| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alma Karen Lomeli-Lepe, José Luis Castañeda-Cabral, Mónica E Ureña-Guerrero, Graciela Gudiño Cabrera, Silvia Josefina López-Pére. Bee Venom Reduces Early Inflammation and Oxidative Stress Associated with Lipopolysaccharide-induced Alpha-synuclein in the Substantia Nigra-striatum Axis. Cell biochemistry and biophysics. 2024-09-29. PMID:39342536. |
we examined whether bv (1.5 mg/kg by acupoint injection st36 six times every 48 h) could change the α-syn and th expression measured by western blotting, also, observed the activation of microglia and astrocytes by immunofluorescence, quantified the proinflammatory cytokines levels of tumoral necrosis factor-α (tnf-α) and interleukin-1β (il-1β) by enzyme-linked immunosorbent assay (elisa), and estimated the lipid peroxidation and the activity of superoxide dismutase (sod) and catalase (cat) by colorimetric kits in lps-treated rats (2.5 µg by a single dose intranigral injection) in substantia nigra (sn) and striatum (str) brain areas. |
2024-09-29 |
2024-10-01 |
rat |
| Tae-Young Ha, Jae-Bong Kim, Yeji Kim, Sang Myun Park, Keun-A Chan. GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models. Pharmacological research. 2024-09-23. PMID:39313081. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn) and accumulation of intracellular α-synuclein (ɑ-syn) aggregates known as lewy bodies and lewy neurites. |
2024-09-23 |
2024-09-26 |
mouse |
| Mei Jiang, Xu Deng, Zixiong Qiu, Jie Li, Zifan Song, Xiaoshuai Chen, Ruiqi Chen, Xianzhi Huang, Xiaojun Cui, Yuan F. Bibliometric analysis of global research trends in magnetic resonance imaging studies of substantia nigra in Parkinson's disease (2001-2024). Frontiers in aging neuroscience. vol 16. 2024-09-18. PMID:39291277. |
numerous studies have been conducted on the application of magnetic resonance imaging (mri) in investigating the substantia nigra (sn) in pd patients. |
2024-09-18 |
2024-09-20 |
Not clear |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. Brain : a journal of neurology. 2024-09-16. PMID:39282945. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-09-16 |
2024-09-19 |
Not clear |
| Szu-Chi Liao, Kohei Kano, Sadhna Phanse, Mai Nguyen, Elyssa Margolis, YuHong Fu, Jonathan Meng, Mohamed Taha Moutaoufik, Zac Chatterton, Hiroyuki Aoki, Jeffrey Simms, Ivy Hsieh, Felecia Suteja, Yoshitaka Sei, Eric J Huang, Kevin McAvoy, Giovanni Manfredi, Glenda Halliday, Mohan Babu, Ken Nakamur. CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism. bioRxiv : the preprint server for biology. 2024-09-11. PMID:39257750. |
nonetheless, chchd2 t61i mice exhibited robust molecular changes in the brain including increased chchd2 insolubility, accumulation of chchd2 protein preferentially in the substantia nigra (sn), and elevated levels of α-synuclein. |
2024-09-11 |
2024-09-13 |
mouse |
| Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong B. Neuromelanin-targeted 18 F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques. EJNMMI research. vol 14. issue 1. 2024-09-03. PMID:39225971. |
neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (sn) pars compacta, and can be detected by magnetic resonance imaging (mri). |
2024-09-03 |
2024-09-05 |
Not clear |
| Mark J Connolly, Sujin Jiang, Lim C Samuel, Claire-Anne Gutekunst, Robert E Gross, Annaelle Devergna. Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures. PloS one. vol 19. issue 8. 2024-08-28. PMID:39197026. |
here, we characterize the involvement of the substantia nigra (sn) and somatosensory cortex (si) during temporal lobe (tl) seizures induced by penicillin injection in the hippocampus (hpc) of two nonhuman primates. |
2024-08-28 |
2024-08-31 |
human |
| Zahra Baridjavadi, Mahmoud Mahmoudi, Narges Abdollahi, Negar Ebadpour, Samaneh Mollazadeh, Dariush Haghmorad, Seyed-Alireza Esmaeil. The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes. Cell biochemistry and function. vol 42. issue 7. 2024-08-27. PMID:39189398. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) in the brain and progressive loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2024-08-27 |
2024-08-30 |
Not clear |
| Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jian. GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy. Redox biology. vol 76. 2024-08-24. PMID:39180981. |
however, in contrast to the strikingly low levels of ghrelin, ghsr is highly expressed in the substantia nigra (sn). |
2024-08-24 |
2024-08-28 |
mouse |
| Alfonso Mata-Bermudez, Ricardo Trejo-Chávez, Marina Martínez-Vargas, Adán Pérez-Arredondo, Maria de Los Ángeles Martínez-Cardenas, Araceli Diaz-Ruiz, Camilo Rios, Luz Navarr. Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders. Frontiers in neuroscience. vol 18. 2024-08-23. PMID:39176379. |
