| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Illia Mushta, Sulev Koks, Anton Popov, Oleksandr Lysenk. Exploring the Potential Imaging Biomarkers for Parkinson's Disease Using Machine Learning Approach. Bioengineering (Basel, Switzerland). vol 12. issue 1. 2025-01-24. PMID:39851285. |
dopamine transporter scan (datscan), based on single-photon emission computed tomography (spect), is commonly used to evaluate the loss of dopaminergic neurons in the striatum. |
2025-01-24 |
2025-01-27 |
Not clear |
| Xing Xiao, Gagik Yeghiazaryan, Fynn Eggersmann, Anna Lena Cremer, Heiko Backes, Peter Kloppenburg, Anne Christine Hause. Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration. eLife. vol 12. 2025-01-22. PMID:39841059. |
to analyze the functional role of ox1r signaling in dopaminergic neurons, we deleted ox1r specifically in dopamine transporter-expressing neurons of mice and investigated the functional consequences. |
2025-01-22 |
2025-01-24 |
mouse |
| C T M I Issa, R D Castro, K L G D Albuquerqu. Cannabis oil in treating Parkinson's disease: improvement of motor and non-motor symptoms: a case report. Brazilian journal of biology = Revista brasleira de biologia. vol 84. 2025-01-22. PMID:39841751. |
parkinson's disease (pd) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. |
2025-01-22 |
2025-01-25 |
Not clear |
| Si-Sheng Huan. Challenges in the management of visual and tactile hallucinations in elderly people. World journal of psychiatry. vol 15. issue 1. 2025-01-20. PMID:39831009. |
the proposed pathophysiological mechanisms may involve dopaminergic imbalances and dysfunction of the striatal dopamine transporter. |
2025-01-20 |
2025-01-23 |
Not clear |
| Satya Eswari Jujjavarapu, Arnav Mishr. Unravelling the Role of Tyrosine and Tyrosine Hydroxylase in Parkinson's Disease: Exploring Nanoparticle-based Gene Therapies. CNS & neurological disorders drug targets. 2025-01-15. PMID:39812066. |
these dopaminergic neurons are the main source of dopamine, the decline of which is responsible for the symptoms. |
2025-01-15 |
2025-01-17 |
Not clear |
| Ana Marques, Simon Lewi. Impulse control disorders in Parkinson's disease: What's new? Journal of neurology. vol 272. issue 2. 2025-01-15. PMID:39812828. |
icds in pd are primarily associated with dopaminergic treatments, particularly dopamine agonists, though not all patients develop these disorders, indicating a role for genetic and other clinical factors. |
2025-01-15 |
2025-01-17 |
Not clear |
| Dóra Keserű, Tünde Hajnik, Máté Pethő, László Détári, Maarten Van Den Bossche, Attila Tót. Simultaneous activation of different subtypes of dopamine receptors may lead to activation of homeostatic sleep regulatory mechanisms. Pharmacology, biochemistry, and behavior. 2025-01-11. PMID:39798808. |
dopaminergic system gains importance in homeostatic sleep regulation, but the role of different dopamine receptors is not well-defined. |
2025-01-11 |
2025-01-16 |
rat |
| Laurence S Pe, Kristine Cate S Pe, Jiraporn Panmanee, Piyarat Govitrapong, Jenq-Lin Yang, Sujira Mukd. Plausible therapeutic effects of melatonin and analogs in the dopamine-associated pathophysiology of bipolar disorder. Journal of psychiatric research. vol 182. 2025-01-10. PMID:39793267. |
dopamine (da) has been implicated in behavioral regulation, reward systems, and mood, highlighting the importance of the dopaminergic system in bd. |
2025-01-10 |
2025-01-14 |
Not clear |
| Morgan G Stykel, Shehani V Siripala, Eric Soubeyrand, Carla L Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W L So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A Akhtar, Joel C Watts, Scott D Rya. G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis. Cell reports. vol 44. issue 1. 2025-01-08. PMID:39772392. |
loss of dopaminergic neurons in parkinson's disease (pd) is preceded by loss of synaptic dopamine (da) and accumulation of proteinaceous aggregates. |
2025-01-08 |
2025-01-13 |
human |
| Natalie L Johnson, Anamaria Cotelo-Larrea, Lucas A Stetzik, Umit M Akkaya, Zihao Zhang, Marie A Gadziola, Adrienn G Varga, Minghong Ma, Daniel W Wesso. Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior. Nature communications. vol 16. issue 1. 2025-01-03. PMID:39747223. |
here, we report that dopamine release into the ventral striatum in mice is coupled with bouts of sniffing and that stimulation of dopaminergic terminals in these regions drives increases in respiratory rate to initiate sniffing whereas inhibition of these terminals reduces respiratory rate. |
2025-01-03 |
2025-01-05 |
mouse |
| A Asadi Rizi, L Amjad, M Shahrani, H Amini Khoe. Investigating the Mechanisms Involved in Scopolamine-induced Memory Degradation. Archives of Razi Institute. vol 79. issue 3. 2024-12-31. PMID:39736944. |
