| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
moreover, we highlight the contribution of neurotrophic factors as endogenous and/or exogenous molecules to slow the progression of midbrain dopaminergic (mda) neurons and further discuss the potential of combined therapeutic approaches employing neuroinflammation modifying agents and neurotrophic factors. |
2016-10-19 |
2023-08-13 |
mouse |
| R Rumpel, O Baron, A Ratzka, M-L Schröder, M Hohmann, A Effenberg, P Claus, C Groth. Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2. Neuroscience. vol 314. 2016-10-13. PMID:26642808. |
increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of fgf-2. |
2016-10-13 |
2023-08-13 |
mouse |
| R Rumpel, O Baron, A Ratzka, M-L Schröder, M Hohmann, A Effenberg, P Claus, C Groth. Increased innervation of forebrain targets by midbrain dopaminergic neurons in the absence of FGF-2. Neuroscience. vol 314. 2016-10-13. PMID:26642808. |
fgf-2 is essential for survival of midbrain dopaminergic (da) neurons and is responsible for their dysplasia and disease-related degeneration. |
2016-10-13 |
2023-08-13 |
mouse |
| Shi-Bin Li, Dan Du, Mazahir T Hasan, Georg Köh. D4 Receptor Activation Differentially Modulates Hippocampal Basal and Apical Dendritic Synapses in Freely Moving Mice. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 2. 2016-10-11. PMID:25270308. |
furthermore, cell type-specific expression of mcherry in datcre mice generated fluorescence in dorsal ca1 that was highest in lacunosum moleculare and similar in or/rad, indicating that midbrain dopaminergic fibers distribute evenly in or/rad. |
2016-10-11 |
2023-08-13 |
mouse |
| G van der Plasse, R van Zessen, M C M Luijendijk, H Erkan, G D Stuber, G M J Ramakers, R A H Ada. Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin. International journal of obesity (2005). vol 39. issue 12. 2016-09-27. PMID:26183405. |
midbrain dopaminergic activity in response to reward-predicting environmental stimuli drives reward-seeking and motivated behavior for food rewards. |
2016-09-27 |
2023-08-13 |
human |
| Carmen Cavada Martíne. [THE THALAMIC DOPAMINERGIC SYSTEM. A NOVEL SYSTEM IN THE PRIMATE BRAIN]. Anales de la Real Academia Nacional de Medicina. vol 131. issue 1. 2016-09-15. PMID:27386678. |
the origin of thalamic dopamine is multiple; it includes dopaminergic nuclei in the hypothalamus, periaqueductal gray, ventral mesencephalon and lateral parabrachial nucleus. |
2016-09-15 |
2023-08-13 |
human |
| Jessica A Kauhausen, Lachlan H Thompson, Clare L Paris. Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice. Molecular and cellular neurosciences. vol 69. 2016-09-12. PMID:26463051. |
simultaneous homotopic transplantation of dopaminergic progenitors, into the ventral midbrain of chabc treated pd mice, had no effect on graft survival but resulted in enhanced axonal growth along the nigrostriatal pathway and reinnervation of the striatum, compared to control grafted mice. |
2016-09-12 |
2023-08-13 |
mouse |
| Hao Yang, Yang Liu, Yanan Hai, Ying Guo, Shi Yang, Zheng Li, Wei-Qiang Gao, Zuping H. Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25373443. |
parkinson's disease (pd) is a common neurodegenerative syndrome characterized by loss of midbrain dopaminergic (da) neurons. |
2016-08-30 |
2023-08-13 |
Not clear |
| Zhixing Hu, Jiali Pu, Houbo Jiang, Ping Zhong, Jingxin Qiu, Feng Li, Xiaomin Wang, Baorong Zhang, Zhen Yan, Jian Fen. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling. Stem cells and development. vol 24. issue 21. 2016-08-29. PMID:26218671. |
the lack of robust parkinson's disease (pd) phenotype in parkin knockout rodents and the identification of defective dopaminergic (da) neurotransmission in midbrain da neurons derived from induced pluripotent stem cells (ipsc) of pd patients with parkin mutations demonstrate the utility of patient-specific ipscs as an effective system to model the unique vulnerabilities of midbrain da neurons in pd. |
2016-08-29 |
2023-08-13 |
mouse |
| Seon-Heui Cha, Yu Ree Choi, Cheol-Ho Heo, Seo-Jun Kang, Eun-Hye Joe, Ilo Jou, Hwan-Myung Kim, Sang Myun Par. Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26627850. |
parkinson's disease (pd) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. |
