| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
double immunofluorescence staining showed that tph2, mammalian achaete-scute homolog-1 and 5-ht were mainly expressed in neurons but rarely in microglia or astrocytes in the piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Na Luo, Ioanna Mosialou, Mattia Capulli, Brygida Bisikirska, Chyuan-Sheng Lin, Yung-Yu Huang, Peter Timothy Shyu, X Edward Guo, Aris Economides, J John Mann, Stavroula Kousten. A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice. The Journal of clinical investigation. 2022-10-04. PMID:36194488. |
sirt1 did so by increasing expression of monoamine oxidase a (mao-a), a sirt1 target that reduces brain serotonin levels by inducing its catabolism, and by suppressing tph2 expression and serotonin synthesis in the brainstem. |
2022-10-04 |
2023-08-14 |
mouse |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
western blot was used to detect the protein expressions of tryptophan hydroxylase 2(tph2), serotonin transporter(sert), and monoamine oxidase a(mao-a) in the hippocampus of rats. |
2022-09-27 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Giulia Braccagni, Simona Scheggi, Marco Bortolat. Elevated levels of serotonin 5-HT European archives of psychiatry and clinical neuroscience. 2022-09-12. PMID:36094569. |
tissues were processed for immunoblotting analyses on eight key serotonergic targets: tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of brain serotonin synthesis; serotonin transporter (sert), the primary carrier for serotonin uptake; monoamine oxidase a (maoa), the primary enzyme for serotonin catabolism; and five serotonin receptors previously shown to influence social behavior: 5-ht |
2022-09-12 |
2023-08-14 |
human |
| Kongfu Zhu, Chao Liu, Yuanzhu Gao, Jianping Lu, Daping Wang, Huawei Zhan. Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. Frontiers in pharmacology. vol 13. 2022-09-01. PMID:36046836. |
human tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the synthesis of serotonin. |
2022-09-01 |
2023-08-14 |
human |
| Yini Zhou, Tonglaga Li, Shangzi Zhou, Han Xu, Xiaoyu Yin, Hao Chen, Xuan Ni, Meirong Bai, Wuliji Ao, Jingfeng Yang, R G Ahmed, Xuefu Zhang, Shuyin Bao, Jianhua Yu, Kevin W H Kwok, Wu Don. Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway. Metabolic brain disease. 2022-07-30. PMID:35907131. |
pse also elevated the expression of serotonin (5-ht)-related genes 5-htr1ab and tph2 and dopamine-related gene dbh. |
2022-07-30 |
2023-08-14 |
zebrafish |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
exposure to short photoperiod decreased locomotor activity in the novel tank diving test, increased the level 5-hiaa, and reduced the level of mao gene mrna, but did not affect the level of 5-ht and expression of tph1a, tph1b, tph2, slc6a4a (transporter), htr1aa, and htr2aa (receptors) genes. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wan. TLR4 in Tph2 neurons modulates anxiety-related behaviors in a sex-dependent manner. Neuropharmacology. 2022-07-05. PMID:35787402. |
tph2 is a rate-limiting enzyme for 5-ht biosynthesis that is expressed at high levels in the drn, which includes the main 5-ht projection to the hippocampus and prefrontal cortex and regulates anxiety disorder. |
2022-07-05 |
2023-08-14 |
mouse |
| Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wan. TLR4 in Tph2 neurons modulates anxiety-related behaviors in a sex-dependent manner. Neuropharmacology. 2022-07-05. PMID:35787402. |
the underlying mechanisms seem to involve alterations in the excitability of tph2 neurons and key components of 5-ht transmission, including synthesis, reuptake, and transmission. |
2022-07-05 |
2023-08-14 |
mouse |
| Giulia Sbrini, Sabrina I Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R Homberg, Francesca Calabres. Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563331. |
while the tph2 isoform is responsible for the production of serotonin in the brain, tph1 is expressed in peripheral organs. |
2022-05-14 |
2023-08-13 |
rat |
| Pingping Zhu, Tiankun Lu, Zhenzhen Chen, Benyu Liu, Dongdong Fan, Chong Li, Jiayi Wu, Luyun He, Xiaoxiao Zhu, Ying Du, Yong Tian, Zusen Fa. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022-05-13. PMID:35550066. |
mechanistically, colorectal cancer (crc)-enriched microbiota metabolite isovalerate suppresses the enrichment of the nurd complex onto tph2 promoter to initiate tph2 expression, leading to 5-ht production. |
2022-05-13 |
2023-08-13 |
mouse |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
additionally, tph1's impact on serotonin synthesis production throughout the body will be discussed with regards to its involvement in neuropsychiatric disorders similar to tph2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 shows a greater affinity for tryptophan, an amino acid used in the production of serotonin, and has a stronger enzymatic activity than tph2 for a developing brain stem. |
2022-05-13 |
2023-08-13 |
Not clear |
| Huawei Li, Peng Wang, Yunping Zhou, Fei Zhao, Xue Gao, Chunfeng Wu, Tianxia Wu, Liping Jiang, Dianliang Zhan. Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. Genes, brain, and behavior. 2022-05-10. PMID:35535862. |
the concentrations of 5-ht and tph2 in the prefrontal and hippocampal tissues were lower, while ido1 was higher. |
2022-05-10 |
2023-08-13 |
rat |
| Diana Marie Battaglia, Maria D Sanchez-Pino, Charles D Nichols, Timothy P Foste. Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease. Frontiers in microbiology. vol 13. 2022-04-08. PMID:35391733. |
intriguingly, tryptophan hydroxylase 2 (tph2), the neuronal specific rate-limiting enzyme for serotonin synthesis, was the most significantly upregulated gene by hsv in an amino acid metabolism pcr array. |
2022-04-08 |
2023-08-13 |
Not clear |
| Tingting Tan, Zhi Xu, Chenjie Gao, Tian Shen, Lei Li, Zimu Chen, Lei Chen, Min Xu, Bingwei Chen, Jiacheng Liu, Zhijun Zhang, Yonggui Yua. Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response. BMC psychiatry. vol 22. issue 1. 2022-03-26. PMID:35337298. |
5-ht biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (tph2). |
2022-03-26 |
2023-08-13 |
Not clear |
| Rosanna Caputo, Vincent-Joseph Poirel, Etienne Challet, Johanna H Meijer, Sylvie Raiso. Bimodal serotonin synthesis in the diurnal rodent, Arvicanthis ansorgei. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-16. PMID:35294080. |
using in situ hybridization, we characterized the anatomical extension of the raphe nuclei and we investigated 24 h mrna levels of the serotonin rate-limiting enzyme, tryptophan hydroxylase 2 (tph2). |
2022-03-16 |
2023-08-13 |
Not clear |
| Rachel A Walker, Rebecca L Suthard, Taylor N Perison, Nora M Sheehan, Caitlin C Dwyer, Jillian K Lee, Eghosa K Enabulele, Madelyn H Ray, Michael A McDannal. Dorsal raphe 5-HT neurons utilize, but do not generate, negative aversive prediction errors. eNeuro. 2022-01-26. PMID:35078807. |
5-ht, synthesized via tryptophan hydroxylase 2 (tph2), is a widely functioning neuromodulator implicated in fear learning. |
2022-01-26 |
2023-08-13 |
rat |