| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Basanisi, K Marche, E Combrisson, P Apicella, A Brovell. Beta oscillations in monkey striatum encode reward prediction error signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-04-04. PMID:37015808. |
rpe signals are encoded in the neural activity of multiple brain areas, such as midbrain dopaminergic neurons, prefrontal cortex and striatum. |
2023-04-04 |
2023-08-14 |
monkey |
| Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Christine Klein, Philip Seibler, Jens C Schwamborn, Rejko Krüge. Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.1290A > G (p.T351A) or c.2067A > G (p.T610A) in the RHOT1 gene encoding Miro1. Stem cell research. vol 69. 2023-04-01. PMID:37003181. |
here, we provide a comprehensive characterization and quality assurance of both isogenic pairs, which will be used to study miro1-related molecular mechanisms underlying neurodegeneration in ipsc-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes). |
2023-04-01 |
2023-08-14 |
Not clear |
| Walaa F Alsanie, Sherin Abdelrahman, Raed I Felimban, Heba A Alkhatabi, Ahmed Gaber, Ebtisam Abdulah Alosimi, Majid Alhomrani, Hamza Habeeballah, Charlotte A E Hauser, Abdulhakeem S Alamri, Aiysha Althobaiti, Abdulaziz Alsharif, Ahmed S Alzahrani, Mohammad S Al-Ghamdi, Bassem M Raafat, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982742. |
the influence of prenatal exposure to methamphetamine on the development of dopaminergic neurons in the ventral midbrain. |
2023-03-29 |
2023-08-14 |
mouse |
| Walaa F Alsanie, Sherin Abdelrahman, Raed I Felimban, Heba A Alkhatabi, Ahmed Gaber, Ebtisam Abdulah Alosimi, Majid Alhomrani, Hamza Habeeballah, Charlotte A E Hauser, Abdulhakeem S Alamri, Aiysha Althobaiti, Abdulaziz Alsharif, Ahmed S Alzahrani, Mohammad S Al-Ghamdi, Bassem M Raafat, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982742. |
here, we examined whether exposure to methamphetamine affects the morphogenesis and diversity of ventral midbrain dopaminergic neurons (vmdns). |
2023-03-29 |
2023-08-14 |
mouse |
| Chang Li, Natalie B Saliba, Hannah Martin, Nicole A Losurdo, Kian Kolahdouzan, Riyan Siddiqui, Destynie Medeiros, Wei L. Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior. Nature communications. vol 14. issue 1. 2023-03-24. PMID:36959176. |
the dopaminergic pathways originating from the midbrain have received the most attention; however, the relevance of the cerebellar dopaminergic system is largely undiscovered. |
2023-03-24 |
2023-08-14 |
Not clear |
| Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H Y Loh, L Miguel Martin. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease. Cell death & disease. vol 14. issue 3. 2023-03-23. PMID:36949073. |
parkinson's disease (pd) is characterised by selective death of dopaminergic (da) neurons in the midbrain and motor function impairment. |
2023-03-23 |
2023-08-14 |
drosophila_melanogaster |
| J Xu, Y Li, G Zhong, Z Fang, C Liu, C Ma, C Wang, Y Guo, C Li. [Directed differentiation of human induced pluripotent stem cells into midbrain]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 43. issue 2. 2023-03-22. PMID:36946035. |
to establish an efficient protocol for directed differentiation of human induced pluripotent stem cells (hipscs) into functional midbrain dopaminergic progenitor cells (daps) |
2023-03-22 |
2023-08-14 |
human |
| Meng-Nan Liu, Xiao-Yu Tian, Ting Fang, Ning Wu, Hong Li, Jin L. Insights into the Involvement and Therapeutic Target Potential of the Dopamine System in the Posttraumatic Stress Disorder. Molecular neurobiology. 2023-03-18. PMID:36933147. |
while the midbrain dopamine system can affect physiological processes such as aversive fear memory learning, consolidation, persistence, and extinction, by altering the functions of the dopaminergic neurons, our viewpoint is that the dopamine system plays a considerable role in the ptsd occurrence and acts as a potential therapeutic target of the disorder. |
2023-03-18 |
2023-08-14 |
Not clear |
| Zhiwen You, Luyue Wang, Hui He, Ziyan Wu, Xinyue Zhang, Shuaixiang Xue, Peibo Xu, Yanhong Hong, Man Xiong, Wu Wei, Yuejun Che. Mapping of clonal lineages across developmental stages in human neural differentiation. Cell stem cell. 2023-03-18. PMID:36933556. |
specifically, we uncovered a ventral midbrain progenitor cluster as the common clonal origin of midbrain dopaminergic (mda) neurons, midbrain glutamatergic neurons, and vascular and leptomeningeal cells and identified a surface marker that can improve graft outcomes. |
2023-03-18 |
2023-08-14 |
human |
