| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Reuter, C Esslinger, C Montag, S Lis, B Gallhofer, P Kirsc. A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: a genetic imaging study. Biological psychology. vol 79. issue 1. 2008-10-23. PMID:18234415. |
recently some molecular genetic studies reported associations between a functional promoter polymorphism of the tryptophan hydroxylase 2 gene (tph2), that regulates the synthesis of serotonin, and attention. |
2008-10-23 |
2023-08-12 |
human |
| Turhan Canli, Eliza Congdon, R Todd Constable, Klaus Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological psychology. vol 79. issue 1. 2008-10-23. PMID:18314252. |
individual differences in brain response to emotional stimuli have previously been associated with gene variations within the serotonin transporter (5-htt) and tryptophan hydroxylase-2 (tph2) genes. |
2008-10-23 |
2023-08-12 |
Not clear |
| F Haghighi, H Bach-Mizrachi, Y Y Huang, V Arango, S Shi, A J Dwork, G Rosoklija, H T Sheng, I Morozova, J Ju, J J Russo, J J Man. Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Molecular psychiatry. vol 13. issue 8. 2008-10-08. PMID:18180764. |
tryptophan hydroxylase-2 (tph2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. |
2008-10-08 |
2023-08-12 |
human |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
two isoforms of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, tph1 and tph2, are known. |
2008-08-11 |
2023-08-12 |
rat |
| Francesco Nonnis Marzano, Milena Maldini, Laura Filonzi, Anna Maria Lavezzi, Stefano Parmigiani, Cinzia Magnani, Giulio Bevilacqua, Luigi Matturr. Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. Genomics. vol 91. issue 6. 2008-07-07. PMID:18387780. |
molecular polymorphisms are discussed considering their functional role in regulating serotonin synthesis (tph2), neuronal reuptake (5-httlpr and 5-htt intron 2), and catabolism (maoa) in the nervous system of italian sids infants. |
2008-07-07 |
2023-08-12 |
Not clear |
| J A Clark, R B Flick, L-Y Pai, I Szalayova, S Key, R K Conley, A Y Deutch, P H Hutson, E Meze. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:17622221. |
moreover, the glucocorticoid-elicited inhibition of tph2 was functionally significant: serotonin synthesis was significantly reduced in the frontal cortex of glucocorticoid-treated mice, an effect that was blocked by mifepristone co-administration. |
2008-07-03 |
2023-08-12 |
mouse |
| J A Clark, R B Flick, L-Y Pai, I Szalayova, S Key, R K Conley, A Y Deutch, P H Hutson, E Meze. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:17622221. |
this study provides further evidence for the glucocorticoid regulation of serotonin biosynthesis via inhibition of tph2 expression, and suggest that elevated glucocorticoid levels may be relevant to the etiology of psychiatric diseases, such as depression, where hypothalamic-pituitary-adrenal axis dysregulation has been documented. |
2008-07-03 |
2023-08-12 |
mouse |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
paradoxically, in the dorsal raphe nucleus (drn) there are more serotonin neurons and more neuronal tryptophan hydroxylase-2 (tph2) expression postmortem in depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
higher tph2 expression in depressed suicides may explain more tph2 protein and reflect a homeostatic response to deficient serotonin levels in the brains of depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |
| Alexander Strobel, Gesine Dreisbach, Johannes Müller, Thomas Goschke, Burkhard Brocke, Klaus-Peter Lesc. Genetic variation of serotonin function and cognitive control. Journal of cognitive neuroscience. vol 19. issue 12. 2008-06-20. PMID:17892388. |
eighty-five healthy participants performed a cued continuous performance task (the ax continuous performance task [axcpt]) and were genotyped for polymorphisms in the transcriptional control regions of the tryptophan hydroxylase 2 gene (tph2 g-703t; rs4570625) and the serotonin transporter gene (5-httlpr). |
