All Relations between tph2 and serotonin

Publication Sentence Publish Date Extraction Date Species
Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenin. Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice. Communications biology. vol 7. issue 1. 2024-12-18. PMID:39695187. in this study, we show that the co-chaperone dnajc12 is downregulated in serotonergic neurons in the brain of mice lacking tph2 and thereby central serotonin. 2024-12-18 2024-12-21 mouse
Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenin. Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice. Communications biology. vol 7. issue 1. 2024-12-18. PMID:39695187. these mice show reduced levels and activity of pah, tph2, and tph1 in liver, brain, and pineal gland, respectively, and experience hyperphenylalaninemia and central and peripheral serotonin deficiency. 2024-12-18 2024-12-21 mouse
Tianhua Wang, Judith R Homberg, Laura Boreggio, Marta C F Samina, Rogério C R Castro, Sharon M Kolk, Natalia Alenina, Michael Bader, Jinye Dai, Markus Wöh. Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits. Molecular autism. vol 15. issue 1. 2024-11-30. PMID:39614401. a lack of serotonin (also known as 5-hydroxytryptamine, 5-ht) in the brain due to deficiency of the rate-limiting enzyme in 5-ht synthesis, tryptophan hydroxylase 2 (tph2), was recently reported to result in impaired maternal affiliation across species, including mice, rats, and monkeys. 2024-11-30 2024-12-02 mouse
Qian Gao, Zhiwei Tang, Haili Wang, Maya Yamazaki, Jia Jiang, Ying-Hui Fu, Louis J Ptacek, Luoying Zhan. Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling. Nature metabolism. 2024-11-11. PMID:39528818. enhanced glucocorticoid signalling represses the transcription of tph2, which encodes the rate-limiting enzyme of serotonin synthesis, leading to increased depression-like behaviours. 2024-11-11 2024-11-17 mouse
Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kub. SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau. PloS one. vol 19. issue 10. 2024-10-30. PMID:39475992. attenuation of the gsk3β pathway and decreased serotonin synthesis through suppression of tph2 expression may contribute to the development of neurological symptoms. 2024-10-30 2024-11-02 mouse
Yuting Wu, Jinyu Ma, Jing Chen, Xiaoyu Liu, Zhe Wang, Lan Luo, Cheng Su. Ablation of CD44 attenuates adipogenesis in white adipocytes via the TPH2/5-HT axis to protect mice from high-fat diet induced obesity. The American journal of pathology. 2024-10-30. PMID:39476955. the application of 5-hydroxytryptamine (5-ht), a product of tph2, rescues the repressed adipogenesis induced by cd44 neutralization. 2024-10-30 2024-11-02 mouse
Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. on day 15, adrenal glands were collected for tph1 and tph2 immunohistochemistry, western blot, and rt-pcr; tph activity was estimated by quantification of 5-hydroxytryptophan (5-htp) and, indirectly, through measurement of 5-ht and 5-hydroxindolacetic acid (5-hiaa) levels and turnover (5-hiaa/5-ht ratio) by hplc. 2024-10-28 2024-10-31 rat
Silvia Elisabetta Portis Bruzzone, Brice Ozenne, Patrick MacDonald Fisher, Gabriela Ortega, Martin Balslev Jørgensen, Gitte Moos Knudsen, Klaus-Peter Lesch, Vibe Gedsoe Frokjae. DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. 2024-10-05. PMID:39368538. dna methylation levels of serotonin transporter (slc6a4) and tryptophan hydroxylase 2 genes (tph2) have been suggested to predict antidepressant clinical outcomes but their applicability remains uncertain. 2024-10-05 2024-10-08 Not clear
Marion Rivalan, Lucille Alonso, Valentina Mosienko, Patrik Bey, Alexia Hyde, Michael Bader, York Winter, Natalia Alenin. Serotonin drives aggression and social behaviors of laboratory male mice in a semi-natural environment. Frontiers in behavioral neuroscience. vol 18. 2024-10-03. PMID:39359324. mice lacking in brain serotonin, due to the ablation of tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in serotonin synthesis, could serve as a potential model for studying pathological aggression. 2024-10-03 2024-10-05 mouse
Inah Park, Mijung Choi, Jeongah Kim, Sangwon Jang, Doyeon Kim, Jihoon Kim, Youngshik Choe, Dongho Geum, Seong-Woon Yu, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Gi Hoon Son, Kyungjin Ki. Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation. Communications biology. vol 7. issue 1. 2024-08-15. PMID:39147805. here, we investigate the role of the circadian nuclear receptor rev-erbα in regulating tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of 5-ht synthesis. 2024-08-15 2024-08-18 mouse
