| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianhua Wang, Judith R Homberg, Laura Boreggio, Marta C F Samina, Rogério C R Castro, Sharon M Kolk, Natalia Alenina, Michael Bader, Jinye Dai, Markus Wöh. Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits. Molecular autism. vol 15. issue 1. 2024-11-30. PMID:39614401. |
a lack of serotonin (also known as 5-hydroxytryptamine, 5-ht) in the brain due to deficiency of the rate-limiting enzyme in 5-ht synthesis, tryptophan hydroxylase 2 (tph2), was recently reported to result in impaired maternal affiliation across species, including mice, rats, and monkeys. |
2024-11-30 |
2024-12-02 |
mouse |
| Qian Gao, Zhiwei Tang, Haili Wang, Maya Yamazaki, Jia Jiang, Ying-Hui Fu, Louis J Ptacek, Luoying Zhan. Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling. Nature metabolism. 2024-11-11. PMID:39528818. |
enhanced glucocorticoid signalling represses the transcription of tph2, which encodes the rate-limiting enzyme of serotonin synthesis, leading to increased depression-like behaviours. |
2024-11-11 |
2024-11-17 |
mouse |
| Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kub. SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau. PloS one. vol 19. issue 10. 2024-10-30. PMID:39475992. |
attenuation of the gsk3β pathway and decreased serotonin synthesis through suppression of tph2 expression may contribute to the development of neurological symptoms. |
2024-10-30 |
2024-11-02 |
mouse |
| Yuting Wu, Jinyu Ma, Jing Chen, Xiaoyu Liu, Zhe Wang, Lan Luo, Cheng Su. Ablation of CD44 attenuates adipogenesis in white adipocytes via the TPH2/5-HT axis to protect mice from high-fat diet induced obesity. The American journal of pathology. 2024-10-30. PMID:39476955. |
the application of 5-hydroxytryptamine (5-ht), a product of tph2, rescues the repressed adipogenesis induced by cd44 neutralization. |
2024-10-30 |
2024-11-02 |
mouse |
| Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. |
on day 15, adrenal glands were collected for tph1 and tph2 immunohistochemistry, western blot, and rt-pcr; tph activity was estimated by quantification of 5-hydroxytryptophan (5-htp) and, indirectly, through measurement of 5-ht and 5-hydroxindolacetic acid (5-hiaa) levels and turnover (5-hiaa/5-ht ratio) by hplc. |
2024-10-28 |
2024-10-31 |
rat |
| Silvia Elisabetta Portis Bruzzone, Brice Ozenne, Patrick MacDonald Fisher, Gabriela Ortega, Martin Balslev Jørgensen, Gitte Moos Knudsen, Klaus-Peter Lesch, Vibe Gedsoe Frokjae. DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. 2024-10-05. PMID:39368538. |
dna methylation levels of serotonin transporter (slc6a4) and tryptophan hydroxylase 2 genes (tph2) have been suggested to predict antidepressant clinical outcomes but their applicability remains uncertain. |
2024-10-05 |
2024-10-08 |
Not clear |
| Marion Rivalan, Lucille Alonso, Valentina Mosienko, Patrik Bey, Alexia Hyde, Michael Bader, York Winter, Natalia Alenin. Serotonin drives aggression and social behaviors of laboratory male mice in a semi-natural environment. Frontiers in behavioral neuroscience. vol 18. 2024-10-03. PMID:39359324. |
mice lacking in brain serotonin, due to the ablation of tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in serotonin synthesis, could serve as a potential model for studying pathological aggression. |
2024-10-03 |
2024-10-05 |
mouse |
| Inah Park, Mijung Choi, Jeongah Kim, Sangwon Jang, Doyeon Kim, Jihoon Kim, Youngshik Choe, Dongho Geum, Seong-Woon Yu, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Gi Hoon Son, Kyungjin Ki. Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation. Communications biology. vol 7. issue 1. 2024-08-15. PMID:39147805. |
here, we investigate the role of the circadian nuclear receptor rev-erbα in regulating tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of 5-ht synthesis. |
2024-08-15 |
2024-08-18 |
mouse |
| Inah Park, Mijung Choi, Jeongah Kim, Sangwon Jang, Doyeon Kim, Jihoon Kim, Youngshik Choe, Dongho Geum, Seong-Woon Yu, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Gi Hoon Son, Kyungjin Ki. Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation. Communications biology. vol 7. issue 1. 2024-08-15. PMID:39147805. |
in mice, genetic ablation of dr 5-htergic rev-erbα increases tph2 expression, leading to elevated dr 5-ht levels and reduced depression-like behaviors at dusk. |
