| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark J Connolly, Sujin Jiang, Lim C Samuel, Claire-Anne Gutekunst, Robert E Gross, Annaelle Devergna. Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures. PloS one. vol 19. issue 8. 2024-08-28. PMID:39197026. |
here, we characterize the involvement of the substantia nigra (sn) and somatosensory cortex (si) during temporal lobe (tl) seizures induced by penicillin injection in the hippocampus (hpc) of two nonhuman primates. |
2024-08-28 |
2024-08-31 |
human |
| Zahra Baridjavadi, Mahmoud Mahmoudi, Narges Abdollahi, Negar Ebadpour, Samaneh Mollazadeh, Dariush Haghmorad, Seyed-Alireza Esmaeil. The humoral immune landscape in Parkinson's disease: Unraveling antibody and B cell changes. Cell biochemistry and function. vol 42. issue 7. 2024-08-27. PMID:39189398. |
parkinson's disease (pd) is a complex neurodegenerative disorder characterized by the accumulation of α-synuclein (α-syn) in the brain and progressive loss of dopaminergic neurons in the substantia nigra (sn) region of the brain. |
2024-08-27 |
2024-08-30 |
Not clear |
| Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jian. GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy. Redox biology. vol 76. 2024-08-24. PMID:39180981. |
however, in contrast to the strikingly low levels of ghrelin, ghsr is highly expressed in the substantia nigra (sn). |
2024-08-24 |
2024-08-28 |
mouse |
| Alfonso Mata-Bermudez, Ricardo Trejo-Chávez, Marina Martínez-Vargas, Adán Pérez-Arredondo, Maria de Los Ángeles Martínez-Cardenas, Araceli Diaz-Ruiz, Camilo Rios, Luz Navarr. Dysregulation of the dopaminergic system secondary to traumatic brain injury: implications for mood and anxiety disorders. Frontiers in neuroscience. vol 18. 2024-08-23. PMID:39176379. |
we describe the changes that occur in the clinical picture of post-tbi patients, such as alterations in mood and anxiety associated with dat activity in the striatum, the relationship between post-tbi major depressive disorders (mdd) with lower availability of the da receptors d2r and d3r in the caudate and thalamus, as well as a decrease in the volume of the substantia nigra (sn) associated with anxiety symptoms. |
2024-08-23 |
2024-08-25 |
Not clear |
| Edward Pajarillo, Sanghoon Kim, Alexis Digman, Itunu Ajayi, Ivan Nyarko-Danquah, Deok-Soo Son, Michael Aschner, Eunsook Le. Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice. The Journal of biological chemistry. 2024-08-23. PMID:39178947. |
restoration of rest in the substantia nigra (sn) with neuronal rest aav vector infusion was performed to further support the role of rest in mn toxicity. |
2024-08-23 |
2024-08-27 |
mouse |
| Gerardo Mendez-Victoriano, Yunting Zhu, Frank Middleton, Paul T Massa, Kachikwulu Ajulu, Maree J Webster, Cynthia S Weicker. Increased Parenchymal Macrophages are associated with decreased Tyrosine Hydroxylase mRNA levels in the Substantia Nigra of people with Schizophrenia and Bipolar Disorder. Psychiatry research. vol 340. 2024-08-17. PMID:39153291. |
herein, we determined whether there were differences in cd163+ cell density in the substantia nigra (sn), and cerebral peduncles (cp) of sz, bd, and mdd compared to controls (ctrl). |
2024-08-17 |
2024-08-20 |
Not clear |
| Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansa. Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson's disease. Molecular brain. vol 17. issue 1. 2024-08-14. PMID:39138468. |
in the second dataset obtained from the substantia nigra (sn), opcs displayed an association with updrs-iii. |
2024-08-14 |
2024-08-16 |
Not clear |
| Yurong Wang, Hao Xu, Saiyong Chen, Junhao Chen, Qimeng Zheng, Yuanyuan Ma, Xinru Zhao, Ying Shi, Lei Xia. Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP-Induced Parkinson's Disease Model. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-08-05. PMID:39099429. |
here, the disturbances of endogenous oxytocin level and the substantia nigra (sn) oxytocin receptor expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model is observed, correlated with the striatal tyrosine hydroxylase (th) expression reduction. |
2024-08-05 |
2024-08-07 |
mouse |
| Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chushen Huang, Zhongquan Q. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model. IUBMB life. 2024-07-31. PMID:39082886. |
parkinson's disease (pd) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (sn) and striatum, resulting in impaired motor functions. |
2024-07-31 |
2024-08-02 |
mouse |
| Divya Bharathi Selvaraj, Anusiya Panneerselvam, Jemi Feiona Vergil Andrews, Mahesh Kandasam. Cysteamine HCl Administration Impedes Motor and Olfactory Functions, Accompanied by a Reduced Number of Dopaminergic Neurons, in Experimental Mice: A Preclinical Mimetic Relevant to Parkinson's Disease. Brain sciences. vol 14. issue 7. 2024-07-27. PMID:39061373. |
