| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
our findings pinpoint the bh4 pathway as a key metabolic program at the intersection of multiple protective mechanisms for the health and function of midbrain dopaminergic neurons, identifying it as a potential therapeutic target for pd. |
2023-05-23 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-05-15 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the gradual loss of midbrain dopaminergic neurons in association with aggregation of α-synuclein. |
2023-05-15 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
here, we demonstrated that preferential accumulation of peroxidized phospholipids and loss of the antioxidant enzyme glutathione peroxidase 4 (gpx4) were responsible for vulnerability of midbrain dopaminergic neurons and progressive motor dysfunctions in a mouse model of pd. |
2023-05-15 |
2023-08-14 |
mouse |
| Jayanth Anantha, Fionnuala E Wilson, Erin McCarthy, Noelia Morales Prieto, Martina Mazzocchi, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. A combined proteomics and bioinformatics analysis of ZNHIT1-interacting proteins reveals a significant enrichment in proteins associated with mitochondrial function. Journal of chemical neuroanatomy. 2023-05-13. PMID:37178741. |
these data suggest that the reported beneficial effects of znhit1 on atp production may be mediated, at least in part, by its direct interaction with mitochondrial proteins and suggest that potential alterations in znhit1 in pd, may contribute to the known impairments in atp generation in midbrain dopaminergic neurons in pd. |
2023-05-13 |
2023-08-14 |
Not clear |
| Cheng-Bo He, Yuan Jin, Yan Li, Qian Zhang, Bai Yang, Mang Xu, Juan Yang, Xi-Nan Yi, Yu-Lin Dong, Jian Wang, Yun-Qing L. Collateral projections from the ventral tegmental area/substantia nigra pars compacta to the nucleus accumbens and insular cortex in the rat. Anatomical science international. 2023-05-10. PMID:37160827. |
midbrain dopaminergic (daergic) regions including ventral tegmental area (vta) and substantia nigra pars compacta (snc) are involved in diverse brain functions. |
2023-05-10 |
2023-08-14 |
rat |
| Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova, Volodymyr V Shvadcha. Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity. ACS chemical neuroscience. 2023-05-10. PMID:37162160. |
parkinson's disease is characterized by the selective death of dopaminergic neurons in the midbrain and accumulation of amyloid fibrils composed of α-synuclein (αsyn). |
2023-05-10 |
2023-08-14 |
rat |
| Mitali A Tambe, Aurelie de Rus Jacquet, Katherine E Strathearn, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163110. |
here, we characterized botanical extracts enriched with a mixed profile of polyphenols, as well as a set of purified polyphenolic standards, in terms of their ability to mitigate dopaminergic cell death in midbrain cultures exposed to another pd-related toxicant, paraquat (pq), and we examined underlying neuroprotective mechanisms. |
2023-05-10 |
2023-08-14 |
Not clear |
| Mitali A Tambe, Aurelie de Rus Jacquet, Katherine E Strathearn, Gad G Yousef, Mary H Grace, Mario G Ferruzzi, Qingli Wu, James E Simon, Mary Ann Lila, Jean-Christophe Roche. Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37163110. |
several extracts or compounds with the ability to protect against pq neurotoxicity increased the activity of the antioxidant transcription factor nrf2 in cultured astrocytes, and pq-induced dopaminergic cell death was attenuated in nrf2-expressing midbrain cultures. |
2023-05-10 |
2023-08-14 |
Not clear |
| Guy C Brown, Marta Camacho, Caroline H Williams-Gra. The Endotoxin Hypothesis of Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2023-05-09. PMID:37157885. |
the evidence supporting this hypothesis includes: (1) gut dysfunction, permeability, and bacterial changes occur early in pd, (2) serum levels of lps are increased in a proportion of pd patients, (3) lps induces α-synuclein expression, aggregation, and neurotoxicity, (4) lps causes activation of peripheral monocytes leading to inflammatory cytokine production, and (5) blood lps causes brain inflammation and specific loss of midbrain dopaminergic neurons, mediated by microglia. |
2023-05-09 |
2023-08-14 |
Not clear |
| Reinis Svarcbahs, Sarah M Blossom, Helena S Baffoe-Bonnie, Kathleen A Trychta, Lacey K Greer, James Pickel, Mark J Henderson, Brandon K Harve. Atransgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis. Transgenic research. 2023-05-03. PMID:37133648. |
