| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luke T Coddington, Joshua T Dudma. Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity. Neuron. vol 104. issue 1. 2020-03-31. PMID:31600516. |
in vertebrates, this is thought to depend upon the release of dopamine from midbrain dopaminergic neurons. |
2020-03-31 |
2023-08-13 |
Not clear |
| Minho Moon, Eun Sun Jung, Seong Gak Jeon, Moon-Yong Cha, Yongwoo Jang, Woori Kim, Claudia Lopes, Inhee Mook-Jung, Kwang-Soo Ki. Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model. Aging cell. vol 18. issue 1. 2020-03-30. PMID:30515963. |
the orphan nuclear receptor nurr1 (also known as nr4a2) is critical for the development and maintenance of midbrain dopaminergic neurons, and is associated with parkinson's disease. |
2020-03-30 |
2023-08-13 |
mouse |
| Douglas R Miller, Joseph J Lebowitz, Dylan T Guenther, Alexander J Refowich, Carissa Hansen, Andrew P Maurer, Habibeh Khoshboue. Methamphetamine regulation of activity and topology of ventral midbrain networks. PloS one. vol 14. issue 9. 2020-03-23. PMID:31536584. |
both gabaergic and dopaminergic neurons were heavily featured within the primary ventral midbrain network model system. |
2020-03-23 |
2023-08-13 |
Not clear |
| John M Bruning, Yan Wang, Francesca Oltrabella, Boxue Tian, Svetlana A Kholodar, Harrison Liu, Paulomi Bhattacharya, Su Guo, James M Holton, Robert J Fletterick, Matthew P Jacobson, Pamela M Englan. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. vol 26. issue 5. 2020-03-12. PMID:30853418. |
nurr1, a nuclear receptor essential for the development, maintenance, and survival of midbrain dopaminergic neurons, is a potential therapeutic target for parkinson's disease, a neurological disorder characterized by the degeneration of these same neurons. |
2020-03-12 |
2023-08-13 |
zebrafish |
| Carl G Gottschalk, Avik Roy, Malabendu Jana, Madhuchhanda Kundu, Kalipada Paha. Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31127527. |
nuclear receptor related 1 protein (nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (da) neurons. |
2020-03-12 |
2023-08-13 |
Not clear |
| Francesca Montarolo, Serena Martire, Simona Perga, Michela Spadaro, Irene Brescia, Sarah Allegra, Silvia De Francia, Antonio Bertolott. NURR1 deficiency is associated to ADHD-like phenotypes in mice. Translational psychiatry. vol 9. issue 1. 2020-03-09. PMID:31455763. |
the transcription factor nurr1 regulates the dopamine (da) signaling pathway and exerts a critical role in the development of midbrain dopaminergic neurons (mda). |
2020-03-09 |
2023-08-13 |
mouse |
| Angelique di Domenico, Giulia Carola, Carles Calatayud, Meritxell Pons-Espinal, Juan Pablo Muñoz, Yvonne Richaud-Patin, Irene Fernandez-Carasa, Marta Gut, Armida Faella, Janani Parameswaran, Jordi Soriano, Isidro Ferrer, Eduardo Tolosa, Antonio Zorzano, Ana Maria Cuervo, Angel Raya, Antonella Consigli. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease. Stem cell reports. vol 12. issue 2. 2020-03-04. PMID:30639209. |
parkinson's disease (pd) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmdans) and the accumulation of toxic α-synuclein. |
2020-03-04 |
2023-08-13 |
Not clear |
| Jianbin Zheng, Sohee Jeon, Weilan Jiang, Lena F Burbulla, Daniel Ysselstein, Kristine Oevel, Dimitri Krainc, Richard B Silverma. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of medicinal chemistry. vol 62. issue 3. 2020-03-03. PMID:30645117. |
pd patient-derived fibroblasts and dopaminergic midbrain neurons were treated with a selected compound (9q) that partially stabilized gcase and improved its activity. |
2020-03-03 |
2023-08-13 |
Not clear |
| Rachel J Sharkey, Josiane Bourque, Kevin Larcher, Bratislav Mišić, Yu Zhang, Ayça Altınkaya, Abbas Sadikot, Patricia Conrod, Alan C Evans, Hugh Garavan, Marco Leyton, Jean R Séguin, Robert Pihl, Alain Daghe. Mesolimbic connectivity signatures of impulsivity and BMI in early adolescence. Appetite. vol 132. 2020-03-02. PMID:30273626. |
to determine how the relationship between sensation-seeking, impulsivity and body mass index (bmi) is related to shared neural correlates we measured their relationships with the connectivity of nuclei in the striatum and dopaminergic midbrain in young adolescents. |
2020-03-02 |
2023-08-13 |
Not clear |