furthermore, we investigated the effect of cys-hcl on the number of dopaminergic tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and olfactory bulb (ob) of the experimental mice using immunohistochemistry. |
2024-07-27 |
2024-07-29 |
mouse |
| Lennart Höfs, David Geißler-Lösch, Kristof M Wunderlich, Eva M Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H Falkenburge. Evaluation of the Effect of β-Wrapin AS69 in a Mouse Model Based on Alpha-Synuclein Overexpression. Biomolecules. vol 14. issue 7. 2024-07-27. PMID:39062470. |
human a53t-αsyn was overexpressed in the mouse substantia nigra (sn) by using recombinant adeno-associated viral vector (raav). |
2024-07-27 |
2024-07-29 |
mouse |
| Hidetomo Tanaka, Seojin Lee, Ivan Martinez-Valbuena, Blas Couto, Maria Carmela Tartaglia, Javier Sanchez-Ruiz de Gordoa, M Elena Erro, Anthony E Lang, Shelley L Forrest, Gabor G Kovac. Ageing-related tau astrogliopathy severely affecting the substantia nigra. Neuropathology and applied neurobiology. vol 50. issue 4. 2024-07-22. PMID:39036836. |
the substantia nigra (sn) is one of the important degenerative areas in tauopathies with parkinsonism. |
2024-07-22 |
2024-07-24 |
Not clear |
| Yi Zhuo, Wen-Shui Li, Wen Lu, Xuan Li, Li-Te Ge, Yan Huang, Qing-Tao Gao, Yu-Jia Deng, Xin-Chen Jiang, Zi-Wei Lan, Que Deng, Yong-Heng Chen, Yi Xiao, Shuo Lu, Feng Jiang, Zuo Liu, Li Hu, Yu Liu, Yu Ding, Zheng-Wen He, De-An Tan, Da Duan, Ming L. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson's disease models and patients. Military Medical Research. vol 11. issue 1. 2024-07-21. PMID:39034405. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-07-21 |
2024-07-24 |
Not clear |
| Jinhan Nam, Christopher T Richie, Brandon K Harvey, Merja H Voutilaine. Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-07-17. PMID:39019902. |
aav-hcdnf resulted in the expression of hcdnf in the striatum (str) and substantia nigra (sn), and no toxic effects on the nigrostriatal pathway were observed. |
2024-07-17 |
2024-07-20 |
mouse |
| Oscar Andersson Forsman, Henrik Sjöström, Per Svenningsson, Tobias Granber. Combined MR quantitative susceptibility mapping and multi-shell diffusion in Parkinson's disease. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2024-07-14. PMID:39004781. |
the g-ratio has, however, not been studied in pd in the substantia nigra (sn) and the putamen. |
2024-07-14 |
2024-07-18 |
Not clear |
| Wessam H Elesawy, Ayman E El-Sahar, Rabab H Sayed, Ahmed M Ashour, Shuruq E Alsufyani, Hany H Arab, Esraa A Kandi. Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy. International immunopharmacology. vol 138. 2024-07-09. PMID:38981225. |
as a severe neurological disorder, parkinson's disease (pd) is distinguished by dopaminergic neuronal degeneration in the substantia nigra (sn), culminating in motor impairments. |
2024-07-09 |
2024-07-12 |
rat |
| Amanda S Latham, Savannah M Rocha, Casey P McDermott, Philip Reigan, Richard A Slayden, Ronald B Tjalken. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. Neurotoxicology. 2024-07-03. PMID:38960072. |
approaches that target neuroinflammation, which occurs prior to dopaminergic neuron (dan) loss in the substantia nigra (sn), represent a promising therapeutic strategy. |
2024-07-03 |
2024-07-10 |
mouse |
| Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Lucrecia Chen, Yang-Kai Ng, Crystal Jing-Jing Yeo, Barry Halliwell, Wei-Yi On. Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929132. |
cell death involving oxidative stress and mitochondrial dysfunction is a major cause of dopaminergic neuronal loss in the substantia nigra (sn) of parkinson's disease patients. |
2024-06-27 |
2024-06-29 |
human |
| Ruqing Qiu, Yunjia Cai, Yana Su, Kangli Fan, Zhihui Sun, Ying Zhan. Emerging insights into Lipocalin-2: Unraveling its role in Parkinson's Disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-20. PMID:38901198. |
substantial research has highlighted marked increases in lcn2 expression within the substantia nigra (sn), cerebrospinal fluid (csf), and blood of individuals with pd. |
2024-06-20 |
2024-06-23 |
Not clear |
| Chand Raza, Sehrish Mohsin, Mehwish Faheem, Uzma Hanif, Hamad Z Alkhathlan, Mohammed Rafi Shaik, Hasib Aamir Riaz, Rabia Anjum, Husna Jurrat, Merajuddin Kha. In Vivo Study of Plants (Basel, Switzerland). vol 13. issue 11. 2024-06-19. PMID:38891288. |
oxidative stress is the primary factor for the neurodegeneration of substantia nigra (sn). |
2024-06-19 |
2024-06-21 |
Not clear |