| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Nahas, C Latou. The human toxicity of marijuana. The Medical journal of Australia. vol 156. issue 7. 1992-05-04. PMID:1313532. |
marijuana smoke is mutagenic in the ames test and in tissue culture and cannabinoids inhibit biosynthesis of macromolecules. |
1992-05-04 |
2023-08-11 |
human |
| R L Balster, W R Prescot. Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neuroscience and biobehavioral reviews. vol 16. issue 1. 1992-04-24. PMID:1313164. |
correlations between these values and potencies for cellular actions of cannabinoids can be used to establish the neural substrates of cannabis intoxication. |
1992-04-24 |
2023-08-11 |
rat |
| D R Compton, M R Johnson, L S Melvin, B R Marti. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1309872. |
opening of the pyran ring of delta 9-tetrahydrocannabinol (thc) produces cannabidiol, a bicyclic cannabinoid devoid of many pharmacological properties produced by delta 8-thc or delta 9-thc. |
1992-02-18 |
2023-08-11 |
mouse |
| L M Shaw, J Edling-Owens, R Matte. Ultrasensitive measurement of delta-9-tetrahydrocannabinol with a high energy dynode detector and electron-capture negative chemical-ionization mass spectrometry. Clinical chemistry. vol 37. issue 12. 1992-02-18. PMID:1662560. |
plasma concentrations of delta-9-tetrahydrocannabinol, the principal psychoactive cannabinoid in marijuana, decline to values substantially less than 1 microgram/l within a few hours after a subject has smoked a marijuana cigarette. |
1992-02-18 |
2023-08-11 |
human |
| F J Evan. Cannabinoids: the separation of central from peripheral effects on a structural basis. Planta medica. vol 57. issue 7. 1992-01-02. PMID:1659702. |
a brief history of the therapeutic uses and legal problems of cannabis as well as the component cannabinoids is given. |
1992-01-02 |
2023-08-11 |
Not clear |
| H Gjerd. Screening for cannabinoids in blood using EMIT: concentrations of delta-9-tetrahydrocannabinol in relation to EMIT results. Forensic science international. vol 50. issue 1. 1991-12-23. PMID:1657743. |
cannabinoid assay of methanolic extracts of blood was found to be usable as a screening method in cases of suspected impairment by cannabis, when delta-9-tetrahydrocannabinol (thc) was analysed in the subsequent assay. |
1991-12-23 |
2023-08-11 |
Not clear |
| M R Hoehe, L Caenazzo, M M Martinez, W T Hsieh, W S Modi, E S Gershon, T I Bonne. Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15. The New biologist. vol 3. issue 9. 1991-12-23. PMID:1931832. |
a cdna encoding a g protein-coupled receptor that appears to mediate the behavioral effects of cannabinoids, the psychoactive ingredients of marijuana, has recently been cloned from rat cerebral cortex and expressed. |
1991-12-23 |
2023-08-11 |
human |
| P Lafolie, O Beck, G Blennow, L Boréus, S Borg, C E Elwin, L Karlsson, G Odelius, P Hjemdah. Importance of creatinine analyses of urine when screening for abused drugs. Clinical chemistry. vol 37. issue 11. 1991-12-23. PMID:1934467. |
in a formerly heavy smoker of cannabis, the excretion of cannabinoids and creatinine was monitored for 93 days. |
1991-12-23 |
2023-08-11 |
Not clear |
| P Lafolie, O Beck, G Blennow, L Boréus, S Borg, C E Elwin, L Karlsson, G Odelius, P Hjemdah. Importance of creatinine analyses of urine when screening for abused drugs. Clinical chemistry. vol 37. issue 11. 1991-12-23. PMID:1934467. |
the substances showed very good correlation throughout this period (r = 0.93, p less than 0.001), whereas simple measurements of cannabinoid concentrations would have falsely indicated several relapses of cannabis abuse. |
1991-12-23 |
2023-08-11 |
Not clear |
| J C Eldridge, L L Murphy, P W Landfiel. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. vol 56. issue 5. 1991-09-24. PMID:1652167. |
it has long been recognized that cannabinoids, including delta 9-tetrahydrocannabinol (thc), the major psychoactive substance of marijuana, bear structural similarities to steroid hormones. |
1991-09-24 |
2023-08-11 |
rat |
