| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
pharmacological identification of the k(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. |
2000-05-25 |
2023-08-12 |
rat |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
hypoglycemia (zero glucose) initially depolarized the membrane and increased the spontaneous firing of rat midbrain dopaminergic neurones (more than 50%) intracellularly recorded in an in vitro slice preparation. |
2000-05-25 |
2023-08-12 |
rat |
| S Marinelli, G Bernardi, P Giacomini, N B Mercur. Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones. Neuropharmacology. vol 39. issue 6. 2000-05-25. PMID:10727712. |
our data suggest that midbrain dopaminergic cells respond to glucose deprivation with a hyperpolarization generated by the opening of several k(+) channels (sulphonylurea-sensitive, charybdotoxin-sensitive and sulphonylurea and charybdotoxin-insensitive) and by the activation of the na(+)/k(+) atpase pump after the hypoglycemic period. |
2000-05-25 |
2023-08-12 |
rat |
| P Liberini, S Parola, P F Spano, L Antonin. Olfaction in Parkinson's disease: methods of assessment and clinical relevance. Journal of neurology. vol 247. issue 2. 2000-05-19. PMID:10751109. |
moreover, indirect evidence suggests that dysfunction of the dopaminergic pathways from mesencephalon to the piriform cortex may play a role in olfactory impairment in pd. |
2000-05-19 |
2023-08-12 |
Not clear |
| F Xu, R R Gainetdinov, W C Wetsel, S R Jones, L M Bohn, G W Miller, Y M Wang, M G Caro. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nature neuroscience. vol 3. issue 5. 2000-05-18. PMID:10769386. |
thus altering net expression significantly modulates midbrain dopaminergic function, an effect that may be an important component of the actions of antidepressants and psychostimulants. |
2000-05-18 |
2023-08-12 |
mouse |
| X Zhou, W Zhang, T Ba. [Expression of glial cells line-derived neurotrophic factor in the central nervous system of rat]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 29. issue 3. 2000-04-25. PMID:10684095. |
glial cell line-derived neurotrophic factor (gdnf) iss a distant member of the transforming growth factor-beta, originally isolated by virtue of its ability to induce dopamine uptake and cell survival in cultures of embryonic ventral midbrain dopaminergic neurons, and more recently it has been shown to be a potent neurotrophic factor for motor neurons. |
2000-04-25 |
2023-08-12 |
rat |
| A Hartmann, S Hunot, P P Michel, M P Muriel, S Vyas, B A Faucheux, A Mouatt-Prigent, H Turmel, A Srinivasan, M Ruberg, G I Evan, Y Agid, E C Hirsc. Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10688892. |
using caspase-3 immunohistochemistry on the postmortem human brain, we observed a positive correlation between the degree of neuronal loss in dopaminergic (da) cell groups affected in the mesencephalon of pd patients and the percentage of caspase-3-positive neurons in these cell groups in control subjects and a significant decrease of caspase-3-positive pigmented neurons in the substantia nigra pars compacta of pd patients compared with controls that also could be observed in an animal model of pd. |
2000-04-25 |
2023-08-12 |
human |
| E Koga, T Momiyam. Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones. The Journal of physiology. vol 523 Pt 1. 2000-04-18. PMID:10673553. |
the effects of dopamine (da) on non-nmda glutamatergic transmission onto dopaminergic neurones in the ventral tegmental area (vta) were examined in rat midbrain slices using the whole-cell patch-clamp technique. |
2000-04-18 |
2023-08-12 |
rat |
| J N Kay, M Blu. Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. Developmental neuroscience. vol 22. issue 1-2. 2000-04-11. PMID:10657698. |
differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. |
2000-04-11 |
2023-08-12 |
mouse |
| R A Barker, E Ratcliffe, A Richards, S B Dunnet. Fetal porcine dopaminergic cell survival in vitro and its relationship to embryonic age. Cell transplantation. vol 8. issue 6. 2000-03-30. PMID:10701488. |
this is especially the case for the developing dopaminergic neurons in the embryonic ventral mesencephalon, which are used for neural grafts in parkinson's disease (pd). |
2000-03-30 |
2023-08-12 |
mouse |
| S Shimazu, H Katsuki, C Takenaka, M Tomita, T Kume, S Kaneko, A Akaik. sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666505. |
when challenged with 100-microm n-methyl-d-aspartate (nmda) for 24 h, dopaminergic neurons in midbrain slice cultures degenerated, and this was prevented by (5r, 10s)-(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,b]-cyclohepten-5, 10-imine (mk-801; 1-10 microm). |
2000-03-16 |
2023-08-12 |
Not clear |
| S Shimazu, H Katsuki, C Takenaka, M Tomita, T Kume, S Kaneko, A Akaik. sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666505. |
these results indicate that sigma receptor ligands attenuate the cytotoxic effects of nmda on midbrain dopaminergic neurons, possibly via inhibition of nmda receptor functions. |
2000-03-16 |
2023-08-12 |
Not clear |
| R H Baloh, M G Tansey, E M Johnson, J Milbrand. Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists. The Journal of biological chemistry. vol 275. issue 5. 2000-03-02. PMID:10652334. |
the glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) (gdnf, neurturin, artemin, and persephin) are critical regulators of neurodevelopment and support the survival of midbrain dopaminergic and spinal motor neurons in vitro and in animal disease models making them attractive therapeutic candidates for treatment of neurodegenerative diseases. |
2000-03-02 |
2023-08-12 |
Not clear |
| N Kubis, B A Faucheux, G Ransmayr, P Damier, C Duyckaerts, D Henin, B Forette, Y Le Charpentier, J J Hauw, Y Agid, E C Hirsc. Preservation of midbrain catecholaminergic neurons in very old human subjects. Brain : a journal of neurology. vol 123 ( Pt 2). 2000-02-25. PMID:10648443. |
parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. |
2000-02-25 |
2023-08-12 |
human |
| C Beyer, M Karolcza. Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658191. |
estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on camp/protein kinase a signalling. |
2000-02-25 |
2023-08-12 |
mouse |
| C Beyer, M Karolcza. Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658191. |
previous work from this laboratory indicates that the differentiation of mouse midbrain dopaminergic neurons is influenced by estrogen. |
2000-02-25 |
2023-08-12 |
mouse |
| C Beyer, M Karolcza. Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling. Journal of neuroscience research. vol 59. issue 1. 2000-02-25. PMID:10658191. |
in addition, estrogen exposure stimulated the phosphorylation of creb in midbrain dopaminergic cells as studied by quantitative double-labelling immunocytochemistry and gel shift assay. |
2000-02-25 |
2023-08-12 |
mouse |
| C Bäckman, T Perlmann, A Wallén, B J Hoffer, M Morale. A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642835. |
recent analyses of nurr1 null mutant mice have shown that nurr1 is essential for the development and survival of midbrain dopaminergic neurons. |
2000-02-24 |
2023-08-12 |
mouse |
| C Bäckman, T Perlmann, A Wallén, B J Hoffer, M Morale. A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642835. |
nurr1 expression was confined to periglomerular and midbrain dopaminergic neurons. |
2000-02-24 |
2023-08-12 |
mouse |
| C Bäckman, T Perlmann, A Wallén, B J Hoffer, M Morale. A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain. Brain research. vol 851. issue 1-2. 2000-02-24. PMID:10642835. |
these results suggest that within the adult mouse brain, nurr1 may participate in dopaminergic functions of the olfactory bulb and midbrain. |
2000-02-24 |
2023-08-12 |
mouse |