| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oscar Andersson Forsman, Henrik Sjöström, Per Svenningsson, Tobias Granber. Combined MR quantitative susceptibility mapping and multi-shell diffusion in Parkinson's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2024-07-14. PMID:39004781. |
the g-ratio has, however, not been studied in pd in the substantia nigra (sn) and the putamen. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wessam H Elesawy, Ayman E El-Sahar, Rabab H Sayed, Ahmed M Ashour, Shuruq E Alsufyani, Hany H Arab, Esraa A Kandi. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy. International immunopharmacology. vol 138. 2024-07-09. PMID:38981225. |
as a severe neurological disorder, parkinson's disease (pd) is distinguished by dopaminergic neuronal degeneration in the substantia nigra (sn), culminating in motor impairments. |
2024-07-09 |
2024-07-12 |
rat |
| Amanda S Latham, Savannah M Rocha, Casey P McDermott, Philip Reigan, Richard A Slayden, Ronald B Tjalken. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. Neurotoxicology. 2024-07-03. PMID:38960072. |
approaches that target neuroinflammation, which occurs prior to dopaminergic neuron (dan) loss in the substantia nigra (sn), represent a promising therapeutic strategy. |
2024-07-03 |
2024-07-10 |
mouse |
| Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Lucrecia Chen, Yang-Kai Ng, Crystal Jing-Jing Yeo, Barry Halliwell, Wei-Yi On. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929132. |
cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's disease patients. |
2024-06-27 |
2024-06-29 |
human |
| Ruqing Qiu, Yunjia Cai, Yana Su, Kangli Fan, Zhihui Sun, Ying Zhan. Emerging insights into Lipocalin-2: Unraveling its role in Parkinson's Disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-20. PMID:38901198. |
substantial research has highlighted marked increases in lcn2 expression within the substantia nigra (sn), cerebrospinal fluid (csf), and blood of individuals with pd. |
2024-06-20 |
2024-06-23 |
Not clear |
| Chand Raza, Sehrish Mohsin, Mehwish Faheem, Uzma Hanif, Hamad Z Alkhathlan, Mohammed Rafi Shaik, Hasib Aamir Riaz, Rabia Anjum, Husna Jurrat, Merajuddin Kha. In Vivo Study of Plants (Basel, Switzerland). vol 13. issue 11. 2024-06-19. PMID:38891288. |
oxidative stress is the primary factor for the neurodegeneration of substantia nigra (sn). |
2024-06-19 |
2024-06-21 |
Not clear |
| Abhishek Kumar Verma, Shea Lowery, Li-Chin Lin, Eazhisaivallabi Duraisami, Juan E Abrahante Lloréns, Qiang Qiu, Marco Hefti, C Ron Yu, Mark W Albers, Stanley Perlma. Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations. bioRxiv : the preprint server for biology. 2024-06-19. PMID:38895239. |
long after recovery from nasal infection, we observed loss of tyrosine hydroxylase (th) expression in olfactory bulb glomeruli and neurotransmitter levels in the substantia nigra (sn) persisted. |
2024-06-19 |
2024-06-21 |
mouse |
| Lanxin Li, Yang Zhang, Zhengqian Chen, Can Xu, Zhongqiu Xu, Haitao Pei, Wei Wang, Ruyong Yao, Cui Ha. Cytarabine prevents neuronal damage by enhancing AMPK to stimulate PINK1 / Parkin-involved mitophagy In Parkinson's disease model. European journal of pharmacology. 2024-06-16. PMID:38880222. |
furthermore, cytarabine can also ameliorate the motor symptoms in the mptp-induced pd-like mice model, and attenuate the neuropathy in the substantia nigra (sn) of pd mice, while compound c antagonized cytarabine's beneficial effects. |
2024-06-16 |
2024-06-19 |
mouse |
| Bruna da Silva Oliveira, Eliana Cristina de Brito Toscano, Larissa Katharina Sabino Abreu, Heliana de Barros Fernandes, Renan Florindo Amorim, Rodrigo Novaes Ferreira, Caroline Amaral Machado, Brener Cunha Carvalho, Maria Carolina Machado da Silva, Antônio Carlos Pinheiro de Oliveira, Milene Alvarenga Rachid, Natália Pessoa Rocha, Antônio Lúcio Teixeira, Elizabeth Ribeiro da Silva, Aline Silva de Mirand. Nigrostriatal Inflammation Is Associated with Nonmotor Symptoms in an Experimental Model of Prodromal Parkinson's Disease. Neuroscience. vol 549. 2024-05-22. PMID:38750924. |
intranasal mptp infusion was able to cause the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-05-22 |
2024-05-27 |
mouse |
| Zarghona Imtiaz, Ayaka Kato, Brian H Kopell, Salman E Qasim, Arianna Neal Davis, Lizbeth Nunez Martinez, Matt Heflin, Kaustubh Kulkarni, Amr Morsi, Xiaosi Gu, Ignacio Sae. Human Substantia Nigra Neurons Encode Reward Expectations. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766086. |
dopamine (da) signals originating from substantia nigra (sn) neurons are centrally involved in the regulation of motor and reward processing. |
2024-05-20 |
2024-05-27 |
human |
| Carmen Gasca-Salas, José A Pineda-Pardo, Marta Del Álamo, Tamara Jiménez, Clara Trompeta, Gabriella Toltsis, Lina Garcia-Cañamaque, Beatriz Fernández-Rodríguez, Michele Matarazzo, Isabel Plaza de Las Heras, Elena Natera-Villalba, Raúl Martínez-Fernández, Alicia Duque, Santiago Ruiz de Aguiar, Javier Blesa, Itay Rachmilevich, José A Obes. Nigrostriatal blood-brain barrier opening in Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. 2024-05-17. PMID:38760152. |
