| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W G Kim, R P Mohney, B Wilson, G H Jeohn, B Liu, J S Hon. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 16. 2000-08-31. PMID:10934283. |
when mixed neuron-glia cultures derived from the rat hippocampus, cortex, or mesencephalon were treated with lps, mesencephalic cultures became sensitive to lps at a concentration as low as 10 ng/ml and responded in a dose-dependent manner with the production of inflammatory factors and a loss of dopaminergic and other neurons. |
2000-08-31 |
2023-08-12 |
rat |
| Y Tan, E A Williams, A J Lancia, D S Zah. On the altered expression of tyrosine hydroxylase and calbindin-D 28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865059. |
it is expressed in midbrain dopaminergic neurons reported to be relatively resistant to degeneration in parkinson's disease and certain of its animal models. |
2000-08-25 |
2023-08-12 |
rat |
| A S Nagano, K Ito, T Kato, Y Arahata, T Kachi, K Hatano, Y Kawasumi, A Nakamura, T Yamada, Y Abe, T Ishigak. Extrastriatal mean regional uptake of fluorine-18-FDOPA in the normal aged brain--an approach using MRI-aided spatial normalization. NeuroImage. vol 11. issue 6 Pt 1. 2000-08-23. PMID:10860800. |
automatic roi analysis of the spatially normalized fdopa k(i) images of the normal subjects, showed high k(i) values in ventral and dorsal regions of the midbrain, amygdala, hippocampus, and medial prefrontal cortex, in addition to caudate nucleus and putamen, which correspond to the dopaminergic projections in the brain. |
2000-08-23 |
2023-08-12 |
human |
| W J Smeets, O Marín, A Gonzále. Evolution of the basal ganglia: new perspectives through a comparative approach. Journal of anatomy. vol 196 ( Pt 4). 2000-08-22. PMID:10923983. |
by using the comparative approach, new insights have been gained with respect to certain features of the bg of vertebrates in general, such as the segmental organisation of the midbrain dopaminergic cell groups, the occurrence of large numbers of dopaminergic cell bodies within the telencephalon itself and the variability in, among others, connectivity and chemoarchitecture. |
2000-08-22 |
2023-08-12 |
Not clear |
| S K Michelhaugh, M E Gneg. Differential regulation of calmodulin content and calmodulin messenger RNA levels by acute and repeated, intermittent amphetamine in dopaminergic terminal and midbrain areas. Neuroscience. vol 98. issue 2. 2000-08-18. PMID:10854758. |
differential regulation of calmodulin content and calmodulin messenger rna levels by acute and repeated, intermittent amphetamine in dopaminergic terminal and midbrain areas. |
2000-08-18 |
2023-08-12 |
rat |
| S J Cragg, D J Clarke, S A Greenfiel. Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877925. |
intrastriatal transplantation of foetal midbrain dopamine (da) neurons ameliorates the fundamental symptoms of dopaminergic denervation in clinical and experimental parkinsonism despite providing only restricted reinnervation. |
2000-08-16 |
2023-08-12 |
Not clear |
| L C Wang, A Shih, J Hongo, B Devaux, M Hyne. Broad specificity of GDNF family receptors GFRalpha1 and GFRalpha2 for GDNF and NTN in neurons and transfected cells. Journal of neuroscience research. vol 61. issue 1. 2000-08-14. PMID:10861794. |
we examined here whether crosstalk between the gdnf ligands and the gfralphas is biologically relevant, using midbrain dopaminergic, and parasympathetic, submandibular gland neurons. |
2000-08-14 |
2023-08-12 |
Not clear |
| M J Thomas, R C Malenka, A Bonc. Modulation of long-term depression by dopamine in the mesolimbic system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908594. |
using whole-cell patch-clamp recording techniques from in vitro slice preparations, we have examined the existence and basic mechanisms of long-term depression (ltd) at excitatory synapses on both gabaergic medium spiny neurons in the nac and dopaminergic neurons in the midbrain. |
2000-08-10 |
2023-08-12 |
Not clear |
| I P Bystron', V A Otelli. [The prenatal development of the tectum mesencephali and substantia nigra in man]. Morfologiia (Saint Petersburg, Russia). vol 117. issue 2. 2000-08-04. PMID:10853251. |
using electron microscopy and immunocytochemistry processes that occur in the anlage of tectum of the midbrain at early stages of formation of dopaminergic populations of cells were followed up. |
