| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Na Hu, Yujie Zheng, Xueru Liu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Li Liu, Xiaobin Wan. CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function. Molecular neurobiology. 2024-08-14. PMID:39138759. |
our findings demonstrated that a novel mechanism of the antidepressant like effect of esketamine may be achieved by reducing the expression of circkat6b in the astrocyte of the hippocampus of depressed mice. |
2024-08-14 |
2024-08-16 |
mouse |
| Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Oj. PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI. Journal of neuroinflammation. vol 21. issue 1. 2024-08-03. PMID:39097742. |
we revealed that pioglitazone treatment attenuated spatial learning and memory impairments at 6 months post-injury and reduced the expression of reactive microglia and astrocyte markers in the cortex, hippocampus, and corpus callosum. |
2024-08-03 |
2024-08-06 |
mouse |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
| AnnaLin M Woo, Harald Sontheime. Interactions between astrocytes and extracellular matrix structures contribute to neuroinflammation-associated epilepsy pathology. Frontiers in molecular medicine. vol 3. 2024-08-01. PMID:39086689. |
we offer epilepsy as a well-studied neurological disorder in which there is clear evidence of astrocyte contribution to diseases as evidenced across several different disease models, including mouse models of hippocampal sclerosis, trauma associated epilepsy, glioma-associated epilepsy, and beta-1 integrin knockout astrogliosis. |
2024-08-01 |
2024-08-03 |
mouse |
| Derek W Nelson, Jessica L Funnell, Conrad H Cheung, Geraldine B Quinones, Christina S Mendoza, Marvin Bentley, Ryan J Gilber. In vitro assessment of protamine toxicity with neural cells, its therapeutic potential to counter chondroitin sulfate mediated neuron inhibition, and its effects on reactive astrocytes. Advanced therapeutics. vol 7. issue 2. 2024-07-29. PMID:39071184. |
in this study, we investigate the therapeutic efficacy of prm with primary cortical neurons, hippocampal neurons, mixed glial cultures, and astrocyte cultures. |
2024-07-29 |
2024-08-02 |
Not clear |
| Opeyemi Babatunde Ogunsuyi, Omodesola Oluwafisayo Ogunruku, Haruna Isiyaku Umar, Ganiyu Obo. Effect of curcumin-donepezil combination on spatial memory, astrocyte activation, and cholinesterase expressions in brain of scopolamine-treated rats. Molecular biology reports. vol 51. issue 1. 2024-07-29. PMID:39073463. |
the study investigated the effect of co-administration of curcumin and donepezil on several markers of cognitive function (such as spatial memory, astrocyte activation, cholinesterase expressions) in the brain cortex and hippocampus of scopolamine-treated rats. |
2024-07-29 |
2024-08-02 |
rat |
| Katharina Ritter, Markus Baalmann, Christopher Dolderer, Ulrike Ritz, Michael K E Schäfe. Brain-Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39061973. |
bone fractures did not aggravate neuropathology or neuroinflammation assessed by cerebral lesion size, hippocampal integrity, astrocyte and microglia activation, and gene expression. |
2024-07-27 |
2024-07-29 |
mouse |
| b' Nata\\xc5\\xa1a Mitrovi\\xc4\\x87, Marija Ad\\xc5\\xbei\\xc4\\x87 Bukvi\\xc4\\x87, Marina Zari\\xc4\\x87 Konti\\xc4\\x87, Milorad Dragi\\xc4\\x87, Snje\\xc5\\xbeana Petrovi\\xc4\\x87, Marija Paunovi\\xc4\\x87, Vesna Vu\\xc4\\x8di\\xc4\\x87, Ivana Grkovi\\xc4\\x8. Flaxseed Oil Alleviates Trimethyltin-Induced Cell Injury and Inhibits the Pro-Inflammatory Activation of Astrocytes in the Hippocampus of Female Rats. Cells. vol 13. issue 14. 2024-07-26. PMID:39056766.' |
exposure to the neurotoxin trimethyltin (tmt) selectively induces hippocampal neuronal injury and astrocyte activation accompanied with resultant neuroinflammation, which causes severe behavioral, cognitive, and memory impairment. |
2024-07-26 |
2024-07-28 |
rat |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. 2024-07-25. PMID:39051915. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-07-25 |
2024-07-28 |
mouse |
| Dabing Li, Qiangwen Pan, Yewei Xiao, Kehui H. Advances in the study of phencyclidine-induced schizophrenia-like animal models and the underlying neural mechanisms. Schizophrenia (Heidelberg, Germany). vol 10. issue 1. 2024-07-22. PMID:39039065. |
in addition, astrocyte and microglial activation and oxidative stress in the cerebral cortex or hippocampus have been observed in pcp-induced models of sz. |
2024-07-22 |
2024-07-25 |
Not clear |
| Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Guang-Hui Xu, Ji-Xiao Zhu, Li-Tao Y. Role of ginsenoside Rb1 in attenuating depression-like symptoms through astrocytic and microglial complement C3 pathway. Metabolic brain disease. 2024-07-21. PMID:39034364. |
in conclusion, our results demonstrate that ginsenoside rb1 produces the antidepressant-like effects by inhibiting astrocyte tlr4/nf-κb/c3 signaling to covert microglia from a pro-inflammatory phenotype (amoeboid) towards an anti-inflammatory phenotype (ramified), which inhibit the synaptic pruning in the hippocampus. |
2024-07-21 |
2024-07-24 |
mouse |
| Priya Tiwari, Sumbul Mueed, Adam Olaitan Abdulkareem, Kashif Hani. Activation of angiotensin-converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/β-catenin signaling in hypertension. Molecular and cellular neurosciences. 2024-07-16. PMID:39013481. |
the results of our study revealed that hypertension induced significant glial activation (astrocyte and microglial), neuroinflammation, and impaired hippocampal neurogenesis. |
2024-07-16 |
2024-07-19 |
rat |
| Charlotte Lorin, Romain Guiet, Nicolas Chiaruttini, Giovanna Ambrosini, Elvis Boci, Marwan Abdellah, Henry Markram, Daniel Kelle. Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex. Glia. 2024-07-15. PMID:39007459. |
structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex. |
2024-07-15 |
2024-07-18 |
mouse |
| Jae-Hong Kim, Nakamura Michiko, In-Sun Choi, Yujung Kim, Ji-Young Jeong, Maan-Gee Lee, Il-Sung Jang, Kyoungho Su. Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice. PLoS biology. vol 22. issue 7. 2024-07-11. PMID:38991663. |
fiber photometry using gcamp revealed a high level of hippocampal astrocyte activation in the neuroinflammation model. |
2024-07-11 |
2024-07-14 |
mouse |
| Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok K. Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation. Brain : a journal of neurology. 2024-07-08. PMID:38976650. |
gut inoculation of α-syn pff increased lewy body accumulation in the hippocampal dentate gyrus, with heightened microglia and astrocyte activation and worsened non-motor symptoms. |
2024-07-08 |
2024-07-12 |
mouse |
| Kenshi Kaku, Takahiro Sasaki, Kenshiro Hara, Kentaro Tanemur. A single dose of clothianidin exposure induces varying sex-specific behavioral changes in adulthood depending on the developmental stage of its administration. The Journal of toxicological sciences. vol 49. issue 7. 2024-06-30. PMID:38945841. |
the behavioral abnormalities observed in female clo-treated mice were consistent with the typical behavioral abnormalities associated with hippocampal astrocyte dysfunction. |
2024-06-30 |
2024-07-03 |
mouse |
| Ana Paula Rodrigues Martini, Livia Machado Schlemmer, Joelma Alves Lucio Padilha, Rafael Bandeira Fabres, Natividade de Sá Couto Pereira, Lenir Orlandi Pereira, Carla Dalmaz, Carlos Alexandre Nett. Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits. Frontiers in rehabilitation sciences. vol 5. 2024-06-28. PMID:38939055. |
acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits. |
2024-06-28 |
2024-06-30 |
rat |
| Ana Paula Rodrigues Martini, Livia Machado Schlemmer, Joelma Alves Lucio Padilha, Rafael Bandeira Fabres, Natividade de Sá Couto Pereira, Lenir Orlandi Pereira, Carla Dalmaz, Carlos Alexandre Nett. Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits. Frontiers in rehabilitation sciences. vol 5. 2024-06-28. PMID:38939055. |
we investigated the effects of acrobatic training on astrocyte remodeling in the ca1 and ca3 subfields of the hippocampus and spatial memory impairment in male and female rats at different stages of the two-vessel occlusion (2vo) model. |
2024-06-28 |
2024-06-30 |
rat |
| Ji-Yun Kang, Jin-Seok Lee, Jing-Hua Wang, Chang-Gue So. Sleep deprivation in adolescent mice impairs long-term memory till early adulthood via suppression of hippocampal astrocytes. Sleep. 2024-06-27. PMID:38934552. |
furthermore, the hippocampal region exhibited significantly diminished protein expressions of astrocyte, characterized by lowered levels of aquaporin 4 (aqp4), a representative molecule involved in brain clearance processes, and reduced protein expressions of brain-derived neurotrophic factor (bdnf). |
2024-06-27 |
2024-06-29 |
mouse |
| Morgan B Patrick, Natalie J Preveza, Shannon E Kincaid, Gueladouan Setenet, Jennifer R Abraham, Adam Cummings, Shifa Banani, W Keith Ray, Richard F Helm, Sydney Trask, Timothy J Jarom. Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus. Brain research bulletin. 2024-06-15. PMID:38879089. |
in the hippocampus, the targets of altered protein degradation were involved in transcription and astrocyte structure or g-protein and interferon signaling in males and females, respectively. |
2024-06-15 |
2024-06-18 |
rat |