Inah Park, Mijung Choi, Jeongah Kim, Sangwon Jang, Doyeon Kim, Jihoon Kim, Youngshik Choe, Dongho Geum, Seong-Woon Yu, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Gi Hoon Son, Kyungjin Ki. Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation. Communications biology. vol 7. issue 1. 2024-08-15. PMID:39147805. in mice, genetic ablation of dr 5-htergic rev-erbα increases tph2 expression, leading to elevated dr 5-ht levels and reduced depression-like behaviors at dusk. 2024-08-15 2024-08-18 mouse
Allison K Warner, Lauren Iskander, Kristen Allen, Isabella Quatela, Hannah Borrelli, Benjamin D Sach. The Effects of Brain Serotonin Deficiency on the Behavioral and Neurogenesis-Promoting Effects of Voluntary Exercise in Tryptophan Hydroxylase 2 (R439H) Knock-in Mice. Neuropharmacology. 2024-07-15. PMID:39009217. complete loss of function of the brain 5-ht synthesis enzyme (tryptophan hydroxylase 2, tph2) has been reported to prevent exercise-induced increases in neurogenesis and to block a subset of antidepressant-like responses to selective serotonin reuptake inhibitors (ssris), but whether partial loss of tph2 function blocks the behavioral and neurogenic effects of exercise has not been established. 2024-07-15 2024-07-18 mouse
A B Arefieva, P D Komleva, M Gubina, A V Kuliko. Effect of (R)-2-Amino-6-(1R,2S)-1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydropterin-4(3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan Hydroxylase 2 with the P447R Mutation. Bulletin of experimental biology and medicine. 2024-06-26. PMID:38922549. the enzyme tryptophan hydroxylase 2 (tph2) catalyzes the hydroxylation of l-tryptophan to l-5-hydroxytryptophan (5-htp), the first and the key step in 5-ht synthesis in the mammalian brain. 2024-06-26 2024-06-29 human
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. 2024-06-08 2024-06-11 rat
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. 2024-06-08 2024-06-11 rat
S E P Bruzzone, B Ozenne, P M Fisher, G Ortega, P S Jensen, V H Dam, C Svarer, G M Knudsen, K P Lesch, V G Frokjae. No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state. Clinical epigenetics. vol 16. issue 1. 2024-05-28. PMID:38802956. here, we evaluated the association between whole-blood-derived methylation of four cpg sites in the serotonin transporter (slc6a4) and six cpg sites of the tryptophan hydroxylase 2 (tph2) gene and in-vivo brain levels of serotonin transporter (5-htt) and serotonin 4 receptor (5-ht 2024-05-28 2024-06-03 Not clear
Ying Zhu, Lifeng Yin, Qing Liu, Yaoxing Guan, Shuang Nie, Yongheng Zhu, Fengfeng M. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Current research in food science. vol 8. 2024-05-13. PMID:38736909. tryptophan supplementation improved the abnormal expression of appetite regulators (e.g., agrp, ox1r, mc4r), and tryptophan supplementation also increased the tryptophan hydroxylase 2 (tph2) and 5-ht receptors in the hypothalamus of cms mice, which indicates that the 5-ht metabolic pathway influences feeding behavior. 2024-05-13 2024-05-27 mouse
Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. 2024-05-13 2024-05-27 rat
Hui-Min Zhu, Bo Wang, Tao Wang, Jing Shao, Hui-Ru Chen, Chi Zhang, Li-Hua Xu, Jing-Jing Li, Min Wang, De-Xiang Xu, Xiu-Hong Men. Prenatal exposure to fenvalerate causes depressive-like behavior in adulthood by inhibiting brain-derived 5-HT synthesis. Environmental pollution (Barking, Essex : 1987). 2024-05-13. PMID:38740245. tryptophan hydroxylase 2 (tph2), a key enzyme for 5-ht synthesis, was downregulated in the midbrain of fenvalerate-exposed gd18 fetuses. 2024-05-13 2024-05-27 mouse
Lucille Alonso, Polina Peeva, Tania Fernández-Del Valle Alquicira, Narda Erdelyi, Ángel Gil Nolskog, Michael Bader, York Winter, Natalia Alenina, Marion Rivala. Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732220. using a novel rat model of inducible serotonin depletion via the genetic knockdown of tryptophan hydroxylase 2 (tph2), we achieved a 20% decrease in serotonin levels in the hypothalamus after three weeks of non-invasive oral doxycycline administration. 2024-05-11 2024-05-27 rat