2000-08-04 |
2023-08-12 |
human |
| D D Song, S N Habe. Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864967. |
in support of compensatory sprouting by tyrosine hydroxylase fibers, mrna for growth associated protein-43 was upregulated in dopaminergic midbrain cells. |
2000-07-26 |
2023-08-12 |
Not clear |
| S Al-Adawi, G S Dawe, A A Al-Hussain. Aboulia: neurobehavioural dysfunction of dopaminergic system? Medical hypotheses. vol 54. issue 4. 2000-07-10. PMID:10859635. |
in this review, various studies will be considered which proffer converging evidence that the dopaminergic brain circuitry running from ventral tegmental areas in the midbrain, via nucleus accumbens in the forebrain, to the frontal cortex, tends to produce aboulia when its restitutive function fails. |
2000-07-10 |
2023-08-12 |
Not clear |
| P P Gao, C H Sun, X F Zhou, E DiCicco-Bloom, R Zho. Ephrins stimulate or inhibit neurite outgrowth and survival as a function of neuronal cell type. Journal of neuroscience research. vol 60. issue 4. 2000-06-23. PMID:10797545. |
interactions between the ligands and receptors cause repulsion or degeneration of receptor-positive axons from several brain regions including the retina, hippocampus, thalamus, and midbrain dopaminergic system. |
2000-06-23 |
2023-08-12 |
Not clear |
| T González-Hernández, M Rodrígue. Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat. The Journal of comparative neurology. vol 421. issue 1. 2000-06-23. PMID:10813775. |
the substantia nigra (sn) is a midbrain center composed of dopaminergic (da-) and gamma aminobutyric acid (gaba)ergic (gaba-) neurons. |
2000-06-23 |
2023-08-12 |
rat |
| K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
it is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-ht2a receptors at the level of their originating nuclei. |
2000-06-21 |
2023-08-12 |
human |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
treatment of rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (lps)-activated microglia, resident immune cells of the brain, to release proinflammatory and neurotoxic factors tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and superoxide and subsequently caused damage to midbrain neurons, including dopaminergic neurons. |
2000-06-21 |
2023-08-12 |
rat |
| B Liu, L Du, J S Hon. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773035. |
these results suggest that naloxone at least in part interferes with the binding of lps to cell membranes to inhibit microglia activation and protect dopaminergic neurons as well as other neurons in the midbrain cultures from inflammatory damage. |
2000-06-21 |
2023-08-12 |
rat |
| S Nakamura, Y Ito, R Shirasaki, F Murakam. Local directional cues control growth polarity of dopaminergic axons along the rostrocaudal axis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818146. |
here, we examined the mechanism that guides midbrain dopaminergic axons rostrally, using flat whole-mount preparations of embryonic rat brain both in vivo and in vitro. |
2000-06-15 |
2023-08-12 |
rat |
| S Nakamura, Y Ito, R Shirasaki, F Murakam. Local directional cues control growth polarity of dopaminergic axons along the rostrocaudal axis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 11. 2000-06-15. PMID:10818146. |
at embryonic day 11 (e11) and early stage e12, dopaminergic neurons in the ventral midbrain extended short axons dorsally. |
2000-06-15 |
2023-08-12 |
rat |
| P Lingor, K Unsicker, K Krieglstei. GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. Experimental neurology. vol 163. issue 1. 2000-06-13. PMID:10785444. |
gdnf and nt-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. |
2000-06-13 |
2023-08-12 |
rat |
| P Hou, A Di, P Huang, C B Hansen, D J Nelso. Impermeability of the GIRK2 weaver channel to divalent cations. American journal of physiology. Cell physiology. vol 278. issue 5. 2000-06-12. PMID:10794678. |
the mutant channel subunit (girk2wv) causes the pleiotropic weaver disease in mice, which is characterized by the selective vulnerability of cerebellar granule cells and purkinje cells, as well as dopaminergic neurons in the mesencephalon, to cell death. |
2000-06-12 |
2023-08-12 |
mouse |