| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J-E Lim, J Pinsonneault, W Sadee, D Saffe. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Molecular psychiatry. vol 12. issue 5. 2007-06-26. PMID:17453063. |
tryptophan hydroxylase isoform 2 (tph2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. |
2007-06-26 |
2023-08-12 |
human |
| Antonio Di Lieto, Damiana Leo, Floriana Volpicelli, Umberto di Porzio, Luca Colucci-D'Amat. FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc. Brain research. vol 1143. 2007-06-13. PMID:17321503. |
here we show that a mesencephalic neural cell line, mes-c-myc a1 (a1) produces 5-ht and expresses sert and both peripheral (tph1) and cns-specific (tph2) form of tryptophan hydroxylase, the limiting enzyme in 5-ht biosynthesis. |
2007-06-13 |
2023-08-12 |
Not clear |
| Martin J Herrmann, Theresa Huter, Frauke Müller, Andreas Mühlberger, Paul Pauli, Andreas Reif, Tobias Renner, Turhan Canli, Andreas J Fallgatter, Klaus-Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16801378. |
prior studies reported that functional variants of both the serotonin transporter (5-htt) and tryptophan hydroxylase-2 genes (tph2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. |
2007-05-31 |
2023-08-12 |
Not clear |
| Ingeborg Winge, Jeffrey A McKinney, Per M Knappskog, Jan Haavi. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17181551. |
variants of tph2 have recently reported to be associated with reduced serotonin production and behavioural alterations in man and mice. |
2007-05-01 |
2023-08-12 |
mouse |
| Roberto Sacco, Veruska Papaleo, Jorg Hager, Francis Rousseau, Rainald Moessner, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Cindy Schneider, Raun Melmed, Maurizio Elia, Paolo Curatolo, Barbara Manzi, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Antonio M Persic. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC medical genetics. vol 8. 2007-04-12. PMID:17346350. |
the tph2 gene encodes the enzyme responsible for serotonin (5-ht) synthesis in the central nervous system (cns). |
2007-04-12 |
2023-08-12 |
Not clear |
| Roberto Sacco, Veruska Papaleo, Jorg Hager, Francis Rousseau, Rainald Moessner, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Cindy Schneider, Raun Melmed, Maurizio Elia, Paolo Curatolo, Barbara Manzi, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Antonio M Persic. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC medical genetics. vol 8. 2007-04-12. PMID:17346350. |
stereotypic and repetitive behaviors are influenced by 5-ht, and initial studies report an association of tph2 alleles with childhood-onset obsessive-compulsive disorder (ocd) and with autism. |
2007-04-12 |
2023-08-12 |
Not clear |
| Kyung-Won Hong, Yuko Sugawara, Hiroyuki Hasegawa, Ikuo Hayasaka, Ryota Hashimoto, Shin'ichi Ito, Miho Inoue-Murayam. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Neuroscience letters. vol 412. issue 3. 2007-04-05. PMID:17123720. |
tryptophan hydroxylase 2 (tph2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. |
2007-04-05 |
2023-08-12 |
mouse |
| Karen Sheehan, Ziarih Hawi, Michael Gill, Lindsey Ken. No association between TPH2 gene polymorphisms and ADHD in a UK sample. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123708. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. |
2007-04-03 |
2023-08-12 |
Not clear |
| Eduard Maron, Innar Tõru, Anne Must, Gunnar Tasa, Egle Toover, Veiko Vasar, Aavo Lang, Jakov Shli. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neuroscience letters. vol 411. issue 3. 2007-03-30. PMID:17123728. |
recently, it has been discovered that the tryptophan hydroxylase gene isoform 2 (tph2), rather than tph1, is preferentially expressed in the neuronal tissue and, therefore, is primarily responsible for the regulation of brain 5-ht synthesis. |
2007-03-30 |
2023-08-12 |
human |
| Victor A Lopez, Sevilla Detera-Wadleigh, Imer Cardona, Layla Kassem, Francis J McMaho. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biological psychiatry. vol 61. issue 2. 2007-03-15. PMID:16806105. |
