| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| Hanfei Wang, Yanrong Sun, Wenjuan Wang, Xiangqiu Wang, Jinglin Zhang, Yu Bai, Ke Wang, Liju Luan, Junhao Yan, Lihua Qi. Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38510058. |
this study clarified that the expression of oestrogen receptor decreased in perimenopause, which regulated the transcription levels of tph2 and maoa, and ultimately led to the reduction of 5-ht content, providing a new target for clinical diagnosis and treatment of perimenopausal diseases. |
2024-03-21 |
2024-03-23 |
mouse |
| L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. |
acute, uncontrollable swim stress increased c-fos immunoreactivity in neurons co-expressing vglut3 and the 5-ht marker tryptophan hydroxylase 2 (tph2) in the dorsal raphe nucleus (drn). |
2024-02-20 |
2024-02-23 |
mouse |
| Jie Gu, Liguo Guo, Chen Chen, Guixiang Ji, Lei Wan. Neurobehavioral toxic effects and mechanisms of 2-aminobenzothiazole exposure on zebrafish. The Science of the total environment. 2023-12-24. PMID:38142985. |
furthermore, the real-time pcr results indicated a significant suppression of genes related to exposure to nth, specifically those in the gaba synthesis pathway (gabrg2, gad2, gad1b, and abat) and the 5-ht synthesis pathway (tph2, tph1b, pet1, and htr1aa). |
2023-12-24 |
2023-12-27 |
zebrafish |
| I E Sorokin, V S Evsyukova, A B Arefieva, V V Sachkova, P A Kulikov, A V Kuliko. Effect of Prolonged Exposure to Short Daylight and a Tryptophan Hydroxylase Inhibitor on the Behavior and Brain Serotonin System in Danio rerio. Bulletin of experimental biology and medicine. 2023-11-18. PMID:37979022. |
on day 31, the fish behavior in the "novel tank diving" test, their sex and body weight were determined, and the levels of pcpa, 5-ht, and its metabolite 5-hiaa were measured by hplc; the levels of the key genes encoding metabolism enzymes (tph1a, tph1b, tph2, and mao) and receptors of 5-ht (htr1aa, htr2aa) were assessed by real-time pcr with reverse transcription. |
2023-11-18 |
2023-11-20 |
zebrafish |
| Neha Sawant, Sudhir Kshirsagar, P Hemachandra Reddy, Arubala P Redd. Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-06. PMID:37931714. |
we then assessed mrna and protein levels of p-tau, total tau, serotonin related proteins such as tph2, sert, and 5htr1a, synaptic proteins and cytoskeletal structure. |
2023-11-06 |
2023-11-08 |
Not clear |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
the potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 2 (tph2) is well characterized to facilitate rapid and long-lasting antidepressant actions. |
2023-11-02 |
2023-11-08 |
mouse |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
we show here that a lack of acetyl-coa synthetase short-chain family member 2 (acss2) causes impairments in bdnf-dependent synaptic plasticity and tryptophan hydroxylase 2 (tph2)-mediated serotonin generation, thereby contributing to spontaneous and chronic restraint stress (crs)-induced depressive-like behavior in mice. |
2023-11-02 |
2023-11-08 |
mouse |
| Alla B Arefieva, Polina D Komleva, Vladimir S Naumenko, Nikita V Khotskin, Alexander V Kuliko. In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892138. |
tryptophan hydroxylase 2 (tph2) is the key and rate-limiting enzyme of serotonin (5-ht) synthesis in the mammalian brain. |
2023-10-30 |
2023-11-08 |
mouse |
| Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. |
a central serotonin regulating gene polymorphism (tph2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. |
2023-09-04 |
2023-09-07 |
Not clear |
| Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. |
the present study aimed to investigate whether individual variations in the tryptophan hydroxylase 2 (tph2) genetics influence susceptibility for behavioral and neural threat reactivity dysregulations during transiently decreased 5-ht signaling. |
2023-09-04 |
2023-09-07 |
Not clear |
| Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. |
