| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda da Silva, Larissa Daniele Bobermin, Camila Leite Santos, Rômulo Rodrigo de Souza Almeida, Lílian Juliana Lissner, Tiago Marcon Dos Santos, Marina Seady, Marina Concli Leite, Angela T S Wyse, Carlos-Alberto Gonçalves, André Quincozes-Santo. Glia-related Acute Effects of Risperidone and Haloperidol in Hippocampal Slices and Astrocyte Cultures from Adult Wistar Rats: A Focus on Inflammatory and Trophic Factor Release. Neurochemical research. vol 50. issue 1. 2024-11-19. PMID:39560678. |
for this, we obtained hippocampal slices and primary astrocyte cultures from 30-day-old wistar rats and incubated them with risperidone or haloperidol (1 and 10 μm) for 30 min and 24 h, respectively. |
2024-11-19 |
2024-11-22 |
rat |
| Isabel H Salas, Adrien Paumier, Tao Tao, Aksinya Derevyanko, Corey Switzler, Jillybeth Burgado, Melia Movsesian, Setareh Metanat, Trinity Dawoodtabar, Quinn Asbell, Arash Fassihi, Nicola J Alle. Astrocyte transcriptomic analysis identifies glypican 5 downregulation as a contributor to synaptic dysfunction in Alzheimer's disease models. bioRxiv : the preprint server for biology. 2024-11-18. PMID:39554197. |
to understand if synapse-supportive functions of astrocytes are altered in ad, we used astrocyte bactrap mice to generate a comprehensive dataset of hippocampal astrocyte transcriptional alterations in two mouse models of alzheimer's pathology (appswe/ps1de9 and tau p301s), characterizing sex and age-dependent changes. |
2024-11-18 |
2024-11-22 |
mouse |
| Mingsong Liu, Lei Li, Ruizhe Chen, Qilin Wang, Tongfei Zeng, Junhong Hu, Changzhi Yan, Jing Xiao, Xuewei Xi. Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. Biogerontology. vol 26. issue 1. 2024-11-16. PMID:39546054. |
whole-body vibration elicits 40 hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats. |
2024-11-16 |
2024-11-18 |
rat |
| Ying Zhang, Jun Wang, Haibo Zhang, Zhenkun Tan, Yingyan Zheng, Junjiao Ping, Jie Zhang, Jiali Luo, Linsen Li, Liming Lu, Xinxia Li. Elevated circulating levels of GFAP associated with reduced volumes in hippocampal subregions linked to mild cognitive impairment among community-dwelling elderly individuals. Frontiers in aging neuroscience. vol 16. 2024-11-14. PMID:39534430. |
the aim of this study is to investigate whether astrocyte activation is correlated with hippocampal atrophy, and to assess the potential of glial fibrillary acidic protein (gfap) as a biomarker for diagnosing mci among community-dwelling older individuals. |
2024-11-14 |
2024-11-17 |
Not clear |
| Leelavathi N Madhu, Maheedhar Kodali, Raghavendra Upadhya, Shama Rao, Yogish Somayaji, Sahithi Attaluri, Bing Shuai, Maha Kirmani, Shreyan Gupta, Nathaniel Maness, Xiaolan Rao, James J Cai, Ashok K Shett. Extracellular vesicles from human-induced pluripotent stem cell-derived neural stem cells alleviate proinflammatory cascades within disease-associated microglia in Alzheimer's disease. Journal of extracellular vesicles. vol 13. issue 11. 2024-11-05. PMID:39499013. |
the extent of astrocyte hypertrophy, amyloid-beta plaques, and p-tau were also reduced in the hippocampus. |
2024-11-05 |
2024-11-08 |
mouse |
| Shoichiro Omura, Rina Ogawa, Tomomi Kawachi, Aya Ogawa, Yuuki Arai, Natsumi Takayama, Aki Masui, Kumiko Kondo, Hiroki Sugimoto, Hiroshi M Shinohara, Tokiharu Takahashi, Hideyuki Maeda, Kyoji Ohyam. Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. Frontiers in cellular neuroscience. vol 18. 2024-11-01. PMID:39484182. |
olig2+/ng2+/blbp+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. |
2024-11-01 |
2024-11-03 |
mouse |
| Mateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Morae. Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsy. Epilepsy & behavior : E&B. vol 161. 2024-10-28. PMID:39467457. |
