| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Blanc, V A Manneh, R Ernst, D E Berger, S A de Keczer, C Chase, J M Centofanti, A J DeLizz. Adsorption losses from urine-based cannabinoid calibrators during routine use. Clinical chemistry. vol 39. issue 8. 1993-09-23. PMID:8394791. |
the major metabolite of cannabis found in urine, 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (delta 9-thc), is the compound most often used to calibrate cannabinoid immunoassays. |
1993-09-23 |
2023-08-12 |
Not clear |
| S Y Nah, D Saya, Z Voge. Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8102606. |
addition of cannabinoids, such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%. |
1993-09-17 |
2023-08-12 |
rat |
| M Bouaboula, M Rinaldi, P Carayon, C Carillon, B Delpech, D Shire, G Le Fur, P Casella. Cannabinoid-receptor expression in human leukocytes. European journal of biochemistry. vol 214. issue 1. 1993-07-15. PMID:8508790. |
marijuana and many of its constituent cannabinoids influence the central nervous system (cns), probably through the cannabinoid receptor, which has recently been cloned in rat and human. |
1993-07-15 |
2023-08-12 |
human |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338215. |
these findings have implications for understanding the mechanisms underlying the performance-impairing effects of marijuana, as well as for aiding forensic interpretation of cannabinoid blood levels. |
1993-04-15 |
2023-08-11 |
human |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338216. |
models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (thc) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (thccooh) two mathematical models are described for the prediction of time of marijuana use from the analysis of a single plasma sample for cannabinoids. |
1993-04-15 |
2023-08-11 |
Not clear |
| M A Huestis, J E Henningfield, E J Con. Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) Journal of analytical toxicology. vol 16. issue 5. 1993-04-15. PMID:1338216. |
the models were derived from cannabinoid data obtained from a controlled clinical study of acute marijuana smoking. |
1993-04-15 |
2023-08-11 |
Not clear |
| L A Matsuda, T I Bonner, S J Lolai. Localization of cannabinoid receptor mRNA in rat brain. The Journal of comparative neurology. vol 327. issue 4. 1993-03-30. PMID:8440779. |
the localization of cannabinoid receptor mrna indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous "cannabinoid" ligand. |
1993-03-30 |
2023-08-12 |
rat |
| C J Heyser, R E Hampson, S A Deadwyle. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8380864. |
neither control injection of the vehicle nor equivalent concentrations of the nonpsychoactive cannabinoid, cannabidiol, produced alterations in dmts performance levels. |
1993-02-23 |
2023-08-12 |
rat |
| D B Houston, A C Howlet. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular pharmacology. vol 43. issue 1. 1993-02-23. PMID:8423766. |
the order of potency for cannabinoid agonists in heterologous equilibrium binding studies was cp-55244 > or = desacetyllevonantradol > delta 9-tetrahydrocannabinol > cannabinol >> cannabidiol, consistent with the relative affinities for these agonists in brain membrane preparations. |
1993-02-23 |
2023-08-12 |
rat |
| G Lercker, F Bocci, N Frega, R Bortolomeazz. Cannabinoid acids analysis. Farmaco (Societa chimica italiana : 1989). vol 47. issue 3. 1992-09-21. PMID:1503600. |
the cannabinoid pattern of vegetable preparations from cannabis sativa (hashish, marijuana) allows to recognize the phenotype of the plants, to be used as drug or for fiber. |
1992-09-21 |
2023-08-11 |
Not clear |
| D W Self, L Stei. Receptor subtypes in opioid and stimulant reward. Pharmacology & toxicology. vol 70. issue 2. 1992-09-18. PMID:1324497. |
the reward-relevant opioid and dopamine receptors, as well as the cannabinoid (marijuana) receptor, share the ability to couple gi proteins that mediate inhibition of adenylate cyclase and stimulation of k+ conductance. |
1992-09-18 |
2023-08-11 |
Not clear |
| J W Hayde. Passive inhalation of marijuana smoke: a critical review. Journal of substance abuse. vol 3. issue 1. 1992-08-18. PMID:1668226. |
a number of research studies have been published which have attempted to determine the relationship of the passive inhalation of marijuana smoke to the consequent production of urinary cannabinoids. |
1992-08-18 |
2023-08-11 |
Not clear |
| L D Chait, J P Zacn. Reinforcing and subjective effects of oral delta 9-THC and smoked marijuana in humans. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1319601. |
the experimental paradigm used here should prove useful for identifying factors that influence the self-administration of marijuana and other cannabinoids by humans. |
1992-07-30 |
2023-08-11 |
human |
| M E Abood, B R Marti. Neurobiology of marijuana abuse. Trends in pharmacological sciences. vol 13. issue 5. 1992-07-14. PMID:1604713. |
while marked tolerance develops to marijuana, it has been difficult to demonstrate physical dependence, and until recently the mechanisms by which cannabinoids produced their behavioral effects were poorly defined. |
1992-07-14 |
2023-08-11 |
Not clear |
| B Watzl, P Scuderi, R R Watso. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. International journal of immunopharmacology. vol 13. issue 8. 1992-06-22. PMID:1667651. |
concentrations of thc and cbd, comparable to plasma levels found after smoking marijuana (10-100 ng/ml), increased the concentration of measurable ifn (139 and 68%), while high concentrations of both cannabinoids (5-20 micrograms/ml) completely blocked synthesis and/or release of this cytokine. |
1992-06-22 |
2023-08-11 |
human |
| A Charalambous, G Marciniak, C Y Shiue, S L Dewey, D J Schlyer, A P Wolf, A Makriyanni. PET studies in the primate brain and biodistribution in mice using (-)-5'-18F-delta 8-THC. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666914. |
cannabinoids, the active constituents of marijuana, are known to have many therapeutic properties; however, their exact mechanism of action is not well understood. |
1992-05-14 |
2023-08-11 |
mouse |
| P Consroe, K Kennedy, K Schra. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666917. |
additionally, no plasma delta-1-thc, the major psychoactive cannabinoid of marijuana, was detected in any subject. |
1992-05-14 |
2023-08-11 |
human |
| Pharmacological, chemical, biochemical and behavioral research on cannabis and the cannabinoids. International conference, Kolympari, Crete, July 8-11, 1990. Issue dedicated to Professor Raphael Mechoulam. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1687228. |
pharmacological, chemical, biochemical and behavioral research on cannabis and the cannabinoids. |
1992-05-14 |
2023-08-11 |
Not clear |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
marijuana and other cannabinoids were long considered "anomalous" drugs of abuse, lacking pharmacological interaction with these brain reward substrates. |
1992-05-14 |
2023-08-11 |
Not clear |
| S K Tahir, A M Zimmerma. Influence of marihuana on cellular structures and biochemical activities. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806949. |
in this paper we review the current evidence describing cannabinoid effects on various levels of cellular structure and activity and we present our current studies on the influence of delta-9-tetrahydrocannabinol, cannabidiol and cannabinol on one cellular system, the cytoskeleton. |
1992-05-14 |
2023-08-11 |
Not clear |