| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wiwin Is Effendi, Tatsuya Nagan. The Crucial Role of NLRP3 Inflammasome in Viral Infection-Associated Fibrosing Interstitial Lung Diseases. International journal of molecular sciences. vol 22. issue 19. 2021-10-27. PMID:34638790. |
during viral infection, activation of the nlrp3 inflammasome by integrating multiple cellular and molecular signaling implicates robust inflammation, fibroblast proliferation, activation of myofibroblast, matrix deposition, and aberrant epithelial-mesenchymal function. |
2021-10-27 |
2023-08-13 |
Not clear |
| Hwan Hee Lee, Dongoh Kim, Joohee Jung, Hyojeung Kang, Hyosun Ch. NLRP3 Deficiency in Hepatocellular Carcinoma Enhances Surveillance of NK-92 through a Modulation of MICA/B. International journal of molecular sciences. vol 22. issue 17. 2021-10-18. PMID:34502191. |
when the expression of nlrp3 in hcc cells was ablated, mica/b on the surface of hcc cells was upregulated through the lowered expression of matrix metalloproteinase. |
2021-10-18 |
2023-08-13 |
mouse |
| Yanan Wang, Hexiao Huang, Weihong He, Shihong Zhang, Ming Liu, Simiao W. Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke. BMC neurology. vol 21. issue 1. 2021-10-15. PMID:34493232. |
we aimed to explore the association of serum level of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (nlrp3) and its related inflammatory biomarkers (hypoxia inducible factor-1α, cathepsin b, caspase-1 and matrix metalloproteinase-9) with malignant brain edema (mbe) in patients with acute ischemic stroke. |
2021-10-15 |
2023-08-13 |
Not clear |
| Jing Wang, Qibiao Wu, Lu Ding, Siyu Song, Yaxin Li, Li Shi, Tan Wang, Daqing Zhao, Zeyu Wang, Xiangyan L. Therapeutic Effects and Molecular Mechanisms of Bioactive Compounds Against Respiratory Diseases: Traditional Chinese Medicine Theory and High-Frequency Use. Frontiers in pharmacology. vol 12. 2021-09-14. PMID:34512360. |
we found that 31 bioactive compounds from the selected 10 common chinese herbs, such as epigallocatechin-3-gallate (egcg), kaempferol, isorhamnetin, quercetin, and β-sitosterol, can mainly regulate nf-κb, nrf2/ho-1, nlrp3, tgf-β/smad, mapk, and pi3k/akt/mtor pathways to inhibit infection, inflammation, extracellular matrix deposition, and tumor growth in a series of lung-related diseases. |
2021-09-14 |
2023-08-13 |
Not clear |
| Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. |
nlrp3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. |
2021-08-17 |
2023-08-13 |
human |
| Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. |
we aimed to determine the impact of nlrp3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix (ecm) remodeling. |
2021-08-17 |
2023-08-13 |
human |
| Yao Zhang, Zihao Lin, Deheng Chen, Yaohua H. CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis. Biochemical and biophysical research communications. vol 553. 2021-07-06. PMID:33765556. |
cy-09 can maintain extracellular matrix (ecm) homeostasis and regulate inflammation in tnf-α treated chondrocytes via inhibition of nlrp3 inflammasome-mediated pyroptosis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Ivan Luzardo-Ocampo, Guadalupe Loarca-Piña, Elvira Gonzalez de Meji. Gallic and butyric acids modulated NLRP3 inflammasome markers in a co-culture model of intestinal inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 146. 2021-06-11. PMID:33130239. |
this is the first report of the nlrp3 inflammasome modulation by digested food matrix components, using a co-culture approach. |
2021-06-11 |
2023-08-13 |
Not clear |
| Xiaowei Chen, Xu Xiang, Teng Xie, Zhijun Chen, Yu Mou, Zixu Gao, Xun Xie, Min Song, Hui Huang, Ziyun Gao, Min Che. Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation. Neuroreport. vol 32. issue 3. 2021-04-19. PMID:33470757. |
behavioral changes, brain edema, levels of nnos ser1412 phosphorylation, peroxynitrite, matrix metalloproteinase (mmp)-9, nlrp3, il-1β and numbers of dying neurons, as well as the cellular localization of gelatinolytic activity, were detected among the groups. |
2021-04-19 |
2023-08-13 |
rat |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
previous studies revealed that nlrp3 inflammasome plays a vital role in idd and nicotinamide phosphoribosyl transferase (nampt) is involved in matrix degradation induced by il-1β. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
the results revealed that nampt downregulation or overexpression controlled the matrix degradation induced by tnf-α by modulating nlrp3 inflammasome activity. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
herein, real-time pcr, western blot analysis, and immunofluorescence staining experiments revealed that melatonin showed protective effects against tnf-α-induced matrix degradation by downregulating nampt and reducing nlrp3 inflammasome activity in np cells. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
the current investigation verified that melatonin could alleviate matrix degradation induced by tnf-α by suppressing nampt and nlrp3 inflammasome activity. |
2021-04-02 |
2023-08-13 |
Not clear |
| Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. |
moreover, nampt downregulation controlled the matrix degradation induced by tnf-α by suppressing nlrp3 inflammasome activity through mapk and nf-κb signaling in np cells. |
2021-04-02 |
2023-08-13 |
Not clear |
| Chengcong Wei, Shenquan Guo, Wenchao Liu, Fa Jin, Boyang Wei, Haiyan Fan, Hengxian Su, Jiahui Liu, Nan Zhang, Dazhao Fang, Guangxu Li, Shixing Shu, Xifeng Li, Xuying He, Xin Zhang, Chuanzhi Dua. Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome. Frontiers in pharmacology. vol 11. 2021-03-20. PMID:33732145. |
rvd1 treatment upregulated the expression of a20, occludin, claudin-5, and zona occludens-1, as well as downregulated nuclear factor-κbp65, nlrp3, matrix metallopeptidase 9, and intercellular cell adhesion molecule-1 expression. |
2021-03-20 |
2023-08-13 |
rat |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity in np cells. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
the present study aims to observe whether brd4 inhibition regulates matrix metabolism by controlling autophagy and nlrp3 inflammasome activity. |
2021-03-10 |
2023-08-13 |
human |
| Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. |
moreover, p65 knockdown or treatment with jq1 and bay11-7082 demonstrated that brd4 inhibition attenuated nlrp3 inflammasome activity through nf-κb signaling, while autophagy inhibition by bafilomycin a1 promoted matrix degradation and nlrp3 inflammasome activity in np cells. |
2021-03-10 |
2023-08-13 |
human |