this pilot study aimed to demonstrate safety, feasibility and tissue penetration (by 18f-choline-positron emission tomography (pet)) of mr-guided focused ultrasound (mrgfus) simultaneous bbb opening (bbb-o) in the substantia nigra (sn) and putamen in pd. |
2024-05-17 |
2024-05-27 |
Not clear |
| Margaret K Tanner, Alyssa A Hohorst, Jessica D Westerman, Carolina Sanchez Mendoza, Rebecca Han, Nicolette A Moya, Jennifer Jaime, Lareina M Alvarez, Miles Q Dryden, Aleezah Balolia, Remla A Abdul, Esteban C Loetz, Benjamin N Greenwoo. Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction reveal opposing roles in fear renewal. Neurobiology of learning and memory. 2024-05-12. PMID:38735637. |
the dorsal striatum (ds), a primary target of the nigrostriatal da system originating in the substantia nigra (sn), is implicated in behaviors beyond its canonical role in movement, such as reward and punishment, goal-directed action, and stimulus-response associations, but whether ds da contributes to fear extinction is unknown. |
2024-05-12 |
2024-05-27 |
rat |
| Rong Yang, Dai-di Li, Xiao-Xian Li, Xin-Xing Yang, Hui-Ming Gao, Feng Zhan. Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation. International journal of biological macromolecules. vol 269. issue Pt 2. 2024-05-11. PMID:38723817. |
parkinson's disease (pd) is a prevalent neurodegenerative disorder, marked by the degeneration of dopamine (da) neurons in the substantia nigra (sn). |
2024-05-11 |
2024-05-27 |
Not clear |
| Xia-Yin Cao, Yi Liu, Jia-Shuo Kan, Xin-Xing Huang, Piniel Alphayo Kambey, Can-Tang Zhang, Jin Ga. Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression. Brain research bulletin. 2024-04-30. PMID:38688414. |
parkinson's disease (pd) is a severe neurodegenerative disease associated with the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-04-30 |
2024-05-03 |
Not clear |
| Jessica Ahrens, Farida Zaher, Rachel A Rabin, Clifford M Cassidy, Lena Palaniyappa. Neuromelanin levels in individuals with substance use disorders: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 161. 2024-04-28. PMID:38678736. |
neuromelanin in the substantia nigra (sn) may reflect dopamine auto-oxidation, and can be quantified using neuromelaninsensitive magnetic resonance imaging (neuromelanin-mri) in a non-invasive manner.in this pre-registered systematic review, we assess the current body of evidence related to neuromelanin levels in substance use disorders, using both post-mortem and mri examinations. |
2024-04-28 |
2024-05-01 |
Not clear |
| b' Olivera Tama\\xc5\\xa1, Milija Mijajlovi\\xc4\\x87, Tamara \\xc5\\xa0vabi\\xc4\\x87, Milutin Kosti\\xc4\\x87, Gorica Mari\\xc4\\x87, Andona Milovanovi\\xc4\\x87, Marta Jeremi\\xc4\\x87, Nata\\xc5\\xa1a Draga\\xc5\\xa1evi\\xc4\\x87-Mi\\xc5\\xa1kovi\\xc4\\x8. Transcranial Sonography Characteristics of Cerebellar Neurodegenerative Ataxias. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38671992.' |
the substantia nigra (sn) hyperechogenicity was identified in 79.7%. |
2024-04-27 |
2024-04-29 |
human |
| Amanda S Latham, Savannah M Rocha, Casey P McDermott, Philip Reigan, Richard A Slayden, Ronald B Tjalken. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659796. |
approaches that target neuroinflammation, which occurs prior to dopaminergic neuron (dan) loss in the substantia nigra (sn), represent a promising therapeutic strategy. |
2024-04-25 |
2024-04-28 |
mouse |
| Marco G Hermann, Nils Schröter, Alexander Rau, Marco Reisert, Nadja Jarc, Michel Rijntjes, Jonas A Hosp, Peter C Reinacher, Wolfgang H Jost, Horst Urbach, Cornelius Weiller, Volker A Coenen, Bastian E A Sajon. The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus. NeuroImage. Clinical. vol 42. 2024-04-21. PMID:38643635. |
this study aimed to explore the impact of microstructural integrity of the substantia nigra (sn), stn, and putamen on motor response to stn-dbs using diffusion microstructure imaging. |
2024-04-21 |
2024-04-24 |
Not clear |
| P Leon Brown, Heather Palacorolla, Dana E Cobb-Lewis, Thomas C Jhou, Pat McMahon, Dana Bell, Greg I Elmer, Paul D Shepar. Substantia nigra dopamine neuronal responses to habenular stimulation and foot shock are altered by lesions of the rostromedial tegmental nucleus. Neuroscience. 2024-04-18. PMID:38636897. |
dopamine (da) neurons of the substantia nigra (sn) and ventral tegmental area generally respond to aversive stimuli or the absence of expected rewards with transient inhibition of firing rates, which can be recapitulated with activation of the lateral habenula (lhb) and eliminated by lesioning the intermediating rostromedial tegmental nucleus (rmtg). |
2024-04-18 |
2024-04-21 |
rat |
| Pengjun Wang, Chen Chen, Min Sha. Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways. Journal of biochemical and molecular toxicology. vol 38. issue 5. 2024-04-17. PMID:38629493. |
in our study, dopaminergic neuron loss was determined through immunohistochemistry staining and western blot analysis of tyrosine hydroxylase (th) expression in the substantia nigra (sn) of pd mice. |
2024-04-17 |
2024-04-19 |
mouse |