| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo L Castillo, Jorge Farías, Cristian Sandoval, Alejandro González-Candia, Esteban Figueroa, Mauricio Quezada, Gonzalo Cruz, Paola Llanos, Gonzalo Jorquera, Sawa Kostin, Rodrigo Carrasc. Role of NLRP3 Inflammasome in Heart Failure Patients Undergoing Cardiac Surgery as a Potential Determinant of Postoperative Atrial Fibrillation and Remodeling: Is SGLT2 Cotransporter Inhibition an Alternative for Cardioprotection? Antioxidants (Basel, Switzerland). vol 13. issue 11. 2024-11-27. PMID:39594530. |
however, given that nlrp3 pathway inhibition may also indirectly affect other pathways, such as inhibition of nf-kappab or inhibition of matrix synthesis, which are strongly linked to poaf and cardiac remodeling, it is reasonable to hypothesize that this type of intervention could play a role in preventing these events. |
2024-11-27 |
2024-11-29 |
Not clear |
| Huifeng Xi, Yuesong Weng, Youmao Zheng, Lizhi Wu, Dawei Ha. Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway. Heliyon. vol 10. issue 21. 2024-11-21. PMID:39568855. |
diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the il-1β-mediated nlrp3 pathway. |
2024-11-21 |
2024-11-23 |
Not clear |
| Alejandro Peñín-Franch, Laura Hurtado-Navarro, Jose Antonio García-Vidal, Pilar Escolar-Reina, Francesc Medina-Mirapeix, Pablo Pelegri. Multiple ASC-dependent inflammasomes drive differential pro-inflammatory cytokine production in a mouse model of tendinopathy. Bioscience reports. 2024-10-29. PMID:39468985. |
here we aimed to investigate the implication of nlrp3 in a mouse model of tendinopathy by collagenase degradation of the extracellular matrix in the achilles' mice tendon. |
2024-10-29 |
2024-10-31 |
mouse |
| Yu-Ting Chang, Kuo-Ching Huang, Rosita Pranata, Yen-Lin Chen, Ssu-Ning Chen, Yung-Hsuan Cheng, Rong-Jane Che. Evaluation of the protective effects of chondroitin sulfate oligosaccharide against osteoarthritis via inactivation of NLRP3 inflammasome by in vivo and in vitro studies. International immunopharmacology. vol 142. issue Pt A. 2024-09-14. PMID:39276449. |
stimulating human sw1353 chondrocytes and human mononuclear macrophage thp-1 cells with ocp showed increased nlrp3 inflammation initiation, nf-κb pathway activation, and the production of inflammatory cytokines (il-1β, il-6) and the metabolic index (mmp-13, adamts-5), leading to cartilage matrix degradation. |
2024-09-14 |
2024-09-18 |
mouse |
| Thu-Hang Nguyen, Hoang-Hanh-Nhan Nguyen, Thuy-Duong Nguyen, Van Thi-Hong Tran, Hoang-Anh Nguyen, Duc-Vinh Pha. NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. Biochemical pharmacology. 2024-08-19. PMID:39159876. |
however, the specific contributions of nlrp3 inflammasomes to determination of the pro-fibrotic phenotype of lung fibroblasts, which play a central role in the production of extracellular matrix protein, remain to be investigated. |
2024-08-19 |
2024-08-22 |
mouse |
| Thu-Hang Nguyen, Hoang-Hanh-Nhan Nguyen, Thuy-Duong Nguyen, Van Thi-Hong Tran, Hoang-Anh Nguyen, Duc-Vinh Pha. NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. Biochemical pharmacology. 2024-08-19. PMID:39159876. |
importantly, blockage of nlrp3 inflammasome signalling, either by gene silencing of nlrp3 or using pharmacological inhibitors of nlrp3, caspase-1, or il-1 receptor, inhibited the proliferation, differentiation, and extracellular matrix protein synthesis of activated lung fibroblasts. |
2024-08-19 |
2024-08-22 |
mouse |
| Baokun Sui, Jianqing Zhao, Jinxiao Wang, Jiaxin Zheng, Rui Zhou, Di Wu, Zonghui Zeng, Yueming Yuan, Zhenfang Fu, Ling Zhao, Ming Zho. Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3. Cell reports. vol 43. issue 7. 2024-07-10. PMID:38985668. |
lyssavirus matrix protein inhibits nlrp3 inflammasome assembly by binding to nlrp3. |
2024-07-10 |
2024-07-13 |
mouse |
| Baokun Sui, Jianqing Zhao, Jinxiao Wang, Jiaxin Zheng, Rui Zhou, Di Wu, Zonghui Zeng, Yueming Yuan, Zhenfang Fu, Ling Zhao, Ming Zho. Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3. Cell reports. vol 43. issue 7. 2024-07-10. PMID:38985668. |