serotonin signaling has long been implicated in both bpad and suicide, and the gene encoding the brain-expressed isoform of tryptophan hydroxlyase (tph2) has been described. |
2007-03-15 |
2023-08-12 |
human |
| Michael D Gershon, Jan Tac. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241888. |
serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, tph1 and tph2, which are found, respectively, in ec cells and neurons. |
2007-03-14 |
2023-08-12 |
Not clear |
| N N Dygalo, G T Shishkina, T S Kalinina, A M Yudina, E S Ovchinnikov. Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16982082. |
two-week fluoxetine treatment also significantly reduced expression of tryptophan hydroxylase-2 (tph2) and 5-ht transporter mrnas as determined by rt-pcr in the brainstem. |
2007-02-23 |
2023-08-12 |
human |
| Ilan A Kerman, Cyrus Shabrang, Larry Taylor, Huda Akil, Stanley J Watso. Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem. The Journal of comparative neurology. vol 499. issue 6. 2007-02-23. PMID:17072838. |
to test this hypothesis we first produced an antibody against tph2, a brain-specific isoform of tryptophan hydroxylase (serotonin synthetic enzyme). |
2007-02-23 |
2023-08-12 |
rat |
| Nicolas Ramoz, Guiqing Cai, Jennifer G Reichert, Thomas E Corwin, Lauren A Kryzak, Christopher J Smith, Jeremy M Silverman, Eric Hollander, Joseph D Buxbau. Family-based association study of TPH1 and TPH2 polymorphisms in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 8. 2007-02-13. PMID:16958027. |
the tph1 and tph2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. |
2007-02-13 |
2023-08-12 |
Not clear |
| Li Ke, Zhang Yu Qi, Yu Ping, Cheng Yi Re. Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17011525. |
the novel tryptophan hydroxylase isoform (tph2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. |
2007-01-30 |
2023-08-12 |
Not clear |
| Zhong-Qiu Zhao, Michael Scott, Santina Chiechio, Jin-Shan Wang, Kenneth J Renner, Robert W Gereau, Randy L Johnson, Evan S Deneris, Zhou-Feng Che. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 49. 2006-12-29. PMID:17151281. |
the loss of gene expression is concomitant with downregulation of lmx1b expression, with the exception of serotonin transporter sert and tryptophan hydroxylase tph2, whose expression appears to be most sensitive to lmx1b. |
2006-12-29 |
2023-08-12 |
mouse |
| John P Dahl, Joseph F Cubells, Riju Ray, Andrew E Weller, Falk W Lohoff, Thomas N Ferraro, David W Oslin, Kyle M Kampman, Charles Dackis, Yilang Tang, Joel Gelernter, Henry R Kranzler, Charles P O'Brien, Wade H Berrettin. Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. Addiction biology. vol 11. issue 1. 2006-11-09. PMID:16759340. |
the focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (tph2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. |
2006-11-09 |
2023-08-12 |
human |
| Rafael Ortíz-Alvarado, Omar Guzmán-Quevedo, Rosalio Mercado-Camargo, Thomas Haertle, Caroline Vignes, Francisco Bolaños-Jiméne. Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS letters. vol 580. issue 22. 2006-11-09. PMID:16989820. |
here, we show by quantitative real time rt-pcr that both isoforms of tryptophan hydroxylase (tph1 and tph2), the first and rate limiting enzyme of serotonin (5-ht) synthesis, are expressed in developing circumvallate papillae. |
2006-11-09 |
2023-08-12 |
mouse |
| G-L Chen, M A Novak, S Hakim, Z Xie, G M Mille. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Molecular psychiatry. vol 11. issue 10. 2006-11-08. PMID:16847459. |
tryptophan hydroxylase-2 (tph2) is a newly identified second form of tph responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. |
2006-11-08 |
2023-08-12 |
monkey |
| Michael S Clark, Ross A McDevitt, John F Neumaie. Quantitative mapping of tryptophan hydroxylase-2, 5-HT1A, 5-HT1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei. The Journal of comparative neurology. vol 498. issue 5. 2006-10-18. PMID:16917826. |
to foster uniform definitions of locations within these nuclei, we have quantitatively mapped gene expression in drn and mrn for tryptophan hydroxylase-2 (tph2), the serotonin transporter, as well as 5-ht1a and 5-ht1b receptors. |
2006-10-18 |
2023-08-12 |
rat |