| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
dopamine is synthesized in the dopaminergic neurons of the sn by the actions of tyrosine hydroxylase (th) and dihydroxyphenylalanine decarboxylase (ddc). |
2024-10-16 |
2024-10-19 |
mouse |
| Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. |
dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). |
2024-10-13 |
2024-10-16 |
Not clear |
| Patrick D Worhunsky, Marcella M Mignosa, Jean-Dominique Gallezot, Brian Pittman, Nabeel B Nabulsi, Adam Stryjewski, Laya Jalilian-Khave, Richard Trinko, Ralph J DiLeone, Richard E Carson, Robert T Malison, Marc N Potenza, Gustavo A Angarit. Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [ Biological psychiatry. 2024-10-12. PMID:39395473. |
vitamin d's capacity to increase amphetamine-induced dopamine release in healthy humans: a clinical translational [ dopaminergic tone and phasic release have transdiagnostic relevance. |
2024-10-12 |
2024-10-15 |
Not clear |
| Iwona Przybylska, Jarosław Marusiak, Beata Toczyłowska, Adam Stępień, Bogdan Brodacki, Józef Langfort, Małgorzata Chalimoniu. Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early‑onset Parkinson's disease. Acta neurobiologiae experimentalis. vol 84. issue 3. 2024-10-11. PMID:39392027. |
brain-derived neurotrophic factor (bdnf) is involved in the maintenance of dopamine level and the survival of dopaminergic neurons, which may affect the functionality of brain structures responsible for motor and cognitive function. |
2024-10-11 |
2024-10-13 |
Not clear |
| Anna Nelke, Silvia García-López, Javier R Caso, Marta P Pereir. The therapeutic use of clonal neural stem cells in experimental Parkinson´s disease. Stem cell research & therapy. vol 15. issue 1. 2024-10-10. PMID:39385216. |
parkinson´s disease (pd), the second most common neurodegenerative disease in the world, is characterized by the death or impairment of dopaminergic neurons (dan) in the substantia nigra pars compacta and dopamine depletion in the striatum. |
2024-10-10 |
2024-10-12 |
mouse |
| Chelsea M Haakenson, Jacques Balthazart, Jonathan W VanRyzin, Ashley E Marquardt, Sydney E Ashton, Margaret M McCarthy, Gregory F Bal. Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study. The Journal of comparative neurology. vol 532. issue 10. 2024-10-10. PMID:39387367. |
highly sensitive in situ hybridization procedures (rnascope) were used to quantify the expression of three dopamine receptors (drd1, drd2, and drd3) in two song control nuclei (hvc and the area x of the basal ganglia) that are known to receive dopaminergic inputs and in the periaqueductal gray (pag) of male and female canaries. |
2024-10-10 |
2024-10-16 |
Not clear |
| Michael Kalyn, Rose Garvey, Hyojin Lee, Herman Aishi Mbesha, Jory Curry, Vishal Saxena, Jan A Mennigen, Marc Ekke. Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish. Journal of neurochemistry. 2024-10-10. PMID:39388214. |
dopaminergic (danergic) dysfunction and imbalanced dopamine (da) levels are known contributors to the pathogenesis of numerous psychiatric and neurodegenerative disorders. |
2024-10-10 |
2024-10-16 |
mouse |
| Zijiao Tian, Yixin Zhang, Jing Xu, Qianwen Yang, Die Hu, Jing Feng, Cong Ga. Primary cilia in Parkinson's disease: summative roles in signaling pathways, genes, defective mitochondrial function, and substantia nigra dopaminergic neurons. Frontiers in aging neuroscience. vol 16. 2024-10-05. PMID:39364348. |
parkinson's disease (pd), a neurodegenerative disease that progresses over time, is primarily caused by a gradual degradation of the dopaminergic pathway in the striatum nigra, which results in a large loss of neurons in the substantia nigra compact (snpc) and a depletion of dopamine (da). |
2024-10-05 |
2024-10-07 |
Not clear |
| Wentao Wang, Dan Wang, Di Zhao, Lihong Xu, Shujun Jiang, Yu Zhang, Minghu Cui, Jing Liu, Fantao Meng, Cuilan Liu, Dunjiang Liu, Wei Li, Chen L. Dorsal raphe dopaminergic neurons target CaMKII Translational psychiatry. vol 14. issue 1. 2024-10-02. PMID:39358336. |
dorsal raphe dopaminergic neurons target camkii dopamine (da) neurons play a crucial role in the development and manifestation of depression, as well as in response to antidepressant treatments. |
2024-10-02 |
2024-10-05 |
mouse |
| Dishank Patel, Ritu Soni, Jigna Sha. Decoding the Role of Nuclear Sirtuins in Parkinson's Pathogenesis. ACS chemical neuroscience. 2024-09-27. PMID:39331405. |
parkinson's disease (pd) is the second most prevailing degenerative disease that deals with dopaminergic neuronal loss and deficiency of dopamine in snpc and striatum. |
2024-09-27 |
2024-09-29 |
Not clear |
| Seung Kwan Kang, Daewoon Kim, Seong A Shin, Yu Kyeong Kim, Hongyoon Choi, Jae Sung Le. Accurate Automated Quantification of Dopamine Transporter PET Without MRI Using Deep Learning-based Spatial Normalization. Nuclear medicine and molecular imaging. vol 58. issue 6. 2024-09-24. PMID:39308485. |