we describe the changes that occur in the clinical picture of post-tbi patients, such as alterations in mood and anxiety associated with dat activity in the striatum, the relationship between post-tbi major depressive disorders (mdd) with lower availability of the da receptors d2r and d3r in the caudate and thalamus, as well as a decrease in the volume of the substantia nigra (sn) associated with anxiety symptoms. |
2024-08-23 |
2024-08-25 |
Not clear |
| Edward Pajarillo, Sanghoon Kim, Alexis Digman, Itunu Ajayi, Ivan Nyarko-Danquah, Deok-Soo Son, Michael Aschner, Eunsook Le. Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice. The Journal of biological chemistry. 2024-08-23. PMID:39178947. |
restoration of rest in the substantia nigra (sn) with neuronal rest aav vector infusion was performed to further support the role of rest in mn toxicity. |
2024-08-23 |
2024-08-27 |
mouse |
| Gerardo Mendez-Victoriano, Yunting Zhu, Frank Middleton, Paul T Massa, Kachikwulu Ajulu, Maree J Webster, Cynthia S Weicker. Increased Parenchymal Macrophages are associated with decreased Tyrosine Hydroxylase mRNA levels in the Substantia Nigra of people with Schizophrenia and Bipolar Disorder. Psychiatry research. vol 340. 2024-08-17. PMID:39153291. |
herein, we determined whether there were differences in cd163+ cell density in the substantia nigra (sn), and cerebral peduncles (cp) of sz, bd, and mdd compared to controls (ctrl). |
2024-08-17 |
2024-08-20 |
Not clear |
| Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansa. Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease. Molecular brain. vol 17. issue 1. 2024-08-14. PMID:39138468. |
in the second dataset obtained from the substantia nigra (sn), opcs displayed an association with updrs-iii. |
2024-08-14 |
2024-08-16 |
Not clear |
| Yurong Wang, Hao Xu, Saiyong Chen, Junhao Chen, Qimeng Zheng, Yuanyuan Ma, Xinru Zhao, Ying Shi, Lei Xia. Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP-Induced Parkinson's Disease Model. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-08-05. PMID:39099429. |
here, the disturbances of endogenous oxytocin level and the substantia nigra (sn) oxytocin receptor expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model is observed, correlated with the striatal tyrosine hydroxylase (th) expression reduction. |
2024-08-05 |
2024-08-07 |
mouse |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Divya Bharathi Selvaraj, Anusiya Panneerselvam, Jemi Feiona Vergil Andrews, Mahesh Kandasam. Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson's Disease. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061373. |
furthermore, we investigated the effect of cys-hcl on the number of dopaminergic tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and olfactory bulb (ob) of the experimental mice using immunohistochemistry. |
2024-07-27 |
2024-07-29 |
mouse |
| Lennart Höfs, David Geißler-Lösch, Kristof M Wunderlich, Eva M Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H Falkenburge. Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression. Biomolecules. vol 14. issue 7. 2024-07-27. PMID:39062470. |
human a53t-αsyn was overexpressed in the mouse substantia nigra (sn) by using recombinant adeno-associated viral vector (raav). |
2024-07-27 |
2024-07-29 |
mouse |
| Hidetomo Tanaka, Seojin Lee, Ivan Martinez-Valbuena, Blas Couto, Maria Carmela Tartaglia, Javier Sanchez-Ruiz de Gordoa, M Elena Erro, Anthony E Lang, Shelley L Forrest, Gabor G Kovac. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-07-22. PMID:39036836. |
the substantia nigra (sn) is one of the important degenerative areas in tauopathies with parkinsonism. |
2024-07-22 |
2024-07-24 |
Not clear |
| Yi Zhuo, Wen-Shui Li, Wen Lu, Xuan Li, Li-Te Ge, Yan Huang, Qing-Tao Gao, Yu-Jia Deng, Xin-Chen Jiang, Zi-Wei Lan, Que Deng, Yong-Heng Chen, Yi Xiao, Shuo Lu, Feng Jiang, Zuo Liu, Li Hu, Yu Liu, Yu Ding, Zheng-Wen He, De-An Tan, Da Duan, Ming L. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson's disease models and patients. Military Medical Research. vol 11. issue 1. 2024-07-21. PMID:39034405. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-07-21 |
2024-07-24 |
Not clear |
| Jinhan Nam, Christopher T Richie, Brandon K Harvey, Merja H Voutilaine. Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-07-17. PMID:39019902. |
aav-hcdnf resulted in the expression of hcdnf in the striatum (str) and substantia nigra (sn), and no toxic effects on the nigrostriatal pathway were observed. |
2024-07-17 |
2024-07-20 |
mouse |