| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonas A Hosp, Helen E Nolan, Andreas R Luf. Topography and collateralization of dopaminergic projections to primary motor cortex in rats. Experimental brain research. vol 233. issue 5. 2015-12-08. PMID:25633321. |
whereas pfc- and nac-projecting neurons are indistinguishably intermingled within the ventral portion of dopaminergic nuclei in middle and caudal midbrain, m1-projecting neurons are only located within the dorsal part of the rostral midbrain. |
2015-12-08 |
2023-08-13 |
rat |
| Simone Mesman, Lars von Oerthel, Marten P Smid. Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling. PloS one. vol 9. issue 5. 2015-12-03. PMID:24865218. |
in the brain, shh is expressed in a gradient starting in the floor plate (fp) progressing ventrally in the midbrain, where it is thought to be involved in the development and specification of mesodiencephalic dopaminergic (mdda) neurons. |
2015-12-03 |
2023-08-13 |
mouse |
| David C Schöndorf, Massimo Aureli, Fiona E McAllister, Christopher J Hindley, Florian Mayer, Benjamin Schmid, S Pablo Sardi, Manuela Valsecchi, Susanna Hoffmann, Lukas Kristoffer Schwarz, Ulrike Hedrich, Daniela Berg, Lamya S Shihabuddin, Jing Hu, Jan Pruszak, Steven P Gygi, Sandro Sonnino, Thomas Gasser, Michela Deleid. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nature communications. vol 5. 2015-12-03. PMID:24905578. |
here we generate induced pluripotent stem cells from subjects with gd and pd harbouring gba1 mutations, and differentiate them into midbrain dopaminergic neurons followed by enrichment using fluorescence-activated cell sorting. |
2015-12-03 |
2023-08-13 |
human |
| Zhiguo Che. Cell Therapy for Parkinson's Disease: New Hope from Reprogramming Technologies. Aging and disease. vol 6. issue 6. 2015-11-30. PMID:26618051. |
parkinson's disease (pd) is a neurodegenerative disease with the major pathology being the progressive loss of dopaminergic (da) midbrain neurons in the substantia nigra. |
2015-11-30 |
2023-08-13 |
Not clear |
| William M Johnson, Chen Yao, Sandra L Siedlak, Wenzhang Wang, Xiongwei Zhu, Guy A Caldwell, Amy L Wilson-Delfosse, John J Mieyal, Shu G Che. Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease. Human molecular genetics. vol 24. issue 5. 2015-11-16. PMID:25355420. |
we first examined the levels of grx1 in postmortem midbrain samples from pd patients, and observed that grx1 content is decreased in pd, specifically within the dopaminergic neurons. |
2015-11-16 |
2023-08-13 |
human |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
midbrain dopaminergic neurons are involved in regulating motor control, reward behavior, and cognition. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
degeneration or dysfunction of midbrain dopaminergic neurons is implicated in several neuropsychiatric disorders such as parkinson's disease, substance use disorders, depression, and schizophrenia. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
understanding the developmental processes that generate midbrain dopaminergic neurons will facilitate the generation of dopaminergic neurons from stem cells for cell replacement therapies to substitute degenerating cells in parkinson's disease patients and will forward our understanding on how functional diversity of dopaminergic neurons in the adult brain is established. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
midbrain dopaminergic neurons develop in a multistep process. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
following the induction of the ventral midbrain, a distinct dopaminergic progenitor domain is specified and dopaminergic progenitors undergo proliferation, neurogenesis, and differentiation. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
subsequently, midbrain dopaminergic neurons acquire a mature dopaminergic phenotype, migrate to their final position and establish projections and connections to their forebrain targets. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sandra Blaess, Siew-Lan An. Genetic control of midbrain dopaminergic neuron development. Wiley interdisciplinary reviews. Developmental biology. vol 4. issue 2. 2015-11-16. PMID:25565353. |
this review will discuss insights gained on the signaling network of secreted molecules, cell surface receptors, and transcription factors that regulate specification and differentiation of midbrain dopaminergic progenitors and neurons, from the induction of the ventral midbrain to the migration of dopaminergic neurons. |
2015-11-16 |
2023-08-13 |
Not clear |
| Lars Brichta, William Shin, Vernice Jackson-Lewis, Javier Blesa, Ee-Lynn Yap, Zachary Walker, Jack Zhang, Jean-Pierre Roussarie, Mariano J Alvarez, Andrea Califano, Serge Przedborski, Paul Greengar. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nature neuroscience. vol 18. issue 9. 2015-11-16. PMID:26214373. |
following the generation of transgenic mice for cell type-specific profiling of midbrain dopaminergic neurons, we established and compared translatome libraries reflecting the molecular signature of these cells at baseline or under degenerative stress. |
2015-11-16 |
2023-08-13 |
mouse |
| Diogo Ribeiro, Rocio Laguna Goya, Geeta Ravindran, Romina Vuono, Clare L Parish, Claire Foldi, Tobias Piroth, Shanzheng Yang, Malin Parmar, Guido Nikkhah, Jens Hjerling-Leffler, Olle Lindvall, Roger A Barker, Ernest Arena. Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiology of disease. vol 49. 2015-11-10. PMID:22940632. |
efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. |
2015-11-10 |
2023-08-12 |
human |
| Diogo Ribeiro, Rocio Laguna Goya, Geeta Ravindran, Romina Vuono, Clare L Parish, Claire Foldi, Tobias Piroth, Shanzheng Yang, Malin Parmar, Guido Nikkhah, Jens Hjerling-Leffler, Olle Lindvall, Roger A Barker, Ernest Arena. Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiology of disease. vol 49. 2015-11-10. PMID:22940632. |
here we present a method for generating large numbers of midbrain dopaminergic (da) neurons based on expanding and differentiating neural stem/progenitor cells present in the human ventral midbrain (hvm) tissue. |
2015-11-10 |
2023-08-12 |
human |
| Nicolas X Tritsch, Won-Jong Oh, Chenghua Gu, Bernardo L Sabatin. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. eLife. vol 3. 2015-11-10. PMID:24843012. |
these findings therefore indicate that gaba co-release is a general feature of midbrain dopaminergic neurons that relies on gaba uptake from the extracellular milieu as opposed to de novo synthesis. |
2015-11-10 |
2023-08-13 |
Not clear |
| Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Droui. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS genetics. vol 10. issue 12. 2015-11-06. PMID:25501001. |
parkinson disease (pd) is characterized by the preferential, but poorly understood, vulnerability to degeneration of midbrain dopaminergic (mda) neurons in the ventral substantia nigra compacta (vsnc). |
2015-11-06 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
neurotensin induces presynaptic depression of d2 dopamine autoreceptor-mediated neurotransmission in midbrain dopaminergic neurons. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
activity of midbrain dopaminergic neurons is under strict control of inhibitory d2 autoreceptors. |
2015-11-05 |
2023-08-13 |
mouse |
| Elisabeth Piccart, Nicholas A Courtney, Sarah Y Branch, Christopher P Ford, Michael J Beckstea. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 31. 2015-11-05. PMID:26245975. |
application of the modulatory peptide neurotensin (nt) to midbrain dopaminergic neurons transiently increases activity by decreasing d2 dopamine autoreceptor function, yet little is known about the mechanisms that underlie long-lasting effects. |
2015-11-05 |
2023-08-13 |
mouse |