this study demonstrates that the matrix protein (m) of lyssavirus can inhibit both the priming step and the activation step of nlrp3 inflammasome activation. |
2024-07-10 |
2024-07-13 |
mouse |
| T L Reeder, D S Zarlenga, A L Zeigler, R M Dye. Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration. Journal of dairy science. 2024-06-02. PMID:38825108. |
these changes were accompanied by upregulation of pro-inflammatory transcripts interleukin 1 α (il1a), interleukin1 β (il1b), interleukin 1 receptor 1 (il1r1), inducible nitric oxide synthase (nos2), the inflammasome components nod like receptor protein 3 (nlrp3), pyrin and caspase recruitment domain (pycard), and caspase-1 interleukin converting enzyme (caspase), the matrix metalloproteinases (mmp2 and mmp9), and anti-inflammatory genes interleukin 1 receptor antagonist (il1rn) and interleukin1 receptor 2 (il1r2). |
2024-06-02 |
2024-06-05 |
cattle |
| Silong Xia, Rong M. Tributyltin chloride induces chondrocyte damage through the activation of NLRP3‑mediated inflammation and pyroptosis. Molecular medicine reports. vol 30. issue 1. 2024-05-24. PMID:38785157. |
moreover, compared with in the control group, tbtc increased the expression levels of interleukin (il)‑1β, il‑18, matrix metalloproteinase (mmp)‑1, mmp‑13, nlr family pyrin domain containing 3 (nlrp3), caspase‑1, pyd and card domain containing, and gasdermin d in chondrocytes. |
2024-05-24 |
2024-05-27 |
mouse |
| Baihui Song, Gaoyuan Zhang, Yitegele Bao, Mohan Zhan. Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. Cell stress & chaperones. 2024-04-23. PMID:38653383. |
this study aimed to investigate the changes in oxidative stress, adenosine monophosphate-activated protein kinase (ampk), connexin43 (cx43), nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) expression, and extracellular matrix (ecm) in the gastric smooth muscle tissues of rats with diabetic gastroparesis (dgp) and high glucose-cultured gastric smooth muscle cells, determine the existence of oxidative stress-ampk-cx43-nlrp3 pathway under high glucose condition, and the involvement of this pathway in ecm remodeling in dgp rats. |
2024-04-23 |
2024-04-26 |
rat |
| Li Zhang, Mengmeng Duan, Xiaohua Pu, Huiling Zheng, Xinjie Ning, Ying Tu, Chunming Xu, Demao Zhang, Chengcheng Liu, Jing Xi. GroEL triggers NLRP3 inflammasome activation through the TLR/NF-κB p-p65 axis in human periodontal ligament stem cells. Acta biochimica et biophysica Sinica. 2024-04-10. PMID:38596842. |
in the present study, we verify that groel can trigger the activation of nlrp3 inflammasome and its downstream effector molecules, il-1β and il-18, in human periodontal ligament stem cells (hpdlscs) and resultantly induce high activation of gelatinases (mmp-2 and mmp-9) to promote the degradation of extracellular matrix (ecm). |
2024-04-10 |
2024-04-12 |
human |
| Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pa. Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development. Autophagy. vol 20. issue 2. 2024-01-25. PMID:37723664. |
a. muciniphila: akkermansia muciniphila; aiec: adherent invasive escherichia coli; aom/dss: azoxymethane-dextran sodium sulfate; atg: autophagy related; becn1: beclin1, autophagy related; cac: colitis-associated colon cancer; ccdc50: coiled-coil domain containing 50; cldn2: claudin 2; copec: colibactin-producing escherichia coli; crc: colorectal cancer; damps: danger/damage-associated molecular patterns; dc: dendritic cell; dss: dextran sulfate sodium; dtp: drug-resistant persistent; er: endoplasmic reticulum; ern1/ire1α: endoplasmic reticulum to nucleus signaling 1; ibd: inflammatory bowel disease; iecs: intestinal epithelial cells; ikk: ikappab kinase; il: interleukin; irgm1: immunity-related gtpase family m member 1; isc: intestinal stem cell; lps: lipopolysaccharide; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mapk: mitogen-activated protein kinase; mdp: muramyl dipeptide; melk: maternal embryonic leucine zipper kinase; mhc: major histocompatibility complex; mirna: microrna; mtor: mechanistic target of rapamycin kinase; nlrp3: nlr family, pyrin domain containing 3; nod2: nucleotide-binding oligomerization domain containing 2; nrbf2: nuclear