| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Matsuda, S J Lolait, M J Brownstein, A C Young, T I Bonne. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. vol 346. issue 6284. 1990-09-06. PMID:2165569. |
marijuana and many of its constituent cannabinoids influence the central nervous system (cns) in a complex and dose-dependent manner. |
1990-09-06 |
2023-08-11 |
Not clear |
| R H Schwartz, S Bogema, M M Thorn. Evaluation of the EZ-SCREEN enzyme immunoassay test for detection of cocaine and marijuana metabolites in urine specimens. Pediatric emergency care. vol 6. issue 2. 1990-08-23. PMID:2196539. |
we compared the results of the ez-screen test with results of specimens analyzed by gas chromatography/mass spectrometry (gc/ms) for 36 clinical specimens positive for cannabinoids (marijuana), 38 clinical specimens positive for benzoylecgonine (cocaine), and 33 drug-free specimens. |
1990-08-23 |
2023-08-11 |
Not clear |
| C J Hillard, J J Pounds, D R Boyer, A S Bloo. Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart. The Journal of pharmacology and experimental therapeutics. vol 252. issue 3. 1990-05-03. PMID:2156989. |
cannabidiol, cannabinol and (+)-delta 9-thc were all without effect, indicating that this effect of delta 9-thc is stereoselective and specific for cannabinoids with psychoactive potency. |
1990-05-03 |
2023-08-11 |
rat |
| D J Harve. Stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. Journal of ethnopharmacology. vol 28. issue 1. 1990-04-25. PMID:2314109. |
stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. |
1990-04-25 |
2023-08-11 |
Not clear |
| D J Harve. Stability of cannabinoids in dried samples of cannabis dating from around 1896-1905. Journal of ethnopharmacology. vol 28. issue 1. 1990-04-25. PMID:2314109. |
cannabinoids from three samples of cannabis obtained from the pitt-rivers museum, oxford, and dating from the turn of the century were examined by gas chromatography and mass spectometry for the presence of cannabinoids. |
1990-04-25 |
2023-08-11 |
Not clear |
| E A Formukong, A T Evans, F J Evan. The inhibitory effects of cannabinoids, the active constituents of Cannabis sativa L. on human and rabbit platelet aggregation. The Journal of pharmacy and pharmacology. vol 41. issue 10. 1990-02-20. PMID:2575149. |
the inhibitory effects of cannabinoids, the active constituents of cannabis sativa l. on human and rabbit platelet aggregation. |
1990-02-20 |
2023-08-11 |
human |
| A C Howlett, D K Scott, G H Wilke. Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies. Biochemical pharmacology. vol 38. issue 19. 1989-11-28. PMID:2554920. |
because cannabinoid drugs partition into membrane lipids and alter membrane fluidity parameters in a number of model systems, it was of interest to examine the influence of delta 9-tetrahydrocannabinol and cannabidiol on enzyme activity analyzed by the arrhenius plot. |
1989-11-28 |
2023-08-11 |
Not clear |
| E Ka. Cannabis plants illicitly grown in Jutland (Denmark). Zeitschrift fur Rechtsmedizin. Journal of legal medicine. vol 102. issue 6. 1989-07-21. PMID:2544068. |
four hundred forty-nine fresh cannabis plants and 26 fruiting tops harvested in jutland (denmark) from july to september 1988 were characterized according to weight, height, marihuana yield, and cannabinoid content. |
1989-07-21 |
2023-08-11 |
Not clear |
| E Ka. Cannabis plants illicitly grown in Jutland (Denmark). Zeitschrift fur Rechtsmedizin. Journal of legal medicine. vol 102. issue 6. 1989-07-21. PMID:2544068. |
all plants contained cannabidiol (cbd), but only negligible concentrations of other cannabinoids. |
1989-07-21 |
2023-08-11 |
Not clear |
| J E Shook, T F Burk. Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents. The Journal of pharmacology and experimental therapeutics. vol 249. issue 2. 1989-06-26. PMID:2542532. |
the purpose of these investigations was to determine whether the major constituents of marijuana and the synthetic cannabinoid nabilone have any effects on gi function which can be detected in rodent models of gi transit and motility. |
1989-06-26 |
2023-08-11 |
mouse |
| E Samara, M Biale. Pharmacokinetics of the dimethylheptyl homolog of cannabidiol in dogs. Drug metabolism and disposition: the biological fate of chemicals. vol 16. issue 6. 1989-06-02. PMID:2907468. |