these autoreceptors are located on dopaminergic presynaptic neurons, and their activation reduces the release of dopamine. |
2024-12-31 |
2025-01-02 |
Not clear |
| Atsushi Fujimoto, Catherine Elorette, Satoka H Fujimoto, Lazar Fleysher, Peter H Rudebeck, Brian E Rus. Pharmacological modulation of dopamine receptors reveals distinct brain-wide networks associated with learning and motivation in non-human primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-12-27. PMID:39730205. |
the neurotransmitter dopamine (da) has a multifaceted role in healthy and disordered brains through its action on multiple subtypes of dopaminergic receptors. |
2024-12-27 |
2024-12-30 |
human |
| Quézia Teixeira Rodrigues, Lucas Rios Drummond, Paulo Marcelo Andrade Lima, Frederico Sander Mansur Machado, Helton Oliveira Campos, Raphael Escorsim Szawka, Laura Hora Rios Leite, Cândido Celso Coimbr. Exercise performance effect of central dopamine is mediated by hypothalamic neuronal activation. Behavioural brain research. vol 480. 2024-12-26. PMID:39722282. |
thus, to evaluate the role of the central dopaminergic system in hypothalamic neuronal activation and its relationship with exercise performance, wistar rats were intracerebroventricularly injected with saline (sal) or sch-23390 (sch, dopamine d1 receptor blocker) at rest and before timed submaximal exercise (∼13 min) or exercise until fatigue. |
2024-12-26 |
2024-12-29 |
rat |
| Talita Rodrigues, Getulio Nicola Bressan, Patrícia Zorzi Juliani, Maria Eduarda Brandli da Silva, Roselei Fachinett. Ketamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD Pharmacology, biochemistry, and behavior. 2024-12-26. PMID:39725040. |
the peroxisome proliferator-activated receptors-gamma (ppar-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of neurotransmitters release like dopamine. |
2024-12-26 |
2024-12-29 |
mouse |
| Judy Cheng, Ellen T Koch, Daniel Ramandi, James P Mackay, Timothy P O'Leary, William Rees-Jones, Lynn A Raymon. Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease. Neurobiology of disease. 2024-12-24. PMID:39716682. |
d2 receptors are also expressed on glutamatergic cortical terminals, cholinergic interneurons, and dopaminergic terminals from substantia nigra where they suppress release of glutamate, acetylcholine and dopamine, respectively, and these cell types may contribute to early striatal dysfunction in hd. |
2024-12-24 |
2024-12-26 |
mouse |
| Aino M Kuusela, Emma A Honkanen, Elina Jaakkola, Elina Myller, Mikael Eklund, Simo Nuuttila, Kirsi-Marja Murtomäki, Tuomas Mertsalmi, Reeta Levo, Toni Ihalainen, Tommi Noponen, Tero Vahlberg, Juho Joutsa, Filip Scheperjans, Valtteri Kaasine. Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus. Movement disorders clinical practice. 2024-12-23. PMID:39714119. |
while previous imaging studies have generally shown normal striatal dopamine transporter (dat) binding in essential tremor (et), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between et and parkinson's disease (pd). |
2024-12-23 |
2024-12-25 |
Not clear |
| Mitchell J Vaughn, Nandini Yellamelli, R Michael Burger, Julie S Haa. Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus. Journal of neurophysiology. 2024-12-20. PMID:39706150. |
although dopaminergic modulation of presynaptic inputs to trn has been described, the direct effect of dopamine on trn neurons and its electrical synapses is largely unknown. |
2024-12-20 |
2024-12-24 |
Not clear |
| Jin Hee Kim, Eugene Huh, Hyeyoon Eo, Jin Se Kim, Youngji Kwon, In Gyoung Ju, Yujin Choi, Hae-Jee Yoon, So-Ri Son, Dae Sik Jang, Seon-Pyo Hong, Hi-Joon Park, Myung Sook O. Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease by suppressing neuroinflammation via JNK signaling. Metabolic brain disease. vol 40. issue 1. 2024-12-19. PMID:39699803. |
in the brains of mptp-induced pd mouse model, tf inhibited the activation of microglia and astrocytes, protected dopaminergic neurons, and increased dopamine levels. |
2024-12-19 |
2024-12-21 |
mouse |
| Thiago Ohno Bezerra, Antonio C Roqu. Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models. PLoS computational biology. vol 20. issue 12. 2024-12-16. PMID:39680609. |
while glutamate released by neurons trigger ca2+ signals through ip3- and glutamate transporter-dependent mechanisms, dopamine released in distant sites activates astrocytes via dopaminergic receptors. |
2024-12-16 |
2024-12-21 |
Not clear |
| Arash Yaghoobi, Homa Seyedmirzaei, Marzie Jamaat, Moein Al. Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease. Heliyon. vol 10. issue 23. 2024-12-10. PMID:39654757. |
striatal dopamine transporter (dat) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across parkinson's disease (pd) spectrum. |
2024-12-10 |
2024-12-12 |
Not clear |