| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
while both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these 2 reward functions is unknown. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
a broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chan. Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion. PLoS biology. vol 22. issue 11. 2024-11-18. PMID:39556592. |
similarly, a more restricted dopaminergic cluster with attractive valence was reliant on dopamine and glutamate; flies avoided opto-inhibition of this narrow subset, indicating the role of this cluster in controlling ongoing behavior. |
2024-11-18 |
2024-11-22 |
drosophila_melanogaster |
| Shobha Kumari, Sakshi Gupta, Rajesh Sukhija, Shaifali Gurjar, Sunil Kumar Dubey, Rajeev Taliya. Neuroprotective potential of Epigenetic modulators, its regulation and therapeutic approaches for the management of Parkinson's disease. European journal of pharmacology. vol 985. 2024-11-15. PMID:39536854. |
the progressive degeneration of dopaminergic neurons in the substantia nigra region of the brain leads to a deficiency of dopamine and, ultimately, the onset of parkinson's disease (pd). |
2024-11-15 |
2024-11-17 |
Not clear |
| Zarah Le Houcq Corbi, Alexander Soutsche. Neural reward system reflects individual value comparison strategy in cost-benefit decisions. Communications biology. vol 7. issue 1. 2024-11-13. PMID:39533059. |
strikingly, manipulating activation in the dopaminergic reward system reveals that dopamine antagonism counteracts the engagement in an individual's dominant value comparison strategy. |
2024-11-13 |
2024-11-17 |
Not clear |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Marcello Serra, Gaia Faustini, Viviana Brembati, Maria Antonietta Casu, Marina Pizzi, Micaela Morelli, Annalisa Pinna, Arianna Bellucc. Early α-synuclein/synapsin III co-accumulation, nigrostriatal dopaminergic synaptopathy and denervation in the MPTPp mouse model of Parkinson's Disease. Experimental neurology. 2024-11-05. PMID:39500391. |
these findings indicate that α-syn/syn iii co-deposition characterizes very early stages of striatal dopaminergic dysfunction in the mptpp model and highlight that vmat2 and syn iii could be two reliable molecular imaging biomarkers to predict dopamine neuron denervation and estimate α-syn-related synaptopathy in prodromal and early symptomatic phases of pd. |
2024-11-05 |
2024-11-08 |
mouse |
| Saeed Kayhanian, Roger A Barke. Dopamine Cell-Based Replacement Therapies. Cold Spring Harbor perspectives in medicine. 2024-11-05. PMID:39500633. |
a conceptually more effective way to treat this aspect of the pd pathology would be to replace the missing dopaminergic system with grafts of new dopamine cells. |
2024-11-05 |
2024-11-08 |
human |
| Wisberty J Gordián-Vélez, Kevin D Browne, Jonathan H Galarraga, Dimple Chouhan, John E Duda, Rodrigo A España, H Isaac Chen, Jason A Burdick, D Kacy Culle. Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Advanced healthcare materials. 2024-11-04. PMID:39494983. |
parkinson's disease is characterized by motor deficits emerging from insufficient dopamine in the striatum after degeneration of dopaminergic neurons and their long-projecting axons comprising the nigrostriatal pathway. |
2024-11-04 |
2024-11-06 |
rat |
| Cong Chen, Tong Wang, Tong-Yao Gao, Ya-Ling Chen, Yun-Bi Lu, Wei-Ping Zhan. Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse. Brain research bulletin. 2024-11-03. PMID:39489186. |
using conditional knockout of the nampt gene in dopaminergic neurons and utilizing a nampt inhibitor in the substantia nigra of mice, we found that the nampt deficiency triggered the time-dependent loss of dopaminergic neurons, the impairment of the dopamine nigrostriatal pathway, and the development of pd-like motor dysfunction. |
2024-11-03 |
2024-11-06 |
mouse |
| Cong Chen, Tong Wang, Tong-Yao Gao, Ya-Ling Chen, Yun-Bi Lu, Wei-Ping Zhan. Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse. Brain research bulletin. 2024-11-03. PMID:39489186. |
