| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew P Baier, Rojina Ranjit, Daniel B Owen, Jenna L Wilson, Megan A Stiles, Anthony M Masingale, Zachary Thomas, Anne Bredegaard, David M Sherry, Sreemathi Loga. Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging. Aging cell. 2025-03-13. PMID:40077862. |
cognitively impaired males exhibited marked reactive gliosis in the hippocampus, characterized by microglial activation, increased astrocyte arborization, and elevated transcriptional expression of reactivity markers. |
2025-03-13 |
2025-03-15 |
mouse |
| Yandara A Martins, Camila A E F Cardinali, Andréa S Torrã. Age-related differences in long-term memory performance and astrocyte morphology in rat hippocampus. Neurobiology of aging. vol 150. 2025-03-05. PMID:40043468. |
age-related differences in long-term memory performance and astrocyte morphology in rat hippocampus. |
2025-03-05 |
2025-03-08 |
rat |
| Yandara A Martins, Camila A E F Cardinali, Andréa S Torrã. Age-related differences in long-term memory performance and astrocyte morphology in rat hippocampus. Neurobiology of aging. vol 150. 2025-03-05. PMID:40043468. |
therefore, this study aimed to characterize astrocyte morphology in the hippocampus of older rats. |
2025-03-05 |
2025-03-08 |
rat |
| Reham M Essam, Yasmin S Mohamed, Sarah S El-Sayed, Nada M Kame. Linking KATP channel activation to p-AKT/mTORC1/eEF2/BDNF axis unravels nicorandil's promise in countering acetaminophen-induced hepatic encephalopathy in mice. Life sciences. 2025-02-21. PMID:39983823. |
histopathological analyses revealed improved liver and hippocampal morphology, while immunohistochemistry showed reduced astrocyte activation with nic treatment. |
2025-02-21 |
2025-02-24 |
mouse |
| Amir Rezagholizadeh, Amin Firoozi, Zohreh Tavassoli, Amir Shojaei, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Kristi Anne Kohlmeier, Yaghoub Fathollah. Vitamin D injection into the dorsal-CA1 hippocampus improves short-term sleep deprivation induced cognitive impairment in male rats. Heliyon. vol 10. issue 15. 2025-02-17. PMID:39959779. |
to determine the role of astrocytes in spatial navigation deficits associated with sd, an inhibitor of astrocyte activation, fluorocitrate (fc), or a suppressor of astrocyte activation, vitamin d, was injected into the dorsal-ca1 hippocampus before subjecting rats to the sd protocol and the effects of these compounds on spatial navigation deficits associated with sd in the mwm were assessed. |
2025-02-17 |
2025-02-23 |
rat |
| Shi-Yu Shen, Ling-Feng Liang, Tian-Le Shi, Zu-Qi Shen, Shu-Yuan Yin, Jia-Rui Zhang, Wei Li, Wen-Li Mi, Yan-Qing Wang, Yu-Qiu Zhang, Jin Y. Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025-01-31. PMID:39888279. |
microglia-derived interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior. |
2025-01-31 |
2025-02-02 |
Not clear |
| André Quincozes-Santos, Larissa Daniele Bobermin, Ana Carolina Tramontina, Krista Minéia Wartchow, Vanessa-Fernanda Da Silva, Vitor Gayger-Dias, Natalie K Thomaz, Aline Daniel Moreira de Moraes, Daniele Schauren, Patrícia Nardin, Carmem Gottfried, Diogo Onofre Souza, Carlos-Alberto Gonçalve. Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway. Neurotoxicity research. vol 43. issue 1. 2025-01-27. PMID:39869271. |
this study aimed to investigate the glioprotective effects of resveratrol against glutamate-induced cellular dysfunction in hippocampal slices and primary astrocyte cultures, with a focus on the role of heme-oxygenase 1 (ho-1). |
2025-01-27 |
2025-01-29 |
Not clear |
| Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni'am Aulanni'am, Ettie Rukmigarsar. Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to organotypic hippocampal slice culture. F1000Research. vol 12. 2025-01-16. PMID:39816762. |
neuronal death, astrocyte reactivity and increased calcium also occur in hippocampal excitotoxicity, but few studies have investigated immediate effect after kainic acid exposure. |
2025-01-16 |
2025-01-19 |
Not clear |
| Kimberley A Stephenson, Polly Peters, Mark G Rae, Dervla O'Malle. Astrocyte proliferation in the hippocampal dentate gyrus is suppressed across the lifespan of dystrophin-deficient mdx mice. Experimental physiology. 2025-01-10. PMID:39792584. |
astrocyte proliferation in the hippocampal dentate gyrus is suppressed across the lifespan of dystrophin-deficient mdx mice. |
2025-01-10 |
2025-01-13 |
mouse |
| Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wan. Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization. Aging and disease. 2025-01-03. PMID:39751866. |
in summary, our study demonstrates that aerobic exercise improves wm integrity and hippocampal function by modulating the anxa1/mapk axis following astrocyte polarization. |
2025-01-03 |
2025-01-05 |
mouse |
| Yang Liu, Haoran Peng, Qi Liu, Jianying Hao, Chao Tang, Hanhui Ya. Differential Expression of GABA Receptor-Related Genes in Alzheimer's Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model. Neuromolecular medicine. vol 27. issue 1. 2025-01-03. PMID:39752101. |
our data highlighted the mechanism by which exercise improves memory performance in ad patients by reducing astrocyte neurotoxicity inducing decreased hippocampal gaba receptor expression. |
2025-01-03 |
2025-01-05 |
mouse |
| Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pilla. Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice. Cells. vol 13. issue 23. 2024-12-17. PMID:39682736. |
furthermore, c2-crry administration significantly decreased microglia/macrophage and astrocyte activation markers in the pfc and hippocampus. |
2024-12-17 |
2024-12-21 |
mouse |
| Lei Wu, Yan Sun, Zhangjie Wu, Ruiyi Liu, Ying Yin, Nga-Lee Wong, Wenzheng Ju, Hailou Zhan. A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 182. 2024-12-15. PMID:39675136. |
subsequently, activation of hippocampal caspase4 blocked mh's antidepressant effects and its effects on suppression of microglia and improvement of astrocyte in the hippocampus. |
2024-12-15 |
2024-12-21 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
while 5-hydroxytryptamine type 3 receptors did not affect baseline neurogenesis in the hippocampal dentate gyrus, 5-hydroxytryptamine type 3 receptors were required for aerobic exercise-induced neurogenesis and astrocyte proliferation in this region. |
2024-12-12 |
2024-12-14 |
mouse |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
these results suggest that aerobic exercise increases hippocampal dentate gyrus neurogenesis and astrocyte proliferation via the up-regulation of 5-hydroxytryptamine type 3 receptors, leading to more brain-derived neurotrophic factor production and release from these cells, which results in long-term potentiation facilitation in the hippocampal ca3 region and help improve memory. |
2024-12-12 |
2024-12-14 |
mouse |
| Delyse McCaffrey, Cynthia Shannon Weickert, Adam K Walke. Blood IL-1α and IL-6 predict specific breast cancer-induced increases in hippocampal pro-inflammatory cytokines in mice. Cytokine. vol 186. 2024-12-12. PMID:39667084. |
we observed region-specific glial cell reactivity, however, only astrocyte and oligodendrocyte markers were correlated with cytokine changes within the hippocampus. |
2024-12-12 |
2024-12-22 |
mouse |
| Lingmin Chen, Jiao Jiao, Fan Lei, Bin Zhou, Hong Li, Ping Liao, Xin Li, Yi Kang, Jin Liu, Ruotian Jian. Ezrin-mediated astrocyte-synapse signaling regulates cognitive function via astrocyte morphological changes in fine processes in male mice. Brain, behavior, and immunity. 2024-11-23. PMID:39580057. |
here, we found that ezrin expression and astrocyte fine process volume in the hippocampus of male mice increased after learning but decreased after lipopolysaccharide injection and in a mouse model of postoperative cognitive dysfunction, both of which involved models with impaired cognitive function. |
2024-11-23 |
2024-11-26 |
mouse |
| Maheedhar Kodali, Leelavathi N Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny J Gonzalez, Chris Oake, Catherine Hering, Roshni Sara Babu, Sanya Kotian, Ashok K Shett. Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy. Aging cell. 2024-11-21. PMID:39571180. |
however, short-term csf1r inhibition did not influence aβ plaques, soluble aβ-42 levels, astrocyte hypertrophy, or hippocampal neurogenesis. |
2024-11-21 |
2024-11-24 |
mouse |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
glia-related acute effects of risperidone and haloperidol in hippocampal slices and astrocyte cultures from adult wistar rats: a focus on inflammatory and trophic factor release. |
2024-11-19 |
2024-11-22 |
rat |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
in the present study, we investigated the effects of acute treatments with the antipsychotics risperidone and haloperidol of hippocampal slices and astrocyte cultures, focusing on neuron-glia communication and how antipsychotics act in astrocytes. |
2024-11-19 |
2024-11-22 |
rat |