Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wan. Spatial Distribution of Neurons Expressing Single, Double, and Triple Molecular Characteristics of Glutamatergic, Dopaminergic, or GABAergic Neurons in the Mouse Ventral Tegmental Area. Journal of molecular neuroscience : MN. 2023-05-27. PMID:37243808. |
the vta contains three main neuronal populations, namely, dopamine (da), γ-aminobutyric acid (gaba), and glutamate neurons, but some neurons exhibit combinatorial molecular characteristics of dopaminergic, gabaergic, or glutamatergic neurons. |
2023-05-27 |
2023-08-14 |
mouse |
Makito Hirano, Makoto Samukawa, Chiharu Isono, Yoshitaka Naga. The effects of safinamide on dysphagia in Parkinson's disease. PloS one. vol 18. issue 5. 2023-05-25. PMID:37228084. |
the transdermal dopamine agonist rotigotine alleviates dysphagia in patients with pd and is more effective than oral levodopa, suggesting the importance of continuous dopaminergic stimulation (cds) in swallowing. |
2023-05-25 |
2023-08-14 |
Not clear |
Le-le Liu, Yu Han, Zi-Jia Zhang, Yi-Qi Wang, Yu-Wei Hu, Elena Kaznacheyeva, Jian-Qing Ding, Dong-Kai Guo, Guang-Hui Wang, Bin Li, Hai-Gang Re. Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation. Acta pharmacologica Sinica. 2023-05-24. PMID:37225849. |
parkinson's disease (pd) is a common neurodegenerative motor disorder characterized by a dramatic reduction in pars compacta of substantia nigra dopaminergic neurons and striatal dopamine (da) levels. |
2023-05-24 |
2023-08-14 |
mouse |
Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
mechanistically, bh4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ros, maintains neuronal excitability and promotes mitochondrial atp production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical pd animal models, human dopaminergic midbrain-like organoids and primary cells from pd-affected individuals. |
2023-05-23 |
2023-08-14 |
mouse |
Peiyu Xu, Sijie Huang, Brian E Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xinheng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L Roth, H Eric X. Structural genomics of the human dopamine receptor system. Cell research. 2023-05-23. PMID:37221270. |
the dopaminergic system, including five dopamine receptors (d1r to d5r), plays essential roles in the central nervous system (cns); and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders, including parkinson's disease (pd) and schizophrenia. |
2023-05-23 |
2023-08-14 |
human |
María Elena Quintanilla, Yedy Israe. Role of Metabolism on Alcohol Preference, Addiction, and Treatment. Current topics in behavioral neurosciences. 2023-05-23. PMID:37221350. |
studies presented in this chapter show that: (1) in the brain, ethanol is metabolized by catalase to acetaldehyde, which condenses with dopamine forming salsolinol; (2) acetaldehyde-derived salsolinol increases the release of dopamine mediating, via opioid receptors, the reinforcing effects of ethanol during the acquisition of ethanol consumption, while (3) brain acetaldehyde does not influence the maintenance of chronic ethanol intake, it is suggested that a learned cue-induced hyperglutamatergic system takes precedence over the dopaminergic system. |
2023-05-23 |
2023-08-14 |
Not clear |
Hannah R Stutt, Matthew A Weber, Rachael C Cole, Alexandra S Bova, Xin Ding, Madison S McMurrin, Nandakumar S Narayana. Sex similarities and dopaminergic differences in interval timing. bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205472. |
because dopamine powerfully affects interval timing, we also examined sex differences with drugs targeting dopaminergic receptors. |
2023-05-19 |
2023-08-14 |
human |
Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
a well-established dopamine replacement therapy for pd is based on dopamine deficiency, primarily due to dopaminergic neuronal loss in the substantia nigra. |
2023-05-17 |
2023-08-14 |
Not clear |
Yuji Saitoh, Kazushi Takahash. [Current Pharmacological Treatment for Parkinson's Disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 5. 2023-05-17. PMID:37194511. |
current dopaminergic pharmacotherapy for pd consists of levodopa and other dopaminergic drugs, such as a dopamine agonist (da) and monoamine oxidase b (maob) inhibitor, and patients with pd are administered these mainly according to age, disability of parkinsonism, and tolerance of the drugs. |
2023-05-17 |
2023-08-14 |
Not clear |
Jie Sun, Xiao-Min Lin, Dan-Hua Lu, Meng Wang, Kun Li, Sheng-Rong Li, Zheng-Qiu Li, Cheng-Jun Zhu, Zhi-Min Zhang, Chang-Yu Yan, Ming-Hai Pan, Hai-Biao Gong, Jing-Cheng Feng, Yun-Feng Cao, Feng Huang, Wan-Yang Sun, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Gen-Long Jiao, Li Zhang, Rong-Rong H. Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. The Journal of clinical investigation. vol 133. issue 10. 2023-05-15. PMID:37183824. |
midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons. |
2023-05-15 |
2023-08-14 |
mouse |