receptor binding factor 2; pamps: pathogen-associated molecular patterns; pi3k: class i phosphoinositide 3-kinase; ptdins3k: class iii phosphatidylinositol 3-kinase; pycard/asc: pyd and card domain containing; ralgapa2/ralgapα2: ral gtpase activating protein protein, alpha subunit 2 (catalytic); ripk2/card3: receptor (tnfrsf)-interacting serine-threonine kinase 2; ripk3: receptor-interacting serine-threonine kinase 3; ros: reactive oxygen species; scrc: sporadic colorectal cancer; smarca4/brg1: swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; sqstm1: sequestosome 1; stat3: signal transducer and activator of transcription 3; tnf/tnfa: tumor necrosis factor; ulk1: unc-51 like autophagy activating kinase 1; upr: unfolded protein response; wt: wild-type. |
2024-01-25 |
2024-01-27 |
Not clear |
| Ziaur Rahman, Arbaz Sujat Shaikh, K Venkata Rao, Manoj P Dandeka. Oxyberberine Protects Middle Cerebral Artery Occlusion Triggered Cerebral Injury Through TLR4/NLRP3 Pathway in Rats. Journal of chemical neuroanatomy. 2024-01-21. PMID:38246265. |
we also observed the decline in plasma levels/mrna transcription of tnf-α, il-1β, nlrp3, il-6, and matrix metalloproteinase-9 and increased expression of occludin and claudin in obb-treated rats. |
2024-01-21 |
2024-01-24 |
rat |
| Xiaotong Wu, Fengshi Zhang, Xiaolin Mao, Fujian Xu, Xiaokang Ding, Xiuli Sun, Jianliu Wan. The mechanism of adipose mesenchymal stem cells to stabilize the immune microenvironment of pelvic floor injury by regulating pyroptosis and promoting tissue repair. Materials today. Bio. vol 24. 2024-01-11. PMID:38204481. |
ros stimulated macrophages to produce nlrp3 inflammatory complex, induced the release of interleukin (il-1β) and pyroptosis and exacerbated the inflammatory state of damaged tissues, persisting chronic inflammation of fibroblasts in supporting tissues, thus causing the pelvic floor's extracellular matrix (ecm) collagen metabolic disorder. |
2024-01-11 |
2024-01-13 |
rat |
| Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yaka. Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168298. |
significant direct correlations were found between ac scores and inflammatory markers in chondrocytes, including matrix metalloproteinase-13 (mmp-13), inducible nitric oxide synthase (inos), and the nlr family pyrin domain containing-3 (nlrp3) inflammasome in both sexes, indicating a link between oa severity and inflammation. |
2024-01-03 |
2024-01-06 |
mouse |
| Zahra Babazade. Involvement of NLRP3 Inflammasome in SARS-Cov-2-Induced Multiorgan Dysfunction in Patients with COVID-19: A Review of Molecular Mechanisms. Tanaffos. vol 22. issue 1. 2023-11-03. PMID:37920322. |
besides, invading host cells via sars-cov-2 further activates the nlrp3 inflammasome and induces pyroptosis in immune cells, resulting in the secretion of higher levels of proinflammatory cytokines into the extracellular matrix. |
2023-11-03 |
2023-11-08 |
Not clear |
| Xiangjing Meng, Sumei Guo, Xiaoxia Zhang, Bo Jiao, Xiaohan Yang, Ming Li, Chao Li, Jin He, Shangya Chen, Cheng Peng, Hua Shao, Qiang Ji. HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway. Ecotoxicology and environmental safety. vol 266. 2023-10-15. PMID:37839183. |
at the molecular level, inhibition of hmgb1 decreased the expressions of hmgb1, toll-like receptor 4, vimentin and matrix metalloproteinase-9 proteins, activated nf-κb and nod-like receptor protein 3 (nlrp3) inflammasome, and increased e-cadherin expression. |
2023-10-15 |
2023-11-08 |
mouse |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |
| Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Zhou Wei, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao W. Macrophage-derived exosomes promote activation of NLRP3 inflammasome and autophagy deficiency of mesangial cells in diabetic nephropathy. Life sciences. 2023-07-31. PMID:37524161. |
here, we found that dn mice appeared renal pathological damage, including dilation of mesangial matrix and significant infiltration of macrophages, accompanied by increased inflammatory response, nlrp3 inflammasome activation and autophagy deficiency. |
2023-07-31 |
2023-08-14 |
mouse |