together the present findings suggest for the first time that individual variations in tph2 genetics render individuals susceptible to the anxiogenic and neural effects of a transient decrease in 5-ht signaling. |
2023-09-04 |
2023-09-07 |
Not clear |
| Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Ki. Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference. Experimental & molecular medicine. 2023-08-03. PMID:37537215. |
to investigate whether the circadian nuclear receptor rev-erbα, a transcriptional repressor of the rate-limiting enzyme tryptophan hydroxylase 2 (tph2) gene in 5-ht biosynthesis, may affect social interaction behaviors, we generated a conditional knockout (cko) mouse by targeting rev-erbα in dorsal raphe (dr) 5-ht neurons (5-ht |
2023-08-03 |
2023-08-14 |
mouse |
| Emmeline R I Howarth, Isabelle D Szott, Claire L Witham, Craig S Wilding, Emily J Bethel. Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta). PloS one. vol 18. issue 8. 2023-08-02. PMID:37531334. |
for four loci the variants genotyped were length polymorphisms (slc6a4 5-hydroxytryptamine transporter length-polymorphic repeat (5-httlpr), slc6a4 stin polymorphism, tryptophan 5-hydroxylase 2 (tph2) and monoamine oxidase a (maoa)) whilst for the other five (5-hydroxytryptamine receptor 2a (htr2a), dopamine receptor d4 (drd4), oxytocin receptor (oxtr), arginine vasopressin receptor 1a (avpr1a), opioid receptor mu(μ) 1 (oprm1)) snps were analysed. |
2023-08-02 |
2023-08-14 |
monkey |
| Polyna D Komleva, Ghofran Alhalabi, Arseniy E Izyurov, Nikita V Khotskin, Alexander V Kuliko. Effects of the Combination of the Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371543. |
effects of the combination of the tryptophan hydroxylase 2 (tph2) is the key and rate-limited enzyme of serotonin (5-ht) synthesis in the brain. |
2023-06-28 |
2023-08-14 |
Not clear |
| Marie Spies, Matej Murgaš, Chrysoula Vraka, Cecile Philippe, Gregor Gryglewski, Lukas Nics, Theresa Balber, Pia Baldinger-Melich, Annette M Hartmann, Dan Rujescu, Marcus Hacker, Edda Winkler-Pjrek, Dietmar Winkler, Rupert Lanzenberge. Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. Translational psychiatry. vol 13. issue 1. 2023-06-15. PMID:37322010. |
variants within the monoamine oxidase a (mao-a, maoa) and tryptophan hydroxylase 2 (tph2) genes, the main enzymes in cerebral serotonin (5-ht) turnover, affect risk for depression. |
2023-06-15 |
2023-08-14 |
human |
| Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jianbing Xu, Meng Yang, Shaowei Mo, Liying Zhuang, Weifu Wan. Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. BMC urology. vol 23. issue 1. 2023-05-10. PMID:37161455. |
the serotonin (5-ht) synthesis rate-limiting enzyme (tph2) and receptor (htr1a) in the 5-ht regulatory system may play a key role in the pathogenesis of lpe. |
2023-05-10 |
2023-08-14 |
Not clear |
| Gabriela Souza Rodrigues Queiroz, Juliana Carron, Ligia Traldi Macedo, Carmen Silvia Passos Lima, Gustavo Jacob Lourenç. Influence of variants in serotonin modulating genes on the risk, aggressiveness, and prognosis of oropharynx cancer. Head & neck. 2023-05-09. PMID:37158249. |
single-nucleotide variations (snvs) in tph1 rs623580 (t>a), tph2 rs4570625 (g>t), and htr1d rs674386 (g>a) may affect 5-ht levels. |
2023-05-09 |
2023-08-14 |
Not clear |
| Ida M Vedel, Andreas Prestel, Zhenwei Zhang, Natalia T Skawinska, Holger Stark, Pernille Harris, Birthe B Kragelund, Günther H J Peter. Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand. Structure (London, England : 1993). 2023-04-29. PMID:37119821. |
tryptophan hydroxylase 2 (tph2) catalyzes the rate-limiting step in serotonin biosynthesis in the brain. |
2023-04-29 |
2023-08-14 |
human |
| Atae Akhrif, Marcel Romanos, Katharina Peters, Ann-Kathrin Furtmann, Julian Caspers, Klaus-Peter Lesch, Eva M Meisenzahl-Lechner, Susanne Neufan. Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD. PloS one. vol 18. issue 4. 2023-04-27. PMID:37104367. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in brain serotonin synthesis. |
2023-04-27 |
2023-08-14 |
Not clear |