| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangjing Meng, Sumei Guo, Xiaoxia Zhang, Bo Jiao, Xiaohan Yang, Ming Li, Chao Li, Jin He, Shangya Chen, Cheng Peng, Hua Shao, Qiang Ji. HMGB1 inhibition reduces TDI-induced occupational asthma through ROS/AMPK/autophagy pathway. Ecotoxicology and environmental safety. vol 266. 2023-10-15. PMID:37839183. |
at the molecular level, inhibition of hmgb1 decreased the expressions of hmgb1, toll-like receptor 4, vimentin and matrix metalloproteinase-9 proteins, activated nf-κb and nod-like receptor protein 3 (nlrp3) inflammasome, and increased e-cadherin expression. |
2023-10-15 |
2023-11-08 |
mouse |
| Yan Chen, Xiankun Cao, Bin Pan, Han Du, Baixing Li, Xiao Yang, Xuzhuo Chen, Xin Wang, Tangjun Zhou, An Qin, Changqing Zhao, Jie Zha. Verapamil attenuates intervertebral disc degeneration by suppressing ROS overproduction and pyroptosis via targeting the Nrf2/TXNIP/NLRP3 axis in four-week puncture-induced rat models both in vivo and in vitro. International immunopharmacology. vol 123. 2023-08-14. PMID:37579541. |
administration of verapamil, a classic clinical drug, mitigated the tbhp-induced overproduction of reactive oxygen species and activation of the nlrp3 inflammasome, thus protecting cells from pyroptosis, apoptosis, and extracellular matrix degradation. |
2023-08-14 |
2023-09-07 |
rat |
| Yaoyu Liu, Xiaojie Li, Minglan Zhao, Yifan Wu, Yuan Xu, Xiuming Li, Lizhe Fu, Liqiao Han, Zhou Wei, Qinghong Hu, Junqi Chen, Jiuyao Zhou, Xusheng Liu, Hua Lin, Junbiao W. Macrophage-derived exosomes promote activation of NLRP3 inflammasome and autophagy deficiency of mesangial cells in diabetic nephropathy. Life sciences. 2023-07-31. PMID:37524161. |
here, we found that dn mice appeared renal pathological damage, including dilation of mesangial matrix and significant infiltration of macrophages, accompanied by increased inflammatory response, nlrp3 inflammasome activation and autophagy deficiency. |
2023-07-31 |
2023-08-14 |
mouse |
| Jing Chen, Qi Li, Yifan Hong, Xiazhu Zhou, Chengjun Yu, Xiaomao Tian, Jie Zhao, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui We. Inhibition of the NF-κB Signaling Pathway Alleviates Pyroptosis in Bladder Epithelial Cells and Neurogenic Bladder Fibrosis. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446339. |
moreover, using the nlrp3 inhibitor mcc950 rescued tgf-β1-induced fibrosis, and the nf-κb signaling pathway inhibitor bay 11-7082 effectively rescued tgf-β1-induced pyroptosis and the deposition of extracellular matrix by sv-huc-1 cells. |
2023-07-14 |
2023-08-14 |
rat |
| Ziaur Rahman, Shubham Ghuge, Manoj P Dandeka. Partial blood replacement ameliorates middle cerebral artery occlusion generated neurological aberrations by intervening TLR4 and NLRP3 cascades in rats. Metabolic brain disease. 2023-07-04. PMID:37402080. |
moreover, elevated levels of toll-like receptor 4 (tlr4) and mrna expression of il-1β, tnf-α, matrix metalloproteinase-9 and nlrp3, and decreased levels of zonula occludens-1 in mcao rats, were reversed following brt. |
2023-07-04 |
2023-08-14 |
rat |
| Baoshan Hu, Shan Lin, Shengrong Lin, Gang Ru. Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome. Immunological investigations. 2023-05-08. PMID:37154418. |
ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of nlrp3 inflammasome. |
2023-05-08 |
2023-08-14 |
Not clear |
| Jialing Xiao, Yali Li, Jie Zhang, Guochao Xu, Jianxing Zhan. Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis. Cell biology international. 2023-04-06. PMID:37021698. |
