| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Murphy, L Ghazi, A Kokabi, G Elliso. Prenatal cocaine produces signs of neurodegeneration in the lateral habenula. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642841. |
the lateral habenula is a nucleus in the dorsal thalamus that innervates midbrain dopaminergic and serotonergic nuclei via projections through its major efferent pathway, the fasciculus retroflexus (fr). |
2000-02-24 |
2023-08-12 |
rat |
| C Perrone-Capano, P Da Pozzo, U di Porzi. Epigenetic cues in midbrain dopaminergic neuron development. Neuroscience and biobehavioral reviews. vol 24. issue 1. 2000-02-17. PMID:10654667. |
midbrain dopaminergic (da) neurons subserve complex and varied neural functions in vertebrate cns. |
2000-02-17 |
2023-08-12 |
Not clear |
| V A Russel. The nucleus accumbens motor-limbic interface of the spontaneously hypertensive rat as studied in vitro by the superfusion slice technique. Neuroscience and biobehavioral reviews. vol 24. issue 1. 2000-02-17. PMID:10654669. |
the behavioral disturbances of attention-deficit hyperactivity disorder (adhd) have been attributed to dysfunction of the mesolimbic dopaminergic (da) projection from the ventral tegmental area of the midbrain. |
2000-02-17 |
2023-08-12 |
rat |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
we utilized organotypic midbrain slice cultures for the assessment of survival and degeneration of dopaminergic neurons in the substantia nigra. |
2000-02-16 |
2023-08-12 |
Not clear |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
application of n-methyl-d-aspartate (nmda) to midbrain slice cultures for 24 h caused a concentration-dependent decrease in the number of surviving dopaminergic neurons visualized by tyrosine hydroxylase immunohistochemistry. |
2000-02-16 |
2023-08-12 |
Not clear |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
we also prepared co-cultures of midbrain and striatal slices to investigate whether the presence of target tissue influences toxic actions of several drugs on dopaminergic neurons. |
2000-02-16 |
2023-08-12 |
Not clear |
| H Katsuki, T Kume, S Kaneko, A Akaik. [Factors regulating survival and death of midbrain dopamine neurons]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 114 Suppl 1. 2000-02-16. PMID:10629879. |
dopaminergic neurons in midbrain--striatum co-cultures were more resistant to the cytotoxic actions of nmda and a nitric oxide donor noc-18, than the same neuronal population in single midbrain cultures. |
2000-02-16 |
2023-08-12 |
Not clear |
| V Seutin, F Mkahli, L Massotte, A Dress. Calcium release from internal stores is required for the generation of spontaneous hyperpolarizations in dopaminergic neurons of neonatal rats. Journal of neurophysiology. vol 83. issue 1. 2000-02-16. PMID:10634866. |
we recently have demonstrated the existence of spontaneous hyperpolarizations in midbrain dopaminergic neurons of neonatal but not adult rats. |
2000-02-16 |
2023-08-12 |
rat |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| S R Sinclair, J W Fawcett, S B Dunnet. Dopamine cells in nigral grafts differentiate prior to implantation. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594660. |
precursor cells that would differentiate into dopaminergic neurons beyond e14 if left in situ in the intact ventral mesencephalon do not readily differentiate into mature dopamine neurons following transplantation. |
2000-02-10 |
2023-08-12 |
rat |
| M Vila, S Vukosavic, V Jackson-Lewis, M Neystat, M Jakowec, S Przedborsk. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. Journal of neurochemistry. vol 74. issue 2. 2000-02-10. PMID:10646524. |
after a regimen of mptp that kills dopaminergic neurons by apoptosis, synuclein mrna and protein levels were increased significantly in midbrain extracts; the time course of these changes paralleled that of mptp-induced dopaminergic neurodegeneration. |
2000-02-10 |
2023-08-12 |
mouse |
| B Gronier, K Rasmusse. Pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. Neuropharmacology. vol 38. issue 12. 2000-01-18. PMID:10608285. |
pertussis toxin treatment differentially affects cholinergic and dopaminergic receptor stimulation of midbrain dopaminergic neurons. |
2000-01-18 |
2023-08-12 |
rat |
| G S Kaminski Schierle, O Hansson, P Brundi. Flunarizine improves the survival of grafted dopaminergic neurons. Neuroscience. vol 94. issue 1. 2000-01-14. PMID:10613492. |
addition of 1 microm flunarizine inhibited cell death in a suspension of cells derived from the rat's ventral mesencephalon and when such a treated suspension was injected into the neostriatum there was a 2.6-fold greater number of surviving dopaminergic neurons, a doubling of the graft volume and a doubling of the volume of the host neostriatum innervated by dopaminergic fibers from the graft, compared with suspensions not exposed to flunarizine. |
2000-01-14 |
2023-08-12 |
rat |
| D C German, K F Manaye, D Wu, L B Hersh, R M Zwei. Mesopontine cholinergic and non-cholinergic neurons in schizophrenia. Neuroscience. vol 94. issue 1. 2000-01-14. PMID:10613494. |
mesopontine cholinergic neurons influence midbrain dopaminergic neurons, and thalamic and cerebellar structures which have been implicated in the neuroanatomy of schizophrenia. |
2000-01-14 |
2023-08-12 |
Not clear |
| M Blum, C Weickert, E Carrasc. The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619558. |
however, when we assessed whether thyroid hormone replacement could rescue midbrain dopaminergic neurons we found that this treatment accelerated rather than attenuated neurodegeneration. |
2000-01-14 |
2023-08-12 |
mouse |
| M Blum, C Weickert, E Carrasc. The weaver GIRK2 mutation leads to decreased levels of serum thyroid hormone: characterization of the effect on midbrain dopaminergic neuron survival. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619558. |
we did not observe that thyroid hormone was able to directly regulate expression of girk2 mrna levels in the midbrain and therefore, speculate that the mechanism by which thyroid hormone accelerates midbrain dopaminergic neurodegeneration is by enhancing the maturation of the striatonigral inputs. |
2000-01-14 |
2023-08-12 |
mouse |
| N le Novère, M Zoli, C Léna, R Ferrari, M R Picciotto, E Merlo-Pich, J P Changeu. Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion. Neuroreport. vol 10. issue 12. 1999-12-21. PMID:10574359. |
the nicotinic receptor subunit alpha6 is, among other subunits, strongly expressed in the dopaminergic neurons of the mesencephalon. |
1999-12-21 |
2023-08-12 |
Not clear |
| S A Oakman, P L Faris, C Cozzari, B K Hartma. Characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579214. |
characterization of the extent of pontomesencephalic cholinergic neurons' projections to the thalamus: comparison with projections to midbrain dopaminergic groups. |
1999-12-21 |
2023-08-12 |
Not clear |
| B Amini, J W Clark, C C Canavie. Calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study. Journal of neurophysiology. vol 82. issue 5. 1999-12-17. PMID:10561403. |
calcium dynamics underlying pacemaker-like and burst firing oscillations in midbrain dopaminergic neurons: a computational study. |
1999-12-17 |
2023-08-12 |
Not clear |