| J C Eldridge, L L Murphy, P W Landfiel. Cannabinoids and the hippocampal glucocorticoid receptor: recent findings and possible significance. Steroids. vol 56. issue 5. 1991-09-24. PMID:1652167. |
cannabidiol, a nonpsychoactive cannabinoid, displayed less competition than thc in all parameters. |
1991-09-24 |
2023-08-11 |
rat |
| L M Bornheim, M A Correi. Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily. Molecular pharmacology. vol 40. issue 2. 1991-09-24. PMID:1875910. |
acute cannabidiol treatment of mice inactivated hepatic microsomal cytochrome p-450iiia (p-450iiia) and markedly inhibited in vitro cannabinoid metabolism. |
1991-09-24 |
2023-08-11 |
mouse |
| L M Bornheim, M A Correi. Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily. Molecular pharmacology. vol 40. issue 2. 1991-09-24. PMID:1875910. |
thus, cannabidiol treatment of mice resulted in the inactivation of at least two constitutive p-450 isozymes, which together account for the majority of the detected cannabinoid metabolites. |
1991-09-24 |
2023-08-11 |
mouse |
| T M Westlake, A C Howlett, S F Ali, M G Paule, A C Scallet, W Slikke. Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain research. vol 544. issue 1. 1991-08-29. PMID:1649662. |
similarly, the cannabinoid receptors in the caudate, prefrontal cortex, and cerebellum of the monkey do not appear to be irreversibly altered by chronic exposure to marijuana smoke. |
1991-08-29 |
2023-08-11 |
rat |
| H Schuel, D Berkery, R Schuel, M C Chang, A M Zimmerman, S Zimmerma. Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. I. Inhibition of the acrosome reaction induced by egg jelly. Molecular reproduction and development. vol 29. issue 1. 1991-07-31. PMID:1647172. |
delta 9-tetrahydrocannabinol (thc) and two other major cannabinoids derived from marihuana--cannabidiol (cbd) and cannabinol (cbn)--inhibit fertilization in the sea urchin strongylocentrotus purpuratus by reducing the fertilizing capacity of sperm (schuel et al., 1987). |
1991-07-31 |
2023-08-11 |
Not clear |
| D B Menkes, R C Howard, G F Spears, E R Cairn. Salivary THC following cannabis smoking correlates with subjective intoxication and heart rate. Psychopharmacology. vol 103. issue 2. 1991-06-12. PMID:1851311. |
salivary thc levels are a sensitive index of recent cannabis smoking, and appear more closely linked with the effects of intoxication than do either blood or urine cannabinoid levels. |
1991-06-12 |
2023-08-11 |
human |
| D J Harvey, E Samara, R Mechoula. Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography-mass spectrometry. Journal of chromatography. vol 562. issue 1-2. 1991-06-10. PMID:2026700. |
urinary metabolites of cannabidiol (cbd), a non-psychoactive cannabinoid of potential therapeutic interest, were extracted from dog, rat and human urine, concentrated by chromatography on sephadex lh-20 and examined by gas chromatography-mass spectrometry as trimethylsilyl (tms), [2h9]tms, methyl ester-tms and methyloxime-tms derivatives. |
1991-06-10 |
2023-08-11 |
human |
| J C Eldridge, P W Landfiel. Cannabinoid interactions with glucocorticoid receptors in rat hippocampus. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1963558. |
binding of [3h]dexamethasone (dex) to hippocampal cytosol, in vitro, was inhibited partially, but not completely, by 100-fold excess unlabeled thc and cannabidiol (cbd), a non-psychoactive cannabinoid. |
1991-04-18 |
2023-08-11 |
rat |
| M A ElSohly, A B Jones, H N ElSohl. Cross-reactivity of selected compounds in the Abbott TDx cannabinoid assay. Journal of analytical toxicology. vol 14. issue 5. 1991-02-01. PMID:2175818. |
this cross-reactivity was evaluated against a group of cannabinoids and noncannabinoid phenolic constituents of cannabis, some cannabinoid metabolites, and other agents that appear in normal urine samples. |
1991-02-01 |
2023-08-11 |
Not clear |
| S Zimmerman, A M Zimmerma. Genetic effects of marijuana. The International journal of the addictions. vol 25. issue 1A. 1991-01-09. PMID:2174024. |
marijuana and its constitutive cannabinoids--tetrahydrocannabinol (thc), cannabinol (cbn), and cannabidiol (cbd)--markedly affect mammalian cells. |
1991-01-09 |
2023-08-11 |
Not clear |