animals were euthanized on day 26, and hippocampal slices were analyzed using fluoro-jade staining for cell death and immunofluorescence staining for iba-1 (microglia) and gfap (astrocyte) labeling. |
2024-10-28 |
2024-10-31 |
rat |
| Ritwick Mondal, Shramana Deb, Dipanjan Chowdhury, Shramana Sarkar, Aakash Guha Roy, Gourav Shome, Vramanti Sarkar, Durjoy Lahiri, Julián Benito-Leo. Neurometabolic substrate transport across brain barriers in diabetes Mellitus: Implications for cognitive function and neurovascular health. Neuroscience letters. 2024-10-26. PMID:39461703. |
furthermore, the critical role of insulin in the hippocampus is highlighted, where insulin enhances neuro-glial coupling and modulates astrocyte glucose uptake, supporting neuronal energy demands. |
2024-10-26 |
2024-10-30 |
Not clear |
| Bin Li, Longfei Du, Shusheng Wu, Yuye Yi. Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2. International immunopharmacology. vol 143. issue Pt 1. 2024-10-15. PMID:39405930. |
the results revealed that taurine ameliorated cognitive deficits following hs in mice and mitigated hs-induced astrocyte and microglia activation as well as blood-brain barrier (bbb) damage in the hippocampus. |
2024-10-15 |
2024-10-18 |
mouse |
| Fanning Xu, Hui Chen, Yubo Gao, Xiaoxia Yang, Chun Zhang, Xinli N. Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice. Neurochemical research. 2024-09-28. PMID:39340594. |
pre-treatment with sodium butyrate inhibited astrocyte activation in the hippocampus, reduced interleukin-1β (il-1β), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α) expression levels, and protected hippocampal neurons. |
2024-09-28 |
2024-10-01 |
mouse |
| ShuangFeng Chen, Cheng Han, XinHao Wang, QingXin Zhang, XiaoLi Yan. Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels. Brain research. vol 1845. 2024-08-30. PMID:39208968. |
furthermore, al lowered the presence of il-6, il-1β, and tnfα in the hippocampal and cortical tissues of p. gingivalis-infected rats by inhibiting astrocyte and microglial activation and nf-κb phosphorylation. |
2024-08-30 |
2024-09-04 |
rat |
| Joel G Hashimoto, Nicholas Margolies, Xiaolu Zhang, Joshua Karpf, Yuefan Song, Brett A Davis, Fuming Zhang, Robert J Linhardt, Lucia Carbone, Marina Guizzett. Astrocyte extracellular matrix modulates neuronal dendritic development. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211148. |
major developmental events occurring in the hippocampus during the third trimester of human gestation and neonatally in altricial rodents include rapid and synchronized dendritic arborization and astrocyte proliferation and maturation. |
2024-08-30 |
2024-09-04 |
mouse |
| Nosarieme Omoregie Abey, Osaretin Albert Taiwo Ebuehi, Ngozi Awa Imag. Effect of perinatal dietary protein deficiency on some neurochemicals and cytoarchitectural balance, in F1 and F2 generations of rats. Nutritional neuroscience. vol 27. issue 9. 2024-08-27. PMID:37995096. |
gfap astrocyte expression was observed to be increased in the prefrontal cortex (pfc) and hippocampal sections, indicating heightened reactivity. |
2024-08-27 |
2024-08-30 |
rat |
| Brenda Lizeth Gutiérrez-Esparza, Marina Liliana González-Torres, Andrés Quintanar-Stephano, J Luis Quintana. Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist. Metabolic brain disease. 2024-08-23. PMID:39177865. |
in this study, we aim to evaluate the effects of la treatment on hippocampus of rats with he induced by portocaval anastomosis (pca) trough cognitive tests, histology analysis and expression of neuronal recovery marker proteins, such as neurofilament (nf200) and neurabin ii, and astrocyte marker glial fibrillary acidic protein (gfap). |