panx3 silencing alleviated the damage of condyle cartilage tissue in tmjoa rats, and reduced expressions of panx3, p2x7r, cartilage matrix degradation related-enzymes, and nlrp3 in condyle cartilage tissue. |
2023-04-06 |
2023-08-14 |
rat |
| Jennifer Adjei-Mosi, Qing Sun, Steven Blake Smithson, Gavyn Lee Shealy, Krupa Dhruvitha Amerineni, Zerong Liang, Hanqing Chen, Mei Wang, Qinggong Ping, Jingyan Han, Masahiro Morita, Amrita Kamat, Nicolas Musi, Mengwei Zan. Age-dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution. Aging cell. 2023-03-31. PMID:36999514. |
in a model of hepatotoxin-induced liver fibrosis, old mice displayed more severe and persistent liver fibrosis than young mice during liver injury and after injury cessation, as characterized by inhibition of sirt1, induction of nlrp3, infiltration of macrophages and neutrophils, activation of hepatic stellate cells (hscs), and excessive deposition and remodeling of the extracellular matrix. |
2023-03-31 |
2023-08-14 |
mouse |
| Armand N Yazdani, Vikrant Rai, Devendra K Agrawa. Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia. Journal of orthopaedics and sports medicine. vol 4. issue 4. 2022-11-16. PMID:36381991. |
subsequent inflammatory pathways including the jak2/stat3 pathway and nlrp3 inflammasome pathway led to persistent inflammation and extracellular matrix (ecm) degradation within the rotator cuff. |
2022-11-16 |
2023-08-14 |
Not clear |
| Nanxing Yi, Yilin Mi, Xiaotong Xu, Naping Li, Baiyi Chen, Ke Yan, Kaiyun Tan, Bo Zhang, Linhua Wang, Gaoyan Kuang, Min L. Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis. International immunopharmacology. vol 113. issue Pt A. 2022-10-27. PMID:36302323. |
moreover, nod inhibited the mrna levels of inflammatory cytokines (cox 2, il-1β, and tnf-α), nod-like receptor family pyrin domain-containing 3 (nlrp3) inflammasome, and matrix metalloproteinase 13 expression in activated chondrocytes. |
2022-10-27 |
2023-08-14 |
mouse |
| Jiangbo Yan, Gangning Feng, Yong Yang, Dong Ding, Long Ma, Xin Zhao, Xiaolei Chen, Hui Wang, Zhirong Chen, Qunhua Ji. Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling. Bosnian journal of basic medical sciences. 2022-07-26. PMID:35880352. |
mechanistically, activation of autophagy in cartilage increased the expression of type ii collagen (col ii), decreased the expression of matrix metalloproteinase 13 (mmp 13) and decreased the pyroptosis mediated by nod-like receptor protein 3 (nlrp3) inflammasome by decreasing the expression of nlrp3, caspase-1, gasdermin d (gsdmd), and il-1β. |
2022-07-26 |
2023-08-14 |
mouse |
| Jiangbo Yan, Dong Ding, Gangning Feng, Yong Yang, Yong Zhou, Long Ma, Haohui Guo, Zhidong Lu, Qunhua Ji. Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-28. PMID:35222699. |
immunohistochemical staining was used to detect type ii collagen (col ii), matrix metalloproteinase 13 (mmp-13), nod-like receptor protein 3 (nlrp3), caspase-1, gasdermin d (gsdmd) and il-1β protein expression. |
2022-02-28 |
2023-08-13 |
mouse |
| Regina Sakalyte, Jaroslav Denkovskij, Eiva Bernotiene, Sigita Stropuviene, Silvija Ona Mikulenaite, Giedrius Kvederas, Narunas Porvaneckas, Vytautas Tutkus, Algirdas Venalis, Irena Butrimien. The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis. Frontiers in immunology. vol 12. 2022-02-07. PMID:35126351. |
in this study, we investigated the expression of nucleotide-binding, oligomerization domain (nod)-like receptor family, pyrin domain containing (nlrp)1, nlrp3 inflammasomes, toll-like receptor (tlr)1, tlr2, tlr4, vitamin d receptor (vdr), and secretion of matrix metalloproteinases (mmps) in sfs isolated from patients with ra, osteoarthritis (oa), ea, and control individuals (cn) after knee surgical intervention. |