in the rotenone-induced pd mouse model, nicotinamide ribose (nr), a precursor of nad, rescued the loss of dopaminergic neurons, the impairment of dopamine nigrostriatal pathway, and mitigated pd-like motor dysfunction. |
2024-11-03 |
2024-11-06 |
mouse |
| Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. |
here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. |
2024-10-29 |
2024-10-31 |
mouse |
| Hans M Dalton, Naomi J Young, Alexys R Berman, Heather D Evans, Sydney J Peterson, Kaylee A Patterson, Clement Y Cho. A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG. PLoS genetics. vol 20. issue 10. 2024-10-28. PMID:39466823. |
loss of both dopamine synthesis and recycling partially rescued the model, suggesting that dopaminergic flux and subsequent binding to d2 receptors is detrimental under dpagt1 deficiency. |
2024-10-28 |
2024-10-31 |
drosophila_melanogaster |
| Erik H Douma, Jesse Stoop, Matthijs V R Lingl, Marten P Smidt, Lars P van der Heid. Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits. Cell & bioscience. vol 14. issue 1. 2024-10-25. PMID:39456033. |
parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the nigrostriatal pathway, leading to dopamine deficiency and motor impairments. |
2024-10-25 |
2024-10-29 |
Not clear |
| Julia Canzian, João V Borba, Cássio M Resmim, Khadija A Mohammed, Camilla W Pretzel, Isaac A Adedara, Denis B Rosember. The dopamine transporter inhibition using GBR 12909 as a novel pharmacological tool to assess bipolar disorder-like neurobehavioral phenotypes in zebrafish. Behavioural brain research. 2024-10-23. PMID:39442564. |
we also emphasize the well-conserved da-mediated signaling in zebrafish and the early expression of dopaminergic biomarkers in the brain, especially focusing on dopamine transporter (dat), the main target of gbr 12909. |
2024-10-23 |
2024-10-26 |
zebrafish |
| Augusta Giglio, Cinzia Valeria Russo, Gabriele Riccio, Simone Braca, Gennaro Cretella, Antonio Stornaiuolo, Luigi Baratto, Enrico Marano, Giuseppe De Michele, Anna De Ros. Prevalence and features of headache in Parkinson's disease: the role of dopamine. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-10-21. PMID:39432180. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, but dopamine also plays a role in the pathophysiology of migraine. |
2024-10-21 |
2024-10-23 |
Not clear |
| Kaitlyn M Roman, Ashok R Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C Savio Chan, H A Jinnah, Ellen J Hes. Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39415987. |
the pattern of mrna dysregulation was specific to dystonia as the adaptations in drd mice were distinct from those in parkinsonian mice where the dopamine deficit occurs in adults, suggesting that the phenotypic outcome is dependent on both the timing of the dopaminergic deficit and the spn-specific adaptions. |
2024-10-17 |
2024-10-19 |
mouse |
| Kaede Ito, Haruka Hosoki, Yuya Kasai, Hiroyuki Sasaki, Atsushi Haraguchi, Shigenobu Shibata, Chihiro Nozak. A Cellulose-Rich Diet Disrupts Gut Homeostasis and Leads to Anxiety through the Gut-Brain Axis. ACS pharmacology & translational science. vol 7. issue 10. 2024-10-17. PMID:39416961. |
additionally, we found that amygdalar dopamine signaling has been modified in crd-fed animals, and the opioid antagonist abolished this dopaminergic modification as well as crd-induced anxiety. |
2024-10-17 |
2024-10-19 |
mouse |
| Yu-Ning Jao, Yu-Jen Chao, Jui-Fen Chan, Yuan-Hao Howard Hs. Mass Spectrometry Analysis of Neurotransmitter Shifting during Neurogenesis and Neurodegeneration of PC12 Cells. International journal of molecular sciences. vol 25. issue 19. 2024-10-16. PMID:39408728. |
in the low-dosage damage process, the amino acids that functioned as dopaminergic pathway precursors could not be absorbed by the cells, and dopamine and l-dopa were secreted and unable to be reuptaken to trigger the cell damage. |
2024-10-16 |
2024-10-18 |
Not clear |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
dopamine is synthesized in the dopaminergic neurons of the sn by the actions of tyrosine hydroxylase (th) and dihydroxyphenylalanine decarboxylase (ddc). |
2024-10-16 |
2024-10-19 |
mouse |