dopamine transporter imaging is crucial for assessing presynaptic dopaminergic neurons in parkinson's disease (pd) and related parkinsonian disorders. |
2024-09-24 |
2024-09-26 |
Not clear |
| Angelika Kunkel, Livia Asan, Isabel Krüger, Clara Erfurt, Laura Ruhnau, Elif Buse Caliskan, Jana Hackert, Katja Wiech, Katharina Schmidt, Ulrike Binge. Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans. PLoS biology. vol 22. issue 9. 2024-09-24. PMID:39316644. |
to this end, we used an established placebo analgesia paradigm in combination with 2 opposing pharmacological modulations of dopaminergic tone, i.e., the dopamine antagonist sulpiride and the dopamine precursor l-dopa which were both applied in an experimental, double-blind, randomized, placebo-controlled trial with a between-subject design in n = 168 healthy volunteers. |
2024-09-24 |
2024-09-27 |
human |
| Raian E Contreras, Tim Gruber, Ismael González-García, Sonja C Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina Garcia-Caceres, Paul T Pfluge. HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice. Molecular metabolism. 2024-09-20. PMID:39304061. |
the lower peripheral sympathetic nervous system (sns) activity in mature male ko mice was linked to higher dopaminergic neuronal activity within the dorsomedial arcuate nucleus (dmarc) and elevated hypothalamic dopamine levels. |
2024-09-20 |
2024-09-23 |
mouse |
| Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
however, despite the importance of dopaminergic signaling in the nacc for motivated behavior, little is known about the role that dopamine (da) plays in the incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |
| Ho Koo, Jigong Wang, Ramesh Pariyar, Regan M Hammond, Jun-Ho L. Modulation of mechanosensation by endogenous dopaminergic signaling in the lateral parabrachial nucleus in mice. Pain reports. vol 9. issue 5. 2024-09-12. PMID:39263005. |
the lateral parabrachial nucleus (lpbn), a crucial hub for integrating and modulating diverse sensory information, is known to express both d1 and d2 dopamine receptors and receive dopaminergic inputs. |
2024-09-12 |
2024-09-14 |
mouse |
| Moritz A Loeffler, Annerose Mengel, Constanze Single, Daniel Weiss, Katharina Fei. Subcutaneous foslevodopa in akinetic crisis. A case report from the neurological intensive care unit. Frontiers in medicine. vol 11. 2024-09-10. PMID:39253538. |
akinetic crisis is a severe deterioration of motor performance occurring in syndromes with pre- or postsynaptic dopaminergic deficit, necessitating effective dopamine replacement therapy. |
2024-09-10 |
2024-09-13 |
Not clear |
| Shuhan Lei, Zhiyong Hu, Huanliang Li. Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans. Chemosphere. 2024-09-09. PMID:39251157. |
treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in caenorhabditis elegans. |
2024-09-09 |
2024-09-13 |
caenorhabditis_elegans |
| Shuhan Lei, Zhiyong Hu, Huanliang Li. Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans. Chemosphere. 2024-09-09. PMID:39251157. |
meanwhile, the increase in the number of worms with dopaminergic neurodegeneration was detected in nematodes exposed to 100 μg/l ps-nps and the decreased dopamine content was observed within nematodes exposed to 10-100 μg/l ps-nps, demonstrating the function of dopaminergic neurodegeneration and disruption of dopamine metabolism in inducing ps-nps toxicity on neuron capacity. |
2024-09-09 |
2024-09-13 |
caenorhabditis_elegans |
| Shuhan Lei, Zhiyong Hu, Huanliang Li. Treatment with quercetin mitigates polystyrene nanoparticle-induced reduction in neuron capacity by inhibiting dopaminergic neurodegeneration and facilitating dopamine metabolism in Caenorhabditis elegans. Chemosphere. 2024-09-09. PMID:39251157. |
consequently, findings in this work demonstrated that long-term ps-nps exposure within the μg/l range (1-100 μg/l) was toxic to neuron capacity, which was associated with the enhancement in dopaminergic neurodegeneration and disruption of dopamine metabolism. |
2024-09-09 |
2024-09-13 |
caenorhabditis_elegans |
| Cristina Cusin, Daniel G Dillon, Emily Belleau, Marc D Normandin, Yoann Petibon, Georges El-Fakri, Maeva Dhaynaut, Jacob Hooker, Ted Kaptchuk, Madison McKee, Emma Hayden, Ashley Meyer, Aava Jahan, Julianne Origlio, Yuen-Siang Ang, Devon Brunner, Min Kang, Yinru Long, Maurizio Fava, Diego A Pizzagall. Novel multi-modal methodology to investigate placebo response in major depressive disorder. Journal of affective disorders. 2024-09-05. PMID:39233242. |
inspired by preclinical and clinical findings that have implicated dopamine in the occurrence, prediction, and expectation of reward, we hypothesized that dopaminergic activity in the mesolimbic system is a critical mediator of placebo response in mdd. |
2024-09-05 |
2024-09-08 |
Not clear |