cannabidiol (cbd) is one of the major nonpsychoactive cannabinoids produced by cannabis sativa l. recent studies have shown that a dimethylheptyl homolog (dmh) of cbd is more active as an anticonvulsant than is the naturally occurring cbd. |
1989-06-02 |
2023-08-11 |
Not clear |
| S Narimatsu, K Watanabe, I Yamamoto, H Yoshimur. Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver. Drug metabolism and disposition: the biological fate of chemicals. vol 16. issue 6. 1989-06-02. PMID:2907469. |
effects of four cannabinoids [cannabidiol (cbd), delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol, and cannabinol] on hepatic microsomal oxidation of testosterone (17 beta-hydroxy-androst-4-ene-3-one) were examined in adult male rats. |
1989-06-02 |
2023-08-11 |
rat |
| P A McDonald, T A Goug. Determination of the distribution of cannabinoids in cannabis resin from the Lebanon using HPLC. Part III. Journal of chromatographic science. vol 22. issue 7. 1989-06-01. PMID:6336369. |
determination of the distribution of cannabinoids in cannabis resin from the lebanon using hplc. |
1989-06-01 |
2023-08-12 |
Not clear |
| P A McDonald, T A Goug. Determination of the distribution of cannabinoids in cannabis resin from the Lebanon using HPLC. Part III. Journal of chromatographic science. vol 22. issue 7. 1989-06-01. PMID:6336369. |
the remaining 47 samples of cannabis resin, all of which were from bags with different marks, were each found to have a unique cannabinoid distribution. |
1989-06-01 |
2023-08-12 |
Not clear |
| H N Bhargava, A Gulat. Selective inhibition of the binding of 3H-(3-MeHis2) thyrotropin releasing hormone to rat amygdala membranes by some naturally occurring cannabinoids. Peptides. vol 9. issue 4. 1989-04-04. PMID:2852360. |
the effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (thc), cannabinol (cbn) and cannabidiol (cbd), on the brain receptors for thyrotropin releasing hormone (trh) was investigated. |
1989-04-04 |
2023-08-11 |
rat |
| M Reichman, W Nen, L E Hoki. Delta 9-tetrahydrocannabinol increases arachidonic acid levels in guinea pig cerebral cortex slices. Molecular pharmacology. vol 34. issue 6. 1989-01-23. PMID:2849049. |
the relative rank-order of potencies in the cannabinoid series we examined were (-)-thc = (+)-thc greater than cannabinol greater than delta 8-thc greater than cannabidiol. |
1989-01-23 |
2023-08-11 |
Not clear |
| E J Cone, R E Johnson, B D Paul, L D Mell, J Mitchel. Marijuana-laced brownies: behavioral effects, physiologic effects, and urinalysis in humans following ingestion. Journal of analytical toxicology. vol 12. issue 4. 1988-12-20. PMID:3184885. |
five drug-free male subjects ingested marijuana-laced brownies in a double-blind crossover study designed to test for behavioral effects, physiologic effects, and urinary cannabinoid metabolites produced as a result of consumption of marijuana plant material cooked in foodstuff. |
1988-12-20 |
2023-08-11 |
human |
| E A Formukong, A T Evans, F J Evan. Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Inflammation. vol 12. issue 4. 1988-11-23. PMID:3169967. |
analgesic and antiinflammatory activity of constituents of cannabis sativa l. two extracts of cannabis sativa herb, one being cannabinoid-free (ethanol) and the other containing the cannabinoids (petroleum), were shown to inhibit pbq-induced writhing in mouse when given orally and also to antagonize tetradecanoylphorbol acetate (tpa)-induced erythema of mouse skin when applied topically. |
1988-11-23 |
2023-08-11 |
mouse |
| E Samara, M Bialer, R Mechoula. Pharmacokinetics of cannabidiol in dogs. Drug metabolism and disposition: the biological fate of chemicals. vol 16. issue 3. 1988-10-11. PMID:2900742. |
cannabidiol (cbd) is one of the major nonpsychoactive cannabinoids produced by cannabis sativa l. recent studies have shown that cbd has a high protective index, comparable to that of phenobarbital and phenytoin. |
1988-10-11 |
2023-08-11 |
Not clear |
| H Friedman, T Klein, S Specter, S Pross, C Newton, D K Blanchard, R Wide. Drugs of abuse and virus susceptibility. Advances in biochemical psychopharmacology. vol 44. 1988-09-08. PMID:2840802. |
cannabinoids present in marijuana also have immunomodulatory effects. |
1988-09-08 |
2023-08-11 |
mouse |