All Relations between nlrp3 and matrix compartment

Publication Sentence Publish Date Extraction Date Species
Jing Wang, Qibiao Wu, Lu Ding, Siyu Song, Yaxin Li, Li Shi, Tan Wang, Daqing Zhao, Zeyu Wang, Xiangyan L. Therapeutic Effects and Molecular Mechanisms of Bioactive Compounds Against Respiratory Diseases: Traditional Chinese Medicine Theory and High-Frequency Use. Frontiers in pharmacology. vol 12. 2021-09-14. PMID:34512360. we found that 31 bioactive compounds from the selected 10 common chinese herbs, such as epigallocatechin-3-gallate (egcg), kaempferol, isorhamnetin, quercetin, and β-sitosterol, can mainly regulate nf-κb, nrf2/ho-1, nlrp3, tgf-β/smad, mapk, and pi3k/akt/mtor pathways to inhibit infection, inflammation, extracellular matrix deposition, and tumor growth in a series of lung-related diseases. 2021-09-14 2023-08-13 Not clear
Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. nlrp3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. 2021-08-17 2023-08-13 human
Xabier Unamuno, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Rodríguez, Sara Becerril, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck, Victoria Catalá. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling. Cellular & molecular immunology. vol 18. issue 4. 2021-08-17. PMID:31551515. we aimed to determine the impact of nlrp3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix (ecm) remodeling. 2021-08-17 2023-08-13 human
Yao Zhang, Zihao Lin, Deheng Chen, Yaohua H. CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis. Biochemical and biophysical research communications. vol 553. 2021-07-06. PMID:33765556. cy-09 can maintain extracellular matrix (ecm) homeostasis and regulate inflammation in tnf-α treated chondrocytes via inhibition of nlrp3 inflammasome-mediated pyroptosis. 2021-07-06 2023-08-13 Not clear
Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. 2021-06-18 2023-08-13 rat
G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. 2021-06-14 2023-08-13 Not clear
Ivan Luzardo-Ocampo, Guadalupe Loarca-Piña, Elvira Gonzalez de Meji. Gallic and butyric acids modulated NLRP3 inflammasome markers in a co-culture model of intestinal inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 146. 2021-06-11. PMID:33130239. this is the first report of the nlrp3 inflammasome modulation by digested food matrix components, using a co-culture approach. 2021-06-11 2023-08-13 Not clear
Xiaowei Chen, Xu Xiang, Teng Xie, Zhijun Chen, Yu Mou, Zixu Gao, Xun Xie, Min Song, Hui Huang, Ziyun Gao, Min Che. Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation. Neuroreport. vol 32. issue 3. 2021-04-19. PMID:33470757. behavioral changes, brain edema, levels of nnos ser1412 phosphorylation, peroxynitrite, matrix metalloproteinase (mmp)-9, nlrp3, il-1β and numbers of dying neurons, as well as the cellular localization of gelatinolytic activity, were detected among the groups. 2021-04-19 2023-08-13 rat
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. previous studies revealed that nlrp3 inflammasome plays a vital role in idd and nicotinamide phosphoribosyl transferase (nampt) is involved in matrix degradation induced by il-1β. 2021-04-02 2023-08-13 Not clear
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. the results revealed that nampt downregulation or overexpression controlled the matrix degradation induced by tnf-α by modulating nlrp3 inflammasome activity. 2021-04-02 2023-08-13 Not clear
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. herein, real-time pcr, western blot analysis, and immunofluorescence staining experiments revealed that melatonin showed protective effects against tnf-α-induced matrix degradation by downregulating nampt and reducing nlrp3 inflammasome activity in np cells. 2021-04-02 2023-08-13 Not clear
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. the current investigation verified that melatonin could alleviate matrix degradation induced by tnf-α by suppressing nampt and nlrp3 inflammasome activity. 2021-04-02 2023-08-13 Not clear
Yingjie Huang, Yan Peng, Jianchao Sun, Shuangxing Li, Junmin Hong, Jie Zhou, Jianchong Chen, Jiansen Yan, Zhengqi Huang, Xiaofei Wang, Weijian Chen, Wei Y. Nicotinamide Phosphoribosyl Transferase Controls NLRP3 Inflammasome Activity Through MAPK and NF-κB Signaling in Nucleus Pulposus Cells, as Suppressed by Melatonin. Inflammation. vol 43. issue 3. 2021-04-02. PMID:31900828. moreover, nampt downregulation controlled the matrix degradation induced by tnf-α by suppressing nlrp3 inflammasome activity through mapk and nf-κb signaling in np cells. 2021-04-02 2023-08-13 Not clear
Chengcong Wei, Shenquan Guo, Wenchao Liu, Fa Jin, Boyang Wei, Haiyan Fan, Hengxian Su, Jiahui Liu, Nan Zhang, Dazhao Fang, Guangxu Li, Shixing Shu, Xifeng Li, Xuying He, Xin Zhang, Chuanzhi Dua. Resolvin D1 ameliorates Inflammation-Mediated Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in rats by Modulating A20 and NLRP3 Inflammasome. Frontiers in pharmacology. vol 11. 2021-03-20. PMID:33732145. rvd1 treatment upregulated the expression of a20, occludin, claudin-5, and zona occludens-1, as well as downregulated nuclear factor-κbp65, nlrp3, matrix metallopeptidase 9, and intercellular cell adhesion molecule-1 expression. 2021-03-20 2023-08-13 rat
Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity in np cells. 2021-03-10 2023-08-13 human
Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. the present study aims to observe whether brd4 inhibition regulates matrix metabolism by controlling autophagy and nlrp3 inflammasome activity. 2021-03-10 2023-08-13 human
Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. moreover, p65 knockdown or treatment with jq1 and bay11-7082 demonstrated that brd4 inhibition attenuated nlrp3 inflammasome activity through nf-κb signaling, while autophagy inhibition by bafilomycin a1 promoted matrix degradation and nlrp3 inflammasome activity in np cells. 2021-03-10 2023-08-13 human
Junmin Hong, Shuangxing Li, Dessislava Z Markova, Anjing Liang, Christopher K Kepler, Yingjie Huang, Jie Zhou, Jiansen Yan, Weijian Chen, Dongsheng Huang, Kang Xu, Wei Y. Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975410. simply, brd4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing nlrp3 inflammasome activity through nf-κb signaling in np cells. 2021-03-10 2023-08-13 human
Ying Han, Hai-Jian Sun, Ying Tong, Yun-Zhi Chen, Chao Ye, Yun Qiu, Feng Zhang, Ai-Dong Chen, Xiao-Hong Qi, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zh. Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFκB-mediated NLRP3 expression in spontaneously hypertensive rats. The Journal of nutritional biochemistry. vol 72. 2020-11-04. PMID:31473513. intragastric administration of curcumin in shr attenuated hypertension and reduced nfκb activation, nlrp3 and matrix metalloproteinase-9 expressions and aortic media thickness. 2020-11-04 2023-08-13 rat
Ava Faridi, Yunxiang Sun, Monika Mortimer, Ritchlynn R Aranha, Aparna Nandakumar, Yuhuan Li, Ibrahim Javed, Aleksandr Kakinen, Qingqing Fan, Anthony W Purcell, Thomas P Davis, Feng Ding, Pouya Faridi, Pu Chun K. Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide. Nano research. vol 12. issue 11. 2020-11-01. PMID:31695851. while iapp can activate the nlrp3 inflammasome and modulate cellular autophagy, apoptosis and extracellular matrix metabolism, no data is available concerning intracellular protein expression upon exposure to the polypeptide. 2020-11-01 2023-08-13 human