| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Darya V Bazovkina, Dariya V Fursenko, Vladimir S Naumenko, Aleksandr V Kuliko. The Role of C1473G Polymorphism in Mouse Triptophan Hydroxylase 2 Gene in the Acute Effects of Ethanol on the c-fos Gene Expression and Metabolism of Biogenic Amines in the Brain. Biochemistry. Biokhimiia. vol 88. issue 3. 2023-04-19. PMID:37076278. |
we studied the effect of acute ethanol administration on the expression of the early response c-fos gene and metabolism of serotonin and catecholamines in the brain structures of b6-1473c and b6-1473g congenic mouse strains differing in the single-nucleotide substitution c1473g in the tph2 gene and activity of the encoded enzyme. |
2023-04-19 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
[alterations in the level of mrna of tph1, tph2 genes, tryptophan hydroxylase activity and serotonin metabolism in mouse brain five days after lipopolysaccharide administration]. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
tryptophan hydroxylases 1 and 2 (tph1 and tph2) play a key role in the synthesis of serotonin (5-ht), a hormone and neurotransmitter, in the peripheral organs and brain, respectively. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
in the frontal cortex, hippocampus, striatum, hypothalamus, and midbrain the concentrations of 5-ht and its main metabolite, 5-hydroxyindole acetic acid (5-hiaa), and tph activity were assayed using hplc, while tph1 and tph2 mrna were quantified using quantitative real-time rt-pcr. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
the highest concentration of tph2 gene mrna was observed in the midbrain in 5-ht neuron bodies, while this gene mrna level was lower in 5-ht endings (cortex, hippocampus, striatum, and hypothalamus). |
2023-03-31 |
2023-08-14 |
mouse |
| Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydeck. HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). Cells. vol 12. issue 6. 2023-03-29. PMID:36980311. |
seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during peg-ifn-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the htr1a, tph2, and 5-htt genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-httlpr rs25531polymorphisms and indoleamine 2,3-dioxygenase (ido) activity, as well as kynurenine (kyn), tryptophan (trp), kynurenic acid (ka), and anthranilic acid (aa) concentrations. |
2023-03-29 |
2023-08-14 |
Not clear |
| Haoyue Deng, Yi Wu, Po Gao, Dexu Kong, Chao Pan, Saihong Xu, Dan Tang, Yingfu Jiao, Daxiang Wen, Weifeng Y. Preoperative Pain Facilitates Postoperative Cognitive Dysfunction via PAG-DR Circuit. Neuroscience. 2023-03-23. PMID:36958595. |
the immunofluorescence staining and western blot results showed that tryptophan hydroxylase 2 (tph2) for serotonin synthesis in the dr was increased significantly in the rats treated with cfa for 7 days and sevoflurane for 3 hours, while chemo-genetic inhibition of the vlpag-dr projection induced obvious spatial learning and memory impairment. |
2023-03-23 |
2023-08-14 |
rat |
| Sergey A Sinenko, Andrey A Kuzmin, Elena V Skvortsova, Sergey V Ponomartsev, Evgeniya V Efimova, Michael Bader, Natalia Alenina, Alexey N Tomili. Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36902295. |
as serotonin is synthesized from tryptophan by the rate limiting enzymes tryptophan hydroxylase-1 and -2 (tph1 and tph2), we have assessed the reprogramming of tph1- and/or tph2-deficient mouse embryonic fibroblasts (mefs) to induced pluripotent stem cells (ipscs). |
2023-03-11 |
2023-08-14 |
mouse |
| Yan Liu, Liang Shan, Tiane Liu, Juan Li, Yongchang Chen, Changhong Sun, Chaojuan Yang, Xiling Bian, Yuyu Niu, Chen Zhang, Jianzhong Xi, Yi Ra. Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron. 2023-03-03. PMID:36868221. |
we report here that elimination of the tph2 gene essential for serotonin synthesis in the brain reduced affiliation in mice, rats, and monkeys. |
2023-03-03 |
2023-08-14 |
mouse |
| Shuyue Cheng, Zemeng Zhu, Haonan Li, Wei Wang, Zhijun Jiang, Fang Pan, Dexiang Liu, Roger C M Ho, Cyrus S H H. Rifaximin ameliorates depression-like behaviour in chronic unpredictable mild stress rats by regulating intestinal microbiota and hippocampal tryptophan metabolism. Journal of affective disorders. 2023-02-26. PMID:36842645. |
indoleamine-2, 3-dioxygenase-1 (ido1) and tryptophan hydroxylase 2 (tph2) are the key rate-limiting enzymes in trp metabolism and play an important role in kyn and 5-ht metabolism. |
2023-02-26 |
2023-08-14 |
rat |
| Cheng-Ting Xie, Mei-Ling Tan, Ying-Wen Li, Qi-Liang Chen, Yan-Jun Shen, Zhi-Hao Li. Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-02-13. PMID:36781090. |
despite the upregulation of tph2 was consistent with increased 5-ht level in the brain, significantly downregulated htr1aa and htr1b may indicate attenuated 5-ht potency. |
2023-02-13 |
2023-08-14 |
zebrafish |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| P D Komleva, E Yu Bazhenova, N V Khotskin, E A Kulikova, A V Kuliko. C1473G Polymorphism in Tph2 Gene Affects Activation of Serotonin Metabolism in Mouse Brain 24 h after LPS Administration. Bulletin of experimental biology and medicine. 2023-01-04. PMID:36600037. |
c1473g polymorphism in tph2 gene affects activation of serotonin metabolism in mouse brain 24 h after lps administration. |
2023-01-04 |
2023-08-14 |
mouse |
| P D Komleva, E Yu Bazhenova, N V Khotskin, E A Kulikova, A V Kuliko. C1473G Polymorphism in Tph2 Gene Affects Activation of Serotonin Metabolism in Mouse Brain 24 h after LPS Administration. Bulletin of experimental biology and medicine. 2023-01-04. PMID:36600037. |
we studied the effect of the c1473g polymorphism in the tph2 gene that reduces the activity of the tryptophan hydroxylase 2 in the brain on the severity of changes in motor activity (23 h after intraperitoneal administration of 0.8 mg/kg lps or saline) and on the level of serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the endings of 5-ht neurons in the cortex, hippocampus, and striatum (24 h after administration) of mature male mice of congenic lines b6-1473cc (high activity) and b6-1473gg (low activity). |
2023-01-04 |
2023-08-14 |
mouse |
| Michael D Gersho. The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah. Advances in experimental medicine and biology. vol 1383. 2022-12-31. PMID:36587168. |
the smaller enteric 5-ht store is biosynthetically dependent upon tph2 and is located within a small subset of myenteric neurons. |
2022-12-31 |
2023-08-14 |
dog |
| Richard L Spinieli, Jennifer Cornelius-Green, Kevin J Cumming. A serotonin-deficient rat model of neurogenic hypertension: influence of sex and sympathetic vascular tone. Journal of neurophysiology. vol 128. issue 5. 2022-10-28. PMID:36169206. |
previously we showed that a loss of central nervous system (cns) 5-hydroxytryptamine (5-ht) (tryptophan hydroxylase 2 knockout; tph2 |
2022-10-28 |
2023-11-08 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus and piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
tph2 and 5-ht were expressed in cell bodies in the dorsal raphe nucleus and piriform cortex, while in other regions they were distributed as filaments and clump shapes in axons. |
2022-10-20 |
2023-08-14 |
mouse |