| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arthur Leblois, David J Perke. Striatal dopamine modulates song spectral but not temporal features through D1 receptors. The European journal of neuroscience. vol 35. issue 11. 2013-04-04. PMID:22594943. |
the activity of midbrain dopaminergic neurons and their projection to the basal ganglia (bg) are thought to play a critical role in the acquisition of motor skills through reinforcement learning, as well as in the expression of learned motor behaviors. |
2013-04-04 |
2023-08-12 |
Not clear |
| Xiaotian Sun, Jin Liu, John F Crary, Cristina Malagelada, David Sulzer, Lloyd A Greene, Oren A Lev. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 6. 2013-04-01. PMID:23392669. |
atf4 was also protective against 6-ohda-induced death of cultured mouse ventral midbrain dopaminergic neurons. |
2013-04-01 |
2023-08-12 |
mouse |
| F L Campos, A C Cristovão, S M Rocha, C P Fonseca, G Baltaza. GDNF contributes to oestrogen-mediated protection of midbrain dopaminergic neurones. Journal of neuroendocrinology. vol 24. issue 11. 2013-03-28. PMID:22672424. |
gdnf contributes to oestrogen-mediated protection of midbrain dopaminergic neurones. |
2013-03-28 |
2023-08-12 |
human |
| Daniel J Costello, Gerard W O'Keeffe, Fiona M Hurley, Aideen M Sulliva. Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease. Journal of cellular and molecular medicine. vol 16. issue 10. 2013-03-26. PMID:22436046. |
growth/differentiation factor 5 (gdf5) is a neurotrophic factor that promotes the survival of midbrain dopaminergic neurons in vitro and in vivo and as such is potentially useful in the treatment of parkinson's disease (pd). |
2013-03-26 |
2023-08-12 |
human |
| Daniel J Costello, Gerard W O'Keeffe, Fiona M Hurley, Aideen M Sulliva. Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease. Journal of cellular and molecular medicine. vol 16. issue 10. 2013-03-26. PMID:22436046. |
this study shows that a continuous supply of gdf5, produced by transplanted gdf5-overexpressing cho cells in vivo, has neuroprotective and neurorestorative effects on midbrain dopaminergic neurons following 6-hydroxydopamine (6-ohda)-induced lesions of the adult rat nigrostriatal pathway. |
2013-03-26 |
2023-08-12 |
human |
| Anh H Pham, Shuxia Meng, Quynh N Chu, David C Cha. Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit. Human molecular genetics. vol 21. issue 22. 2013-03-26. PMID:22859504. |
however, the loss of dopaminergic neurons in the midbrain occurs weeks after the onset of these motor and striatal deficits, suggesting a retrograde mode of neurodegeneration. |
2013-03-26 |
2023-08-12 |
mouse |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
emerging evidence suggests that motivation enhances episodic memory formation through interactions between medial-temporal lobe (mtl) structures and dopaminergic midbrain. |
2013-03-25 |
2023-08-12 |
human |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
here, we used high-resolution fmri to determine how motivation influences associative encoding and retrieval processes within human mtl subregions and dopaminergic midbrain. |
2013-03-25 |
2023-08-12 |
human |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
the magnitude of behavioral reward modulation was associated with reward-related activation changes in dentate gyrus/ca(2,3) during encoding and enhanced functional connectivity between dentate gyrus/ca(2,3) and dopaminergic midbrain during both the encoding and retrieval phases of the task. |
2013-03-25 |
2023-08-12 |
human |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
these findings suggests that, within the hippocampus, reward-based motivation specifically enhances dentate gyrus/ca(2,3) associative encoding mechanisms through interactions with dopaminergic midbrain. |
2013-03-25 |
2023-08-12 |
human |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
furthermore, within parahippocampal cortex and dopaminergic midbrain regions, activation associated with successful memory formation was modulated by reward across the group. |
2013-03-25 |
2023-08-12 |
human |