| Javier A Suarez, James D Howard, Geoffrey Schoenbaum, Thorsten Kahn. Sensory prediction errors in the human midbrain signal identity violations independent of perceptual distance. eLife. vol 8. 2020-02-28. PMID:30950792. |
the firing of dopaminergic midbrain neurons is thought to reflect prediction errors (pe) that depend on the difference between the value of expected and received rewards. |
2020-02-28 |
2023-08-13 |
human |
| Qiuyu Lin, Sen Hou, Yuyin Dai, Nan Jiang, Yingjie Li. LncRNA HOTAIR targets miR-126-5p to promote the progression of Parkinson's disease through RAB3IP. Biological chemistry. vol 400. issue 9. 2020-02-17. PMID:30738012. |
parkinson's disease (pd) is a common neurological disorder characterized by dopaminergic (da) neuron degeneration and death in the midbrain, and the long noncoding rna hotair has been shown to affect disease progression in pd. |
2020-02-17 |
2023-08-13 |
mouse |
| Francesca Montarolo, Serena Martire, Simona Perga, Antonio Bertolott. NURR1 Impairment in Multiple Sclerosis. International journal of molecular sciences. vol 20. issue 19. 2020-02-10. PMID:31574937. |
in parallel, nurr1 has been also linked to dopamine-associated brain disorders, such as parkinson's disease (pd) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mda). |
2020-02-10 |
2023-08-13 |
human |
| Courtney A Marshall, Kirsten M King, Sandhya Kortager. Limitations of the rat medial forebrain lesion model to study prefrontal cortex mediated cognitive tasks in Parkinson's disease. Brain research. vol 1702. 2020-02-07. PMID:29608880. |
parkinson's disease (pd) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. |
2020-02-07 |
2023-08-13 |
rat |
| Kirsten E Zeuner, Eva Schäffer, Franziska Hopfner, Norbert Brüggemann, Daniela Ber. Progress of Pharmacological Approaches in Parkinson's Disease. Clinical pharmacology and therapeutics. vol 105. issue 5. 2020-02-07. PMID:30661251. |
the progressive neurodegenerative process in parkinson's disease (pd) is not restricted to dopaminergic midbrain neurons but involves the entire nervous system. |
2020-02-07 |
2023-08-13 |
Not clear |
| Andrew Lutas, Hakan Kucukdereli, Osama Alturkistani, Crista Carty, Arthur U Sugden, Kayla Fernando, Veronica Diaz, Vanessa Flores-Maldonado, Mark L Anderman. State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala. Nature neuroscience. vol 22. issue 11. 2020-01-31. PMID:31611706. |
state-specific gating of salient cues by midbrain dopaminergic input to basal amygdala. |
2020-01-31 |
2023-08-13 |
Not clear |
| Susan E Maloney, Michael A Rieger, Ream Al-Hasani, Michael R Bruchas, David F Wozniak, Joseph D Doughert. Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning. Genes, brain, and behavior. vol 18. issue 7. 2020-01-16. PMID:31215739. |
characterization of celf6 gene expression showed high levels in monoaminergic populations such as the dopaminergic midbrain populations. |
2020-01-16 |
2023-08-13 |
mouse |
| Fanpeng Zhao, Sandra L Siedlak, Sandy L Torres, Qian Xu, Beisha Tang, Xiongwei Zh. Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease. Molecular neurobiology. vol 56. issue 7. 2020-01-14. PMID:30519817. |
the canonical wnt pathway is critical for both the development and adulthood survival and homeostatic maintenance of the midbrain dopaminergic (da) neurons. |
2020-01-14 |
2023-08-13 |
mouse |
| Shanzheng Yang, Enrique M Toledo, Pedro Rosmaninho, Changgeng Peng, Per Uhlén, Diogo S Castro, Ernest Arena. A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Communications biology. vol 1. 2020-01-11. PMID:30271956. |
zeb2 is a homeodomain transcription factor that plays pleiotropic functions during embryogenesis, but its role for midbrain dopaminergic (mda) neuron development is unknown. |
2020-01-11 |
2023-08-13 |
Not clear |
| Hiromi Sano, Atsushi Namb. The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice. Neurochemistry international. vol 124. 2019-12-24. PMID:30639196. |
parkinson's disease (pd) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain and shows motor dysfunctions. |
2019-12-24 |
2023-08-13 |
mouse |
| Karim Fifel, Johanna H Meijer, Tom Deboe. Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures. Scientific reports. vol 8. issue 1. 2019-12-20. PMID:29773830. |
circadian and homeostatic modulation of multi-unit activity in midbrain dopaminergic structures. |
2019-12-20 |
2023-08-13 |
mouse |