| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rainald Mössner, Susanne Walitza, Frank Geller, André Scherag, Lise Gutknecht, Christian Jacob, Lisa Bogusch, Helmut Remschmidt, Michael Simons, Beate Herpertz-Dahlmann, Christian Fleischhaker, Eberhard Schulz, Andreas Warnke, Anke Hinney, Christoph Wewetzer, Klaus-Peter Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 9. issue 4. 2006-10-10. PMID:16146581. |
the aim of this study was to investigate the effect of polymorphic variants in the gene of the novel brain-specific tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain, in ocd with disease onset in childhood and adolescence. |
2006-10-10 |
2023-08-12 |
Not clear |
| Rainald Mössner, Susanne Walitza, Frank Geller, André Scherag, Lise Gutknecht, Christian Jacob, Lisa Bogusch, Helmut Remschmidt, Michael Simons, Beate Herpertz-Dahlmann, Christian Fleischhaker, Eberhard Schulz, Andreas Warnke, Anke Hinney, Christoph Wewetzer, Klaus-Peter Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 9. issue 4. 2006-10-10. PMID:16146581. |
in conclusion, the results link tph2 variations to the pathogenesis of early-onset ocd and further support the aetiological relevance of 5-ht signalling in ocd. |
2006-10-10 |
2023-08-12 |
Not clear |
| Rainald Mössner, Christine M Freitag, Lise Gutknecht, Andreas Reif, Ralf Tauber, Petra Franke, Jürgen Fritze, Gerd Wagner, Gregor Peikert, Berit Wenda, Philipp Sand, Marcella Rietschel, Henk Garritsen, Christian Jacob, K Peter Lesch, Jürgen Decker. The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. Journal of psychopharmacology (Oxford, England). vol 20. issue 4. 2006-08-18. PMID:16401665. |
the novel brain-specific 5-ht synthesizing enzyme, tryptophan hydroxylase-2 (tph2), which represents the rate-limiting enzyme of 5-ht production in the brain, may therefore be of particular importance in panic disorder. |
2006-08-18 |
2023-08-12 |
Not clear |
| Rainald Mössner, Christine M Freitag, Lise Gutknecht, Andreas Reif, Ralf Tauber, Petra Franke, Jürgen Fritze, Gerd Wagner, Gregor Peikert, Berit Wenda, Philipp Sand, Marcella Rietschel, Henk Garritsen, Christian Jacob, K Peter Lesch, Jürgen Decker. The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. Journal of psychopharmacology (Oxford, England). vol 20. issue 4. 2006-08-18. PMID:16401665. |
moreover, a recently described loss-of-function mutation of tph2 which results in an 80% reduction of serotonin production, was assessed. |
2006-08-18 |
2023-08-12 |
Not clear |
| T Canli, E Congdon, L Gutknecht, R T Constable, K P Lesc. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 11. 2006-07-27. PMID:16245070. |
the tryptophan hydroxylase-2 gene (tph2) codes for the enzyme of serotonin (5-ht) synthesis in the brain and variation of tph2 has been implicated in disorders of emotion regulation. |
2006-07-27 |
2023-08-12 |
Not clear |
| Nina K Popov. From genes to aggressive behavior: the role of serotonergic system. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 28. issue 5. 2006-06-23. PMID:16615082. |
specifically, it describes: (1) the effect of the knockout of mao a, the principal enzyme in 5-ht degradation, (2) the association of intermale aggression with the polymorphism in the tph2 gene encoding the key enzyme in 5-ht synthesis in the brain, tryptophan hydroxylase (tph), and (3) the effect of selective breeding for nonaggressive behavior on 5-ht metabolism, tph activity and 5-ht(1a) receptors in the brain. |
2006-06-23 |
2023-08-12 |
Not clear |
| V De Luca, D Hlousek, O Likhodi, H H M Van Tol, J L Kennedy, A H C Won. The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses. Genes, brain, and behavior. vol 5. issue 1. 2006-05-03. PMID:16436194. |
tryptophan hydroxylase isoform 2 (tph2) is a rate-limiting enzyme in the biosynthesis of serotonin (5-ht) and is predominantly localized in the brain. |
2006-05-03 |
2023-08-12 |
human |
| Stacey A Sakowski, Timothy J Geddes, Donald M Kuh. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16405505. |