2016-08-24 |
2023-08-13 |
Not clear |
| Celia van der Merwe, Jonathan Carr, Brigitte Glanzmann, Soraya Bardie. Exonic rearrangements in the known Parkinson's disease-causing genes are a rare cause of the disease in South African patients. Neuroscience letters. vol 619. 2016-08-24. PMID:27001088. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2016-08-24 |
2023-08-13 |
Not clear |
| M W Howe, D A Dombec. Rapid signalling in distinct dopaminergic axons during locomotion and reward. Nature. vol 535. issue 7613. 2016-08-24. PMID:27398617. |
dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in parkinson disease results in profound movement deficits. |
2016-08-24 |
2023-08-13 |
mouse |
| Ryan E Hillmer, Joanne P Boisvert, Monica J Cucciare, Michael B Dwinell, Milan Joksimovi. Generation and characterization of mice harboring a conditional CXCL12 allele. The International journal of developmental biology. vol 59. issue 4-6. 2016-08-23. PMID:26505253. |
as expected from the global mutant phenotype, our mutants were also characterized by highly irregular cerebellar cytoarchitecture of the external granule layer as well as altered radial migration of midbrain dopaminergic neurons. |
2016-08-23 |
2023-08-13 |
mouse |
| S Torii, S Kasai, A Suzuki, Y Todoroki, K Yokozawa, K-I Yasumoto, N Seike, H Kiyonari, Y Mukumoto, A Kakita, K Sogaw. Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease. Cell death discovery. vol 1. 2016-08-23. PMID:27551449. |
ipas was markedly induced in the midbrain following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) administration, and ipas-deficient mice showed resistance to mptp-induced degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc). |
2016-08-23 |
2023-08-13 |
mouse |
| Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franc. Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiology of disease. vol 81. 2016-08-22. PMID:25497688. |
short-term overexpression of wild type (wt) or mutant a53t α-synuclein had no toxic effect in human dopaminergic cells and primary midbrain cultures, but it exerted a synergistic effect on cu-induced cell death. |
2016-08-22 |
2023-08-13 |
human |
| Nobuyuki Kai, Kayo Nishizawa, Yuji Tsutsui, Shuichi Ueda, Kazuto Kobayash. Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization. Journal of neurochemistry. vol 135. issue 6. 2016-08-22. PMID:26442961. |
it receives dopaminergic afferents from the ventral midbrain and is divided into two distinct subregions: shell and core. |
2016-08-22 |
2023-08-13 |
mouse |
| Yujeong Lee, Hye Jeong Chun, Kyung Moon Lee, Young-Suk Jung, Jaewon Le. Silibinin suppresses astroglial activation in a mouse model of acute Parkinson's disease by modulating the ERK and JNK signaling pathways. Brain research. vol 1627. 2016-08-17. PMID:26434409. |
parkinson's disease (pd) is the second-most common neurodegenerative disease after alzheimer's disease, and is characterized by dopaminergic neuronal loss in midbrain. |
2016-08-17 |
2023-08-13 |
mouse |
| Maria Weinert, Tharakeswari Selvakumar, Travis S Tierney, Kambiz N Alavia. Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains. Journal of visualized experiments : JoVE. issue 96. 2016-08-10. PMID:25741798. |
here we present a detailed method for the isolation, culturing and maintenance of midbrain dopaminergic neurons from e12.5 mouse (or e14.5 rat) embryos. |
2016-08-10 |
2023-08-13 |
mouse |
| Sarah X Luo, Eric J Huan. Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. The American journal of pathology. vol 186. issue 3. 2016-08-09. PMID:26724386. |
midbrain dopaminergic (da) neurons in the substantia nigra pars compacta and ventral tegmental area regulate extrapyramidal movement and important cognitive functions, including motivation, reward associations, and habit learning. |
2016-08-09 |
2023-08-13 |
Not clear |
| Angela Anderegg, Rajeshwar Awatraman. Making a mes: A transcription factor-microRNA pair governs the size of the midbrain and the dopaminergic progenitor pool. Neurogenesis (Austin, Tex.). vol 2. issue 1. 2016-08-09. PMID:27502145. |
making a mes: a transcription factor-microrna pair governs the size of the midbrain and the dopaminergic progenitor pool. |
2016-08-09 |
2023-08-13 |
Not clear |