2024-08-15 |
2024-08-18 |
mouse |
| Allison K Warner, Lauren Iskander, Kristen Allen, Isabella Quatela, Hannah Borrelli, Benjamin D Sach. The Effects of Brain Serotonin Deficiency on the Behavioral and Neurogenesis-Promoting Effects of Voluntary Exercise in Tryptophan Hydroxylase 2 (R439H) Knock-in Mice. Neuropharmacology. 2024-07-15. PMID:39009217. |
complete loss of function of the brain 5-ht synthesis enzyme (tryptophan hydroxylase 2, tph2) has been reported to prevent exercise-induced increases in neurogenesis and to block a subset of antidepressant-like responses to selective serotonin reuptake inhibitors (ssris), but whether partial loss of tph2 function blocks the behavioral and neurogenic effects of exercise has not been established. |
2024-07-15 |
2024-07-18 |
mouse |
| A B Arefieva, P D Komleva, M Gubina, A V Kuliko. Effect of (R)-2-Amino-6-(1R,2S)-1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydropterin-4(3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan Hydroxylase 2 with the P447R Mutation. Bulletin of experimental biology and medicine. 2024-06-26. PMID:38922549. |
the enzyme tryptophan hydroxylase 2 (tph2) catalyzes the hydroxylation of l-tryptophan to l-5-hydroxytryptophan (5-htp), the first and the key step in 5-ht synthesis in the mammalian brain. |
2024-06-26 |
2024-06-29 |
human |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| S E P Bruzzone, B Ozenne, P M Fisher, G Ortega, P S Jensen, V H Dam, C Svarer, G M Knudsen, K P Lesch, V G Frokjae. No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state. Clinical epigenetics. vol 16. issue 1. 2024-05-28. PMID:38802956. |
here, we evaluated the association between whole-blood-derived methylation of four cpg sites in the serotonin transporter (slc6a4) and six cpg sites of the tryptophan hydroxylase 2 (tph2) gene and in-vivo brain levels of serotonin transporter (5-htt) and serotonin 4 receptor (5-ht |
2024-05-28 |
2024-06-03 |
Not clear |
| Ying Zhu, Lifeng Yin, Qing Liu, Yaoxing Guan, Shuang Nie, Yongheng Zhu, Fengfeng M. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Current research in food science. vol 8. 2024-05-13. PMID:38736909. |
tryptophan supplementation improved the abnormal expression of appetite regulators (e.g., agrp, ox1r, mc4r), and tryptophan supplementation also increased the tryptophan hydroxylase 2 (tph2) and 5-ht receptors in the hypothalamus of cms mice, which indicates that the 5-ht metabolic pathway influences feeding behavior. |
2024-05-13 |
2024-05-27 |
mouse |
| Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. |
in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. |
2024-05-13 |
2024-05-27 |
rat |
| Hui-Min Zhu, Bo Wang, Tao Wang, Jing Shao, Hui-Ru Chen, Chi Zhang, Li-Hua Xu, Jing-Jing Li, Min Wang, De-Xiang Xu, Xiu-Hong Men. Prenatal exposure to fenvalerate causes depressive-like behavior in adulthood by inhibiting brain-derived 5-HT synthesis. Environmental pollution (Barking, Essex : 1987). 2024-05-13. PMID:38740245. |
tryptophan hydroxylase 2 (tph2), a key enzyme for 5-ht synthesis, was downregulated in the midbrain of fenvalerate-exposed gd18 fetuses. |
2024-05-13 |
2024-05-27 |
mouse |
| Lucille Alonso, Polina Peeva, Tania Fernández-Del Valle Alquicira, Narda Erdelyi, Ángel Gil Nolskog, Michael Bader, York Winter, Natalia Alenina, Marion Rivala. Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732220. |
using a novel rat model of inducible serotonin depletion via the genetic knockdown of tryptophan hydroxylase 2 (tph2), we achieved a 20% decrease in serotonin levels in the hypothalamus after three weeks of non-invasive oral doxycycline administration. |
2024-05-11 |
2024-05-27 |
rat |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| Hanfei Wang, Yanrong Sun, Wenjuan Wang, Xiangqiu Wang, Jinglin Zhang, Yu Bai, Ke Wang, Liju Luan, Junhao Yan, Lihua Qi. Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38510058. |
this study clarified that the expression of oestrogen receptor decreased in perimenopause, which regulated the transcription levels of tph2 and maoa, and ultimately led to the reduction of 5-ht content, providing a new target for clinical diagnosis and treatment of perimenopausal diseases. |
2024-03-21 |
2024-03-23 |
mouse |