| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Yih-Ru Wu, Yi-Jing Chen, Jia-Li Lin, Meng Li, I-Cheng Chen, Yen-Shi Lo, Hsiu-Chuan Wu, Chiung-Mei Che. Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease. Parkinsonism & related disorders. vol 24. 2016-12-13. PMID:26797011. |
parkinson's disease (pd) is associated with the progressive degeneration of dopaminergic neurons with abnormal accumulation of α-synuclein mainly in the ventral midbrain. |
2016-12-13 |
2023-08-13 |
human |
| Fumio Yamashita, Makoto Sasaki, Kentaro Fukumoto, Kotaro Otsuka, Ikuko Uwano, Hiroyuki Kameda, Jin Endoh, Akio Saka. Detection of changes in the ventral tegmental area of patients with schizophrenia using neuromelanin-sensitive MRI. Neuroreport. vol 27. issue 5. 2016-12-13. PMID:26901057. |
the ventral tegmental area (vta), one of the neuromelanin-containing dopaminergic nuclei in the midbrain, is closely related to the pathogenesis of schizophrenia, but its imaging findings remain unclear. |
2016-12-13 |
2023-08-13 |
human |
| Pedro Espinosa, Roxana A Silva, Nicole K Sanguinetti, Francisca C Venegas, Raul Riquelme, Luis F González, Gonzalo Cruz, Georgina M Renard, Pablo R Moya, Ramón Sotomayor-Zárat. Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Neural plasticity. vol 2016. 2016-12-13. PMID:26904299. |
we sought to determine the long-term changes produced by neonatal sex hormone administration on the functioning of midbrain dopaminergic neurons in adult male rats. |
2016-12-13 |
2023-08-13 |
rat |
| Pedro Espinosa, Roxana A Silva, Nicole K Sanguinetti, Francisca C Venegas, Raul Riquelme, Luis F González, Gonzalo Cruz, Georgina M Renard, Pablo R Moya, Ramón Sotomayor-Zárat. Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Neural plasticity. vol 2016. 2016-12-13. PMID:26904299. |
however, neonatal exposure to dht, a nonaromatizable androgen, did not affect midbrain dopaminergic neurons. |
2016-12-13 |
2023-08-13 |
rat |
| John I Broussard, Kechun Yang, Amber T Levine, Theodoros Tsetsenis, Daniel Jenson, Fei Cao, Isabella Garcia, Benjamin R Arenkiel, Fu-Ming Zhou, Mariella De Biasi, John A Dan. Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus. Cell reports. vol 14. issue 8. 2016-12-13. PMID:26904943. |
immunohistochemistry and molecular techniques verified sparse dopaminergic innervation of the hippocampus from the midbrain. |
2016-12-13 |
2023-08-13 |
mouse |
| François-Xavier Blaudin de Thé, Hocine Rekaik, Alain Prochiantz, Julia Fuchs, Rajiv L Josh. Neuroprotective Transcription Factors in Animal Models of Parkinson Disease. Neural plasticity. vol 2016. 2016-11-09. PMID:26881122. |
a number of transcription factors, including en1/2, foxa1/2, lmx1a/b, nurr1, otx2, and pitx3, with key roles in midbrain dopaminergic (mda) neuron development, also regulate adult mda neuron survival and physiology. |
2016-11-09 |
2023-08-13 |
mouse |
| Emilie Werlen, Matthew W Jone. Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions. Progress in brain research. vol 219. 2016-10-31. PMID:26072240. |
salient events activate the midbrain dopaminergic system and have important impacts on various aspects of mnemonic function, including the stability of hippocampus-dependent memories. |
2016-10-31 |
2023-08-13 |
Not clear |
| HongNa Yang, Jing Wang, Feng Wang, XiaoDun Liu, Heng Chen, WeiMing Duan, TingYu Q. Dopaminergic Neuronal Differentiation from the Forebrain-Derived Human Neural Stem Cells Induced in Cultures by Using a Combination of BMP-7 and Pramipexole with Growth Factors. Frontiers in neural circuits. vol 10. 2016-10-31. PMID:27147976. |
transplantation of dopaminergic (da) neurons is considered to be the most promising therapeutic strategy for replacing degenerated dopamine cells in the midbrain of parkinson's disease (pd), thereby restoring normal neural circuit function and slow clinical progression of the disease. |
2016-10-31 |
2023-08-13 |
human |
