| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thiago Ohno Bezerra, Antonio C Roqu. Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models. PLoS computational biology. vol 20. issue 12. 2024-12-16. PMID:39680609. |
while glutamate released by neurons trigger ca2+ signals through ip3- and glutamate transporter-dependent mechanisms, dopamine released in distant sites activates astrocytes via dopaminergic receptors. |
2024-12-16 |
2024-12-21 |
Not clear |
| Arash Yaghoobi, Homa Seyedmirzaei, Marzie Jamaat, Moein Al. Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease. Heliyon. vol 10. issue 23. 2024-12-10. PMID:39654757. |
striatal dopamine transporter (dat) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across parkinson's disease (pd) spectrum. |
2024-12-10 |
2024-12-12 |
Not clear |
| Kaili Liang, Li Yang, Jiawei Kang, Bo Liu, Ding Zhang, Liyan Wang, Wei Wang, Qing Wan. Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier. Asian journal of pharmaceutical sciences. vol 19. issue 6. 2024-12-06. PMID:39640059. |
levodopa, a key component of dopamine replacement therapy, effectively enhances dopaminergic activity. |
2024-12-06 |
2024-12-08 |
mouse |
| Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyong Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae-In Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong-Gyu J. Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease. Journal of extracellular vesicles. vol 13. issue 12. 2024-12-06. PMID:39641313. |
these findings collectively indicate that surface modification of evs with dopamine presents a potent strategy for targeting dopaminergic neurons in the brain. |
2024-12-06 |
2024-12-08 |
mouse |
| Kielen R Zuurbier, Rene Solano Fonseca, Sonja L B Arneaud, Jordan M Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M Dougla. Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39632864. |
extending observations of neurotrauma in c. elegans and mice, human dopaminergic neurons capable of surviving severe cellular challenges both decrease spontaneous activity and modulate dopamine homeostasis through the transcriptional regulator yin yang 1 (yy1). |
2024-12-05 |
2024-12-07 |
mouse |
| Kielen R Zuurbier, Rene Solano Fonseca, Sonja L B Arneaud, Jordan M Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M Dougla. Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39632864. |
this dopaminergic stress response has the potential to cause circuit inactivation, yet safeguards neurons by minimizing the toxic accumulation of cytosolic dopamine and inducing a state of neuronal dormancy. |
2024-12-05 |
2024-12-07 |
mouse |
| Marta Lapo Pais, Joana Crisóstomo, Antero Abrunhosa, Miguel Castelo-Branc. Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity. Journal of molecular medicine (Berlin, Germany). 2024-12-04. PMID:39630278. |
central dopamine receptors: radiotracers unveiling the role of dopaminergic tone in obesity. |
2024-12-04 |
2024-12-06 |
Not clear |
| Hongquan Wang, Shuang Wu, Xiaodong Jiang, Wenjing Li, Qiang Li, Huiyan Sun, Yumin Wan. Acteoside alleviates salsolinol-induced Parkinson's disease by inhibiting ferroptosis via activating Nrf2/SLC7A11/GPX4 pathway. Experimental neurology. 2024-12-04. PMID:39631720. |
salsolinol (sal), i.e.1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline, is a dopamine metabolite and endogenous neurotoxin that is toxic to dopaminergic neurons, and is involved in the genesis of parkinson's disease (pd). |
2024-12-04 |
2024-12-07 |
Not clear |
| Christopher I Esezobor, Girish C Bhatt, Emmanuel E Effa, Elisabeth M Hodso. Fenoldopam for preventing and treating acute kidney injury. The Cochrane database of systematic reviews. vol 11. 2024-11-28. PMID:39607014. |
fenoldopam is a short-acting benzazepine selective dopaminergic a1 (da1) receptor agonist with increased activity at the d1 receptor compared with dopamine. |
2024-11-28 |
2024-11-30 |
Not clear |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
it is characterized by the progressive loss of dopaminergic (danergic) neurons in the substantia nigra and decreased dopamine (da) levels, which lead to both motor and non-motor symptoms. |
2024-11-27 |
2024-11-29 |
Not clear |
| Kaijie She, Naijun Yuan, Minyi Huang, Wenjun Zhu, Manshi Tang, Qingyu Ma, Jiaxu Che. Emerging role of microglia in the developing dopaminergic system: perturbation by early life stress. Neural regeneration research. 2024-11-26. PMID:39589170. |
furthermore, inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons, inhibiting dopamine synthesis, reuptake, and receptor activity. |
2024-11-26 |
2024-11-28 |
Not clear |
| Zu-Ming Duan, Yi-Tong Xu, Zheng Li, Jian-Xiang Pang, Jing-Juan Xu, Wei-Wei Zha. Neuromorphic Nanofluidic Sense Digitalization. Angewandte Chemie (International ed. in English). 2024-11-21. PMID:39569596. |
by inspiration of dopaminergic nerve, here a nanofluidic nerve with sense digitalization is devised by engineering a dopamine (da)-specific nanofluidic synapse as mediated by pc-12 cells to manage the robotic arm. |
2024-11-21 |
2024-11-23 |
Not clear |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
while both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these 2 reward functions is unknown. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
a broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
similarly, a more restricted dopaminergic cluster with attractive valence was reliant on dopamine and glutamate; flies avoided opto-inhibition of this narrow subset, indicating the role of this cluster in controlling ongoing behavior. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Shobha Kumari, Sakshi Gupta, Rajesh Sukhija, Shaifali Gurjar, Sunil Kumar Dubey, Rajeev Taliya. Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease. European journal of pharmacology. vol 985. 2024-11-15. PMID:39536854. |
the progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain leads to a deficiency of dopamine and, ultimately, the onset of parkinson's disease (pd). |
2024-11-15 |
2024-11-17 |
Not clear |
| Zarah Le Houcq Corbi, Alexander Soutsche. Neural reward system reflects individual value comparison strategy in cost-benefit decisions. Communications biology. vol 7. issue 1. 2024-11-13. PMID:39533059. |
strikingly, manipulating activation in the dopaminergic reward system reveals that dopamine antagonism counteracts the engagement in an individual's dominant value comparison strategy. |
2024-11-13 |
2024-11-17 |
Not clear |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Marcello Serra, Gaia Faustini, Viviana Brembati, Maria Antonietta Casu, Marina Pizzi, Micaela Morelli, Annalisa Pinna, Arianna Bellucc. Early α-synuclein/synapsin III co-accumulation, nigrostriatal dopaminergic synaptopathy and denervation in the MPTPp mouse model of Parkinson's Disease. Experimental neurology. 2024-11-05. PMID:39500391. |
these findings indicate that α-syn/syn iii co-deposition characterizes very early stages of striatal dopaminergic dysfunction in the mptpp model and highlight that vmat2 and syn iii could be two reliable molecular imaging biomarkers to predict dopamine neuron denervation and estimate α-syn-related synaptopathy in prodromal and early symptomatic phases of pd. |
2024-11-05 |
2024-11-08 |
mouse |
| Saeed Kayhanian, Roger A Barke. Dopamine Cell-Based Replacement Therapies. Cold Spring Harbor perspectives in medicine. 2024-11-05. PMID:39500633. |
a conceptually more effective way to treat this aspect of the pd pathology would be to replace the missing dopaminergic system with grafts of new dopamine cells. |
2024-11-05 |
2024-11-08 |
human |