao, Fei Gao, Lina Qu, Xinxia Ca. Implanted multichannel microelectrode array for simultaneous electrophysiological signal detection of hippocampal CA1 and DG neurons of simulated microgravity rats. Biochemical and biophysical research communications. vol 531. issue 3. 2021-03-10. PMID:32800539. |
in these experiments, microelectrode array was inserted into normal, 28-day tail suspension model, and 3-day recovered after modulation rats to record electrophysiological signals in the ca1 and dg regions of the hippocampus. |
2021-03-10 |
2023-08-13 |
rat |
| Scott D Sawchuk, Hannah M O Reid, Katie J Neale, James Shin, Brian R Christi. Effects of Ethanol on Synaptic Plasticity and NMDA Currents in the Juvenile Rat Dentate Gyrus. Brain plasticity (Amsterdam, Netherlands). vol 6. issue 1. 2021-03-10. PMID:33680851. |
we examined how acute ethanol (etoh) exposure affects long term depression (ltd) in the dentate gyrus (dg) of the hippocampus in juvenile rats. |
2021-03-10 |
2023-08-13 |
rat |
| Kyohei Kin, Takao Yasuhara, Masahiro Kameda, Yousuke Tomita, Michiari Umakoshi, Ken Kuwahara, Ittetsu Kin, Naoya Kidani, Jun Morimoto, Mihoko Okazaki, Tatsuya Sasaki, Naoki Tajiri, Cesario V Borlongan, Isao Dat. Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30108315. |
the implantation of encapsulated mscs (emscs) into the lateral ventricle counteracted depressive-like behavior and enhanced the endogenous neurogenesis in the subventricular zone (svz) and the dentate gyrus (dg) of the hippocampus, whereas the implantation of mscs without encapsulation or the implantation of emscs into the striatum did not show such ameliorative effects. |
2021-03-09 |
2023-08-13 |
rat |
| Yotam Sagi, Lucian Medrihan, Katia George, Miles Barney, Kathryn A McCabe, Paul Greengar. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Molecular psychiatry. vol 25. issue 6. 2021-03-09. PMID:30804492. |
the behavioral response to antidepressants is closely associated with physiological changes in the function of neurons in the hippocampal dentate gyrus (dg). |
2021-03-09 |
2023-08-13 |
mouse |
| Ricardo Gómez-Oliva, Noelia Geribaldi-Doldán, Samuel Domínguez-García, Livia Carrascal, Cristina Verástegui, Pedro Nunez-Abades, Carmen Castr. Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling. Aging. vol 12. issue 13. 2021-03-08. PMID:32554862. |
neurogenesis occurs in the adult brain in neurogenic regions, such as the dentate gyrus of the hippocampus (dg). |
2021-03-08 |
2023-08-13 |
Not clear |
| John T Madden, Shannon M Thompson, Christy M Magcalas, Jennifer L Wagner, Derek A Hamilton, Daniel D Savage, Benjamin J Clark, Nathan S Pentkowsk. Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring. Neuroscience letters. vol 718. 2021-03-01. PMID:31874217. |
to explore the effects of moderate pae on gabaergic interneuron expression, this study used a rat model of moderate pae to examine the effects of pae on parvalbumin (parv)-positive cells in fields ca1, ca3 and the dentate gyrus (dg) of the dorsal hippocampus (dhc). |
2021-03-01 |
2023-08-13 |
rat |