| Rachel J Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C Parr-Brownlie, John N J Reynolds, Dorothy E Oorscho. Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. The Journal of comparative neurology. vol 524. issue 5. 2016-10-24. PMID:26355230. |
marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. |
2016-10-24 |
2023-08-13 |
rat |
| Rachel J Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C Parr-Brownlie, John N J Reynolds, Dorothy E Oorscho. Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. The Journal of comparative neurology. vol 524. issue 5. 2016-10-24. PMID:26355230. |
elucidating the link between cellular activity and goal-directed behavior requires a fuller understanding of the mechanisms underlying burst firing in midbrain dopaminergic neurons and those that suppress activity during aversive or non-rewarding events. |
2016-10-24 |
2023-08-13 |
rat |
| Rachel J Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C Parr-Brownlie, John N J Reynolds, Dorothy E Oorscho. Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. The Journal of comparative neurology. vol 524. issue 5. 2016-10-24. PMID:26355230. |
these data from identified neurons are pivotal for interpreting their electrophysiological responses to afferent activity and for generating realistic computer models of neuronal networks of striatal and midbrain dopaminergic function. |
2016-10-24 |
2023-08-13 |
rat |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
oxygen tension within the neurogenic niche regulates dopaminergic neurogenesis in the developing midbrain. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
oxygen tension is an important factor controlling stem cell proliferation and maintenance in various stem cell populations with a particular relevance in midbrain dopaminergic progenitors. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
however, all available studies on oxygen effects in dopaminergic neuroprogenitors were performed in vitro and thus it remains unclear whether tissue oxygen tension in the embryonic midbrain is also relevant for the regulation of dopaminergic neurogenesis in vivo. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
we thus dissect here the effects of oxygen tension in combination with hif-1α conditional knockout on dopaminergic neurogenesis by using a novel experimental design allowing for the control of oxygen tension within the microenvironment of the neurogenic niche of the murine fetal midbrain in vivo. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
the microenvironment of the midbrain dopaminergic neurogenic niche was detected as hypoxic with oxygen tensions below 1.1%. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
fetal midbrain hypoxia hampered the generation of dopaminergic neurons and is accompanied with restricted fetal midbrain development. |
2016-10-20 |
2023-08-13 |
Not clear |
| Lisa Wagenführ, Anne Karen Meyer, Lara Marrone, Alexander Storc. Oxygen Tension Within the Neurogenic Niche Regulates Dopaminergic Neurogenesis in the Developing Midbrain. Stem cells and development. vol 25. issue 3. 2016-10-20. PMID:26577812. |
our study provides the initial framework for future studies on molecular mechanisms mediating oxygen regulation of dopaminergic neurogenesis within the fetal midbrain as its natural environment. |
2016-10-20 |
2023-08-13 |
Not clear |
| Ting-Yi Wang, Kiara F Bruggeman, Jessica A Kauhausen, Alexandra L Rodriguez, David R Nisbet, Clare L Paris. Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease. Biomaterials. vol 74. 2016-10-19. PMID:26454047. |
in vitro we confirmed the ability of the scaffolds to support ventral midbrain (vm) dopamine progenitors, and provide sustained delivery of gdnf - capable of eliciting effects on cell survival and dopaminergic axon growth. |
2016-10-19 |
2023-08-13 |
mouse |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
parkinson's disease (pd) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (da) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. |
2016-10-19 |
2023-08-13 |
mouse |