in lsl-sercamp × alb-cre mice, robust gluc activity was observed only in the liver and blood, whereas in lsl-sercamp × dat-cre mice, gluc activity was seen in midbrain dopaminergic neurons and tissue samples innervated by dopaminergic projections. |
2023-05-03 |
2023-08-14 |
mouse |
| Amirah E-E Aly, Tao Sun, Yongzhi Zhang, Zejun Li, Margee Kyada, Qingxi Ma, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Nathan J McDannold, Barbara L Waszcza. Focused ultrasound enhances transgene expression of intranasal hGDNF DNA nanoparticles in the sonicated brain regions. Journal of controlled release : official journal of the Controlled Release Society. 2023-05-01. PMID:37127076. |
additionally, fus with intranasal delivery increased transgene expression in the sonicated hemisphere by over 80%, altered cellular transfection patterns at the sonication sites, and improved penetration of plasmid nps into the brain parenchyma (with a 1-fold and 3-fold increase in proximity of transgene expression to neurons in the forebrain and midbrain respectively, and a 40% increase in proximity of transgene expression to dopaminergic neurons in the substantia nigra). |
2023-05-01 |
2023-08-14 |
Not clear |
| Delaney L Davis, Daniel B Metzger, Philip H Vann, Jessica M Wong, Ritu A Shetty, Michael J Forster, Nathalie Sumie. Effects of chronic methamphetamine exposure on rewarding behavior and neurodegeneration markers in adult mice. Psychopharmacology. 2023-05-01. PMID:37127834. |
the midbrain and striatum, regions involved in reward circuit, were assessed for markers associated with neurotoxicity, dopaminergic function, neuroinflammation and epigenetic changes after behavioral testing.previous exposure to chronic meth did not have significant short-term effects on cpp response but led to a decreased cpp response in 10-month-old females. |
2023-05-01 |
2023-08-14 |
mouse |
| Benjamin D Hobson, Adrien T Stanley, Mark B De Los Santos, Bruce Culbertson, Eugene V Mosharov, Peter A Sims, David Sulze. Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain. Brain, behavior, and immunity. 2023-04-26. PMID:37100211. |
we found that ifn-γ upregulated mhc-i and associated mrnas in ventral midbrain microglia, astrocytes, oligodendrocytes, and gabaergic, glutamatergic, and dopaminergic neurons. |
2023-04-26 |
2023-08-14 |
mouse |
| Naisarg Gamit, Arun Dharmarajan, Gautam Sethi, Sudha Warrie. Want of Wnt in Parkinson's disease: Could sFRP disrupt interplay between Nurr1 and Wnt signaling? Biochemical pharmacology. 2023-04-23. PMID:37088155. |
nuclear receptor related 1 (nurr1) is a transcription factor known to regulate the development and maintenance of midbrain dopaminergic (mda) neurons. |
2023-04-23 |
2023-08-14 |
Not clear |
| L Sofia Gonzalez, Austen A Fisher, Shane P D'Souza, Evelin M Cotella, Richard A Lang, J Elliott Robinso. Ventral striatum dopamine release encodes unique properties of visual stimuli in mice. eLife. vol 12. 2023-04-17. PMID:37067979. |
in this circuitry, ascending dopaminergic projections from the ventral midbrain innervate targets throughout the limbic forebrain, such as the ventral striatum/nucleus accumbens (nac). |
2023-04-17 |
2023-08-14 |
mouse |
| Athanasios Kournoutis, Terje Johanse. LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons. The Journal of cell biology. vol 222. issue 5. 2023-04-10. PMID:37036692. |
cell biol.https://doi.org/10.1083/jcb.201910133) report that nuclear lc3b binds to the lim homeodomain transcription factor lmx1b and acts as a cofactor for lmx1b-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons. |
2023-04-10 |
2023-08-14 |
Not clear |
| Jeong Pyo Seo, Dong Kyun Ko. Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study. Medicine. vol 102. issue 14. 2023-04-07. PMID:37026940. |
the nigrostriatal tract (nst) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. |
2023-04-07 |
2023-08-14 |
human |
| Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lan. ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. The Journal of cell biology. vol 222. issue 5. 2023-04-04. PMID:37014324. |
atg8-dependent lmx1b-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. |
2023-04-04 |
2023-08-14 |
human |
| Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lan. ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. The Journal of cell biology. vol 222. issue 5. 2023-04-04. PMID:37014324. |
the lim homeodomain transcription factors lmx1a and lmx1b are essential mediators of midbrain dopaminergic neuronal (mdan) differentiation and survival. |
2023-04-04 |
2023-08-14 |
human |