| Sasha M Wolosin, Dagmar Zeithamova, Alison R Presto. Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval. Journal of cognitive neuroscience. vol 24. issue 7. 2013-03-25. PMID:22524296. |
during the retrieval phase, we also observed enhanced activation in hippocampus and dopaminergic midbrain for high-value associations that occurred in the absence of any explicit cues to reward. |
2013-03-25 |
2023-08-12 |
human |
| D Ko, C J Wilson, C J Lobb, C A Paladin. Detection of bursts and pauses in spike trains. Journal of neuroscience methods. vol 211. issue 1. 2013-03-22. PMID:22939922. |
midbrain dopaminergic neurons in vivo exhibit a wide range of firing patterns. |
2013-03-22 |
2023-08-12 |
Not clear |
| Francesca L'Episcopo, Cataldo Tirolo, Nunzio Testa, Salvatore Caniglia, Maria C Morale, Francesco Impagnatiello, Stefano Pluchino, Bianca Marchett. Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345222. |
aging and exposure to environmental toxins including mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) are strong risk factors for developing parkinson's disease (pd), a common neurologic disorder characterized by selective degeneration of midbrain dopaminergic (daergic) neurons and astrogliosis. |
2013-03-20 |
2023-08-12 |
mouse |
| Rajeswara B Mythri, Gangadharappa Harish, M M Bharat. Therapeutic potential of natural products in Parkinson's disease. Recent patents on endocrine, metabolic & immune drug discovery. vol 6. issue 3. 2013-03-14. PMID:22827714. |
the central objective in treating patients with parkinson's disease (pd) is two-fold (i) to increase the striatal dopamine content and (ii) to prevent further degeneration of the surviving dopaminergic neurons in the substantia nigra region of the ventral midbrain. |
2013-03-14 |
2023-08-12 |
Not clear |
| Pamela C Rodriguez, Daniela B Pereira, Anders Borgkvist, Minerva Y Wong, Candace Barnard, Mark S Sonders, Hui Zhang, Dalibor Sames, David Sulze. Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 3. 2013-03-14. PMID:23277566. |
here, we describe a ph-responsive ffn probe, ffn102, which as a polar dopamine transporter substrate selectively labels dopamine cell bodies and dendrites in ventral midbrain and dopaminergic synaptic terminals in dorsal striatum. |
2013-03-14 |
2023-08-12 |
Not clear |
| L M Alba-Ferrara, Gabriel A de Erausqui. What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia. Frontiers in integrative neuroscience. vol 7. 2013-03-14. PMID:23483798. |
we review data revealing increased anisotropy in dopaminergic tracts in the mesencephalon of schizophrenics and their unaffected relatives, and discuss the possible biological underpinnings and physiological significance of this finding. |
2013-03-14 |
2023-08-12 |
Not clear |
| Olga Momčilović, Justine Montoya-Sack, Xianmin Zen. Dopaminergic differentiation using pluripotent stem cells. Journal of cellular biochemistry. vol 113. issue 12. 2013-03-08. PMID:22807388. |
the motor symptoms of pd are caused by the loss of dopaminergic (da) neurons in the substantia nigra pars compacta of mesencephalon. |
2013-03-08 |
2023-08-12 |
Not clear |
| Jiajie Xi, Yan Liu, Huisheng Liu, Hong Chen, Marina E Emborg, Su-Chun Zhan. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem cells (Dayton, Ohio). vol 30. issue 8. 2013-02-28. PMID:22696177. |
by sequentially applying sonic hedgehog (c25ii) and chir99021 (gsk3β inhibitor) to induce the midbrain floor plate (fp) progenitors and fibroblast growth factor 8 (fgf8) to promote dopaminergic differentiation in a chemically defined medium, we have established a robust system for the generation of midbrain dopamine (da) neurons from human and rhesus monkey embryonic stem cells and induced pluripotent stem cells (pscs). |
2013-02-28 |
2023-08-12 |
human |
| Jiajie Xi, Yan Liu, Huisheng Liu, Hong Chen, Marina E Emborg, Su-Chun Zhan. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem cells (Dayton, Ohio). vol 30. issue 8. 2013-02-28. PMID:22696177. |
fgf8 enhances the dopaminergic fate of the progenitors, thus generating da neurons with midbrain characteristics, including expression of tyrosine hydroxylase, lmx1a/b, foxa2, foxp1, nurr1, and en1 as well as typical electrophysiological properties. |
2013-02-28 |
2023-08-12 |
human |