2008-06-20 |
2023-08-12 |
human |
| Karen L Murphy, Xiaodong Zhang, Raul R Gainetdinov, Jean-Martin Beaulieu, Marc G Caro. A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18339632. |
because this domain is unique to tph2, these data provide evidence for selective regulation of brain serotonin synthesis. |
2008-06-17 |
2023-08-12 |
Not clear |
| Basudha Basu, Radha Desai, J Balaji, Raghothama Chaerkady, V Sriram, Sudipta Maiti, Mitradas M Panicke. Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction (Cambridge, England). vol 135. issue 5. 2008-06-11. PMID:18304982. |
pre-implantation mouse embryos were also examined at various developmental stages for the presence of transcripts of the peripheral and neuronal forms of tryptophan hydroxylase (tph1 and tph2 respectively) and the classical serotonin transporter (slc6a4). |
2008-06-11 |
2023-08-12 |
mouse |
| J John Mann, Dianne Currier, Lauren Murphy, Yung-yu Huang, Hanga Galfalvy, David Brent, Laurence Greenhill, Maria Oquend. No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover. Journal of affective disorders. vol 106. issue 1-2. 2008-05-14. PMID:17604842. |
tph2 is a recently discovered isoform that is expressed predominantly in serotonin neurons. |
2008-05-14 |
2023-08-12 |
Not clear |
| Alicia K Smith, Irina Dimulescu, Virginia R Falkenberg, Supraja Narasimhan, Christine Heim, Suzanne D Vernon, Mangalathu S Rajeeva. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. vol 33. issue 2. 2008-05-06. PMID:18079067. |
a total of 77 polymorphisms in genes related to serotonin synthesis (tph2), signaling (htr1a, htr1e, htr2a, htr2b, htr2c, htr3a, htr3b, htr4, htr5a, htr6, and htr7), transport (slc6a4), and catabolism (maoa) were examined in 137 clinically evaluated subjects (40 cfs, 55 with insufficient fatigue, and 42 non-fatigued, nf, controls) derived from a population-based cfs surveillance study in wichita, kansas. |
2008-05-06 |
2023-08-12 |
human |
| Katja Tenner, Fatimunnisa Qadri, Bettina Bert, Jörg-Peter Voigt, Michael Bade. The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neuroscience letters. vol 431. issue 1. 2008-05-01. PMID:18082956. |
tryptophan hydroxylase 2 (tph2) is the rate limiting enzyme of serotonin synthesis in the brain. |
2008-05-01 |
2023-08-12 |
mouse |
| Katja Tenner, Fatimunnisa Qadri, Bettina Bert, Jörg-Peter Voigt, Michael Bade. The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neuroscience letters. vol 431. issue 1. 2008-05-01. PMID:18082956. |
a recently described functional (c1473g) single nucleotide polymorphism in mouse tph2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-ht levels and behaviour between mice strains. |
2008-05-01 |
2023-08-12 |
mouse |
| Guo-Lin Chen, Eric J Vallender, Gregory M Mille. Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Human genetics. vol 122. issue 6. 2008-04-30. PMID:17972101. |
tryptophan hydroxylase-2 (tph2) is a recently identified tph isoform responsible for neuronal serotonin (5-ht) synthesis, and tph2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. |
2008-04-30 |
2023-08-12 |
human |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme in 5-ht synthesis in the brain, is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-ht reuptake inhibitors such as fluoxetine. |
2008-04-03 |
2023-08-12 |
rat |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
a significant induction of tph2 and 5-ht transporter (5-htt) mrnas was detected in the midbrain of untreated rats 24 h after the swim test. |
2008-04-03 |
2023-08-12 |
rat |
| Ingeborg Winge, Jeffrey A McKinney, Ming Ying, Clive S D'Santos, Rune Kleppe, Per M Knappskog, Jan Haavi. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. The Biochemical journal. vol 410. issue 1. 2008-04-01. PMID:17973628. |
tph (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: tph1, mainly found in peripheral tissues and the pineal body, and tph2, a neuronal form. |
2008-04-01 |
2023-08-12 |
human |