Maksym Galkin, Oleksandra Topcheva, Anastasiia Priss, Tatiana Borisova, Volodymyr V Shvadcha. Dopamine-Induced Oligomers of α-Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity. ACS chemical neuroscience. 2023-05-10. PMID:37162160. |
current treatment involves approaches that compensate the death of dopaminergic neurons by increasing the dopamine levels in remaining cells. |
2023-05-10 |
2023-08-14 |
rat |
Mahesh Rachamalla, Arash Salahinejad, Maria Khan, Ashok Kumar Datusalia, Som Niyog. Chronic dietary exposure to arsenic at environmentally relevant concentrations impairs cognitive performance in adult zebrafish (Danio rerio) via oxidative stress and dopaminergic dysfunction. The Science of the total environment. 2023-05-10. PMID:37164085. |
dopaminergic system in the brain is known to play a critical role in regulating cognitive behaviours in fish, and our observations suggested that chronic dietary treatment with medium and high arsenic doses leads to significant alterations in the expression of genes involved in dopamine signalling (dopamine receptors), synthesis (thyroxine hydroxylase) and metabolism (monoamine oxidase) in the zebrafish brain. |
2023-05-10 |
2023-08-14 |
zebrafish |
D Woitalla, C Buhmann, R Hilker-Roggendorf, G Höglinger, J Koschel, T Müller, D Weis. Role of dopamine agonists in Parkinson's disease therapy. Journal of neural transmission (Vienna, Austria : 1996). 2023-05-10. PMID:37165120. |
the occurrence of side effects can be explained by the different receptor affinity to the individual dopaminergic and non-dopaminergic receptors of the individual dopamine agonists. |
2023-05-10 |
2023-08-14 |
Not clear |
Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang, Hsiung-Lin T. Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection. ACS sensors. 2023-05-08. PMID:37155824. |
dopamine (da) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
Joanne Ng, Serena Barral, Simon N Waddington, Manju A Kuria. Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases. Movement disorders : official journal of the Movement Disorder Society. 2023-05-06. PMID:37147851. |
here, we review recent advances in gene therapy, focused on the targeted delivery of dopaminergic genes for parkinson's disease and the primary neurotransmitter disorders, aadc deficiency and dopamine transporter deficiency syndrome (dtds). |
2023-05-06 |
2023-08-14 |
Not clear |
P Tall, M A Qamar, L Batzu, V Leta, C Falup-Pecurariu, K Ray Chaudhur. Non-oral continuous drug delivery based therapies and sleep dysfunction in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-05-01. PMID:37126118. |
cdd aims to mimic the physiological tonic dopamine release from striatal dopaminergic neurons and thus reduces the severity and duration of motor and non-motor fluctuations partly related to pulsatile levodopa stimulation. |
2023-05-01 |
2023-08-14 |
Not clear |
Emily C Mahoney-Rafferty, Heidi R Tucker, Kainat Akhtar, Rachael Herlihy, Aliyah Audil, Dia Shah, Megan Gupta, Eliyahu M Kochman, Paul J Feustel, Eric S Molho, Julie G Pilitsis, Damian S Shi. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats. Neuroscience. 2023-04-28. PMID:37116741. |
limited research suggests that dopaminergic signaling exists in the cerebellum with functional dopamine receptors, tyrosine hydroxylase (th) and dopamine transporters (dats); however, much of this information is largely derived from healthy animals and humans. |
2023-04-28 |
2023-08-14 |
rat |
Thomas Akam, Mark E Walto. What is dopamine doing in model-based reinforcement learning? Current opinion in behavioral sciences. vol 38. 2023-04-21. PMID:37082448. |
here we examine two possible accounts for dopamine's involvement in model-based rl: the first that dopamine neurons carry a prediction error used to update a type of predictive state representation called a successor representation, the second that two well established aspects of dopaminergic activity, rpes and surprise signals, can together explain dopamine's involvement in model-based rl. |
2023-04-21 |
2023-08-14 |
Not clear |
Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn D R Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yi. Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement. eLife. vol 12. 2023-04-21. PMID:37083584. |
these neurons are located in the dentate gyrus, receive dopaminergic projections from the locus coeruleus, and express d1 dopamine receptors. |
2023-04-21 |
2023-08-14 |
mouse |
Renata Aparecida Nedel Pertile, Rachel Brigden, Vanshika Raman, Xiaoying Cui, Zilong Du, Darryl Eyle. Vitamin D: A potent regulator of dopaminergic neuron differentiation and function. Journal of neurochemistry. 2023-04-21. PMID:37084159. |
here we provide further evidence of vitamin d's role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein redistribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including sh-sy5y cells, primary mesencephalic cultures and mesencephalic/striatal explant co-cultures. |
2023-04-21 |
2023-08-14 |
Not clear |