2024-08-23 |
2024-08-25 |
rat |
| Paras S Minhas, Jeffrey R Jones, Amira Latif-Hernandez, Yuki Sugiura, Aarooran S Durairaj, Qian Wang, Siddhita D Mhatre, Takeshi Uenaka, Joshua Crapser, Travis Conley, Hannah Ennerfelt, Yoo Jin Jung, Ling Liu, Praveena Prasad, Brenita C Jenkins, Yeonglong Albert Ay, Matthew Matrongolo, Ryan Goodman, Traci Newmeyer, Kelly Heard, Austin Kang, Edward N Wilson, Tao Yang, Erik M Ullian, Geidy E Serrano, Thomas G Beach, Marius Wernig, Joshua D Rabinowitz, Makoto Suematsu, Frank M Longo, Melanie R McReynolds, Fred H Gage, Katrin I Andreasso. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science (New York, N.Y.). vol 385. issue 6711. 2024-08-22. PMID:39172838. |
we report that inhibition of indoleamine-2,3-dioxygenase 1 (ido1), which metabolizes tryptophan to kynurenine (kyn), rescues hippocampal memory function in mouse preclinical models of ad by restoring astrocyte metabolism. |
2024-08-22 |
2024-08-25 |
mouse |
| Masoud Kaboutari, Masoumeh Asle-Rousta, Sanaz Mahmaz. Protective effect of menthol against thioacetamide-induced hepatic encephalopathy by suppressing oxidative stress and inflammation, augmenting expression of BDNF and α7-nACh receptor, and improving spatial memory. European journal of pharmacology. 2024-08-18. PMID:39154831. |
menthol also reduced neuronal death in the hippocampal cornu ammonis-1 and dentate gyrus regions and reduced astrocyte swelling, which led to improved learning and spatial memory in rats with he. |
2024-08-18 |
2024-08-21 |
rat |
| Na Hu, Yujie Zheng, Xueru Liu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Li Liu, Xiaobin Wan. CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function. Molecular neurobiology. 2024-08-14. PMID:39138759. |
our findings demonstrated that a novel mechanism of the antidepressant like effect of esketamine may be achieved by reducing the expression of circkat6b in the astrocyte of the hippocampus of depressed mice. |
2024-08-14 |
2024-08-16 |
mouse |
| Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Oj. PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI. Journal of neuroinflammation. vol 21. issue 1. 2024-08-03. PMID:39097742. |
we revealed that pioglitazone treatment attenuated spatial learning and memory impairments at 6 months post-injury and reduced the expression of reactive microglia and astrocyte markers in the cortex, hippocampus, and corpus callosum. |
2024-08-03 |
2024-08-06 |
mouse |
| Iardja S L Sales, Alana G de Souza, Adriano J M Chaves Filho, Tiago L Sampaio, Daniel M A da Silva, José T Valentim, Raquell de C Chaves, Michelle V R Soares, Dilailson C Costa Júnior, José M Barbosa Filho, Danielle S Macêdo, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice. Behavioural pharmacology. vol 35. issue 6. 2024-08-02. PMID:39094014. |
expressions of microglia (ionized calcium-binding adaptor molecule-1 - iba-1) and astrocyte (glial fibrillary acidic protein - gfap) markers and levels of cytokines tumor necrosis factor alfa (tnf-α) and interleukin 1 beta (il-1β) were measured in the hippocampus. |
2024-08-02 |
2024-08-06 |
mouse |
| AnnaLin M Woo, Harald Sontheime. Interactions between astrocytes and extracellular matrix structures contribute to neuroinflammation-associated epilepsy pathology. Frontiers in molecular medicine. vol 3. 2024-08-01. PMID:39086689. |
we offer epilepsy as a well-studied neurological disorder in which there is clear evidence of astrocyte contribution to diseases as evidenced across several different disease models, including mouse models of hippocampal sclerosis, trauma associated epilepsy, glioma-associated epilepsy, and beta-1 integrin knockout astrogliosis. |
2024-08-01 |
2024-08-03 |
mouse |