in view of the importance of tph in determining brain 5-ht function, we cloned tph2 and produced the p447r mutant to assess the importance of this proline in enzyme function. |
2006-03-30 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| S Walitza, T J Renner, A Dempfle, K Konrad, Ch Wewetzer, A Halbach, B Herpertz-Dahlmann, H Remschmidt, J Smidt, M Linder, L Flierl, U Knölker, S Friedel, H Schäfer, C Gross, J Hebebrand, A Warnke, K P Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16116490. |
here, we investigated the effect of polymorphic variants in the gene of the tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain, in children and adolescents with adhd. |
2006-03-01 |
2023-08-12 |
Not clear |
| S Walitza, T J Renner, A Dempfle, K Konrad, Ch Wewetzer, A Halbach, B Herpertz-Dahlmann, H Remschmidt, J Smidt, M Linder, L Flierl, U Knölker, S Friedel, H Schäfer, C Gross, J Hebebrand, A Warnke, K P Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16116490. |
our results link potentially functional tph2 variations to the pathophysiology of adhd, and further support the relevance of 5-ht in disorders related to altered motor activity and cognitive processes. |
2006-03-01 |
2023-08-12 |
Not clear |
| X Zhang, J-M Beaulieu, R R Gainetdinov, M G Caro. Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. Cellular and molecular life sciences : CMLS. vol 63. issue 1. 2006-02-21. PMID:16378243. |
tryptophan hydroxylase-2 (tph2) is the neuronal-specific enzyme that controls brain serotonin synthesis. |
2006-02-21 |
2023-08-12 |
Not clear |
| A V Kulikov, D V Osipova, V S Naumenko, N K Popov. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Genes, brain, and behavior. vol 4. issue 8. 2006-01-23. PMID:16268992. |
the main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (tph) 2 encoded by the tph2 gene. |
2006-01-23 |
2023-08-12 |
mouse |
| S M Brown, E Peet, S B Manuck, D E Williamson, R E Dahl, R E Ferrell, A R Harir. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular psychiatry. vol 10. issue 9. 2005-11-08. PMID:16044172. |
recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (tph2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. |
2005-11-08 |
2023-08-12 |
human |
| Zhifeng Zhou, Alec Roy, Robert Lipsky, Kavi Kuchipudi, Guanshan Zhu, Julie Taubman, Mary-Anne Enoch, Matti Virkkunen, David Goldma. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Archives of general psychiatry. vol 62. issue 10. 2005-10-24. PMID:16203956. |
tryptophan hydroxylase 2 (tph2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. |
2005-10-24 |
2023-08-12 |
Not clear |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
these data show that the circadian 5-ht synthesis within the serotonergic neurons projecting to the circadian system might be explained by the rhythmic transcription of the tph2 gene in raphe nuclei. |
2005-10-18 |
2023-08-12 |
rat |
| Jeffrey McKinney, Per M Knappskog, Jan Haavi. Different properties of the central and peripheral forms of human tryptophan hydroxylase. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663479. |
the differences between tph1 and tph2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for tph from different sources in the past. |
2005-05-26 |
2023-08-12 |
human |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
we report a functional (c1473g) single-nucleotide polymorphism in mouse tph2 that results in the substitution of pro447 with arg447 and leads to decreased serotonin levels in pc12 cells. |
2004-08-02 |
2023-08-12 |
mouse |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
our data provide direct evidence for a fundamental role of tph2 in brain serotonin synthesis. |
2004-08-02 |
2023-08-12 |
mouse |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
the rate limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes: the well characterized tph1 gene and a recently identified tph2 gene. |
2004-07-19 |
2023-08-12 |
mouse |