2022-02-07 |
2023-08-13 |
Not clear |
| Maria-Alexandra Martu, George-Alexandru Maftei, Ionut Luchian, Ovidiu Mihail Stefanescu, Mihaela Monica Scutariu, Sorina Mihaela Solomo. The Effect of Acknowledged and Novel Anti-Rheumatic Therapies on Periodontal Tissues-A Narrative Review. Pharmaceuticals (Basel, Switzerland). vol 14. issue 12. 2021-12-28. PMID:34959607. |
several alternatives are currently being tested, such as matrix metalloproteinases (mmp) inhibitors, toll-like receptors (tlr) blockers, pro-resolution mediators, anti-hypoxia inducing factors, stem cell therapy, nlrp3 inhibitors and even natural derived compounds. |
2021-12-28 |
2023-08-13 |
Not clear |
| Narayanappa Amruta, Gregory Bi. ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34420157. |
atn-161 treatment (10 µm) effectively inhibited ogd/r-induced extracellular matrix (ecm) deposition by reducing integrin α5, mmp-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ros, inflammation by reducing nlrp3 inflammasome, tight junction loss by reducing claudin-5 and zo-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-fak and p-akt levels. |
2021-11-26 |
2023-08-13 |
mouse |
| Qing Wang, Lujing Ying, Bing Wei, Yikui Ji, Yi X. Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress-mediated pyroptosis. Journal of biochemical and molecular toxicology. 2021-11-18. PMID:34791735. |
results showed that quercetin could reduce lps-induced c28/i2 cell apoptosis, extracellular matrix (ecm) degradation, and cell pyroptosis, and overexpression of nucleotide-binding domain and leucine-rich-repeat-containing (nlr) family, pyrin domain-containing 3 (nlrp3) revealed that quercetin reduced chondrocyte apoptosis and ecm degradation by inhibiting nlrp3-mediated pyroptosis. |
2021-11-18 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
atorvastatin inhibited tnf-α induced matrix degradation in rat nucleus pulposus cells by suppressing nlrp3 inflammasome activity and inducing autophagy through nf-κb signaling. |
2021-11-05 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
the results revealed that atorvastatin might suppress matrix degradation induced by tnf-α by suppressing nlrp3 inflammasome activity and inducing autophagic flux. |
2021-11-05 |
2023-08-13 |
rat |
| Jiancong Chen, Jiansen Yan, Shuangxing Li, Jianxiong Zhu, Jie Zhou, Jun Li, Yangyang Zhang, Zhengqi Huang, Liang Yuan, Kang Xu, Weijian Chen, Wei Y. Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. Cell cycle (Georgetown, Tex.). vol 20. issue 20. 2021-11-05. PMID:34494933. |
overall, the present study demonstrated that atorvastatin might suppress matrix degradation induced by tnf-α and further revealed the crosstalk among nlrp3 inflammasome activity, autophagy and nf-κb signaling. |
2021-11-05 |
2023-08-13 |
rat |
| Susanne Gaul, Karen Marie Schaeffer, Lena Opitz, Christina Maeder, Alexander Kogel, Luisa Uhlmann, Hermann Kalwa, Ulf Wagner, Jan Haas, Amirhossein Behzadi, Pablo Pelegrin, Jes-Niels Boeckel, Ulrich Lauf. Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34312415. |
extracellular nlrp3-yfp inflammasome particles promoted the secretion of pro-atherogenic and inflammatory cytokines such as ccl2/mcp1, cxcl1 and il-17e, and increased hcasmc migration (1.8-fold) and extracellular matrix production, such as fibronectin (5.8-fold) which was dependent on nfκb and nlrp3 activation. |
2021-11-03 |
2023-08-13 |
human |