| Xiaoyi Chen, Yunjiang Feng, Ronald J Quinn, Dean L Pountney, Des R Richardson, George D Mellick, Linlin M. Pharmacological reviews. 2023-03-14. PMID:36918260. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) region of the midbrain. |
2023-03-14 |
2023-08-14 |
Not clear |
| Yu Shikano, Sho Yagishita, Kenji F Tanaka, Norio Takat. Slow-rising and fast-falling dopaminergic dynamics jointly adjust negative prediction error in the ventral striatum. The European journal of neuroscience. 2023-02-27. PMID:36843200. |
although it is well-documented that better-than-expected outcomes are encoded quantitatively via midbrain dopaminergic (da) activity, it has been less addressed experimentally whether worse-than-expected outcomes are expressed quantitatively as well. |
2023-02-27 |
2023-08-14 |
mouse |
| Andrea Becerra-Calixto, Abhisek Mukherjee, Santiago Ramirez, Sofia Sepulveda, Tirthankar Sinha, Rabab Al-Lahham, Nicole De Gregorio, Camila Gherardelli, Claudio Sot. Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson's Disease Patient. Cells. vol 12. issue 4. 2023-02-25. PMID:36831291. |
lewy body-like pathology and loss of dopaminergic neurons in midbrain organoids derived from familial parkinson's disease patient. |
2023-02-25 |
2023-08-14 |
human |
| Rachel J Boyd, Sarah A McClymont, Nelson B Barrientos, Paul W Hook, William D Law, Rebecca J Rose, Eric L Waite, Jay Rathinavelu, Dimitrios Avramopoulos, Andrew S McCallio. Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons. Research square. 2023-02-24. PMID:36824793. |
evaluating the mouse neural precursor line, sn4741, as a suitable proxy for midbrain dopaminergic neurons. |
2023-02-24 |
2023-08-14 |
mouse |
| Shanti Sibuea, Joan K Ho, Colin W Pouton, John M Hayne. TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation. Frontiers in cell and developmental biology. vol 11. 2023-02-23. PMID:36819101. |
the generation of midbrain dopaminergic neurons (mdas) from pluripotent stem cells (hpsc) holds much promise for both disease modelling studies and as a cell therapy for parkinson's disease (pd). |
2023-02-23 |
2023-08-14 |
Not clear |
| Aymen H Sadaka, Justin Canuel, Marcelo Febo, Clare T Johnson, Heather B Bradshaw, Richard Ortiz, Federica Ciumo, Praveen Kulkarni, Michael A Gitcho, Craig F Ferri. Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study. Frontiers in aging neuroscience. vol 15. 2023-02-23. PMID:36819730. |
voxel based morphometry showed a decrease in midbrain dopaminergic volume to chronic Δ9-thc followed but an increase after a two-week washout. |
2023-02-23 |
2023-08-14 |
mouse |
| Aymen H Sadaka, Justin Canuel, Marcelo Febo, Clare T Johnson, Heather B Bradshaw, Richard Ortiz, Federica Ciumo, Praveen Kulkarni, Michael A Gitcho, Craig F Ferri. Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study. Frontiers in aging neuroscience. vol 15. 2023-02-23. PMID:36819730. |
the dopaminergic midbrain system was sensitive to chronic Δ9-thc but not cbd showing robust plasticity in volume and water diffusivity prior to and following drug cessation an effect possibly related to the abuse liability of Δ9-thc. |
2023-02-23 |
2023-08-14 |
mouse |
| Aditi Verma, Reddy Peera Kommaddi, Barathan Gnanabharathi, Etienne C Hirsch, Vijayalakshmi Ravindranat. Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-02-23. PMID:36820885. |
genes essential for midbrain development and determination of dopaminergic phenotype such as, lmx1b, foxa1, rspo2, klhl1, ebf3, pitx3, rgs4, aldh1a1, ret, foxa2, en1, dlk1, gfra1, lmx1a, nr4a2, gap43, snca, pbx1, and grb10 were downregulated in human pd and overexpression of gfp tagged lmx1b rescued mpp |
2023-02-23 |
2023-08-14 |
mouse |
| Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wan. Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect. Cell reports. 2023-02-16. PMID:36796365. |
furthermore, intravenous fentanyl self-administration enhanced gabaergic striatonigral transmission and reduced midbrain dopaminergic activity. |
2023-02-16 |
2023-08-14 |
Not clear |
| Surjeet Mastwal, Xinjian Li, Rianne Stowell, Matthew Manion, Wenyu Zhang, Nam-Shik Kim, Ki-Jun Yoon, Hongjun Song, Guo-Li Ming, Kuan Hong Wan. Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function. bioRxiv : the preprint server for biology. 2023-02-13. PMID:36778456. |
the frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. |
2023-02-13 |
2023-08-14 |
mouse |
| Jayaraj John Marshal, Beena Briget Kuriakose, Amani Hamed Alhazmi, Karthikeyan Muthusam. Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease. Journal of cellular biochemistry. 2023-02-13. PMID:36780350. |
parkinson's disease (pd) is the second most common neurodegenerative disorder that affects dopaminergic neurons in the midbrain. |
2023-02-13 |
2023-08-14 |
Not clear |