| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattor. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. Frontiers in neuroscience. vol 17. 2023-07-28. PMID:37502682. |
parkinson's disease (pd) is a progressive neurodegenerative condition that primarily affects motor functions; it is caused by the loss of midbrain dopaminergic (mda) neurons. |
2023-07-28 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
one-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of parkinson's disease. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
transplantation of midbrain dopaminergic progenitor cells is a promising treatment for parkinson's disease. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
here, we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
these beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion, effectively maintaining axonal integrity in vitro. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. |
2023-07-25 |
2023-08-14 |
human |
| Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wan. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation Neural regeneration research. vol 19. issue 2. 2023-07-25. PMID:37488911. |
overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation. |
2023-07-25 |
2023-08-14 |
human |
| Cameron D Hassall, Yan Yan, Laurence T Hun. The neural correlates of continuous feedback processing. Psychophysiology. 2023-07-24. PMID:37485986. |
such studies have led to the hypothesis that rapid phasic midbrain dopaminergic activity tracks reward prediction errors (rpes), the effects of which are measurable at the scalp via electroencephalography (eeg). |
2023-07-24 |
2023-08-14 |
human |
| Cameron D Hassall, Yan Yan, Laurence T Hun. The neural correlates of continuous feedback processing. Psychophysiology. 2023-07-24. PMID:37485986. |
although studies using continuous feedback are sparse, recent animal work suggests that moment-to-moment changes in reward are tracked by slowly ramping midbrain dopaminergic activity. |
2023-07-24 |
2023-08-14 |
human |
| Amélie Weiss, Peter Sommer, Johannes H Wilbert. Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons. Journal of visualized experiments : JoVE. issue 197. 2023-07-24. PMID:37486112. |
phenotypic profiling of human stem cell-derived midbrain dopaminergic neurons. |
2023-07-24 |
2023-08-14 |
human |
| Amélie Weiss, Peter Sommer, Johannes H Wilbert. Phenotypic Profiling of Human Stem Cell-Derived Midbrain Dopaminergic Neurons. Journal of visualized experiments : JoVE. issue 197. 2023-07-24. PMID:37486112. |
parkinson's disease (pd) is linked to a range of cell biological processes that cause midbrain dopaminergic (mda) neuron loss. |
2023-07-24 |
2023-08-14 |
human |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
perturbation of serine enantiomers homeostasis in the striatum of mptp-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. |
2023-07-14 |
2023-08-14 |
mouse |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the post-mortem caudate putamen (cpu) of parkinson's disease (pd) patients. |
2023-07-14 |
2023-08-14 |
mouse |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
here, through high-performance liquid chromatography (hplc), we measured the levels of these amino acids in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys and mptp-plus-probenecid (mptpp)-treated mice to determine whether and how dopaminergic midbrain degeneration affects the levels of serine enantiomers in various basal ganglia subregions. |
2023-07-14 |
2023-08-14 |
mouse |
| Hiromi Sano, Atsushi Namb. Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice. Frontiers in aging neuroscience. vol 15. 2023-07-13. PMID:37441679. |
however, it has also shown its beneficial effects on parkinson's disease (pd), a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain. |
2023-07-13 |
2023-08-14 |
mouse |
| Virginie J Oberto, Jumpei Matsumoto, Marco N Pompili, Ralitsa Todorova, Francesco Papaleo, Hisao Nishijo, Laurent Venance, Marie Vandecasteele, Sidney I Wiene. Rhythmic oscillations in the midbrain dopaminergic nuclei in mice. Frontiers in cellular neuroscience. vol 17. 2023-07-10. PMID:37426551. |
rhythmic oscillations in the midbrain dopaminergic nuclei in mice. |
2023-07-10 |
2023-08-14 |
mouse |
| Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 13. 2023-07-03. PMID:37395283. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-07-03 |
2023-08-14 |
Not clear |
| Jeong Pyo Seo, Heun Jae Ry. Neural Injury of the Dopaminergic Pathways in Patients with Middle Cerebral Artery Territory Infarct: A Diffusion Tensor Imaging Study. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371405. |
the mesocortical tract (mct) and mesolimbic tract (mlt), dopaminergic pathways originating from the ventral tegmental area in the midbrain to the ventral striatum (nucleus accumbens) and prefrontal cortex, play a crucial role in regulating incentive salience. |
2023-06-28 |
2023-08-14 |
Not clear |
| Erika D L R M Cabrera Ranaldi, Karen Nuytemans, Anisley Martinez, Corneliu C Luca, Robert W Keane, Juan Pablo de Rivero Vaccar. Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 6. 2023-06-28. PMID:37375830. |
parkinson's disease (pd) is a neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain, the accumulation of α-synuclein aggregates, and motor deficits. |
2023-06-28 |
2023-08-14 |
human |
| Takeshi Kato, Kaneyasu Nishimura, Masahiro Hirao, Shun Shimohama, Kazuyuki Takat. Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells. Neuropsychopharmacology reports. 2023-06-27. PMID:37366076. |
nicotinic acetylcholine receptors (nachrs) expressed in midbrain dopaminergic (mda) neurons modulate mda neuronal activity. |
2023-06-27 |
2023-08-14 |
human |